ISMRM 23rd Annual Meeting
& Exhibition • 30 May - 05 June 2015 • Toronto, Ontario, Canada |
Note: The videos
below are only the slides from each presentation. They do not have
audio. |
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Wednesday, 3 June 2015
Exhibition Hall |
13:30 - 14:30 |
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Computer # |
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4161. |
1 |
Time efficient and
quantitative Sodium imaging at 7T using compressed sensing
accelerated FID spectroscopic imaging
Jetse van Gorp1, Paul de Bruin2,
and Peter Seevinck1
1Image Sciences Institute, University Medical
Center Utrecht, Utrecht, Utrecht, Netherlands, 2Department
of Radiology, Leiden University Medical Center, Leiden,
Zuid-Holland, Netherlands
In this work we propose a flexible and quantitative
method for sodium (23Na) imaging to determine the total
sodium concentration (TSC) and characterize the signal
decay, which is related to bound and unbound 23Na. A
(compressed sensing accelerated) 3D FID spectroscopic
imaging sequence is used to maximize the ratio between
sampling time and total acquisition time to optimize the
SNR, obtain a high temporal resolution and acquire 23Na
images in both a calibration phantom and in the knee of
a healthy volunteer.
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4162. |
2 |
Four-fold reduction in scan
time for skeletal age examination enabled by adaptive
compressed sensing MRI
Yasuhiko Terada1, Keiichiro Ishi1,
Daiki Tamada1, Katsumi Kose1,
Taiki Nozaki2, Yasuhito Kaneko2,
Ryo Miyagi2, and Hiroshi Yoshioka2
1Institue of Applied Physics, University of
Tsukuba, Tsukuba, Ibaraki, Japan, 2Department
of Radiological Sciences, University of California
Irvine, Irvine, CA, United States
Skeletal age of a young child is assessed by rating the
maturity stage of left-hand bones in the MRI images. We
have used a 0.3 T open scanner to provide a comfortable
examination environment for children, and showed the
validity of the skeletal age examination. However, the
long scan times for 3D imaging are uncomfortable for
children and often induce motion artifacts in the
images. In the previous study, we used compressed
sensing (CS) to shorten the long scan time, but the
acceleration factor (AF) was limited to 2 because of the
low signal-to-noise ratio. To further decrease the scan
time, it is necessary to optimize the CS sampling
pattern for skeletal age examination with knowledge of
the nature of data to be reconstructed. In this study,
we optimize the sampling pattern using the database of
hand images obtained in the previous study and realize
the 40-second scan (AF = 4). Both the simulation and
experimental results reveal the validity of the CS-based
skeletal examination using optimal sampling.
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4163. |
3 |
10 minute isotropic MRI of
the knee using accelerated 3D SPACE with incoherent
undersampling and iterative reconstruction: Comparison with
standard 2D TSE MRI
Jan Fritz1, Gaurav Thawait1,
Shivani Ahlawat1, Shadpour Demehri1,
Heiko Meyer2, Wesley Gilson3, and
Esther Raithel2
1Russell H. Morgan Department of Radiology
and Radiological Science, Johns Hopkins University
School of Medicine, Baltimore, MD, United States, 2Healthcare
Sector, Siemens AG, Erlangen, Bavaria, Germany, 3Siemens
Healthcare USA, Baltimore, MD, United States
While high spatial resolution, isotropic 3D MRI of knee
can achieve similar diagnostic performance than standard
2D MRI, the acquisition of 3D data can be time-consuming
and may conflict with its practicability. K-space
undersampling and iterative reconstruction is a method
that can yield substantial acceleration of 3D data
acquisition. In this study, we show how the
implementation of k-space undersampling and iterative
reconstruction into a SPACE pulse sequence prototype
enables accelerated, comprehensive,
high-spatial-resolution 3D MRI of the knee in under 10
min with image qualities that rivals standard 2D TSE
images and potential to replace a more time-consuming 20
min standard 2D TSE MRI protocol.
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4164. |
4 |
Improving Slice Resolution
of Knee Imaging Using Multiband Slice Accelerated TSE - permission withheld
Dingxin Wang1,2, Chen Lin3,
Abraham Padua4, Bruce Spottiswoode5,
Jutta Ellermann2, Edward Auerbach2,
Kamil Ugurbil2, Kenneth Buckwalter3,
and Vibhas Deshpande6
1Siemens Healthcare, Minneapolis, Minnesota,
United States, 2CMRR,
Department of Radiology, University of Minnesota,
Minneapolis, Minnesota, United States, 3Department
of Radiology, University of Indiana, Indianapolis,
Indiana, United States, 4Siemens
Healthcare, Houston, Texas, United States, 5Siemens
Healthcare, Chicago, Illinois, United States, 6Siemens
Healthcare, Austin, Texas, United States
Our study demonstrates the utility of multiband slice
accelerated TSE for improving slice resolution (2.5 mm
vs 3 mm) of clinical knee imaging at 3T with no time
penalty. Multiband slice acceleration improves the
acquisition efficiency of TSE, allowing more number of
thinner slices to be covered per TR.
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4165. |
5 |
Investigation of In-vivo
Relationship between Cartilage Contact and Cartilage
Quantitative MR Parameters
Fang Liu1, Jarred Kaiser2, Walter
F. Block1,3, Darryl G. Thelen2,3,
and Richard Kijowski4
1Department of Medical Physics, University of
Wisconsin-Madison, Madison, Wisconsin, United States, 2Department
of Mechanical Engineering, University of
Wisconsin-Madison, Madison, Wisconsin, United States, 3Department
of Biomedical Engineering, University of
Wisconsin-Madison, Madison, Wisconsin, United States, 4Department
of Radiology, University of Wisconsin-Madison, Madison,
Wisconsin, United States
A novel dynamic and static MR method was proposed to
investigate the in-vivo relationship between cartilage
contact and quantitative cartilage MR parameters in an
asymptomatic subject following anterior cruciate
ligament reconstruction surgery. A cartilage contact map
of the tibia plateau was created using dynamic SPGR-VIPR
imaging performed during active loaded knee flexion and
extension, cartilage thickness map was created using 3D
fast spin-echo imaging, and cartilage single-component
T2 and fast relaxing water fraction (Ff) maps were
created using mcDESPOT imaging. Cartilage contact was
found to positively correlate with cartilage thickness
and cartilage Ff and negatively correlate with cartilage
T2.
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4166. |
6 |
A comprehensive 7 Tesla MRI
protocol for quantitative (T1-, T2-, T2*-mapping) and
morphological hip cartilage imaging
Andrea Lazik1,2, Jens M Theysohn1,
Stephan Orzada2, Harald H Quick2,3,
and Oliver Kraff2
1Department of Diagnostic and Interventional
Radiology and Neuroradiology, University Hospital Essen,
Essen, NRW, Germany, 2Erwin
L. Hahn Institute for Magnetic Resonance Imaging,
University Duisburg-Essen, Essen, NRW, Germany, 3High
Field and Hybrid MR Imaging, University Hospital Essen,
Essen, NRW, Germany
A comprehensive hip cartilage protocol was established
at 7T MRI on 11 volunteers, combining morphological
(DESS, T1 VIBE) and quantitative imaging techniques
(T1-mapping in dGEMRIC-technique, T2-, T2*-mapping) with
high spatial resolution, and applied in patients with
acetabular cartilage transplants. Delineation of
acetabular and femoral cartilage increased after
intravenous contrast-agent administration in DESS and T1
VIBE, and was also good to excellent in the relaxation
maps. Values of T2- and T2*-relaxation times were not
affected by intravenous contrast agent administration.
