ISMRM 23rd Annual Meeting
& Exhibition • 30 May - 05 June 2015 • Toronto, Ontario, Canada |
Note: The videos
below are only the slides from each presentation. They do not have
audio. |
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Tuesday 2 June 2015
Exhibition Hall |
16:00 - 17:00 |
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Computer # |
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3810. |
1 |
Radiation induced hypoxia
in TRAMP tumor detected using BOLD MRI - permission withheld
Yu-Chun Lin1, Gigin Lin1, Chun-Chieh
Wang2, and Jiun-Jie Wang3
1Department of Diagnostic Radiology, Chang
Gung Memorial Hospital, Linkou, Taiwan, Taiwan, 2Department
of Radiation Oncology, Chang Gung Memorial Hospital,
Linkou, Taiwan, 3Department
of Medical Imaging and Radiological Sciences, Chang Gung
University, Yaoyuan, Taiwan
This study monitored the changes of microvasculature and
hypoxia after radiotherapy in TRAMP tumor using carbogen
challenging BOLD MRI. A single dose irradiation was
delivered in peripheral half of the tumor. The BOLD
response to carbogen in the irradiated portion decreased
compared with the non-irradiated portion. The
immunohistochemistry images of CD31 and pimonidazole
showed less hypoxia in the irradiated portion, while a
trend of acute hypoxia in the non-irradiated region was
noticed to shift to chronic hypoxia in the irradiated
region. Carbogen-challenging BOLD MRI can be used to
detect the hypoxic change within a tumor in response to
radiotherapy
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3811. |
2 |
Biomarkers of Aggressive
Breast Cancer Revealed by Combining Magnetic Resonance
Spectroscopic Imaging and Mass Spectrometric Imaging - permission withheld
Lu Jiang1, Kamila Chughtai2,
Tiffany Greenwood1, Zaver M. Bhujwalla1,
Venu Raman1, Gert Eijkel2, Ron
Heeren2, and Kristine Glunde1
1Department of Radiology, Johns Hopkins
University School of Medic, BALTIMORE, MD, United
States, 2FOM-Institute
AMOLF, Amsterdam, Netherlands
The total choline (tCho) signal in magnetic resonance
spectroscopic imaging (MRSI) of tumors is a potential
biomarker of breast cancer aggressiveness and can be
visualized in vivo by H1 MRSI tCho maps. Mass
spectrometry imaging (MSI) of histologic tumor sections
is able to detect thousands of biomolecules, including
tryptic peptides from on-tissue digested proteins, from
the tissue surface. We have investigated differentially
regulated proteins in high- versus low-tCho regions in a
human breast cancer model by combining in vivo MRSI with
ex vivo MSI, which identified specific protein species
that are spatially correlated with tCho.
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3812. |
3 |
In vivo Lactate
T1 and
T2 Relaxation
Times in Preclinical Cancer Models – Absolute Quantification
of Tumor Lactate ![](play.gif)
Ellen Ackerstaff1, H. Carl LeKaye1,
Natalia Kruchevsky1, Kristen L. Zakian1,
Nirilanto Ramamonjisoa1, Ekaterina Moroz1,
Inna S. Serganova1, Ronald G. Blasberg1,
and Jason A. Koutcher1
1Memorial Sloan Kettering Cancer Center, New
York, NY, United States
Increased lactate has been associated with aggressive,
treatment-resistant tumors. To quantify in
vivo lactate
from MR spectra acquired using lactate-editing, knowing in
vivo lactate
T1 and
T2 relaxation
times is essential. Preclinically, accurate in
vivo T1 and
T2 values
are difficult to obtain and few are reported. We aim to
fill this void. We found similar T1 and
T2 values
for two prostate cancer models, which were lower than
previously reported values in other cancers. We now
expand our studies to include more tumor models for our
future research studying the role of lactate in tumor
development, progression, and treatment response.
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3813. |
4 |
Comparison of APT- and
NOE-CEST in rat glioma at 7 T– Potentials for tumor
characterization and detection of tumor cell infiltration ![](play.gif)
Mona Salehi Ravesh1, Monika Huhndorf2,
Amir Moussavi1, Kristin Koetz1,
Judith Becker1, Kirsten Hattermann3,
and Susann Boretius1
1Clinic of Radiology and Neuroradiology,
Section Biomedical Imaging, Kiel, Schleswig-Holstein,
Germany, 2Department
of Radiology and Neuroradiology, Schleswig-Holstein,
Germany, 3Christian-Albrechts-University
of Kiel, Anatomical Institute, Schleswig-Holstein,
Germany
Amide proton transfer (APT) and the Nuclear Overhauser
Enhancement (NOE) have emerged as potential new imaging
contrasts. Here we applied these techniques on a glioma
model in rats. Maps of the magnetization transfer rate,
both at -3.5 ppm and +3.5 ppm, revealed a reduction of
the MTR in the tumor. NOE-CEST however revealed
additional information about the tumor boundaries. Thus,
NOE-CEST MRI may confer specific benefits in the
detection and characterization of glioblastoma in
patients.
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3814. |
5 |
cPLA2IVA inhibition in
basal-like breast cancer: Reduced tumor growth with
metabolic, vascular and gene expression changes ![](play.gif)
Hanna Maja Tunset1, Eugene Kim1,
Jana Cebulla1, Muhammad Riyas Vettukattil1,
Astrid Jullumstrø Feuerherm2, Berit Johansen 2,
Tone Frost Bathen1, and Siver Andreas Moestue1
1MR Cancer Group, Department of Circulation
and Medical Imaging, Norwegian University of Science and
Technology, Trondheim, Norway, 2Avexxin
AS, Department of Biology, Norwegian University of
Science and Technology, Trondheim, Norway
The cPLA2IVA gene PLA2G4A is highly expressed in
aggressive basal-like breast cancer (BLBC) and may be
represent a new therapeutic target. 1H HR MAS MRS, µCT,
and gene expression analysis were used to explore the
effect of cPLA2IVA inhibition in BLBC xenografts.
Treatment significantly inhibited tumor growth and
induced early favorable metabolic changes (higher PCho,
lower GPC), intermediate anti-angiogenic effects
(smaller vessels, avascular regions), and late gene
expression changes (up-regulated transcription and
translation, possibly apoptosis). Thus, cPLA2IVA
inhibition may represent a novel strategy for targeted
treatment of BLBC
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3815. |
6 |
Spectroscopic imaging with
hyperpolarized [1-13C]pyruvate shows an elevated
lactate/pyruvate ratio in contrast enhancing and
non-enhancing brain tumors of orthotopic patient-derived
xenograft models of glioblastoma. ![](play.gif)
Richard Mair1,2, Alan Wright1,
Kieren Allinson3, Tiago Rodrigues1,
Colin Watts2, and Kevin Brindle1
1CRUK Cambridge Institute, University of
Cambridge, Cambridge, Cambridgeshire, United Kingdom, 2Division
of Neurosurgery, University of Cambridge, Cambridge,
Cambridgeshire, United Kingdom, 3Department
of Pathology, Cambridge University Hospitals NHS
Foundation Trust, Cambridgeshire, United Kingdom
Glioblastoma is the most common
human-primary-intracranial neoplasm and has the worst
prognosis. Novel orthotopic patient-derived xenograft
models that recapitulate the pathophysiological
phenotype of the disease allow development of novel
imaging modalities for downstream clinical applications
in treatment planning and monitoring. We demonstrate
that 13C
magnetic resonance spectroscopic imaging with
hyperpolarized [1-13C]pyruvate shows the
presence of tumor through an elevated lactate/pyruvate
ratio in both contrast enhancing and non-enhancing brain
tumor lesions including areas where tumor is
undetectable on T2weighted MRI but present on
histology.
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3816. |
7 |
Magnetization transfer
imaging in a mouse model of orthotopic pancreatic cancer ![](play.gif)
Amir Moussavi1, Kristin Koetz1,
Sanjay Tiwari1, and Susann Boretius1
1Section Biomedical Imaging, Department of
Radiology and Neuroradiology,
Christian-Albrechts-University, Kiel, Germany
Pancreatic ductal adenocarcinoma (PDAC) is still among
the most devastating types of cancer characterized by
infiltrative growth often with extensive fibrosis, the
latter being an important predictor of poor chemotherapy
response. In an orthotopic mouse model of PDAC with
variable degree of fibrosis, we established and
evaluated in-vivo radial imaging with magnetization
transfer weighting. MT saturation correcting the
MT-weighted signal for signal amplitude and T1
relaxation allowed quantification of tumor associated
desmoplasia. Transfer of these methods to humans may
allow individualized adjustments of chemotherapy.
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3817. |
8 |
In vivo Monitoring of
Enzyme Activity in a Transgenic Breast Cancer Model with
Hyperpolarized C-13 Metabolic Activity Decomposition MRSI ![](play.gif)
Zihan Zhu1,2, Peter J. Shin1,2,
Christine Leon Swisher3, Peder E.Z. Larson1,2,
Hsin-Yu Chen1,2, Hong Shang1,2,
Eugene Milshteyn1,2, Robert A. Bok1,
Andrei Goga4, and Daniel B. Vigneron1,2
1Department of Radiology and Biomedical
Imaging, University of California, San Francsico, San
Francisco, CA, United States, 2UC
Berkeley-UCSF Graduate Program in Bioengineering, San
Francisco, CA, United States, 3Massachusetts
General Hospital and Harvard Medical School, MA, United
States, 4Department
of Cell and Tissue Biology, University of California,
San Francsico, San Francisco, CA, United States
Molecular imaging with hyperpolarized C-13 substrates
provides valuable metabolic exchange information
non-invasively. In this work, the dynamic Metabolic
Activity Decomposition Stimulated-echo Acquisition Mode
(MAD-STEAM) sequence was applied to a switchable
oncogene-driven breast cancer mouse model. The results
showed the feasibility of using MAD-STEAM to detect
enzymatic activity changes within tumor and demonstrated
its potential to monitor tumor progression and
regression.
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3818. |
9 |
Multi-Parametric mpMRI to
Characterize Brain and Bone Metastases in Disseminated
Breast Cancer ![](play.gif)
Natalie Julie Serkova1, Diana M Cittelly1,
Kendra M Huber1, and Carol A Sartorius1
1University of Colorado Anschutz Medical
Center, Aurora, Colorado, United States
Non-invasive multiparametric mpMRI of multifocal
metastatic breast cancer provides characteristic MRI
signatures for brain versus bone lesions in a mouse
model of disseminated breast cancer. Brain metastatic
phenotype is characterized by low vascularity and cell
density as revealed by low Ktrans and ADC values,
respectively. In future, quantitative mpMRI end-points
have potential to stratify patients into “smart”
targeted treatment regimens based on a particular tumor
radiologiocal profile.
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3819. |
10 |
Source-based nosologic
imaging of response to therapy in pre-clinical glioblastoma ![](play.gif)
Sandra Ortega-Martorell1,2, Ivan Olier3,
Teresa Delgado-Goñi4, Magdalena Ciezka2,5,
Ana Paula Candiota2,5, Margarida Julià-Sapé2,5,
Martí Pumarola2,5, Paulo Lisboa1,
and Carles Arús2,5
1Liverpool John Moores University, Liverpool,
Merseyside, United Kingdom, 2Networking
Research Center on Bioengineering, Biomaterials and
Nanomedicine, CIBER-BBN, Cerdanyola del Vallès, Spain, 3The
University of Manchester, Manchester, United Kingdom, 4The
Institute of Cancer Research, London, United Kingdom, 5Universitat
Autònoma de Barcelona, Cerdanyola del Vallès, Spain
A source-based extraction method is shown to produce
nosological images allowing convenient non-invasive
tracking of preclinical GBM response to therapy. The
source-based classifier was developed from a training
set of 14 C57Bl/6 mice harbouring GL261 GBM and
validated in a further independent set of 24 additional
mice using comparison with post-sacrifice
histopathology.
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3820. |
11 |
Evaluation of metronomic
chemotherapy in a mouse model using DCE-MRI and DWI ![](play.gif)
Melanie Freed1,2, Kerryanne Winters1,2,
Jin Zhang1,2, and Sungheon G. Kim1,2
1Center for Advanced Imaging Innovation and
Research (CAI2R), Dept. Radiology, NYU School of
Medicine, New York, NY, United States, 2Bernard
and Irene Schwartz Center for Biomedical Imaging, Dept.
Radiology, NYU School of Medicine, New York, NY, United
States
Metronomic chemotherapy is a promising method that
delivers chemotherapy in low, frequent doses and has
been shown to demonstrate superior response over
traditional chemotherapy in some cases. There is a need
to develop mouse models and techniques for evaluating
dose and scheduling of metronomic chemotherapy to
optimize its usage and benefits. In this study, we
investigate the use of DCE-MRI and DWI to evaluate
metronomic chemotherapy of BALB/c mice with implanted
4T1 mouse mammary tumor cells. Our data suggests this
may be a good model for advanced breast cancer and that
ADC values may be sensitive to early therapy response.
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3821. |
12 |
Molecular MR imaging of
micrometastasis of breast cancer ![](play.gif)
Zhuxian Zhou1, Mohammed Qutaish1,
Zheng Han1, Rebecca Schur1, David
Wilson1, and Zheng-Rong Lu1
1Department of Biomedical Engineering, Case
Western Reserve University, Cleveland, Ohio, United
States
We evaluated a targeted contrast agent
CREKA-Tris(Gd-DOTA)3 for MR molecular imaging of breast
cancer micrometastases.