Unenhanced pre-scans for dGEMRIC were nonessential.
According to these results, combining morphological and
quantitative hip cartilage imaging is possible at 7T.
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4167. |
7 |
Quantitative Magnetic
Resonance Imaging for Evaluation of ACL Injuries: a pilot
multicenter study
Keiko Amano1, Valentina Pedoia2,
Drew A Lansdown1, Cory Wyatt2,
Narihiro Okazaki2, Favian Su2,
Dragana Savic2, Kimberly Amrami3,
Matthew Frick4, Joel Felmlee3,
Matthew F Koff5, Aaron Krych6,
Hollis Potter5, C. Benjamin Ma1,
Scott Rodeo7, Xiaojuan Li2, and
Sharmila Majumdar2
1Department of Orthopaedic Surgery,
University of California, San Francisco, San Francisco,
California, United States, 2Department
of Radiology, University of California, San Francisco,
San Francisco, California, United States, 3Department
of Radiology, Mayo Clinic, Minnesota, United States, 4Radiology,
Mayo Clinic, Minnesota, United States, 5Department
of Radiology, Hospital for Special Surgery, New York,
United States, 6Department
of Orthopaedic Surgery, Mayo Clinic, Minnesota, United
States, 7Department
of Orthopaedic Surgery, Hospital for Special Surgery,
New York, United States
We present the feasibility of detecting cartilage
degeneration using T1ρ and T2 in ACL-injured patients in
a multicenter study. MRIs of 37 patients with ACL
injuries were obtained at three institutions after
injury and prior to surgery. Two healthy volunteers were
scanned at all sites for reliability testing. T1ρ and T2
values were computed with an in-house Matlab program.
Mean inter-site differences were between 0.8-1.6ms for
the volunteers, and mean relaxation times were
significantly higher on the injured knee. These data
indicate good reproducibility across the three sites,
and demonstrates the feasibility of expanding this
technology to multiple institutions.
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4168. |
8 |
A New 3D Isotropic T1 Mapping
Technique for In
Vivo Human
Knee Cartilage at 7T MRI - permission withheld
Guruprasad Krishnamoorthy1, Puneet Bagga1,
Ravi Prakash Reddy Nanga1, Hari Hariharan1,
John Bruce Kneeland2, and Ravinder Reddy1
1Center for Magnetic Resonance and Optical
Imaging, University of Pennsylvania, Philadelphia, PA,
United States, 2Department
of Radiology, University of Pennsylvania, Philadelphia,
PA, United States
Osteoarthritis (OA) is a degenerative disease affecting
Articular Cartilage (AC) of synovial joints like knee,
shoulder, hip, etc. Spin-lattice relaxation in the
rotating frame (T1ρ) has been a promising quantitative
MRI technique to detect biochemical changes in the AC.
High resolution MRI is desired across the thickness of
AC particularly in the OA subjects to identify the
extent of the cartilage degeneration. Here we propose a
new 3D-GRE based time efficient method to acquire T1ρ
weighted images of the whole knee at an isotropic
resolution that allows the reformatting of the isotropic
images of knee to any desired orientation.
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4169. |
9 |
Cartilage assessment in
femoroacetabular impingement using Bloch-simulation-based T2
mapping at 3 T: preliminary validation against
intra-operative findings
Noam Ben-Eliezer1,2, Matthieu Guillemin1,
Akio Yoshimoto1, Kai Tobias Block1,2,
Roy Davidovitch3, Thomas Youm3,
Robert Meislin3, Michael Recht4,
Daniel K Sodickson1,2, and Riccardo Lattanzi1,2
1Center for Biomedical Imaging, Department of
Radiology, New York University Medical Center, New York,
NY, United States, 2Center
for Advanced Imaging Innovation and Research (CAI2R),
Department of Radiology, New York University School of
Medicine, New York, NY, United States, 3Department
of Orthopedic Surgery, New York University Hospital for
Joint Diseases, New York, NY, United States, 4Department
of Radiology, New York University Langone Medical
Center, New York, NY, United States
Early diagnosis of articular cartilage defects is
critical to the success of corrective surgical
procedures in patients with femoroacetabular impingement
(FAI). Quantitative T2 mapping
can detect early degeneration of cartilage, but it is
challenging to perform in vivo, mostly due to the
contamination of multi spin-echo protocols by stimulated
and indirect echoes, non-rectangular slice profiles, and
inhomogeneous (B1+) fields. We use
a recently-developed T2 mapping
technique – the echo-modulation curve (EMC)
algorithm – which is able to overcome these limiting
factors, for retrospective assessment of cartilage
damage in FAI patients, to show increased specificity of
the EMC technique versus conventional mono-exponential
fitting.
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4170. |
10 |
Highly-Accelerated 3D T1rho
Mapping of the Knee Using k-t SPARSE-SENSE
Ding Xia1,2, Li Feng1,2, Tiejun
Zhao3, and Ravinder R. Regatte1,2
1Center for Advanced Imaging Innovation and
Research (CAI2R), Department of Radiology, New York
University School of Medicine, New York, NY, United
States, 2Bernard
and Irene Schwartz Center for Biomedical Imaging,
Department of Radiology, New York University School of
Medicine, New York, NY, United States, 3Siemens
Medical Solution USA. Inc, New York, NY, United States
This work investigates the feasibility of
highly-accelerated 3D-T1rho mapping in human knee
cartilage using a combination of compressed sensing and
parallel imaging. Fully sampled dynamic k-space data
were retrospectively undersampled at different
acceleration rates from 2 to 6 and reconstructed using
k-t SPARSE-SENSE, a reconstruction framework that
exploits joint multicoil sparsity in dynamic imaging.
The 3D T1rho maps estimated from the accelerated
datasets was compared with the fully sampled reference.
Accurate T1rho maps can be obtained up to 5-fold
acceleration, which suggest that the proposed approach
could be useful in assessing musculoskeletal diseases
such as osteoarthritis with reduced scan times.
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4171. |
11 |
High Isotropic, Balanced
SSFP 3D Radial Imaging for Hip Joint Assessment at 3.0T
Larry Hernandez1, Habib Al saleh1,
Kevin Johnson1, Walter F. Block1,2,
and Richard Kijowski3
1Medical Physics, University of
Wisconsin-Madison, Madison, WI, United States, 2Biomedical
Engineering, University of Wisconsin-Madison, Madison,
WI, United States, 3Radiology,
University of Wisconsin-Madison, Madison, WI, United
States
VIPR-ATR can produce 0.5mm isotropic resolution images
of the hip joint with SSFP tissue contrast which can be
reformatted in any orientation following a single 7.7
minute acquisition. This study compared VIPR-ATR with
two-dimensional fast spin-echo (2D FSE) sequences for
evaluating the hip joint in 24 patients. VIPR-ATR had
significantly higher (p<0.05) normalized SNR efficiency
for cartilage and fluid and significantly higher
(p<0.05) normalized CNR efficiency between cartilage and
other joint structures than 2D FSE sequences. VIPR-ATR
had similar ability as 2D FSE images for detecting
labral tears and improved ability for identifying
cartilage lesions within the hip joint.
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4172. |
12 |
T1 Voxel
Based Relaxometry for the Local Evaluation of the Knee
Cartilage
Valentina Pedoia1, Favian Su1,
Deepak Kumar1, Richard Souza1,
Benjamin Ma1, Xiaojuan Li1, and
Sharmila Majumdar1
1UCSF, San Francisco, California, United
States
T1rho MRI quantitative assessment of cartilage
degenerative change is usually addressed through
ROI-based approaches considering T1rho mean as
descriptor. However, previous studies showed that
spatially assessing T1rho using laminar and texture
analyses could lead to better and probably earlier
identification of cartilage matrix abnormalities. Voxel
Based Relaxometry (VBR) is a technique that could
potentially be used for investigating local cartilage
microstructural composition. In this study we show the
use of VBR to study the knee cartilage. VBR showed the
capability to detect specific local patterns of T1ρ
increase that maybe potentially useful for a more
accurate analysis and disease phenotyping
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4173. |
13 |
Characterization of knee
osteoarthritis using spatial distribution of T1p values: A
longitudinal study
Aditi Guha1, Deepak Kumar1,
Lorenzo Nardo1, Richard Souza1,
Thomas Link1, Xiaojuan Li1, and
Sharmila Majumdar1
1Radiology and Biomedical Imaging, UCSF, San
Francisco, CA, United States
The goal of this study is to evaluate the spatial
changes in T1p values longitudinally in osteoarthritic
and healthy knee using texture analysis
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4174. |
14 |
Characterization of
Cartilage using Diffusion Imaging and Correlation with
T1p/T2 relaxation times: A Longitudinal Evaluation in Knee
Osteoarthritis
Aditi Guha1, Cory Wyatt1,
Dimitrios Karampinos2, Lorenzo Nardo1,
Thomas Link1, and Sharmila Majumdar1
1Radiology and Biomedical Imaging, UCSF, San
Francisco, CA, United States, 2Radiology,
Technische Universität München, Munich, Germany
in this study, longitudinal evaluation of our
pervasively proposed stimulated echo MAPSS sequence is
done. Correlation between the three non invasive
biomarkers for knee osteoarthritis is evaluated.
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4175. |
15 |
Evaluation of Multiband
Slice-Accelerated TSE in Knee Joint MR Imaging
Xiaona Li1, Zhigang Peng1, Pan-Li
Zuo2, Dingxin Wang3, and Jianling
Cui4
1the 3rd Hospital of Hebei Medical
University, Shijiazhuang, Hebei, China, 2Siemens
Healthcare, Beijing, China, 3Siemens
Medical Solutions USA, Minnesota, Armenia, 4the
3rd Hospital of Hebei Medical University, Hebei, China
To compare the simultaneous acquisition of multiple
slices (SMS) with turbo spin echo (TSE) sequences to
routine TSE sequences in musculoskeletal (MSK) imaging.
10 healthy volunteers and 8 patients with knee joint
disorders were examined in two sequences at 3T. The
basic acquisition parameters for two sequences were
similar. Slice accelerated factor was 2 and FOV shift
factor was 2 for SMS sequences. Signal-to-noise ratio
(SNR) and contrast-to-noise ratio were calculated in
volunteers, respectively. Two radiologists visually
evaluated the images of patients double blindly. SMS TSE
requires less scan time and offers higher SNR,
especially for large coverage MSK examination.
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4176. |
16 |
T2, dGEMRIC and gagCEST
Cartilage Assessment in an in Vivo OA Canine Model - permission withheld
Maria I Menendez1, Daniel Clark1,
Bianca Hettlich1, and Michael Knopp1
1The Ohio State University, Columbus, Ohio,
United States
The purpose of this study was to use T2, dGEMRIC and
gagCEST to serially evaluate articular cartilage in an
in vivo ACL OA canine model. T2 was higher in the ACL
transected knee. At T2 was higher than baseline. Lower
T1 was found in the ACL versus control at 12 weeks. For
ACL knees, lower T1 at 6 and 12 weeks than baseline.
MTRasym was not statistically significant between
control and ACL knees, neither among timelines. T2 and
dGEMRIC correlated moderately negative. This study
showed that T2 and dGEMRIC serially evaluated cartilage
in an ACL OA canine model.
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4177. |
17 |
A Robust Way to Make Good
Contrast in the Deeper Layer of Articular Cartilage using
UTE imaging
Chanhee Lee1 and
Jang-Yeon Park1
1Biomedical Engineering, IBS Center for
Neuroscience Imaging Research, Sungkyunkwan University,
Suwon, Gyeonggi, Korea
The subtraction between minimum TE1 (~50-200 ƒÝs) and
longer TE2 (>~5ms) images was typically performed to
provide a better contrast from the deeper layers of
cartilage. Here, we show that decreasing ƒ´TE is more
critical to enhance the image contrast of the deeper
layers of articular cartilage rather than minimizing TE1
when the subtraction method is used with UTE imaging.
This was demonstrated by simulation and UTE imaging.
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4178. |
18 |
Assessment of the clinical
relevance of triple-echo steady-state T2 mapping in
articular cartilage
Vladimir Juras1,2, Klaus Bohndorf1,
Rahel Heule3, Claudia Kronnerwetter1,
Pavol Szomolanyi1,2, Benedikt Hager1,
Oliver Bieri3, and Siegfried Trattnig1
1High Field MR Centre, Department of
Biomedical Imaging and Image-Guided Therapy, Medical
University of Vienna, Vienna, Austria, 2Department
of Imaging Methods, Institute of Measurement Science,
Bratislava, Slovakia, 3Division
of Radiological Physics, Department of Radiology,
University of Basel Hospital, Basel, Switzerland
A clinical relevance of T2 mapping in cartilage measured
by recently introduced triple-echo steady-state
(3D-TESS) sequence was assessed by comparing to standard
multi-echo spin-echo T2 at 3T MRI. Both methods
demonstrated the ability to distinguish between healthy
cartilage and lesions. Most importantly, 3D-TESS
provides results similar to CPMG within substantially
shorter scan times and are B0- and B1-insensitive. This
benefit will be even more pronounced at ultra-high-field
MR systems, where the TA of conventional T2 mapping is
substantially compromised due to specific absorption
rate issues.