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Tuesday 2 June 2015
Exhibition Hall |
16:00 - 17:00 |
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Computer # |
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3822. |
13 |
MRI-based measurement of
tissue O2 ![](play.gif)
Scott C. Beeman1, Ying-Bo Shui2,
John A. Engelbach1, Joseph J.H. Ackerman1,3,
and Joel R. Garbow1
1Radiology, Washington University, Saint
Louis, Missouri, United States, 2Ophthalmology,
Washington University, Saint Louis, Missouri, United
States,3Chemistry, Washington University,
Saint Louis, Missouri, United States
Diatomic oxygen (O2), as found dissolved in
tissue, is a critical component in aerobic metabolism
and a fundamental determinant of physiological
functional status. Reliable, non-invasive methods for
measuring tissue O2 content
are lacking. We quantify the relaxivity of brain-tissue
O2 and,
subsequently, changes in brain-tissue oxygenation in
healthy brain, radiation lesions, and tumor lesions. By
quantifying the change in brain tissue oxygenation with
MRI, we were able to differentiate tumor lesions from
radiation necrosis lesions – two pathologies that have
proven extremely difficult to differentiate with common
radiological techniques.
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3823. |
14 |
In vivo MRI-based 3-D
Printed Molds and Individualized Tissue Sectioning
Apparatuses Improve MRI-Histopathologic Co-Registration in
Brain Cancer Patients ![](play.gif)
Alexander E. Salmon1, Brian J. Pellatt2,
Nikolai J. Mickevicius3, Elizabeth J. Cochran4,
and Peter S. LaViolette5
1Neuroscience, Medical College of Wisconsin,
Milwaukee, WI, United States, 2Medical
College of Wisconsin, Milwaukee, WI, United States, 3Biophysics,
Medical College of Wisconsin, Milwaukee, WI, United
States, 4Pathology,
Medical College of Wisconsin, Milwaukee, WI, United
States, 5Radiology,
Medical College of Wisconsin, Milwaukee, WI, United
States
Precise co-registration of brain tissue and medical
imaging is critical for validation of novel imaging
biomarkers. Brain tissue distortion during fixation and
traditional brain sectioning techniques may complicate
co-registration. To prevent tissue distortion, a
clinical MRI-based mesh mold was 3D-printed for use
during fixation. To obtain representative axial cuts, an
individualized tissue sectioning apparatus was designed
from a high resolution clinical scan and the slice
profile of 6.5mm images. After sectioning, consistency,
and co-registration error was analyzed by AFNI. Using a
layer resolution of 0.40mm, printing cost for each brain
was approximately $61 and printing duration was
approximately 38 hours.
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3824. |
15 |
Gadolinium-free
extracellular MR contrast agent for tumor imaging - permission withheld
Joris Tchouala Nofiele1, Inga E Haedicke2,
Yong Le Zhu2, Xiao-an Zhang2, and
Hai-Ling Margaret Cheng1,3
1Hospital for Sick Children, Toronto,
Ontario, Canada, 2Chemistry,
University of Toronto, Toronto, Ontario, Canada, 3Institute
of Biomaterials & Biomedical Engineering, University of
Toronto, Toronto, Ontario, Canada
Contrast administration is integral to tumor diagnostic
imaging, and gadolinium (Gd)-based contrast agents are
the current approved standard for clinical workflow.
However, a number of patients, particularly those with
impaired kidney function, are exempt from the benefits
of a contrast-enhanced examination. In this study, we
investigate the potential of a recently described novel
extracellular and renally filtered manganese porphyrin
T1 agent for tumor imaging. Results in tumor-bearing
rats demonstrate that the new agent, MnTCP, exhibits
similar pharmacokinetics but provides consistently
greater enhancement than Gd-DTPA. MnTCP can potentially
provide contrast-enhanced MRI for tumor diagnosis in a
broader patient base.
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Tuesday 2 June 2015
Exhibition Hall |
16:00 - 17:00 |
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Computer # |
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3825. |
16 |
Monitoring gas-induced
haemodynamic changes in the breast with BOLD contrast ![](play.gif)
Tess Catherwood1, Andrew Patterson1,
Martin Graves1, Reem Bedair1, Roie
Manavaki1, Mary McLean2, John
Griffiths2, and Fiona Gilbert1
1Radiology, Cambridge University Hospitals
NHS Foundation Trust, Cambridge, Cambridgeshire, United
Kingdom, 2Cancer
Research UK Cambridge Institute, Cambridge,
Cambridgeshire, United Kingdom
BOLD contrast MRI with hyperoxic gas challenge may
provide a biomarker of breast tumour oxygenation and
vascular function, with the potential to predict
treatment response. This study measured the strength of
BOLD response to ‘carbogen-light’ (2% CO2)
interleaved with medical air and oxygen, compared to an
all-air control, in six healthy volunteers.
‘Carbogen-light’ was effective in inducing a measurable
BOLD effect with respect to background physiological
noise, without the respiratory discomfort often reported
with 5% CO2 mixtures.
In general ‘carbogen-light’ versus oxygen induced a
larger response, consistent with the opposing
vasomodulatory effects of these two stimuli.
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3826. |
17 |
Quantitative assessment of
procedure success in MR-guided breast biopsy exams ![](play.gif)
Xiaofeng Liu1, E Morris2, Robert
Darrow1, and Ileana Hancu1
1GE Global Research, Niskayuna, NY, United
States, 2Memorial
Sloan Kettering Cancer Center, NY, United States
Many factors contribute to MR-guided breast biopsy
procedure success or failure. Significantly, there is no
immediate verification of specimen retrieval and no
quantitative measures to indicate adequate removal of
the enhancing lesion. This work demonstrates a tool
enabling quantitative assessment of success of MR-guided
breast biopsy. Results from 4 patients indicated that
the ratio between volumes of the suspicious lesion and
total tissue removed in a biopsy procedure averaged 52%,
ranging from 4% to 99%. The availability of real time
quantitative assessment of lesion removal, prior to
procedure completion, should enable improved
verification of lesion sampling.
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3827. |
18 |
Accurate Discrimination of
Benign and Malignant Breast Cancer in Suspicious Tumors
Based on Semi-Quantitative DCE-MRI Employing Support Vector
Machine ![](play.gif)
Saeedeh Navaei Lavasani1,2, Masoomeh Gity3,
Mahnaz Nabil1,4, Anahita Fathi Kazerooni1,2,
and Hamidreza Saligheh Rad1,2
1Quantitative MR Imaging and Spectroscopy
Group, Research Center for Molecular and Cellular
Imaging, Tehran University of Medical Sciences, Tehran,
Iran,2Department of Medical Physics and
Biomedical Engineering, School of Medicine, Tehran
University of Medical Sciences, Tehran, Iran, 3Department
of Radiology, School of Medicine, Tehran University of
Medical Sciences, Tehran, Iran, 4Department
of Statistics, Tarbiat Modares University, Tehran, Iran
Dynamic Contrast Enhanced-Magnetic Resonance Imaging
(DCE-MRI) is widely used as sensitive tool in breast
tumor diagnosis. Interpretation of breast MRI requires
focusing not only on morphologic changes, but also on
the quantification of the areas with increased
enhancement. In this setting, accurate selection of
quantitative parameters and classification approach
could result in reliable tumor differentiation. We
propose an accurate approach, based on support vector
machine classification of dynamic features of suspicious
tumors within the breast to discriminate malignant or
benign breast lesions.
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3828. |
19 |
Evaluation of Benign and
High-Risk, Nonmalignant Breast Lesions, assessed as
False-Positive at Contrast-Enhanced (CE) MRI using DW
imaging and CE MR Imaging Features ![](play.gif)
Sunitha B Thakur1, Jung Hun Oh2,
Milans Soledad2, Harini Veeraraghavan2,
Merlin M Gnanasigamani2, Elizabeth J Sutton2,
Joseph O Deasy2, and Elizabeth A Morris2
1Memorial Sloan Kettering Cancer Center, New
York, NY, United States, 2Memorial
Sloan Kettering Cancer Center, NY, United States
Lesions that are classified ‘high-risk’ typically
require complete surgical excision; a procedure that is
expensive and can cause anxiety and morbidity.
Therefore, the ability to distinguish between lesions,
especially to differentiate the high-risk benign group
from other benign lesions would be extremely helpful in
a clinical setting. We conducted this study in order to
evaluate the imaging characteristics of non-malignant
lesions and classify them using (i) apparent diffusion
coefficient (ADC) values, (ii) morphological and (iii)
texture-based image features derived from contrast
enhanced magnetic resonance imaging. We used 3.0T MRI
data from 111 women and found that lower ADC values
appear to correlate with high-risk breast lesions. This
study is useful because it probes the concept of
distinguishing not just between malignant and benign
lesions but goes further to classify benign lesions into
subgroups that could be treated differently at the
clinical level.
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3829. |
20 |
Accurate Segmentation of
Breast Lesions Based on Wavelet Kinetics: Comparison with
Semi-Quantitative Features ![](play.gif)
Saeedeh Navaei Lavasani1,2, Masoomeh Gity3,
Anahita Fathi Kazerooni1,2, and Hamidreza
Saligheh Rad1,2
1Quantitative MR Imaging and Spectroscopy
Group, Research Center for Molecular and Cellular
Imaging, Tehran University of Medical Sciences, Tehran,
Iran,2Department of Medical Physics and
Biomedical Engineering, School of Medicine, Tehran
University of Medical Sciences, Tehran, Iran, 3Department
of Radiology, School of Medicine, Tehran University of
Medical Sciences, Tehran, Iran
Breast cancer is a significant public health problem in
the world. Automatic and objective analysis of DCE-MRI
studies can greatly assist the radiologist to gain
accurate evaluation of tumor size, malignancy and
perfusion in the surrounding tissues, which is essential
in diagnosis. In this work, we proposed breast lesion
segmentation by means of fuzzy c-means clustering
technique using wavelet kinetic and semi-quantitative
features, extracted from the pixel-based time-signal
intensity curves.
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3830. |
21 |
Fast bilateral breast
coverage with high spectral and spatial resolution (HiSS)
MRI at 3T ![](play.gif)
Milica Medved1, William A Weiss1,
Hiroyuki Abe1, Gillian M Newstead1,
Olufunmilayo I Olopade2, Maryellen L Giger1,
and Gregory S Karczmar1
1Department of Radiology, University of
Chicago, Chicago, Illinois, United States, 2Department
of Medicine, University of Chicago, Chicago, Illinois,
United States
High spectral and spatial resolution (HiSS) MR imaging
provides excellent diagnostic images of breast cancer
even without the use of contrast agent. We report on a
fast implementation of HiSS MRI using parallel imaging
at 3T to achieve clinically feasible imaging times in <
2 mm3 voxels,
with full bilateral coverage. Non-contrast HiSS MRI can
be used to obtain images of lesions without artifacts
resulting from contrast administration. In addition,
spectral information obtained with HiSS MRI can be used
to improve detection of small amounts of glandular
tissue and improve breast density measurements in risk
assessment studies.
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3831. |
22 |
Prediction of neoadjuvant
therapy response using multiparametric MRI at 3T ![](play.gif)
Lenka Minarikova1, Wolfgang Bogner1,
Katja Pinker-Domenig2, Thomas Helbich2,
Siegfried Trattnig1, and Stephan Gruber1
1MRCE, Department of Biomedical Imaging and
Image-guided Therapy, Medical University of Vienna,
Vienna, Austria, 2Division
of Molecular and Gender Imaging, Department of
Biomedical Imaging and Image-guided Therapy, Medical
University of Vienna, Vienna, Austria
Response prediction during neoadjuvant chemotherapy
(NAC) should have an important role in therapy plan
modifications, which would result in increase of
disease-free survival. In our study we measured breast
cancer patients in three time points: before, during and
after the NAC, using DCE and DWI MRI at 3T to look for
potentially better response prediction markers. Our
results suggest that multiparametric data measured
during the ongoing NAC correspond better with
histopathologic outcome than data measured after NAC
completion. However, mean ADC values alone didn’t show
any outcome prediction ability.
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3832. |
23 |
Fat suppression techniques
for high resolution breast DCE MRI at 7 tesla: a qualitative
and quantitative comparison ![](play.gif)
Tijl A. van der Velden1, Alexander M. Th.
Schmitz1, Kenneth G.A. Gilhuijs1,
Wouter B. Veldhuis1, Peter R. Luijten1,
Vincent O. Boer1, and Dennis W.J. Klomp1
1Radiology, University Medical Center
Utrecht, Utrecht, Utrecht, Netherlands
Fat suppression is essential in high-resolution DCE-MRI
of the breast. While chemical shift selective excitation
(i.e. ProSet) is sensitive to magnetic field
distortions, Dixon techniques may be sensitive to T2* effects
due to their multi echo acquisition (ME-Dixon), or to
motion when applied as multi acquisition (MA-Dixon). In
this study, we investigated the efficiency of these fat
suppression techniques at ultra-high resolutions
obtained at 7 tesla. In ten healthy volunteers ProSet
revealed structural details that were not observed with
Dixon. Despite a non-uniform fat suppression of ProSet,
the technique remains superior in CNR and time
efficiency over other techniques.
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3833. |
24 |
Statistical Assessment of
Diffusion Weighted Signal Decay in Breast Cancer Tumors at
3T: Mono-exponential or Bi-exponential? ![](play.gif)
Jing Yuan1, Gladys G. Lo2, Oi Lei
Wong1, Helen H.L. Chan2, Abby Y.
Ding1, Ting Ting Wong3, and Polly
S.Y. Cheung3
1Medical Physics and Research Department,
Hong Kong Sanatorium & Hospital, Happy Valley, Hong
Kong, China, 2Department
of Diagnostic & Interventional Radiology, Hong Kong
Sanatorium & Hospital, Happy Valley, Hong Kong, China, 3Breast
Care Center, Hong Kong Sanatorium & Hospital, Happy
Valley, Hong Kong, China
This study prompts to rigorously assess and
statistically compare DWI signal fitting in malignant
breast tumor by using mono-exponential ADC model and
bi-exponential intra-voxel incoherent motion (IVIM)
model via F-test. ROI-averaged analysis showed that more
tumors (n=24) were significantly better fitted by
bi-exponential than by mono-exponential models (n=14).
In contrast, voxel-wise analysis showed that more voxels
presented mono-exponential DWI signal decay in tumors.
With clinically achievable SNR, IVIM-MRI should be
helpful for ROI-averaged DWI fitting to characterize
tumor microvascularity while voxel-wise IVIM values
should be carefully interpreted with caution due to
possible inaccuracy and high uncertainty.
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Tuesday 2 June 2015
Exhibition Hall |
16:00 - 17:00 |
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Computer # |
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3834.
![](http://www.ismrm.org/15/program_files/MAGNA25.jpg) |
25 |
Impact of Temporal
Resolution on Diagnostic Performance of Quantitative DCE-MRI
of Prostate Cancer: Evaluation using a Novel Golden-Angle
Radial Compressed-Sensing Sequence and Single Contrast
Injection ![](play.gif)
Nainesh Parikh1, Justin Ream1,
Tobias Block2, Weisheng Xu3, Hersh
Chandarana1, Li Feng2, Samir
Taneja4, and Andrew Rosenkrantz1
1Radiology, NYU School of Medicine, New York,
NY, United States, 2Radiology,
Center for Advanced Imaging Innovation and Research NYU
School of Medicine, New York, NY, United States, 3Pathology,
NYU School of Medicine, New York, NY, United States, 4Urologic
Oncology, NYU School of Medicine, New York, NY, United
States
We used a novel DCE-MRI sequence [Golden-angle RAdial
Sparse Parallel (GRASP)] that employees compressed
sensing and continuous radial acquisition to
retrospectively reconstruct prostate DCE-MRI data
obtained after a single contrast injection at temporal
resolutions varying between approximately 1 and 10
seconds. The temporal resolution did not impact
diagnostic performance of quantitative DCE metrics for
tumor detection.
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3835. |
26 |
Unsupervised quality
control of prostate MRSI using Non Negative Matrix
Factorization ![](play.gif)
Nassim Tayari1, Anca R. Croitor Sava2,
Diana M. Sima2, Sabine Van Huffel2,
and Arend Heerschap1
1Department of Radiology and Nuclear
Medicine, Radboud University Medical Center, Nijmegen,
Netherlands, 2Department
of Electrical Engineering, Katholieke Universiteit
Leuven, Leuven, Belgium
An automated quality control algorithm plays an
important role in automation of the analysis of MRSI
data of the prostate cancer patients. In this work we
present an automated unsupervised quality control
algorithm for 3D 1H MRSI data sets. The method is based
on feature extraction using Non Negative Matrix
Factorization(NNMF). Consensus decisions of spectral
quality judged by four experts is used as a Gold
Standard for performance evaluation showing that the
algorithm can separate good quality from bad quality
spectra with 90% sensitivity and 90% specificity.
|
3836. |
27 |
Development of Quantitative
Multi-Parametric MRI Models for Prostate Cancer Assessment
using Registered Correlative Pathology ![](play.gif)
Gregory J. Metzger1, Chaitanya Kalavagunta1,
Stephen C Schmechel2, Patrick J. Bolan1,
Badrinath Konety3, Benjamin Spilseth4,
Christopher A. Warlick3, and Joseph S.
Koopmeiners5
1Center for Magnetic Resonance Research,
University of Minnesota, Minneapolis, MN, United States, 2Department
of Pathology, University of Washington, Washington,
United States, 3Department
of Urologic Surgery, University of Minnesota,
Minneapolis, MN, United States, 4Department
of Radiology, University of Minnesota, Minneapolis, MN,
United States, 5Division
of Biostatistics, University of Minnesota, Minneapolis,
MN, United States
A process is presented for generating critical
correlative pathology for developing predictive models
from voxel-wise mpMRI data based on mapping regions of
disease from assembles pathology to in vivo MRI. The
models generated from this novel data show improved
performance over single quantitative MRI parameters for
detection. The generation of composite biomarker maps
has the potential to improve the use of mpMRI in the
management of prostate cancer by providing a
quantitative means to assess and monitor disease.
|
3837. |
28 |
Computer Aided Quantitative
Analysis of T2-Weighted prostate MR Images ![](play.gif)
Kai Zhao1, Chengyan Wang2, Juan Hu1,
Xiaodong Zhang1, Jue Zhang2, and
Xiaoying Wang1
1Department of Radiology, Peking University
First Hospital, Beijing, Beijing, China, 2College
of Engineering, Peking University, Beijing, Beijing,
China
We extract 12 quantitative features from the T2 weighted
images of prostate cancer and non-cancer by CAD, within
the central gland and peripheral zone of the prostate,
respectively.You can find out which feature can differ
cancer from non-cancer better and the different feature
weight of each feature in our research. This could be
widely used and help us in the prostate cancer
diagnosis.
|
3838. |
29 |
Intraprostatic Lipid
Spectroscopic Imaging of the Prostate Cancer ![](play.gif)
Xin Li1, Jackilen Shannon1, Mark G
Garzotto1,2, Chris Amling1,
William J Woodward1, George Thomas1,
Elizabeth Dacey1,2, Xiaohua Wang1,2,
Paige Farris1, Wesley Stoller2,
Ann Martinez Acevedo1, Amy Palma1,
Manoj K Sammi1, William D Rooney1,
Fergus V Coakley1, and Jonathan Q Purnell1
1Oregon Health & Science University,
Portland, Oregon, United States, 2Portland
VA Medical Center, Portland, Oregon, United States
The lipogenic fatty acid synthase (FAS) is responsible
for de novo fatty acid and triglyceride synthesis in
tissue. Recently, FAS has been characterized as an
oncogene and its overexpression is reported in several
cancers which include that of the prostate. The altered
lipid deposition of cancerous tissue thus can
potentially be an independent biomarker for cancer
aggressiveness monitoring. In this work, MR
spectroscopic imaging (MRSI) is used to quantify
prostatic lipid concentration for prostate cancer.
|
3839. |
30 |
Zone Specific ADC + DCE-MRI
Composite Maps to Aid in the Detection and Evaluation of
Prostate Cancer ![](play.gif)
Naira Muradyan1, Osama Elbuluk2,
Baris Turkbey2, Sandeep Sankineni2,
Maria J Merino3, Senthil Periaswamy1,
Marcelino Bernardo2, Francois Cornud4,
and Peter L Choyke2
1iCAD, Inc., Nashua, NH, United States, 2Molecular
Imaging Program, NCI, NIH, Bethesda, MD, United States, 3Laboratory
of Pathology, NCI, NIH, Bethesda, MD, United States, 4Tourville
Imaging Centre, Paris, France
This study describes a combined analysis method of
Diffusion Weighted and Dynamic Contrast Enhanced MRI for
prostate imaging, which minimizes the need for separate
evaluation of these sequences. Images of 105 patients
from two sites were used retrospectively to develop and
test the prostate zone-specific composite colormaps,
showing better accuracy than standalone Apparent
Diffusion Coefficient outcome. Such objective display of
combined information, which could be easily added to
routine imaging, may be useful for lesion visualization,
evaluation and minimizing reader variability during
multiparametric prostate imaging.
|
3840. |
31 |
Performance of High b-Value
DWI in identifying high risk prostate cancer patients ![](play.gif)
Francesca Mertan1,2, Harsh K Agarwal2,3,
Sandeep Sankineni2, Marcelino Bernardo2,4,
Dagane Daar2,4, Maria Merino2,
Bradford Wood2, Peter Pinto2,
Peter L Choyke2, and Baris Turkbey2
1Grove City College, Grove City, PA, United
States, 2National
Institutes of Health, Bethesda, MD, United States, 3Philips
Research NA, Briarcliff Manor, New York, United States, 4Leidos
Biomedical Research Inc., Frederic National Laboratory
for Cancer Research, Frederick, MD, United States
ADC maps have been shown to detect and stage prostate
cancer. However, at high b-value (b>800mm/s2) DWI signal
from tumor tissue does not follow the mono-exponential
diffusion decay. Therefore high b-value DWI is typically
accessed as part of prostate MRI reading. In this
abstract we have shown that the performance of high
b-value DWI to detect high risk prostate cancer patients
improves with the increase in b-value and its
performance did not change significantly with the
increase in data acquisition time from 23msec to 102msec
for b≥0s/mm2 DWI. High b-value DWI also performed better
than ADC from b≤750s/mm2.
|
3841. |
32 |
Hyperpolarized Lactate
Production Correlates with Gleason Grade in Patient-Derived
Tissues of Prostate Cancer ![](play.gif)
Renuka Sriram1, Mark Van Criekinge1,
Justin DeLos Santos1, Daniel B Vigneron1,
Robert Bok1, Donna Peehl2, Kayvan
Rahimi Keshari3, and John Kurhanewicz1
1University of California, San Francisco, San
Francisco, CA, United States, 2Stanford
University, CA, United States, 3Memorial
Sloan Kettering Cancer Center, New York, United States
The goal of the current study was to correlate
hyperpolarized lactate with the pathologic grade of
prostate cancer using living human prostate tissue
slices (TSCs) obtained at surgery in a MR compatible 3D
tissue culture bioreactor. TSCs obtained from 38 radical
prostatectomy patients were studied after injection of
hyperpolarized pyruvate and demonstrated that in
addition to increased lactate production, high grade
prostate cancer had significantly higher lactate efflux.
Knowledge of significant extracellular HP lactate in
aggressive prostate cancer will be useful for improving
interpretation of the in vivo HP signals and
interrogated using diffusion weighted HP 13C
MR approaches.
|
3842. |
33 |
Development of a Screening
MRI Protocol for the Detection of Prostate Cancer: Initial
Experience ![](play.gif)
Shivani Pahwa1, Robert Abouassaly2,
Yun Jiang3, Karin Herrmann4,5, Raj
Paspulati5,6, William Tabayoyong7,
Soham Shah7, Brian Minnillo7,
Gregory MacLennan7, Mark Griswold1,8,
Lee Ponsky5,9, and Vikas Gulani5,10
1Radiology, Case Western Reserve University,
Cleveland, Ohio, United States, 2University
Hospitals, Ohio, United States, 3Biomedical
Engineering, Case Western Reserve University, Cleveland,
Ohio, United States, 4Radiology,
University Hospitals, Ohio, United States, 5CWRU
School of Medicine, Ohio, United States, 6UH
Case Medical Center, Ohio, United States, 7Urology,
University Hospitals, Ohio, United States, 8Biomedical
Engineering, Case Western Reserve University, Ohio,
United States, 9Urology,
UH Case Medical Center, Ohio, United States, 10Radiology,
UH Case Medical Center, Ohio, United States
Serum PSA measurement and digital rectal examination
(DRE) are the current standards of care for detection of
prostate cancer. However, the performance of these
methods as screening tools has been criticized because
they over diagnose a large number of patients with
clinically insignificant disease, adding to a
significant morbidity for the patient without improving
the outcome. We propose a novel, short non-contrast
imaging protocol as a secondary screening tool that
helps direct targeted biopsies on suspicious lesions.
Our preliminary experience indicated that this strategy
increases the accuracy of detecting clinically
significant disease, and improves risk stratification
for biopsy.
|
3843. |
34 |
Small Field-of-view
single-shot EPI-DWI of the prostate: Evaluation of
spatially-tailored two-dimensional radiofrequency excitation
pulses ![](play.gif)
Daniel Hausmann1, Nils Rathmann1,
Metin Sertdemir1, Philipp Riffel1,
Anja Weidner1, Stephan Kannengiesser2,
John N. Morelli3, Stefan O. Schoenberg1,
and Ulrike I. Attenberger1
1Institute of Clinical Radiology and Nuclear
Medicine, University Medical Center Mannheim, Medical
Faculty Mannheim, University of Heidelberg, Germany,
Mannheim, Baden-Württemberg, Germany, 2MR
Applications Development, Siemens Healthcare, Erlangen,
Germany, 3Department
of Radiology, St. John’s Medical Center, Tulsa,
Oklahoma, United States
The use of spatially-tailored, two-dimensional
radiofrequency (RF) excitation pulses in single-shot
echo-planar imaging (EPI), combined with a decreased FOV
in the phase-encoding direction, results in a reduced
amount of k-space acquisition lines, which shortens the
EPI echo train length (ETL) and reduces susceptibility
artifacts without an increase in acquisition time.