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4179. |
19 |
Does cartilage
transplantation harm or regenerate adjacent cartilage ? A
longitudinal study
Alina Messner1, Sebastian Apprich2,
Lukas Zak3, Pavol Szomolanyi1, and
Siegfried Trattnig1
1High Field MR Center, Department of
Biomedical Imaging and Image-guided Therapy, Medical
University of Vienna, Vienna, Austria, 2Department
of Orthopaedics, Medical University of Vienna, Vienna,
Austria, 3Department
of Traumatology, Medical University of Vienna, Vienna,
Austria
The integrity of cartilage adjacent to repair tissue was
assessed with zonal T2-mapping. Twelve months after
MACT, the mean T2 values in cartilage surrounding the
repair tissue were significantly higher than in the
normal cartilage, and significantly lower than in the
repair tissue zone (both p<0.001). Two years after the
procedure, no significant differences between the
regional T2 values could be observed. The results
indicate that cartilage surrounding the transplant shows
early degenerative changes one year after MACT. If this
degeneration predates the MACT, cartilage
transplantation may have a positive influence on the
adjacent cartilage.
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4180. |
20 |
Optimization of adiabatic T1 and
T2 for
quantification of articular cartilage at 3T
Victor Casula1,2, Mikko J. Nissi3,4,
Joonas Autio3, Michaeli Shalom4,
Silvia Mangia4, Edward Auerbach4,
Jutta Ellermann4, Eveliina Lammentausta3,
and Miika T. Nieminen1,3
1Radiology, University of Oulu, Oulu, Oulu,
Finland, 2Medical
Research Center Oulu, Oulu University Hospital and
University of Oulu, Oulu, Oulu, Finland,3Department
of Diagnostic Radiology, Oulu University Hospital, Oulu,
Finland, 4Center
for Magnetic Resonance Research, Department of
Radiology, University of Minnesota, Minneapolis, United
States
Adiabatic T 1 and
T 2 sequences
were evaluated with a 3 T clinical system. The optimal
parameters for in vivo quantitative imaging of articular
cartilage were determined on the basis of the evaluation
of relaxation time maps and in order to minimize
scanning time and power deposition and maximize image
quality. The results show that adiabatic T 1 and
adiabatic T 1 are
suitable for in vivo quantitative assessment of
articular cartilage at 3 T. The preliminary results are
encouraging when the techniques were applied to
discriminate normal and early osteoarthritis cartilage.
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4181. |
21 |
Comparison of T1rho imaging
between spoiled gradient echo (SPGR) and balanced steady
state free precession (b-FFE) sequence of knee cartilage at
3 tesla - permission withheld
Taiki Nozaki1, Yasuhito Kaneko1,
Hon J. Yu1, Kayleigh Kaneshiro1,
Ran Schwarzkopf2, and Hiroshi Yoshioka1
1Radiological Sciences, University of
California, Irvine, Orange, California, United States, 2Orthopaedic
Surgery, University of California, Irvine, Orange,
California, United States
T1rho-weighted MR imaging has recently been proposed as
an attractive biomarker to existing conventional
morphological MRI methods, and enables us to detect
early cartilage degeneration in early osteoarthritis
patients before appearing morphological change. However
the factors affecting the T1rho mapping such as MR
sequences and operator-dependent manual cartilage
segmentation is not well understood. The objective of
this study was to investigate the difference of T1rho
profiles between spoiled gradient echo (SPGR) and
balanced steady state free precession (b-FFE) sequences.
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4182. |
22 |
Cluster Analysis for T2 and
T1rho Relaxation
Times using 3D Projection Maps of the Femoral Condyle in a
Healthy and ACL-injured Population
Uchechukwuka Diana Monu1,2, Brian A
Hargreaves1,2, Caroline D Jordan2,3,
Garry E Gold2,3, and Emily J McWalter2
1Electrical Engineering, Stanford University,
Stanford, California, United States, 2Radiology,
Stanford University, Stanford, California, United
States,3Bioegineering, Stanford University,
Stanford, California, United States
Osteoarthritis (OA) is a heterogeneous and
multifactorial joint disease that is characterized by
morphological, biochemical and structural changes to the
cartilage. The etiology and progression of the disease
remains largely uncertain making disease modifying
treatments challenging. This works uses parametric MRI
modeling and a 3D visualization technique to track
clusters of elevated T2 and T1rho relaxation times in an
ACL-injured population. Results show the potential for
cluster analysis to identify and quantify focal defects
in cartilage over time. This may provide a useful
biomarker for tracking early cartilage degeneration.
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4183. |
23 |
Assessment of Ankle
Condition After Fixator Distraction for OA with T1 MRI:
8-10 Year Follow-Up
Daniel R Thedens1, Mai P Nguyen2,
Annunziato Amendola2, and Douglas R Pedersen2
1Radiology, University of Iowa, Iowa City,
IA, United States, 2Orthopaedics
and Rehabilitation, University of Iowa, Iowa City, IA,
United States
The purpose of this study was to non-invasively assess
the joint condition of subjects who underwent
joint-preserving distraction arthroplasty in an 8-10
year follow-up study. Six subjects were evaluated and
compared with T1, T2, and quantitative T1 imaging,
showing outcomes with a range of cartilage and
subchondral bone inhomogeneities. The results
demonstrated that T1 has
value to gauge cartilage and joint condition in
longitudinal studies of OA progression and treatment
planning.
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4184. |
24 |
Multiparametric MRI
Assessment of Necrotic Epiphyseal Cartilage Induced by
Transection of Cartilage Canal Blood Vessels in Goat Kids
Luning Wang1, Mikko J Nissi2,
Ferenc Toth3, Michael Garwood1,
Cathy Carlson3, and Jutta Ellermann1
1Center for Magnetic Resonance Research,
University of Minnesota, Twin Cities, Minneapolis, MN,
United States, 2Medical
Research Center Oulu, Oulu University Hospital and
University of Oulu, Finland, 3University
of Minnesota, Twin Cities, Minneapolis, MN, United
States
Juvenile Osteochondritis Dissecans (OCD) is an
orthopaedic disease of children and young adults that
may result in significant lifelong disabilities. The
etiology is likely related to ischemic vascular events
and subsequent epiphyseal cartilage necrosis occuring
during skeletal maturation, but is poorly understood. In
this work, we present multiparametric relaxation time
mapping and histology of epiphyseal cartilage in a goat
model of surgically-induced ischemia at different stages
of lesion development. T1, T2, (CW) T1Ï, adiabatic T1Ï
and TRAFF provided a sensitive, noninvasive way to
detect ischemic necrosis. These noninvasive MR methods
are promising both for staging lesion development and
for outcome assessment after intervention in children
with OCD.
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Wednesday, 3 June 2015
Exhibition Hall |
13:30 - 14:30 |
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Computer # |
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4185. |
25 |
Water-selective 3D bSSFP
imaging of biomaterials promoting bone repair in rats;
Comparison with micro-CT
Emeline Julie Ribot1, Clément Tournier2,
Aurélien Julien Trotier1, Didier Wecker3,
Didier Letourneur4, Joelle Amédée2,
and Sylvain Miraux1
1RMSB - UMR5536, CNRS - University Bordeaux,
Bordeaux, France, Metropolitan, 2Biotis
- U1026, INSERM - University Bordeaux, Bordeaux, France,
Metropolitan, 3Bruker
Biospin GmbH, Ettlingen, Germany, 4LRVT
- UMR1148, INSERM - University Paris 7, Paris, France,
Metropolitan
The conventional imaging method to follow bone repair is
based on X-ray. To circumvent repetitive irradiation
exposures, a MRI 3D bSSFP sequence was performed
longitudinally on rats with biomaterials implanted in
femoral condyle bone defects. Due to the insertion of a
water-selective binomial radiofrequency pulse, the
signal from adipose tissue within the bone marrow
dropped, allowing the visualization of the biomaterials
with hyperintense signal. Thus, their volumes were
measured precisely over time. Their degradations
corresponded with bone regeneration observed on ex vivo
micro-CT.