Zoomed EPI leads to significant improvements in image
quality and artifacts as well as image blur reduction
improving prostate DWI and enabling accurate fusion with
conventional sequences.
|
3844. |
35 |
The ADC ratio of tumour to
normal prostate as a robust method for quantifying diffusion
weighted imaging of the prostate - permission withheld
Tristan Barrett1, Andrew N Priest2,
Edward M Lawrence1, Debra Goldman3,
Vincent J. Gnanapragasam4, Evis Sala5,
and Ferdia A. Gallagher1
1Radiology, Cambridge University Hospitals,
Cambridge, Cambridgeshire, United Kingdom, 2Cambridge
University Hospitals, Cambridge, Cambridgeshire, United
Kingdom, 3Department
of Epidemiology and Biostatistics, Memorial Sloan
Kettering Cancer Center, New York, New York, United
States, 4Urology,
Cambridge University Hospitals, Cambridge,
Cambridgeshire, United Kingdom, 5Radiology,
Memorial Sloan Kettering Cancer Center, New York, New
York, United States
We investigate the ability of apparent diffusion
coefficient (ADC) ratios of tumour-to-normal prostate to
improve concordance between ADC values obtained from
different b-value combinations within the same patients.
Whole gland histopathology was used as a gold-standard.
Concordance correlation between different b-value
combinations was higher for ADC ratios compared to
absolute ADC values. ADC maps incorporating a b-0 value
demonstrated greater variability for both ratio and
absolute values, likely relating to pseudo-perfusion
effects. ADC ratios showed stronger inverse
relationships to Gleason grade than absolute values. ADC
ratios may therefore provide a more robust means of
assessing restricted diffusion in the prostate.
|
3845. |
36 |
Investigation of reduced
FOV CEST in probing prostate cancer ![](play.gif)
Chunmei Li1, Bing Wu2, and Min
Chen1
1Beijing Hospital, Beijing, Beijing, China, 2GE
healthcare China, Beijing, Beijing, China
We investigate the use of a novel reduced FOV CEST
method that allows us to zoom in the prostate region
that helps delineating the tumor region from the benign
region and improves accuracy in grading using CEST. The
use of reduced FOV CEST in prostate was validated by
comparing the APT map and MTRasym to those obtained
using normal CEST, highly consistent results were
obtained despite its lower intrinsic SNR. Reduced FOV
CEST has the advantage of revealing the heterogeneity of
the prostate, which may be difficult due to the
constrained portion of the prostate region in normal FOV
image.
|
3846. |
37 |
Prostate Diffusion
Distortion Correction with Restriction Spectrum Imaging ![](play.gif)
Rebecca Rakow-Penner1, Nathan White1,
Daniel Margolis2, J. Kellogg Parsons3,
Natalie Schenker-Ahmed1, Joshua Kuperman1,
Hauke Bartsch1, Hyung Choi2,
William Bradley1, Ahmed Shabaik4,
Jiaoti Huang5, Michael Liss6,
Leonard Marks7, Christopher Kane3,
Robert Reiter7, Steven Raman2,
David Karow1, and Anders Dale1
1Radiology, University of California San
Diego, San Diego, CA, United States, 2Radiology,
University of California Los Angeles, Los Angeles,
California, United States, 3Urology,
University of California San Diego, San Diego, CA,
United States, 4Pathology,
University of California San Diego, San Diego, CA,
United States, 5Pathology,
University of California Los Angeles, Los Angeles, CA,
United States, 6Urology,
University of Texas Health Science Center San Antonio,
San Antonio, TX, United States, 7Urology,
University of California Los Angeles, Los Angeles, CA,
United States
Distortion maps were generated to reflect the offset of
the collected data versus the corrected data.
|
3847. |
38 |
Discriminating low-grade
from high-grade peripheral zone prostate cancer by
multiparametric MRI: a multicenter study ![](play.gif)
Marnix C. Maas1, Geert J.S. Litjens1,2,
Alan J. Wright3, Masoom A. Haider4,
Katarzyna J. Macura5, Kirsten M. Selnæs6,
Daniel J.A. Margolis7, Thomas Helbich8,
Berthold Kiefer9, Jurgen J. Fütterer1,
and Tom W.J. Scheenen1
1Radiology and Nuclear Medicine, Radboud
University Medical Center, Nijmegen, GLD, Netherlands, 2Pathology,
Radboud University Medical Center, Nijmegen, GLD,
Netherlands, 3Cancer
Research UK Cambridge Institute, University of
Cambridge, Cambridge, United Kingdom, 4Sunnybrook
Health Sciences Center, University of Toronto, Toronto,
ON, Canada, 5Russel
H. Morgan Department of Radiology and Radiological
Science, Johns Hopkins University, Baltimore, MD, United
States, 6Department
of Circulation and Medical Imaging, Norwegian University
of Science and Technology, Trondheim, Norway, 7Radiology,
UCLA David Geffen School of Medicine, Los Angeles, CA,
United States, 8Biomedical
Imaging and Image-guided Therapy, Medical University
Vienna - General Hospital Vienna, Vienna, Austria, 9Siemens
AG Healthcare, Erlangen, Germany
This study investigates the ability of multiparametric
MRI (mpMRI) including DWI, 1H-MRSI and DCE-MRI to
discriminate low-grade from higher-grade peripheral zone
(PZ) prostate cancer in a multi-center setting, using
whole-mount section histopathology as the gold standard.
Guided by histology and blinded to functional imaging,
ROIs were defined on T2w imaging in PZ tumors in 39
patients from 5 centers, and transferred to functional
parameter maps. ROC analysis resulted in areas under the
curve of 0.80±0.13 for ADC and 0.83±0.15 for a
multivariate model including both ADC and MRSI.
Multicenter mpMRI can yield good separation between low
and higher grade PZ tumors.
|
3848. |
39 |
Quantitative
differentiation of prostate cancer from normal peripheral
zone using Magnetic Resonance Fingerprinting (MRF) and
Diffusion Mapping ![](play.gif)
Chaitra Badve1, Alice Yu2, Shivani
Pahwa3, Matthew Rogers2, Yun Jiang4,
Yiying Liu5, Mark Schluchter5, Lee
Ponsky6,7, Mark Griswold4, and
Vikas Gulani1,3
1Radiology, University Hospitals, Cleveland,
Ohio, United States, 2School
of Medicine, Case Western Reserve University, Cleveland,
Ohio, United States,3Radiology, Case Western
Reserve University, Cleveland, Ohio, United States, 4Biomedical
Engineering, Case Western Reserve University, Cleveland,
Ohio, United States, 5Biostatistics,
Case Western Reserve University, Cleveland, Ohio, United
States, 6Urology,
University Hospitals, Cleveland, Ohio, United States,7Urology,
Case Western Reserve University, Cleveland, Ohio, United
States
Magnetic resonance fingerprinting (MRF) was acquired in
patients with clinical suspicion of prostate cancer.
After diagnoses were confirmed by pathology, T1 and T2
values from MRF were used with ADC values to
retrospectively separate malignancy from normal
peripheral zone (NPZ). All MR parameters showed
significant difference between prostate cancer and NPZ.
Furthermore, T2 and ADC used in conjunction had a high
discriminatory power (AUC = 0.996). Further research is
needed to determine the robustness of using T2 and ADC
to identify prostate cancer prospectively, and to
explore the possibly utility of T1 in identifying
malignancy.
|
3849. |
40 |
Evaluation of the
diagnostic differentiation of prostate cancer from benign
prostate hyperplasia using Intra-voxel incoherent motion MR
imaging ![](play.gif)
Meiyu Sun1, Ailian Liu1, Ye Li1,
Lihua Chen1, Qingwei Song1, Bin Xu1,
and Ziheng Zhang2
1the first affiliated hospital of Dalian
Medical University, Dalian, Liaoning, China, 2GE
healthcare China, Beijing, China
The MR imaging of prostate cancer (PCa) was
undistinguishable from that of benign prostatic
hyperplasia (BPH) on conventional T2WI and dynamic
contrast enhancement imaging. In this study, intravoxel
incoherent motion (IVIM) DWI were performed to
investigate the diffusion and perfusion features of PCa
and BPH, and to evaluate the relationship of the
parameters, standard ADC, slow ADC, fast ADC and
fraction of fast ADC, as well as their sensitivity and
specificity in diagnosis. It was demonstrated standard
ADC and slow ADC from IVIM MRI maybe a significant MRI
biomarkers to differentiate PCa from BPH with satisfying
sensitivity and specificity.
|
3850. |
41 |
The role of multiparametric
MRI in detection of prostate cancer in patients with total
serum prostate specific antigen levels of 4-10 ng/mL: a
prospective cohort study ![](play.gif)
Rui Wang1, Juan Hu1, Yuanyuan
Jiang1, and Xiaoying Wang1
1Radiology, Peking university first hospital,
Beijing, Beijing, China
In patients with PSA levels of 4-10 ng/mL, it is
difficult to distinguish prostate cancer (PCa) from
prostatitis. So our study is to evaluate the role of
multiparametric MRI (mp-MRI) in detection of PCa and
prediction of PCa incidence in patients with total PSA
levels of 4¨C10 ng/mL by a prospective cohort study.
Mp-MRI showed excellent area under the ROC curve,
suggesting obviously clinically relevant predictive
characteristics. Furthermore, with 137 months of
follow-up, higher score of mp-MRI was proved to be
significantly associated with a greater risk of
detection rate of PCa.
|
3851. |
42 |
Saturation duration and
power optimization for APT MRI of prostate cancer ![](play.gif)
Harsh K Agarwal1,2, Jochen Keupp3,
Marcelino Bernardo2, Baris Turkbey2,
and Peter L Choyke2
1Philips Research NA, Briarcliff Manor, New
York, United States, 2National
Institutes of Health, Bethesda, MD, United States, 3Philips
Research Laboratories, Hamburg, Germany
Amide proton transfer (APT) MRI has been shown to
localize and stage prostate. However there are multiple
parameters such as saturation power and saturation
duration that affect the APT MRI contrast. In this
abstract we have shown that MTR asymmetry increased with
the decrease in the pulse duration. Also the peak of MTR
asymmetry shifted with the change in saturation power.
However spurious MTR was observed over prostate
especially in peripheral zone which could be due to the
incoherent motion such as rectal spasm.
|
3852. |
43 |
Correlation between
diameter of prostate cancer foci on multiparametric prostate
MRI and whole mount histopathology: Stratified by PI-RADS
and Gleason Score ![](play.gif)
Pooria Khoshnoodi1, Nelly Tan1,
Daniel J. A. Margolis1, Wei-Chan Lin1,
Somrach Thamtorawat1, David Y. Lu2,
Jiaoti Huang2, Robert E. Reiter3,
and Steven S. Raman1
1Radiology, University of California, Los
Angeles, Los Angeles, California, United States, 2Pathology,
University of California, Los Angeles, Los Angeles,
California, United States, 3Urology,
University of California, Los Angeles, Los Angeles,
California, United States
Multiparametric magnetic resonance imaging (MP-MRI) is
used more frequently to detect and evaluate prostate
cancer (CaP). We studied the size of the tumor prior to
surgery on MP-MRI and its correlation with the actual
size of tumor on pathology after prostatectomy. This
correlation was stratified by overall PI-RADS suspecious
score on multiparametric MRI and also Gleason Score at
histopathology.
|
3853. |
44 |
Diagnostic accuracy of NaF
PET-MRI in differentiating bone metastases from benign bone
lesions in metastatic prostate cancer. ![](play.gif)
Taylor Stone1 and
Luis Beltran2
1New York University, New York, NY, United
States, 2New
York University, NY, United States
NaF PET-MRI as a hybrid imaging study shows higher
specificity, sensitivity, and overall accuracy than bone
scintigraphy, PET or MRI in isolation in differentiating
between metastatic and benign bone lesions. Accurately
defining the number of lesions has important treatment
implications as prostate cancer treatment is generally
based on disease burden.
|
3854. |
45 |
Combined MR Volumetry and
Diffusion Weighted imaging to better predict clinically
significant prostate cancer on MRI/Ultrasound fused guided
biopsy? ![](play.gif)
Stephanie Nougaret1, Nicola L Robertson1,
Evis Sala1, Hedvik Hricak1, Behfar
Ehdaie2, and Hebert A Vargas1
1Radiology department, Memorial Sloan
Kettering Cancer Center, New York, NY, United States, 2Urology
department, Memorial Sloan Kettering Cancer Center, New
York, NY, United States
To evaluate the combined efficacy of MR Volumetry and
Diffusion Weighted Imaging (DWI), in the detection of
clinically significant prostate cancer using MRI-US
fusion biopsy. This preliminary study demonstrates the
potential added predictive value of using tumor
volumetry in combination with DWI, in the diagnosis of
clinically significant prostate cancer using MRI-US
fusion biopsy. Furthermore, it evaluates the feasibility
of quantitative assessment in tumor burden.
|
3855. |
46 |
Clinical Application of 3D
High Resolution Multi-shot Diffusion-Weighted MRI in
Prostate Cancer Patients undergoing Active Surveillance
Protocol for Low-Risk Prostate Cancer ![](play.gif)
Christopher Nguyen1,2, Ali-Reza Sharif-Afshar3,
Zhaoyang Fan1, Sidney Wilson2,
Xiaoming Bi4, Lucas Payor5, Rola
Saouaf5, Hyung Kim3, and Debiao Li1,2
1Biomedical Imaging Research Institute,
Cedars Sinai Medical Center, Los Angeles, CA, United
States, 2Bioengineering,
University of California Los Angeles, Los Angeles, CA,
United States, 3Surgery
/ Urology, Cedars-Sinai Medical Center, Los Angeles, CA,
United States, 4Siemens
Healthcare, Los Angeles, CA, United States, 5Radiology,
Cedars-Sinai Medical Center, Los Angeles, CA, United
States
In a small group of prostate cancer patients undergoing
active surveillance (AS-PC) patients, a recently
developed novel 3D diffusion-prepared multi-shot
balanced steady-state free precession technique
demonstrated improved suspicious low risk prostate
cancer lesion detection compared with single-shot
diffusion-weighted echo planar imaging (SS-DW-EPI). We
conducted a follow-up study in a significantly larger
cohort to further investigate the clinical impact of the
proposed technique. The proposed technique continued to
yield significantly better lesion detection of
biopsy-confirmed lesions compared with SS-DW-EPI. By
improving lesion detection, the proposed technique may
allow DW MRI to potentially monitor low-risk prostate
cancer lesions in AS-PC.