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4186. |
26 |
7T MRI of Trabecular
Microarchitecture at the Distal Radius: How Bone Quality
Varies at the Epiphysis, Metaphysis, and Diaphysis
Lindsay M Griffin1, Stephen Honig2,
Yinxiao Liu3, Cheng Chen3, Punam K
Saha3, Ravinder Regatte1, and
Gregory Chang1
1Department of Radiology, New York University
School of Medicine, New York, New York, United States, 2Department
of Medicine, New York University, New York, United
States, 3University
of Iowa, Iowa, United States
This study utilized 7T MRI at the distal radius to
describe how microarchitectural parameters vary
depending upon distance from the end-of-bone and the
relationship between microarchitectual parameters at the
diaphysis, epiphysis, and metaphysis. Quality of
trabecular microarchitecture appears to be greatest at
the epiphysis and lowest at the diaphysis. While bone
volume and trabecular connectivity were highly
correlated with trabecular number at all sites, the
association of trabecular network resorption (a measure
of bone resorption by osteoclasts) with other measures
of microarchitecture was significant in the metaphysis
and epiphysis only. Future study includes how site and
parameters relate to fracture risk or response to
treatment.
|
4187. |
27 |
MRI study of the changes of
perfusion and fat content in radiation-induced bone marrow
injury in rats
kejun wang1, Yunfei Zha1, and Hao
Lei2
1Department Of Radiology, Renmin Hospital Of
Wuhan University, Wuhan, Hubei, China, 2Wuhan
Institute Of Physics and Mathematics,Chinese Academy of
Sciences, Wuhan, Hubei, China
To investigate microvascular perfusion status, changes
of fat content and fatty acid composition in bone marrow
of rats femur after irradiation by x-ray via
quantitative perfusion parameters of dynamic
contrast-enhanced MRI (DCE-MRI) andex vivo
high-resolution MAS1H NMR spectroscopy
|
4188. |
28 |
Significant reduction in
scan time for ultra short TE imaging of the knee
Zhe Liu1, Alexey Dimov1, Jiang Du2,
and Yi Wang3
1Biomedical Engineering, Cornell University,
New York, New York, United States, 2Radiology,
University of California, San Diego, San Diego, CA,
United States, 3Radiology,
Weill Cornell Medical College, NY, United States
The clinical application of UTE for quantitative
susceptibility mapping is hampered by the long
acquisition times needed to image the entire volume
excited. Here we report on the use of compressed sensing
to reduce scan time by a factor of 5 while largely
maintaining image quality.
|
4189. |
29 |
Age estimation in
adolescents and young adults using MRI data of the manubrium
Naira P. Martinez Vera1, Johannes Höller1,
Bernhard Neumayer1, Thomas Widek1,
Sabine Grassegger1,2, Thomas Ehammer1,
Eva Scheurer1,2, and Martin Urschler1
1Ludwig Boltzmann Institute for Clinical
Forensic Imaging, Graz, Styria, Austria, 2Institute
of Forensic Medicine, Medical University of Graz, Graz,
Styria, Austria
Skeletal age estimation based on MRI data of the
manubrium is of great interest due to an age-related
shape change of the manubrium and the use of a
non-invasive imaging technique. MRI data from male
adolescents and young adults were used to analyze the
age dependence of manubrium volume, area and shape. The
shape analysis was based on a non-linear PCA which
allowed to identify a principal component and to
simulate age-related change of the shape of the
manubrium. All parameters show a statistical correlation
with age and the PCA provides a new simulation tool
which may give further insight into the manubrium’s
age-related behavior.
|
4190. |
30 |
The value of BOLD-MRI in
early diagnosis of osteonecrosis of the femoral Head in
patients with steroid treatment - permission withheld
Jing Li1, Fei Yuan1, Quan Zhang1,
Jun Zhao1, and Yu Zhang2
1MRI Department, PingJin Hospital, He Dong
District, TianJin, China, 2Philips
Healthcare, Beijing, China
Patients who require long-term steroid use are at high
risk for occurrence of osteonecrosis. Early diagnosis of
this complication is essential as the prognosis is
affected by the stage of the disease. However, there is
no consensus on whether screening of bone necrosis
should be performed for long-term glucocorticoid.
Magnetic resonance imaging (MRI) is more sensitive than
plain film for diagnosing early-stage bone necrosis [1].
Traditionally functional magnetic resonance imaging
(fMRI) using blood oxygenation level-dependent (BOLD)
contrast has appeared to measure vascular oxygenation
change due to neuron activity. This study attempted to
compare BOLD-MRI with conventional MRI sequence on
determining the onset of osteonecrosis of the femoral
head following steroid-related osteonecrosis.
|
4191. |
31 |
Intermittent Parathyroid
hormone treatment reduces scar tissue formation at the
proximity of calvarial grafts, demonstrate by
collagen-sensitive MRI scanning methods
Doron Cohn Yakubovich1, Uzi Eliav2,
Gadi Pelled1,3, Dan Gazit1,3,
Zulma Gazit1,3, and Gil Navon2
1Skeletal Biotech Laboratory, Hebrew
University of Jerusalem, Jerusalem, Israel, Israel, 2School
of Chemistry, Tel Aviv University, Tel Aviv, Israel,
Israel,3Department of Surgery and
Cedars-Sinai Regenerative Medicine Institute,
Cedars-Sinai Medical Center, Los Angeles, California,
United States
Calvarial bone grafts often fail to integrate due scar
tissue formation at the grafts proximity. In order to
examine parathyroid hormone (PTH, a bone anabolic agent)
effect on the extent of scaring, we used MTC and the
magnetization exchange μMRI scanning protocol, MEX. The
results show that μMRI reveals changes in the extent of
scaring and bone formation as a result of the PTH
administration in comparison to the control animals,
enabling differentiation between new bone formation and
scar tissue. Our technique will enable clinical
longitudinal, non-invasive follow up of various fibrosis
related conditions.
|
4192. |
32 |
Bone Curvature Changes of
the Knee in OA Subjects as on Detected on MRI Can Predict
Who Will Progress to TKR in Five Years Time: Data From the
OAI - permission withheld
Joshua Michael Farber1, Jose Tamez-Pena2,
David Hunter3, Michael Hannon4,
Saara Totterman5, Zhijie Wang6,
Robert Boudreau7, and Kent Kowh8
1Radiology, Qmetrics Technologies,
Cincinnati, Ohio, United States, 2Imaging
Sciences, Escuela de Medicina, Tec de Monterray,
Monterray, Monterray, Mexico, 3Rheumatology,
Royal North Shore Hosp. and Northern Clinical Sch, Univ.