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Tuesday 2 June 2015
Exhibition Hall |
16:00 - 17:00 |
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Computer # |
|
3856. |
49 |
Constrained multi-agent
tracer-kinetic modeling to assess tumor vascular changes
induced by DMXAA treatment ![](play.gif)
Igor Jacobs1, Stefanie Hectors1,
Gustav Strijkers1,2, Klaas Nicolay1,
and Matthias Schabel3,4
1Biomedical NMR, Department of Biomedical
Engineering, Eindhoven University of Technology,
Eindhoven, Netherlands, 2Biomedical
Engineering and Physics, Academic Medical Center,
University of Amsterdam, Amsterdam, Netherlands, 3Advanced
Imaging Research Center, Oregon Health and Science
University, Portland, Oregon, United States, 4Utah
Center for Advanced Imaging Research, University of
Utah, Salt Lake City, Utah, United States
Accurate evaluation of antivascular tumor therapies
requires detailed analysis of vascular alterations. We
have recently proposed a novel multi-agent
tracer-kinetic modeling approach for DCE-MRI, which
allows simultaneous and self-consistent assessment of
blood flow and permeability within one imaging session.
In the present study, we have applied this approach to
evaluate DMXAA treatment. An early increase in
extraction fraction of the dendrimer-based contrast
agents and reduced blood flow were simultaneously
observed, thereby identifying increased permeability as
the main mechanism of DMXAA-induced vascular shutdown,
in agreement with literature. This demonstrates the
potential of the multi-agent approach to assess
therapy-induced vascular changes.
|
3857. |
50 |
Micro-vascular effects of
photodynamic therapy in tumors evaluated with dynamic
contrast-enhanced MRI ![](play.gif)
Tom Schreurs1,2, Stefanie Hectors1,
Igor Jacobs1, Holger Grüll1,3,
Gustav Strijkers1,2, and Klaas Nicolay1
1Biomedical Engineering, Eindhoven University
of Technology, Eindhoven, Netherlands, 2Biomedical
Engineering and Physics, Academic Medical Center,
Amsterdam, Netherlands, 3Oncology
Solutions, Philips Research, Eindhoven, Netherlands
Micro-vascular effects of photodynamic therapy (PDT)
were assessed using Dynamic Contrast Enhanced (DCE) MRI
in a mouse tumor model. PDT is an emerging cancer
therapy based on a light-activated drug. DCE-MRI showed
that tumors were almost completely perfused before PDT,
but partly non-perfused after 1 hour and largely non-perfused
after 24 hours. The results clearly indicated
PDT-induced vascular occlusion. Remaining enhanced
regions coincided with tumor recurrences. This work
shows that DCE-MRI has large potential to monitor PDT
efficacy, early after treatment.
|
3858. |
51 |
Multiparametric MRI
analysis for the evaluation of MR-guided High Intensity
Focused Ultrasound treatment ![](play.gif)
Stefanie Hectors1, Igor Jacobs1,
Edwin Heijman2, Jochen Keupp3,
Monique Berben2, Gustav Strijkers1,4,
Holger Grüll1,2, and Klaas Nicolay1
1Biomedical NMR, Department of Biomedical
Engineering, Eindhoven University of Technology,
Eindhoven, Netherlands, 2Oncology
Solutions, Philips Research Europe, Eindhoven,
Netherlands, 3Tomographic
Imaging Systems, Philips Research Europe, Hamburg,
Germany, 4Biomedical
Engineering and Physics, Academic Medical Center,
University of Amsterdam, Amsterdam, Netherlands
A multiparametric MRI protocol, consisting of
quantitative T1, T2, ADC, amide
proton transfer (APT) and T1ρ measurements,
was used to evaluate MR-guided HIFU treatment of
subcutaneous rat tumors. K-means clustering was
performed on the multiparametric data using all
different combinations (feature vectors) of MRI
parameters. For feature vector {ADC, APTw signal} a
strong correlation (r=0.92) between histology-derived
and clustering-derived non-viable tumor fractions was
observed, which was higher than correlations between
histology-derived non-viable fractions and HIFU-treated
fractions derived from MR thermometry and dynamic
contrast-enhanced MRI. In conclusion, our data
demonstrate that a multiparametric MR analysis can
accurately identify HIFU-treated tumor tissue.
|
3859. |
52 |
Prediction of Treatment
Response and Tumor Recurrence Using MR Elastography - permission withheld
Kay Pepin1, Steven Ansell2,
Richard L Ehman3, and Kiaran McGee3
1Graduate School, Mayo Clinic, Rochester,
Minnesota, United States, 2Hematology,
Mayo Clinic, Minnesota, United States, 3Radiology,
Mayo Clinic, Minnesota, United States
Change in tumor mechanical properties measured using MR
Elastography may be a biomarker of response to
chemotherapy. The ability to determine failure to
therapy is a critical function of an imaging biomarker.
The results of this animal study demonstrate that MRE is
sensitive to an increase in tumor stiffness prior to an
increase in tumor volume. Similarly, change in tumor
shear stiffness is dose-dependent; the higher the
chemotherapy dose the greater the subsequent decrease in
tumor stiffness. These results suggest that MRE-derived
shear stiffness measurements reflect the observed
response to chemotherapy.
|
3860. |
53 |
Metabolic Imaging of Early
Tumor Therapy ![](play.gif)
Charles S. Springer1,2, Xin Li3,
Mohan L. Jayatilake4, Martin M. Pike2,3,
William D. Rooney3, Rosalie C. Sears2,5,
and Wei Huang2,3
1Advanced Imaging Research Center, Oregon
Health & Science University, Portland, Or, United
States, 2Knight
Cancer Institute, Oregon Health & Science University,
Portland, Oregon, United States, 3Advanced
Imaging Research Center, Oregon Health & Science
University, Portland, Oregon, United States,4Radiography
and Radiotherapy, University of Peradeniya, Peradeniya,
Peradeniya, Sri Lanka, 5Molecular
and Medical Genetics, Oregon Health & Science
University, Portland, Oregon, United States
Normally, DCE-MRI estimates vascular parameters, Ktrans and
vp. However, shutter-speed analysis allows
determination of cellular, metabolic parameters, kio and
vi. The kio quantity
tracks cell membrane Na+,K+-ATPase
activity. Exemplified with human and murine breast
cancers, we show that these enable the discrimination of
cytotoxic and targeted therapies in their early actions.
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3861. |
54 |
Immunocytokine facilitation
of natural killer cells accumulation in tumors ![](play.gif)
Naomi S. Sta Maria1, Samuel R. Barnes1,
David Colcher2, Andrew A. Raubitschek2,
and Russell E. Jacobs1
1Biology and Biological Engineering,
California Institute of Technology, Pasadena, CA, United
States, 2Cancer
Immunotherapeutics & Tumor Immunology, City of Hope,
Duarte, CA, United States
We investigated whether the priming of tumors with
immunocytokines can potentiate the accumulation of
adoptive human natural killer cells labeled with
ferumoxytol, an FDA-approved USPIO, in tumors. We used
T2* weighted multi-gradient echo to generate parametric
R2* maps of the tumors in NOD-scid-gamma-null mice with
human colorectal adenocarcinoma cells, LS-174T.luc. Mice
were differentiated into control or immunocytokine
treated groups and were imaged pre and post (5hr and
10hr) injection of NK cells. Pretreated mice showed
significant increases in tumor R2* values at the 10hr
time point. MRI can be used to assess efficacy of
adoptive NK cell transfer.
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3862. |
55 |
Whole body mDixon MRI in
multiple myeloma: Quantitative derived parameters changes
following chemotherapy ![](play.gif)
Arash Latifoltojar1, Margaret Hall-Craggs2,
Alan Bainbridge2, Stuart Taylor3,
Kwee Yong3, Neil Rabin2, Matthew
Benger2, Liam Watson2, Michelle
Siu2, and Shonit Punwani3
1University College London, London, London,
United Kingdom, 2University
College London Hospital, London, United Kingdom, 3University
College London, London, United Kingdom
Whole body anatomical and functional MRI is being
increasingly used for initial assessment and treatment
response monitoring in patients with multiple myeloma.
The replacement of the normal fatty marrow cells by
neoplastic cells in multiple myeloma and its changes
following therapy could be explored, using quantitative
derive parameters from MR imaging. In this study we
investigated the changes in quantitative derived
parameters from whole body mDixon changes following
therapy in patients with multiple myeloma.
|
3863. |
56 |
DCE-MRI kinetic model and
curve pattern analyses for predicting response and survivals
in osteosarcoma patients ![](play.gif)
Junyu Guo1 and
Wilburn E. Reddick1
1Radiological Sciences, St Jude Children's
Research Hospital, Memphis, TN, United States
This study investigated two DCE-MRI data analysis
methods for evaluating response to treatment and
prognosis of event-free-survival (EFS) and
overall-survival in 42 patients with osteosarcoma. In
two methods, eight parameters and their
absolute-difference (ABD) between two neighboring time
points were assessed for the role of predicting clinical
results. Three ABD parameters before week5 could
potentially predict response. The CPA parameter ![lower case Greek beta](http://submissions.mirasmart.com/ISMRM2015/Images/LCGreek/beta.gif) on
Day5 is the potential prognostic factor for EFS. Four
ABD parameters before week5 are potential prognostic
factors for overall-survival. All results show that two
DCE-MRI analysis methods could provide valuable
predictive information for clinical outcomes.
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3864. |
57 |
Predicting Response to
Sunitinib Second-line Therapy in Gastrointestinal Stromal
Tumors Using Non-Gaussian Diffusion MRI ![](play.gif)
Yi Sui1,2, Lei Tang3, Kejia Cai2,4,
Shun-Yu Gao3, Frederick C. Damen2,4,
Ying-Shi Sun3, and Xiaohong Joe Zhou2,5
1Bioengineering, University of Illinois at
Chicago, Chicago, IL, United States, 2Center
for MR Research, University of Illinois Hospital &
Health Sciences System, Chicago, IL, United States, 3Radiology,
Peking University Cancer Hospital & Institute, Beijing,
China, 4Radiology,
University of Illinois Hospital & Health Sciences
System, Chicago, IL, United States, 5Departments
of Radiology, Neurosurgery and Bioengineering,
University of Illinois Hospital & Health Sciences
System, Chicago, IL, United States
Sunitinib offers a second line treatment to
gastrointestinal stromal tumor (GIST) patients with
imatinib-resistant progressive lesions. Prediction of
the treatment response is crucial for achieving optimal
outcomes. We used a non-Gaussian diffusion model, known
as the fractional order calculus model (FROC), to assess
the early response to sunitinib treatment in
imatinib-resistant GIST lesions. Our results showed that
the FROC model outperformed the conventional means of
using tumor size in predicting tumor response at as
early as 2 weeks after receiving sunitinib treatment.
This study suggests that non-Gaussian diffusion imaging
can provide timely information to evaluate sunitinib
targeted therapy of GIST.
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3865. |
58 |
DCE-MRI Assessment of
Soft-Tissue Sarcoma Response to Preoperative Therapy ![](play.gif)
Wei Huang1, Megan L Holtorf1,
Aneela Afzal1, Yiyi Chen1, Brooke
R Beckett1, and Christopher W Ryan1
1Oregon Health & Science University,
Portland, OR, United States
Twenty patients with extremity soft-tissue sarcoma who
underwent preoperative chemoradiotherapy consented to
research DCE-MRI, performed before, after one cycle of
chemotherapy, and after completion of therapy before
surgery. Ktrans and kep at baseline, after one cycle of
therapy, and percent change were much better than RECIST
tumor size measurement for early prediction of therapy
response. Post-therapy Ktrans, ve, and kep were
negatively correlated with necrosis percentage (NP) of
the surgical specimen. No significant relationship was
observed between post-therapy RECIST and NP.
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3866. |
59 |
Feasibility of performing
weekly intravoxel incoherent motion DW-MRI and monitoring
anatomical and functional changes in nasopharynx tumors
during chemoradiation therapy - permission withheld
Yonggang Lu1, Nancy Lee1, Vaois
Hatzoglou1, Nadeem Riaz1, Joseph
O. Deasy1, and Amita Shukla-Dave1
1Memorial Sloan-Kettering Cancer Center, NEW
YORK, New York, United States
Our aim is to identify imaging biomarkers predictive of
treatment response in nasopharyngeal cancer for
personalizing radiotherapy. A total of 37 weekly
intravoxel incoherent motion DW-MRI studies were
performed on 5 patients to assess early chemoradiation
treatment response. The results demonstrated that
chemoradiation treatment led to a decrease of tumor
volumes in all 5 patients and an increase of diffusion
and perfusion metrics in 4 patients. One patient had
tumor infiltration of the muscle and the diffusion
metric remained unchanged in this patient during
treatment. The study concludes that diffusion and
perfusion metrics are potential imaging biomarkers of
tumor response.
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3867. |
60 |
The diagnostic performance
of hybrid FDG-PET/MR compared to FDG-PET/CT in adult
lymphoma patients ![](play.gif)
Alexander R Guimaraes1,2, Wendy Atkinson3,
Ephraim Hochberg4, Jeremy Abramson5,
Onofrio Catalano2, Bruce R Rosen2,
and Ciprian Catana2
1Radiology, Oregon Health Sciences
University, Portland, OR, United States, 2Radiology,
Martinos Center for Biomedical imaging, Charlestown, MA,
United States,3Radiology, Martinos Center for
Biomedical imaging, Charlesown, MA, United States, 4Medicine,
Massachusetts General Hospital, Boston, MA, United
States,5Medicine, Massachusetts General
Hospital, MA, United States
FDG-PET/CT has become an essential tool in the initial
staging of Hodgkin lymphoma and aggressive non-Hodgkin
lymphomas. In select histologies, early interim PET/CT
has also shown to be a strong independent predictor of
outcome. Hybrid PET/MR imaging is a novel imaging
modality that offers improved soft tissue contrast,
conspicuity of bone marrow infiltration, diffusion
weighted imaging, and lower radiation dose: all factors
that could have dramatic impact in the management of
lymphoma. The overarching goal of this work was to test
the hypothesis that PET/MRI offers an equivalent
qualitative and quantitative imaging staging algorithm
to PET/CT, but with decreased-risk of late
radiation-associated toxicities.
|
3868. |
61 |
Spontaneous R2*
Fluctuations for Non-Invasive Detection of Cyclic Hypoxia in
Head and Neck Squamous Cell Carcinoma Xenografts ![](play.gif)
Rafal Panek1, Lauren C.J. Baker2,
Liam Welsh1, Carol Box2, Suzanne
A. Eccles2, Kate L. Newbold1,
Kevin J. Harrington1, Maria A. Schmidt1,
Martin O. Leach1, and Simon P. Robinson2
1Royal Marsden NHS FT and Institute of Cancer
Research, Sutton, Surrey, United Kingdom, 2Institute
of Cancer Research, Sutton, Surrey, United Kingdom
The importance of acutely hypoxic tumour cells,
resulting from intermittent tumour blood flow, on tumour
progression and radioresistance is recognised. The
potential of continuous intrinsic susceptibility MRI
measurements of tumour R 2* to non-invasively
detect acute, cyclic hypoxia through changes in the oxy/deoxyhaemoglobin
ratio has been previously demonstrated. In this study we
have tested the feasibility of measuring spontaneous
fluctuations in tumour R 2* to identify
regions with varying erythrocyte or plasma channels flow
in head and neck squamous cell carcinoma xenografts on a
clinical 3T platform. Additionally, hyperoxia-induced R 2*
and tissue histology were used to spatially confirm
hypoxic and perfused tumour regions.
|
3869. |
62 |
Effects of Acquisition
Time Variation on DCE-MRI Prediction of Breast Cancer
Therapy Response ![](play.gif)
Andy J Kaempf1, Yiyi Chen1, Alina
Tudorica1, Stephen Y-C Chui1,
Arpana Naik1, Karen Y Oh1, Nicole
Roy1, Megan L Troxell1, Aneela
Afzal1, Megan L Holtorf1, Mohan
Jayatilake1, and Wei Huang1
1Oregon Health & Science University,
Portland, OR, United States
DCE-MRI data with ~10 min acquisition time were
collected from 14 breast cancer patients (15 primary
tumors) who received neoadjuvant chemotherapy (NACT).
Data points were dropped incrementally from the far end
of DCE time course to simulate ~9, 8, 7, and 6 min
acquisition time. The original and simulated data were
subjected to standard and shutter-speed model
pharmacokinetic analyses. The results suggest 8 min
acquisition time is needed to retain the Ktrans and kep
abilities as early predictors of therapy response.
|
3870. |
63 |
Effects of AIF
Variations on DCE-MRI Prediction of Breast Cancer Therapy
Response ![](play.gif)
Aneela Afzal1, Alina Tudorica1,
Yiyi Chen1, Stephen Y-C Chui1,
Arpana Naik1, Megan L Troxell1,
Kathleen A Kemmer1, Karen Y Oh1,
Nicole Roy1, Megan L Holtorf1, Xin
Li1, and Wei Huang1
1Oregon Health & Science University,
Portland, OR, United States
Breast DCE-MRI data from 29 patients at baseline and
after one cycle of neoadjuvant chemotherapy were
analyzed using pharmacokinetic (PK) modeling and three
different arterial input functions (AIFs). Despite
considerable AIF-caused PK parameter variations (except
for the Tau_i parameter), several PK parameters after 1
cycle of therapy and their percent changes remained good
to excellent early predictors of pathologic response.
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Tuesday 2 June 2015
Exhibition Hall |
16:00 - 17:00 |
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Computer # |
|
3871. |
64 |
Using UTE images for
bone/air segmentation: applications for radiation therapy - permission withheld
Weili Zheng1, Joshua P. Kim1,
Indrin J. Chetty1, and Carri K. Glide-Hurst1
1Radiation Oncology, Henry Ford Health
System, Detroit, Michigan, United States
Accurate bone segmentation is essential for the
generation of (i) electron density maps needed for dose
calculation in MR-only radiotherapy treatment planning (RTP)
and (ii) MR-based attenuation correction maps in hybrid
PET/MRI systems. While UTE sequences improve the
visualization of tissues with short T2 such as cortical
bone (1), efficient and robust segmentation of bone and
air remains a significant challenge (2). To address this
need, we introduce an application that uses a novel
hybrid magnitude and phase UTE approach to differentiate
tissue types, facilitate accurate segmentation, and
generate synthetic CTs (synCTs) for the brain.
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Tuesday 2 June 2015
Exhibition Hall |
16:00 - 17:00 |
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Computer # |
|
3872. |
65 |
Evaluating sources of
uncertainty on DCE-MRI parameter estimates when using
different AIFs ![](play.gif)
Mihaela Rata1, Matthew R Orton1,
Christina Messiou1, Helen Young2,
Nandita de Souza1, David J Collins1,
and Martin O Leach1
1Radiotherapy and Imaging Department, CR-UK
and EPSRC Cancer Imaging Centre, Institute of Cancer
Research and Royal Marsden Hospital, Sutton, Surrey,
United Kingdom, 2Early
Clinical Development, AstraZeneca, Macclesfield,
Cheshire, United Kingdom
Dynamic contrast-enhanced (DCE) MRI method is a
technique employed in the assessment of tumour response
to novel antiangiogenic therapy. Pharmacokinetic
modelling of such data requires a reliable measure of
the arterial input function (AIF) in order to obtain
robust estimates of physiological parameters
characterising tumour properties. This study explore the
impact on Ktrans estimate of various sources of
uncertainty affecting a MR-DCE acquisition. Three
experiments were performed to separate sources of
uncertainties. The best CoV of measured Ktrans is still
obtained when using a population AIF. A perfect measure
of AIF may yet improve a Ktrans repeatability up to 10%.
|
3873. |
66 |
Classical and
Knowledge-Based Pharmacokinetic Model Selection Techniques
in Analysis of Dynamic Contrast Enhanced MRI Studies:
Performance and Bias Comparison ![](play.gif)
Hassan Bagher-Ebadian1,2, Mohammadreza
Mohammadian-Behbahani3,4, Azimeh Noorizadeh
Vahed Dehkordi3,5, James R Ewing2,6,
Alireza Kamali-Asl3, Siamak P Nejad-Davarani7,
Hamed Moradi8, Stephen Brown2,9,
Brent Griffith10, Ali S Arbab11,
Tom Mikkelsen12, Lisa Scarpace12,
and Hamid Soltanian-Zadeh1,13
1Radiology and Research Administration, Henry
Ford Hospital, Detroit, Michigan, United States, 2Physics,
Oakland University, Rochester, Michigan, United States,3Nuclear
Engineering, Shahid Beheshti University, Tehran, Iran, 4Nuclear
Engineering, Amir-Kabir University of Technology,
Tehran, Iran, 5Nuclear
Engineering, Najaf Abad Branch, Islamic Azad University,
Isfahan, Iran, 6Neurology,
Henry Ford Hospital, Detroit, Michigan, United States, 7Neurology,
Henry Ford Hospital, Michigan, Iran, 8Nuclear
Engineering, Shiraz University, Shiraz, Fars, Iran, 9Radiation
Oncology, Henry Ford Hospital, Detroit, Michigan, United
States,10Radiology, Henry Ford Hospital,
Detroit, Michigan, United States, 11GRU
Cancer Center, Georgia Regents University, Atlanta,
Georgia, United States,12Neurosurgery, Henry
Ford Hospital, Detroit, Michigan, United States, 13CIPCE,
School of Electrical and Computer Engineering,
University of Tehran, Tehran, Iran
Given Dynamic-Contrast-Enhanced MRI data, accurate
estimation of Pharmacokinetic (PK) parameters strongly
relies on appropriate selection of the best PK model to
fit the data. This study investigates the impact of
different classical and adaptive MS technique such as
F-Statistic (F-test), Akaike-Information-Criterion
(AIC), Bayesian-Information-Criterion (BIC),
Log-Likelihood-Ratio (LLR) and Artificial Neural Network
(ANN) on estimation of vascular permeability parameters.
Results imply that ANN generates significantly
less-biased estimates of PK parameters compared to other
techniques while both the LLR and BIC methods outperform
the other classical MS techniques, the ANN, LLR and BIC
are the best candidates for PK analysis of DCE-MRI data.
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3874. |
67 |
Dynamic Contrast Enhanced
Magnetic Resonance Imaging Evaluates Therapeutic Mechanism
of nab-Paclitaxel in Pancreatic Cancer Patient Derived
Xenograft Mouse Models. ![](play.gif)
Hyunki Kim1, Sharon Samuel1, Marie
Warren1, Guihua Zhai1, William
Grizzle1, Denise Oelschlager1,
Pedro Lopez-Casas2, Manuel Hidalgo2,
Joy Kovar3, Kurt Zinn1, and Donald
Buchsbaum1
1University of Alabama at Birmingham,
Birmingham, AL, United States, 2Spanish
National Cancer Research Center, Madrid, Spain, 3LI-COR
Biosciences, Nebraska, United States
Dynamic contrast enhanced magnetic resonance imaging
(DCE-MRI) was employed to identify the therapeutic
mechanism of nab-paclitaxel in pancreatic cancer patient
derived xenograft mouse models. DCE-MRI demonstrated
that nab-paclitaxel did not significantly increase the
microvascular perfusion in tumor xenografts for 3 weeks
of nab-paclitaxel treatment, although gemcitabine did.
Also, histologic analysis showed that tumor stroma was
not significantly reduced by nab-paclitaxel, but high
tumor retention of fluorophore labeled nab-paclitaxel
was observed. Therefore the significant clinical
benefits of nab-paclitaxel may result from its effective
delivery into tumors in pancreatic cancer.
|
3875. |
68 |
Dynamic Contrast Enhanced
MRI Detection of a Central Defect in Clear Cell Renal Cell
Carcinoma Correlates with a Tumor Scar and Lower Tumor
Proliferation Rate ![](play.gif)
Yue Zhang1, Payal Kapur2,3, Qing
Yuan1, Ananth Madhuranthakam1,4,
Ingrid Carvo5, Sabina Signoretti5,
Ivan Dimitrov6, Yin Xi1, Katherine
Wicks1, Jeffrey Cadeddu1,3, Vitaly
Margulis3, James Brugarolas7,8,
and Ivan Pedrosa1,4
1Radiology, University of Texas Southwestern
Medical Center, Dallas, Texas, United States, 2Pathology,
University of Texas Southwestern Medical Center, Dallas,
Texas, United States, 3Urology,
University of Texas Southwestern Medical Center, Dallas,
Texas, United States, 4Advanced
Imaging Research Center, University of Texas
Southwestern Medical Center, Dallas, Texas, United
States, 5Pathology,
Brigham and Women’s Hospital, Boston, Massachusetts,
United States, 6Philips
Medical Systems, Cleveland, Ohio, United States, 7Internal
Medicine, University of Texas Southwestern Medical
Center, Dallas, Texas, United States,8Developmental
Biology, University of Texas Southwestern Medical
Center, Dallas, Texas, United States
The purpose was to investigate if the central
non-enhancing defect seen commonly on contrast-enhanced
MRI in clear cell renal cell carcinoma (ccRCC)
correlates with coagulation necrosis at histopathology
in the same tumor, a known poor prognostic feature for
these tumors. We found that non-enhancing defects in
ccRCC represent tumor scars instead of coagulative
necrosis. Ki-67 staining revealed significantly lower
cell proliferation rate for RCC with scar than that for
those without scar. We hypothesize that this scar is the
result of rapid enlargement of the tumor leading to a
central infarct and may be formed during a subsequent
reparative phase.