of Sydney, Sydney, Sydney, Australia, 4Epidemiology,
Dept. of Epidemiology, Univ. of Pittsburgh, Pittsburgh,
Pennsylvania, United States, 5Radiology,
Qmetrics Technologies, Rochester, New York, United
States, 6Dept.
of Epidemiology, Univ. of Pittsburgh, Pittsburgh,
Pennsylvania, United States, 7Epidemiology,
dept. of Epidemiology, Univ. of Pittsburgh, Pittsburgh,
Pennsylvania, United States, 8Rheumatology,
The University of Arizona, Arthritis Center, Tuscon,
Arizona, United States
This work analyzes knee bone curvature from OAI data
sets in patients with OA and predicts which subjects
will advance to TKR within five years of the initial
imaging. The MRI analysis is correlated with KL scores
and all TKR subjects are compared with match controls
who do not advance to TKR. The result is the development
of a biomarker, based on MRI bone curvatre changes, for
end-stage knee OA as defined by the need for TKR.
|
4193. |
33 |
Native 3T MRI for skeletal
age assessment of the hand and wrist: a comparison of two
methods
Sabine GRASSEGGER1,2, Thomas EHAMMER1,
Thomas WIDEK1, Andreas PETROVIC3,
Pia BAUMANN4, and Eva SCHEURER1,2
1Ludwig Boltzmann Institute for
Clinical-Forensic Imaging, Graz, Styria, Austria, 2Institute
of Forensic Medicine, Medical University of Graz, Graz,
Styria, Austria, 3Institute
of Medical Engineering, Graz University of Technology,
Graz, Styria, Austria, 4University
Centre of Legal Medicine, University of Lausanne,
Lausanne, Vaud, Switzerland
The application of ionizing radiation without medical
indication is prohibited in many countries. Thus, for
the application in age assessment (i.e., in criminal
proceedings and sports regulations) the Dvorak method
based on MRI of the wrist was developed as an
alternative to the standard X-ray based methodology
according to Greulich&Pyle, and is regularly used by the
FIFA for age testing in adolescent soccer athletes. The
accuracy of both methods was evaluated in volunteers
comparing estimated with chronological age. While
Greulich&Pyle was quite accurate, Dvorak showed a great
systematic deviation and cannot be recommended for age
estimation.
|
4194. |
34 |
Relaxation time constants
T1 and T2* of bound and free water in cortical bone at 600
MHz and 700 MHz.
Bainan Wu1, Robert Nikolov2,
Hongda Shao2, Jun Chen2, Graeme
Bydder2, Maurizio Pellecchia1, and
Jiang Du2
1Sanford-Burnham Medical Research Institute,
La Jolla, California, United States, 2Radiology,
University of California, San Diego, San Diego,
California, United States
The purpose of this study is to measure and report the
field dependence of NMR relaxation times (T* and T1) of
the free and bound water in cortical bone at magnetic
field strenghts corresponding to frequencies of 600 MHz
and 700MHz. T2* of bound/free water is measured to be
6.2(0.1)µs /80(3)µs at 600MHz and decreases to
5.4(0.1)µs /63(5)µs at 700 MHz. T1 of bound/free water
is reported to be 628/632ms at 600 MHz and 661/672 ms at
700 MHz. At both field strengths, the free water
contributes to about 10% of the NMR signal.
|
4195. |
35 |
Knee Cartilage and
Subchondral Bone Marrow Changes of Chronic Kidney Disease in
a Rat Model Investigated by Quantitative MR Imaging
Chao-Ying Wang1, Guo-Shu Huang2,
Shih-Wei Chiang2,3, Yi-Chih Hsu2,
Ming-Huang Lin4, and Hsiao-Wen Chung3
1Department of Biology and Anatomy, National
Defense Medical Center, Taipei, Taiwan, Taiwan, 2Department
of Radiology, Tri-Service General Hospital, Taipei,
Taiwan, Taiwan, 3Graduate
Institute of Biomedical Electronics and Bioinformatics,
National Taiwan University, Taipei, Taiwan, Taiwan, 4Institute
of Biomedical Sciences, Academic Sinica, Taipei, Taiwan,
Taiwan
A rat model study of Chronic Kidney Disease(CKD)
investigated by quantitative MR imaging
|
4196. |
36 |
Musculoskeletal MR-Imaging
in fracture dating - permission withheld
Katharina Baron1, Bernhard Neumayer1,
Thomas Widek1, Sylvia Scheicher1,
Eva Maria Hassler2, Fritz Schick3,
and Eva Scheurer1
1Ludwig Boltzmann Institute for
Clinical-Forensic Imaging (LBI-CFI), Graz, Styria,
Austria, 2Department
of Radiology, Medical University of Graz, Styria,
Austria, 3Diagnostic
and Interventional Radiology, Eberhard-Karls-University
Tübingen, Baden-Württemberg, Germany
The determination of the time frame of fracture healing
is of particular interest in the field of clinical
forensic examinations of child abuse, but can also be
applied to accident reconstructions and medical
investigations regarding bone healing. The preliminary
results of this clinical study indicate that the
determination of the quantitative parameters T1, T2, and
MTR is a promising method for an accurate determination
of fracture healing phases. Provided that the discovered
characteristics are confirmed for a larger number of
volunteers this will allow for the application in an
improved, objective estimation of the age of a fracture.
|
4197. |
37 |
Combined microCT-microMR
imaging in the tridimensional evaluation of bone
regeneration
Allegra Conti1, Raffaele Sinibaldi1,
Sara Spadone1, Tonino Traini2,
Giuliana Tromba3, Silvia Capuani4,
Gian Luca Romani1,5, and Stefania Della Penna1,5
1Department of Neuroscience, Imaging and
Clinical Sciences, G. D'Annunzio Univ. of Chieti and
Pescara, Chieti, CH, Italy, 2Department
of Stomatology and Biotechnologies, G. D'Annunzio Univ.
of Chieti and Pescara, Chieti, CH, Italy, 3Elettra-Sincrotrone
Trieste S.C.p.A., Basovizza, TS, Italy, 4Physics
Department, 'La Sapienza' University of Rome, Roma, RM,
Italy, 5Institute
for Advanced Biomedical Technologies (ITAB), G.
D'Annunzio Univ. of Chieti and Pescara, Chieti, CH,
Italy
We present here a 3D analysis of extracted human jawbone
cores following restoration of bone mass. First, X-ray
Synchtron-Radiation-micro-CT and micro-MR images were
co-registered using a new in-house software. Then, a
clusterization algorithm was applied to generate a 3D
meta-structure of the sample, producing six clusters.
Histology made on sample slabs was used to label the
clusters as mature bone, two types of newly formed bone,
soft tissue, multinucleate cells and empty spaces.
Notably, the presence of two different phases of newly
formed bone was not revealed by MRI
and SR CT
when used as separate imaging tools.
|
4198.
|
38 |
Comparison of
Relaxation-Based NMR Methods for Quantifying Bound and Pore
Bone Water Fractions
Alan C. Seifert1, Suzanne L. Wehrli2,
and Felix W. Wehrli1
1University of Pennsylvania, Philadelphia,
PA, United States, 2Children's
Hospital of Philadelphia, Philadelphia, PA, United
States
Increased cortical porosity is a major cause of the
impaired strength of osteoporotic bone. MicroCT and
gravimetry are accepted methods for validation of
porosity and matrix density, but involve long scan times
and destruction of specimens, respectively. In this
work, we compare several NMR methods for quantification
of bound and pore water (biomarkers for matrix density
and porosity, respectively). T2 fitting of CPMG data at
9.4T outperforms T2* fitting of FIDs at 3T, while 2H IR
at 9.4T performs approximately as well as T2* fitting.
Incorporation of a second T1 dimension yields improved
fidelity for both T2 and T2* fitting.
|
4199. |
39 |
Cortical Bone Porosity: A
Novel MRI-Based Clinical Biomarker to Assess Cortical Bone
Quality In Vivo
Shahrokh Abbasi Rad1,2, Atena Akbari1,
Niloofar Tondro3, Mohsen Shojaee-Moghaddam3,
and Hamidreza Saligheh Rad1,2
1Quantitative MR Imaging and Spectroscopy
Group, Research Center for Molecular and Cellular
Imaging, Tehran University of Medical Sciences, Tehran,
Iran, 2Medical
Physics and Biomedical Engineering Department, Tehran
University of Medical Sciences, Tehran, Iran, 3Imaging
Center, Payambaran Hospital, Tehran, Iran
There exist three types of proton pools in the cortical
bone: loosely bonded to the collagen matrix, tightly
bonded to the minerals, and mobile protons residing in
the pores of cortical bone like Haversian canals,
lacunae and canaliculi. Mobile water can be considered
as a reliable determinant of cortical bone porosity. As
the porosity increases with age, we hypothesized that
mobile water concentration of the cortical bone must be
in good correlation with age, and investigated it using
a clinically available MRI pulse sequence named Short
Echo Time (STE), which employs echo-time in the range of
0.5 to 1.5 ms.
|
4200. |
40 |
MRI of Intraneural
Perineurioma: Review of 27 Cases with Histopathologic
Correlation - permission withheld
Gavin McKenzie1, Michelle Mauermann2,
Robert Spinner2, Doris Wenger2,
Joel Felmlee2, Shuji Nagata3,
Benjami Howe2, and Kimberly Amrami2
1Radiology, Mayo Clinic, Rochester, MN,
United States, 2Mayo
Clinic, MN, United States, 3Kurume
University School of Medicine, Kurume, Japan
To present the characteristic MRI findings of peripheral
nerve intraneural perineurioma.
|
4201. |
41 |
Microstructural
Organization and Macromolecular Contents in Fibrous Tissues
of Normal and Hypertensive Eyes with Diffusion Tensor
Imaging and Magnetization Transfer Imaging
Leon C. Ho1,2, Ian A. Sigal3,
Ning-Jiun Jan3, Tao Jin1, Ed X. Wu2,
Seong-Gi Kim1,4, Joel S. Schuman3,
and Kevin C. Chan1,3
1Neuroimaging Laboratory, University of
Pittsburgh, Pittsburgh, Pennsylvania, United States, 2Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Pokfulam, Hong Kong, China, 3Departments
of Ophthalmology and Bioengineering, University of
Pittsburgh, Pittsburgh, Pennsylvania, United States, 4Center
for Neuroscience Imaging Research, Institute for Basic
Science, Sungkyunkwan University, Suwon, Korea
The sclera and cornea are fibrous connective tissues in
the outer coat of the eye which may undergo microscopic
structural realignment and macromolecular changes in
healthy aging and in diseases such as myopia, ocular
hypertension and glaucoma. Recently, we demonstrated the
use of the magic-angle effect to improve MRI sensitivity
to reveal T2 and T2* relaxation changes in scleral and
corneal tissues upon intraocular pressure loading. In
this study, we further evaluated the corneoscleral
shells using high-field DTI and MTI at the magic angle
in order to test the hypotheses that (1) the
microstructural organization and macromolecular contents
of the sclera and cornea can be detected and
differentiated with high-field MRI; and (2) acute ocular
hypertension may alter DTI and MTI properties in these
fibrous tissues.
|
4202. |
42 |
Assessment of extent and
activity of musculoskeletal involvement in systemic
sclerosis using hybrid [18F]-FDG-PET/MRI
Marius Stefan Horger1, Nina Schwenzer1,
Sergios Gatidis1, Christian la Fougere2,
Konstantin Nikolaou1, and Alexander Walter
Sauter1,3
1Radiology, Eberhard-Karls-University
Tuebingen, Tuebingen, Germany, 2Nuclear
Medicine, Eberhard-Karls-University Tuebingen,
Tuebingen, Germany,3Radiology and Nuclear
Medicine, University Hospital Basel, Tuebingen, Germany
PET/MRI as a combined morphologic and functional
technique offers valuable data with respect to disease
extent and activity in SSc and results correlate
positively with clinical and laboratory scores.
Interestingly, FDG-PET and MRI seem to assess the
inflammatory processes from different points of view and
thus providing complementary information.
|
4203. |
43 |
Characterizing the Blood
Oxygen Level-Dependent Fluctuation in Musculoskeletal Tumors
Using Functional Magnetic Resonance Imaging
Li-Sha Duan1, Meng-Jun Wang1, Feng
Sun1, Zhen-Jiang Zhao1, Mei Xing1,
Yu-Feng Zang2, Steven Louis3,
Sheng-Jie Cui4, Han Zhang2, and
Jianling Cui1
1Department of Radiology, The Third Hospital
of Hebei Medical University, Shijiazhuang, Hebei, China, 2Center
for Cognition and Brain Disorders and the Affiliated
Hospital, Hangzhou Normal University, Hangzhou,
Zhejiang, China, 3Physics
Department, Oakland University, Rochester, Michigan,
United States,4Department of Anatomy and Cell
Biology, Wayne State University School of Medicine, East
Canfield Avenue, Detroit, United States
Fifty-two patients with MSK tumors were examined using
1.5 T MR scanner with EPI BOLD. The BOLD time series in
each ROI was transformed from temporal to frequency
domain with a fast Fourier transformation. This power
spectrum was then divided into four frequency bands. In
the frequency band between 0.073 and 0.198 Hz, the BOLD
fluctuations were stronger in the periphery than that in
the center of malignant MSK tumors; however, no such a
difference was observed for the benign tumors, which may
provide the first evidence that BOLD fMRI could be
utilized to delineate vascularization characteristics in
MSK tumors.