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3876. |
69 |
Measurements of Spontaneous
R2* Fluctuations for Acute Hypoxia Detection in Head and
Neck Cancer ![](play.gif)
Rafal Panek1, Liam Welsh1, Maria
A. Schmidt1, Kate L. Newbold1, Kee
Wong1, Angela M. Riddell1, Dow-Mu
Koh1, Alex Dunlop1, Dualta Mcquaid1,
Shreerang A. Bhide1, Kevin J. Harrington2,
Christopher M. Nutting2, Georgina Hopkinson3,
Cheryl Richardson3, Simon P. Robinson4,
and Martin O. Leach1
1Royal Marsden NHS FT and Institute of Cancer
Research, Sutton, Surrey, United Kingdom, 2Royal
Marsden NHS FT and Institute of Cancer Research, London,
United Kingdom, 3Royal
Marsden NHS FT, London, United Kingdom, 4Institute
of Cancer Research, Sutton, Surrey, United Kingdom
In this study we tested the feasibility of measuring
spontaneous fluctuations in the transverse relaxation
rate, R2*, to identify regions with intermittent
erythrocyte and plasma flow, and hence oscillating
oxygen delivery, in patients with advanced squamous cell
carcinoma of the head and neck. Non-random fluctuations
were detected in parts of lymph nodes with low Ktrans
and R2* values, often in the vicinity, but not in the
centre, of necrotic nodal core, suggesting the presence
of fluctuating blood oxygen levels, which could be
caused by an insufficient or intermittent blood
delivery.
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Tuesday 2 June 2015
Exhibition Hall |
16:00 - 17:00 |
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Computer # |
|
3877. |
70 |
Evaluation of Renal Masses
using Multiparametric MRI: Correlation with Histopathology ![](play.gif)
Durgesh Kumar Dwivedi1,2, Girdhar Singh Bora3,
Rajeev Kumar3, Sanjay Sharma4,
Sanjay Thulkar4, Siddhartha Datta Gupta5,
and Naranamangalam Raghunathan Jagannathan2
1Radiodiagnosis, King George's Medical
University, Lucknow, U.P., India, 2NMR
& MRI Facility, All India Institute of Medical Sciences,
New Delhi, Delhi, India,3Urology, All India
Institute of Medical Sciences, New Delhi, Delhi, India, 4Radiodiagnosis,
All India Institute of Medical Sciences, New Delhi,
Delhi, India,5Pathology, All India Institute
of Medical Sciences, New Delhi, Delhi, India
RCC is a heterogeneous disease and therapy relies on
accurate histologically subtype of tumors. mpMRI have
shown its potential in diagnosing various malignancies.
We studied RCC lesions using MRS and DW-MRI. MRS showed
increased signal to noise ratio in mobile lipids in RCC
and the resonance at 5.4 ppm was significantly higher in
RCC. ADC was significantly decreased in RCC as compared
to normal kidney. mpMRI could reliably differentiate
malignant tissue from normal kidney parenchyma.
|
3878. |
71 |
Multi-parametric whole body
MRI in paediatric lymphoma; A comparison with reference
standard PET-CT ![](play.gif)
Arash Latifoltojar1, Paul Humphries2,
Stuart Taylor3, Ananth Shankar2,
Stephen Daw2, and Shonit Punwani3
1University College London, London, London,
United Kingdom, 2University
College London Hospital, London, United Kingdom, 3University
College London, London, United Kingdom
Positron emission tomography remains gold standard
imaging for initial investigation and monitoring
treatment response in paediatric lymphoma despite
associated radiation exposure risk factors. Whole body
MRI (WBMRI) provides a non-ionising alternative imaging
modality for assessment of this group of patients.
Anatomical and functional imaging such as diffusion
weighted imaging can be implemented in WBMRI protocols
for a comprehensive assessment of different aspects of
suspected malignancy. In this work we investigated the
diagnostic performance of whole body anatomical and
functional imaging compared to reference standard
PET-CT.
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Tuesday 2 June 2015
Exhibition Hall |
16:00 - 17:00 |
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Computer # |
|
3879. |
73 |
Clinical Evaluation of
TWIST DIXON Sequence with Flexible View Sharing for Breast
DCE MRI: Can Initial Uptake Phase Provide Accurate Diagnosis ![](play.gif)
Yuan Le1, Hal D Kipfer1, Shadie S
Majidi1, Brian Dale2, Marcel
Dominik Nickel3, Randall Kroeker2,
Elisabeth Weiland3, and Chen Lin1
1Radiology and Imaging Science, Indiana
University School of Medicine, Indianapolis, IN, United
States, 2Siemens
Medical Solutions, NC, United States, 3Siemens
Healthcare, Erlangen, Bavaria, Germany
A modified Time-resolved angiography With Stochastic
Trajectories (TWIST) sequence with flexible view sharing
and dual-echo DIXON was evaluated in clinical breast DCE-MRI
for its capability of measuring initial uptake phase
with fast acquisitions in addition to providing high
resolution peak- and post-contrast images. A good
correlation between the results based on the maximum
slope of the signal enhancement in the initial phase and
that based on the standard protocol was found,
indicating a potential of shortening the breast MRI scan
time and in turn a lowering of the breast MRI cost with
this new technique.
|
3880. |
74 |
Assessment of the
correlation between ADC values and Oncotype DX score in
estrogen-receptor positive, lymph node negative, breast
cancers ![](play.gif)
Sunitha B Thakur1, Manuela Durando2,
Milans Soledad3, Elizabeth J Sutton2,
Dilip Giri2, and Elizabeth A Morris2
1Memorial Sloan Kettering Cancer Center, New
York, NY, United States, 2Memorial
Sloan Kettering Cancer Center, NY, United States, 3Memorial
Sloan Kettering Cancer Center, New YORK, NY, United
States
Preliminary studies have attempted to evaluate Apparent
Diffusion Coefficient (ADC) values for its potential
prognostic utility. However the impact of ADC on
prognosis remains to be clearly defined. This study was
conducted with the goal of determining whether there
exists a correlation between ADC values and Oncotype Dx
scores in estrogen-receptor positive and lymph node
negative breast cancers. We found that mean ADC values
were higher in Oncotype DX score stratified low risk
cancers than in intermediate risk cancers. Our data at
3.0T MRI suggests that lower ADC values correlate with a
higher Oncotype DX score and consequently, an increased
risk of recurrence.
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3881. |
75 |
Multi-parametric
Longitudinal Study for the Evaluation of Tumor Heterogeneity
in Breast Cancer Patients Using Simultaneous MRSI & DWI
Techniques ![](play.gif)
Naranamangalam R Jagannathan1, Khushbu
Agarwal1, Uma Sharma1, Smriti Hari2,
Vurthaluru Seenu3, and Rajinder Parshad3
1Department of NMR & MRI Facility, All India
Institute of Medical Sciences, New Delhi, Delhi, India, 2Department
of Radiodiagnosis, All India Institute of Medical
Sciences, New Delhi, Delhi, India, 3Department
of Surgical Disciplines, All India Institute of Medical
Sciences, New Delhi, Delhi, India
ChoSNR and ADC were measured from same voxels in
different breast tumor regions (solid tumor, necrosis
and margin) prior to and after III NACT in 11 LABC
patients (6 clinical responders and 5 non-responders).
In responders, increased ChoSNR with decreased ADC of
solid tumor was observed after therapy. ChoSNR decreased
significantly with no ADC change at tumor margin. At
necrosis no change in ChoSNR or ADC was seen. In
non-responders ChoSNR and ADC did not change in tumor
regions. Positive Pearson correlation between ChoSNR and
ADC change signifies combined utility of both techniques
simultaneously in therapeutic management of breast
cancer.
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3882. |
76 |
Implementation of
Multiparametric Magnetic Resonance Imaging with
High-Resolution Dynamic Contrast-Enhanced and
Diffusion-Weighted Magnetic Resonance Imaging at 7T Improves
the Assessment of Breast Tumors: A Feasibility Study ![](play.gif)
Katja Pinker1, Pascal Baltzer1,
Wolfgang Bogner2, Doris Leithner1,
Siegfried Trattnig2, Olgica Zaric2,
Peter Dubsky3, Rupert Bartsch4,
Zsuzsanna Bago-Horvath3, Stephan Gruber2,
Michael Weber1, and Thomas H Helbich1
1Dept. of Biomedical Imaging and Image-guided
Therapy, Division of Molecular and Gender Imaging,
Medical University of Vienna, Vienna, Austria, 2Dept.
of Biomedical Imaging and Image-guided Therapy, MR
Centre of Excellence, Medical University of Vienna,
Vienna, Vienna, Austria, 3Dept.
of Surgery, Medical University of Vienna, Vienna,
Austria, 4Dept.
of Internal Medicine, Division of Oncology, Medical
University of Vienna, Vienna, Austria
The clinical use of multiparametric MR imaging at 7T is
feasible with good or excellent image quality.
Multiparametric MR imaging of the breast with DCE MR
imaging and DWI at 7T seems to have the potential to
diagnose breast cancer with high diagnostic accuracy
(AUC 0.941). Multiparametric MR imaging of the breast
with DCE MR imaging and DWI at 7T improves specificity
as compared to interpretation of DCE MRI alone
(p=0.031). Multiparametric MR imaging of the breast with
DCE MR imaging and DWI at 7T can avoid unnecessary
breast biopsies recommended with DCE MR imaging, in our
series in 6/8 (75%, p=0.031) of benign breast tumors.
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3883. |
77 |
Registration of
Multiparametic Breast MRI ![](play.gif)
Lawrence Kenning1, Martin Pickles1,
and Lindsay Turnbull1
1Centre for MR Investigations, Hull York
Medical School at University of Hull, Hull, United
Kingdom
Motion during breast MR examination can degrade DCE data
and cause spatial mismatches between sequences. Data
acquired from 19 patients was retrospectively corrected
using rigid and non-rigid schemes. For the DCE series,
mean coefficients of variation were found to be
45.2±3.9%, 40.0±3.1% and 35.7±2.5% for the original
data, rigid motion corrected data and the non-rigid
motion corrected data. Non-rigid registration between MR
series was successfully applied to all patients and
showed good visual agreement. The global 4D registration
methodology enables researchers and clinicians to
contour single volume of interests that can be used to
simultaneously interrogate multiple breast MR series.
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3884. |
78 |
Multi-parametric MRI in
evaluating pre-and post-menopausal ER positive breast cancer ![](play.gif)
Elizabeth O'Flynn1, David Collins1,
James D'Arcy1, Maria Schmidt1, and
Nandita deSouza1
1CRUK Cancer Imaging Centre, The Institute of
Cancer Research, Sutton, Surrey, United Kingdom
The purpose of this study was to compare multiparametric
MRI parameters of ER positive tumours in pre- and
postmenopausal women to assess any differences in tumour
functional characteristics and to establish which
parameter correlated significantly with response as
defined by tumor volume reduction.In premenopausal women
with ER positive breast cancer, tumors were larger and
more vascular than in postmenopausal women. A rise in
the ve correlated significantly with volume reduction in
premenopausal women; no specific parameter correlated
with response in postmenopausal women.
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3885. |
79 |
Assessment of Pathologic
Complete Response of Breast Cancer with Different Molecular
Subtypes after Neoadjuvant Chemotherapy with Dynamic
Contrast-enhanced MR Imaging ![](play.gif)
Yuan Jiang1, Naishan Qin1,
Xiaoying Wang1, and Li Guo1
1Radiology Department, Peking University
First Hospital, Beijing, Beijing, China
Different molecular subtypes of breast cancer respond
differently to neoadjuvant chemotherapy. Patients who
achieve pathologic complete response (pCR) have better
prognosis than non-pCR. In our study, semi-quantitative
analysis of dynamic contrast-enhanced (DCE) MR Imaging
between pCR and non-pCR was performed in four types of
breast cancer (Luminal A, Luminal B, HER2+ and Triples
negative), and our results showed that DCE-MR Imaging
could become the potential predictor of pCR to NAC in
breast cancer with Luminal B and Triples negative types.
Maybe further study should be performed based on
molecular subtypes of breast cancer.
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3886. |
80 |
Optimization of
Quantitative MRI Background Parenchymal Enhancement Metrics
to Predict Breast Cancer Risk ![](play.gif)
Cheng-Liang Liu1, Savannah C Partridge1,
Diana L Lam1, Constance D Lehman1,
and Habib Rahbar1
1Department of Radiology, University of
Washington, Seattle, Washington, United States
Background parenchymal enhancement (BPE) on MRI has been
proposed to be a biomarker of breast cancer risk. We
sought to develop an optimal method to measure BPE
quantitatively for breast cancer risk assessment. By
measuring various BPE metrics at enhancement thresholds
ranging from 5-100% in a case-control (n=36), we found
that quantitative BPE measures are higher in women who
developed breast cancer than in controls, with a 70%
enhancement threshold for BPE area providing the highest
accuracy for predicting risk. Our findings suggest
quantitative BPE measures can assess breast cancer risk,
potentially allowing individualized screening and
prevention strategies.
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3887. |
81 |
Clinical Utility of
Sequential DWI in Studying Tumor Margins as an aid to Breast
Conservation Surgery ![](play.gif)
Naranamangalam R Jagannathan1, Khushbu
Agarwal1, Rani G Sah1, Uma Sharma1,
Smriti Hari2, Vurthaluru Seenu3,
and Rajinder Parshad3
1Department of NMR & MRI Facility, All India
Institute of Medical Sciences, New Delhi, Delhi, India, 2Department
of Radiodiagnosis, All India Institute of Medical
Sciences, New Delhi, Delhi, India, 3Department
of Surgical Disciplines, All India Institute of Medical
Sciences, New Delhi, Delhi, India
ADC were measured at whole tumor (WT), and from five
geographical zones from inside tumor margin (IM) in a
layerwise manner to outside tumor margin III (OM1, OM2,
OM3) and intra-tumoral necrotic domains (Nec)
sequentially i.e., prior to (Tp0), after I (Tp1) and III
(Tp3) neoadjuvant chemotherapy (NACT) in 36 breast
cancer patients. A significant increase in ADC was seen
for WT and IM, while it decreased at OM1 compared to OM2
and OM3 at Tp3. The change in ADC of WT and nec after
therapy showed positive Pearson correlation. Results
indicated the utility of DWI in breast conservation
surgery.
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3888. |
82 |
Evaluation of the
Efficiency of DTI Anisotropy Indices to Detect Breast Cancer ![](play.gif)
Edna Furman-Haran1, Dov Grobgeld2,
Noam Nissan2, Myra Feinberg-Shapiro3,
Tania Zehavi3, Zvi Kaufman3, and
Hadassa Degani2
1Department of Biological Services, The
Weizmann Institute of Science, Rehovot, Israel, 2Department
of Biological Regulation, The Weizmann Institute of
Science, Rehovot, Israel, 3Meir
Medical Center, Kfar Saba, Israel
DTI tracks the water diffusion in different directions
and thereby allows characterizing breast microstructures
with restricted diffusion, revealing their organization
in vector/ellipsoid-maps and parametric-maps of
anisotropy-indices, derived from the diffusion tensor
eigenvectors and eigenvalues, respectively. The study
evaluates of the various anisotropy-indices
investigating their ability to detect breast cancer. The
results indicate that the commonly used normalized
anisotropy-indices fail to differentiate cancer from
normal tissue, while the un-normalized maximal
anisotropy index is significantly lower in cancer as
compared to normal tissue and can be efficiently used
for detecting breast cancer in conjunction with the
reduction in the diffusion coefficients.
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3889. |
83 |
A Preliminary Study of
Diffusion Kurtosis Imaging for Assessment of Breast Lesions ![](play.gif)
Shiteng Suo1, Fang Cheng1, He Wang2,
Jia Hua1, and Jianrong Xu1
1Department of Radiology, Ren Ji Hospital,
School of Medicine, Shanghai Jiao Tong University,
Shanghai, China, China, 2Philips
Research Chinia, Shanghai, China, China
In the study, the preliminary results showed that the
water diffusion followed a non-Gaussian behavior by
using diffusion kurtosis imaging (DKI) in breast
lesions. The malignant tumors tended to have a
restricted diffusion pattern and an increased K value
compared to fibroadenoma. With the capability to
quantify the deviation from Gaussian distribution, the K
value may give insight into the microstructure
complexity in vivo.
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3890. |
84 |
Improved Diagnostic
Performance of 3T Breast MRI using Perfusion-Adjusted ADC
Values ![](play.gif)
Niloufar Fozouni1, Cheng-Liang Liu1,
Habib Rahbar1, Constance D Lehman1,
and Savannah C Partridge1
1Department of Radiology, University of
Washington, Seattle, Washington, United States
Diffusion-weighted imaging (DWI) holds potential for
reducing false positives on conventional breast MRI
based on differences in apparent diffusion coefficient
(ADC) values between benign and malignant lesions.
However, standard DWI approaches can result in ADC
values strongly influenced by perfusion, potentially
increasing overlap in ADC between pathologies. In this
study, we found that separation of perfusion and
diffusion-weighted components of lesion ADC measures
using a simplified approach can improve diagnostic
performance. Furthermore, we found that a
multiparametric combination of DWI and DCE features can
provide more accurate assessment of suspicious
MRI-detected breast lesions.
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3891. |
85 |
Intravoxel incoherent
motion MRI may reveal microvascular variation of
fibroglandular tissues in breast cancer ![](play.gif)
Jing Yuan1, Gladys G. Lo2, Oi Lei
Wong1, Helen H.L. Chan2, Abby Y.
Ding1, Ting Ting Wong3, and Polly
S.Y. Cheung3
1Medical Physics and Research Department,
Hong Kong Sanatorium & Hospital, Happy Valley, Hong
Kong, China, 2Department
of Diagnostic & Interventional Radiology, Hong Kong
Sanatorium & Hospital, Happy Valley, Hong Kong, China, 3Breast
Care Center, Hong Kong Sanatorium & Hospital, Happy
Valley, Hong Kong, China
This study aims to investigate the micro-vascularity of
fibroglandular tissues (FGTs) in breast cancer (BC)
using intravoxel incoherent motion (IVIM) MRI. 21
histology-confirmed patients received IVIM-MRI at 3T.
True diffusion D, pseudo-diffusion D*, pseudo-diffusion
fraction f and ADC in ipsilateral and contralateral
breast FGTs were compared. Results show that FGT D* and
f in the ipsilateral tumor-bearing breast were higher
than those in the contralateral breast (D*:
24.96¡Ó9.37¡Ñ10-3mm2/s v.s.
19.98¡Ó9.37¡Ñ10-3mm2/s; f:
0.123¡Ó0.034 v.s. 0.109¡Ó0.030), with D* being
significant (p=0.033). FGT microvascular variation
revealed by IVIM-MRI may potentially be used for breast
cancer risk assessment, characterization and/or
prognosis
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3892. |
86 |
Intralesional
Characteristics of Correlated 18-Fluorodeoxyglucose PET and
Intravoxel Incoherent Motion Parameters in Locally Advanced
Breast Cancer ![](play.gif)
Jason Ostenson1, Linda Moy1,
Sungheon G. Kim1, Amy Melsaether1,
Komal Jhaveri2, Christian Geppert3,
David Faul3, Francisco Esteva2,
Sylvia Adams2, Freya Schnabel4,
Kimberly Jackson1, Joon Lee1,
Christopher Glielmi3, Gene Young Cho1,5,
Thorsten Feiweier6, and Eric E. Sigmund1
1Department of Radiology, NYU Langone Medical
Center, New York, NY, United States, 2Perlmutter
Cancer Center, NYU Langone Medical Center, New York, NY,
United States, 3Siemens
Medical Solutions, New York, NY, United States, 4Department
of Surgery, NYU Langone Medical Center, New York, NY,
United States,5Sackler Institute of Graduate
Biomedical Sciences, NYU School of Medicine, New York,
NY, United States, 6Siemens
AG, Erlangen, Germany
Simultaneously acquired diffusion weighted imaging and
18-fluorodeoxyglucose(FDG)-PET are employed to explore
the relationship between glucose avidity, diffusion, and
perfusion in breast cancer. Intravoxel incoherent motion
metrics are calculated and combined with correlated FDG-PET
standard uptake values (SUV) for all voxels in 16
histopathologically proven breast cancer lesions.
Two-dimensional histograms and Pearson’s correlations
are used to define three lesion types. Each lesion’s
voxels are separated into three groups according to
their SUV, diffusion, and perfusion fraction. The
results yield insight into the heterogeneity of the
tumor microenvironment and show significant correlations
with estrogen receptor expression and a cellular
proliferation marker (Ki-67).
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3893. |
87 |
Initial results of the
Application of a Modified TWIST Sequence with Flexible View
Sharing in Breast DCE-MRI ![](play.gif)
Yuan Le1, Hal D Kipfer1, Marcel
Dominik Nickel2, Randall Kroeker3,
Stephanie P Holz1, Elisabeth Weiland2,
and Chen Lin1
1Radiology and Imaging Science, Indiana
University School of Medicine, Indianapolis, IN, United
States, 2Siemens
Healthcare, Erlangen, Bavaria, Germany,3Siemens
Medical Solutions, NC, United States
Time-resolved angiography With Stochastic Trajectories
(TWIST) Sequence was modified with flexible TWIST view
sharing and flexible echo time Dixon for the acquisition
of images with high and flexible spatial and temporal
resolution as well as uniform fat suppression. Our
initial experience shows that it provides potentially
valuable information on early tumor enhancement
characteristics while maintaining excellent image
quality at post-contrast enhancement in breast DCE-MRI,
allowing more optimized spatial and temporal resolution
in clinical breast imaging.
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Tuesday 2 June 2015
Exhibition Hall |
16:00 - 17:00 |
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Computer # |
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3894. |
88 |
2HG Metabolic Profiling
Analysis based on 13C-NMR Spectroscopy with
Stable13C-labeled Isotope - permission withheld
Hyeon-Man Baek1,2, Youngjae Jeon1,
Jooyun Kim1, and Mirim Bang1
1Center for MR Research, Korea Basic Science
Institute, Ochang, Chungbuk, Korea, 2Department
of Bio-Analytical Science, University of Science &
Technology, Daejeon, Chungnam, Korea
The aim of this study was two-fold: first, to
investigate the metabolic profiling analysis based on
13C-NMR spectroscopy with stable 13C-labeled isotope,
and second, to demonstrate whether 2HG labeling from
[U-13C]glucose substrate feeding could be detected in
IDH1 or 2 mutated cells.The analysis of 1H- and 13C-NMR
spectra of the cell extracts showed a significant
increase in the concentration of the 2HG in IDH mutated
cells, but not in IDH wild type and mutant IDH cells
with low transfection efficiency.
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3895. |
89 |
Evaluation of PET/MR and
DWI in malignant lymphoma: initial results in 17 patients ![](play.gif)
Chiara Giraudo1, Michael Weber1,
Markus Raderer2, Georgios Karanikas1,
and Marius Erik Mayerhoefer1
1Departments of Biomedical Imaging and
Image-guided Therapy, Medical University of Vienna,
Vienna, Austria, 2Internal
Medicine I, Medical University of Vienna, Vienna,
Austria
This study was performed to assess the diagnostic value
of PET/MR and DWI in the evaluation of nodal and
extranodal lymphoma. PET/MR is an emerging hybrid
technique that has already demonstrated very good
results for the diagnosis of malignancies in different
anatomical districts but up to now, only few data are
available in the literature about its application on
patients affected by lymphoma. Our initial results
demonstrated that, for both nodal and extranodal
disease, PET/MR is a highly promising technique and DWI
confirmed to be an essential tool to improve the
diagnostic work-up of this heterogeneous cancer group.
|
3896. |
90 |
Automated Planning of Scan
Geometry in Follow-up Prostate MRI Examinations ![](play.gif)
Peter Mazurkewitz1, Daniel Bystrov1,
Peter Koken1, Torbjoern Vik1, and
Julien Sénégas1
1Philips Research Laboratories, Hamburg,
Germany
In this work, we present a robust and accurate method
for the automated planning of scan geometry in follow-up
prostate exams. In order to better cope with the
specific challenges of prostate MR exams, where
high-resolution scans with small FOV generally need to
be planned, the rigid registration method presented
recently was adapted by using an image based organ
detection as initialization of the registration
algorithm. This step ensures a robust and stable
registration. This new approach was evaluated
retrospectively on volunteer data and tested on a
commercial MRI system.
|
3897. |
91 |
DCE-MRI of prostate cancer:
perfusion quantification with Tofts model vs. shutter-speed
model. Initial experience. ![](play.gif)
Cecilia Besa1, Guido Jajamovich2,
Adnan Ali3, Wei Huang4, Kenneth
Haines5, Ash Tewari3, and Bachir
Taouli6
1Radiology, Icahn School of Medicine at Mount
Sinai, New York, NY, United States, 2icahn
School of Medicine at Mount Sinai, NY, United States, 3Urology,
Icahn School of Medicine at Mount Sinai, NY, United
States, 4Radiology,
Oregon Health & Science University, Portland, OR, United
States, 5Pathology,
Icahn School of Medicine at Mount Sinai, NY, United
States, 6Icahn
School of Medicine at Mount Sinai, New York, NY, United
States
Synopsis: The purpose of this study was to evaluate the
value of quantitative diffusion weighted imaging (DWI)
and dynamic contrast enhanced (CE) MRI in predicting
histopathologic characteristics of liver metastatic
neuroendocrine tumors (NET). We found that
neuroendocrine carcinoma (G3) liver metastases had
significantly lower ADC values and higher arterial
enhancement rate (ER) than Grade 1 and 2 NETs. In
addition, significant negative correlation was observed
between ADC and ER and mitotic count and Ki-67% labeling
index. DWI with ADC quantification and CE-MRI may be
useful for predicting tumor grade in metastatic hepatic
NET.
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3898. |
92 |
The Effect of Groupwise
Elastic Registration in Discrimination of Benign and
Malignant Ovarian Cancers by Pharmacokinetic Parameters ![](play.gif)
Elaheh Kia1,2, Anahita Fathi Kazerooni1,2,
Saeedeh Navaei Lavasani1,2, Alireza Ahmadian2,
and Hamidreza Saligheh Rad1,2
1Quantitative MR Imaging and Spectroscopy
Group, Research Center for Molecular and Cellular
Imaging, Tehran University of Medical Sciences, Tehran,
Iran,2Department of Medical Physics and
Biomedical Engineering, School of Medicine, Tehran
University of Medical Sciences, Tehran, Iran
Dynamic contrast enhanced MRI (DCE-MRI) has shown to be
promising for quantitative assessment of complex ovarian
cancers. Quantification of DCE-MR images could be
affected by motion artifacts and intensity inhomogeneity
induced by bias fields. Proper selection of a
registration algorithm could impact the outcome of this
problem. In this work, we proposed an efficient
non-rigid registration method in a group-wise setting to
non-rigidly align DCE-MR images to reliable
quantification of ovarian masses.
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