|
4204. |
44 |
Quantitative Assessments of
Facial Soft-Tissue Mobility by means of Watershed
Segmentation and Constrained Elastic Registration in Upright
Accelerated 3D MRI
Marco Vicari1, Stefan Heldmann2,
Hans Meine1, Frank Hug3, Juergen
Hennig4, and Niklas Iblher3
1Fraunhofer MEVIS, Bremen, Germany, 2Fraunhofer
MEVIS, Luebeck, Germany, 3Department
of Plastic and Hand Surgery, University Medical Center
Freiburg, Freiburg, Germany, 4Department
of Radiology, Medical Phyisics, University Medical
Center Freiburg, Freiburg, Germany
Reconstructive and aesthetic facial plastic surgery can
strongly benefit from quantitative assessments of the
facial soft-tissue mobility. This clinical challenge can
be risen by a modern and original comprehensive imaging
method, joining advanced MRI and image analysis. In
particular, 3D accelerated upright MRI provides, in
reasonable acquisition times, high-resolution and
high-contrast facial soft-tissue depiction in natural
stance under physiological weight-bearing. Moreover,
soft-tissue layer watershed segmentations and their
constrained elastic registration between lying and
sitting positions give access to full quantitative
information about the complex 3D anatomy of the face
structure, as a function of aging and gravity.
|
4205. |
45 |
Protein MRI Contrast Agents
(ProCAs) with Unique Capability in Early detection and
Molecular Imaging of Varies Types of Cancer - permission withheld
Jenny Yang1,2, Jingjuan Qiao1,
Shenghui Xue1, Fan Pu1, Shanshan
Tan1, Jie Jiang1, Anvi Patel1,
and Zhi-ren Liu2,3
1Chemistry Department, Georgia State
University, Atlanta, Georgia, United States, 2Center
for Diagnostics and Therapeutics, Georgia State
University, Atlanta, Georgia, United States, 3Biology
Department, Georgia State University, Atlanta, Georgia,
United States
This research focuses on developing rational protein
based MRI contrast agents for cancer imaging. Various
cancer models including breast cancer, prostate cancer
and liver cancers have been successfully imaged with
high sensitive and resolution under MRI.
|
4206. |
46 |
MR micro-neurography in the
investigation of amyloid-related neuropathy - permission withheld
Paolo F Felisaz1, Eric Y Chang2,
Polesel Marco1, Irene Carne3,
Maugeri Giulia1, Giovanni Palladini4,
Obici Laura4, Giampaolo Merlini4,
Baldi Maurizia5, Stefano Bastianello6,
and Fabrizio Calliada1
1Radiology Department, University of Pavia,
Pavia, Italy, 2Radiology
Service, VA San Diego Healthcare System, San Diego, CA,
United States, 3Medical
Physics Department, IRCCS Salvatore Maugeri Foundation,
Scientific Institute of Pavia, Italy, 4Amyloid
Research and Treatment Center, Scientific Institute
Policlinico San Matteo, Pavia, Italy, 5Radiology
Department, IRCCS Salvatore Maugeri Foundation,
Scientific Institute of Pavia, Italy, 6Department
of Brain and Behavioral Sciences, University of Pavia,
Pavia, Italy
The aim of this study is to evaluate peripheral nerves
in amyloid-related neuropathy using high-resolution MRI.
A clinical 3T scanner with readily available sequences
and coils are used. Our MRI protocol allows spatial
resolution down to 100 μm, with demonstration of tissue
detail comparable with light microscopy after
histological staining. We evaluated 6 patients with
various grades of amyloid-related neuropathy of the
lower limbs. Amyloid neuropathy MR micro-neurograms
demonstrate an obvious pathologic pattern with increased
amounts of epineurial fat and decreased number of
fascicles. Early diagnosis of this neuropathy may impact
patient treatment and outcome.
|
4207. |
47 |
UTE-based Short-T2* Mapping
and PLM Optical Imaging for Evaluating Disruption of
Collagen Fibers in the Knee Cartilage Explants
Yongxian Qian1, Ashley A. Williams2,
and Constance R. Chu2
1Qian's Lab for MRI, General Labs Cloud LLC,
Pittsburgh, PA, United States, 2Orthopaedic
Surgery, Stanford University, Redwood City, CA, United
States
Very initial testing results on human knee cartilage
explants are presented to demonstrate the consistency in
evaluation of collagen fiber disruption between
noninvasive UTE-based short-T2* mapping and destructive
imaging of polarized light microscopy (PLM). This
consistency is suggestive of the potential of short
component of transverse (T2) relaxation as an imaging
biomarker for detecting disruption of collagen fibers in
cartilage.
|
4208. |
48 |
Characterization of [18F]-FDG
uptake by hybrid PET-MRI in osteoarthritis of the hip
Audrey P. Fan1, Feliks Kogan1,
Dawn Holley1, Andrei Iagaru1, Greg
Zaharchuk1, and Garry E. Gold1
1Radiology, Stanford University, Stanford,
CA, United States
[18F]-FDG tracer uptake is a potential PET
marker of musculoskeletal inflammation, but its
biodistribution in osteoarthritis (OA) and
colocalization with morphological changes are not well
studied. We characterized [18F]-FDG tracer
uptake within different areas of OA joint damage in the
hip identified on simultaneously acquired structural MRI
scans. Twenty patients (mean age = 67 years) were
scanned on a 3T hybrid PET-MR system with time-of-flight
PET and with T2 STIR (short TI inversion recovery) MRI.
An experienced radiologist identified 7 subchondral
cysts and 10 areas of bone marrow lesions (BMLs) on the
MR images. Mean standard uptake value (SUVmean)
was highest in joint fluid, which may reflect increased
tracer diffusion or high glucose metabolism due to
inflammation. SUVmean was
also elevated in subchondral cysts and BMLs relative to
SUV in normal regions of the femoral head. Our
observations enable improved understanding of [18F]-FDG
uptake in normal and diseased joint tissue.
|
|
|
Wednesday, 3 June 2015
Exhibition Hall |
14:30 - 15:30 |
|
|
|
|
Computer # |
|
4209. |
1 |
Quantitative Susceptibility
Mapping of Meniscus at 11.7T
Qun He1, Zhe Liu2, Hongda Shao1,
Alexey Dimov2, Graeme M Bydder1,
Yi Wang2, and Jiang Du1
1Radiology, University of California, San
Diego, CA, United States, 2Biomedical
Engineering, Cornell University, Ithaca, New York,
United States
We aim to assess the feasibility of QSM within meniscus
by studying bovine specimens at 11.7 T using a
pre-clinical system to provide short TE images of high
spatial resolution.
|
4210. |
2 |
Using the Ratio of T1ρ and
T2 MR Parameters to Examine the Relationship Between
Anterior Cruciate Ligament (ACL) Abnormalities and
Patellofemoral Cartilage Integrity
Nathaniel E. Calixto1, Lorenzo Nardo1,
Deepak Kumar2, Richard B. Souza1,
Xiaojuan Li1, Thomas M. Link1, and
Sharmila Majumdar1
1Department of Radiology and Biomedical
Imaging, University of California, San Francisco, San
Francisco, California, United States, 2Division
of Physical Therapy, College of Health Professions,
Medical University of South Carolina, Charleston, South
Carolina, United States
While T1ρ and T2 MR relaxation times have become
established metrics for cartilage assessment, the T1ρ/T2
ratio could eliminate hydration effects and better
represent macromolecular integrity. A lowered T1ρ/T2
ratio in patellofemoral cartilage was associated with
ACL lesions, consistent with the relationship between
ACL pathology and patellofemoral osteoarthritis. In
subjects with healthy patellofemoral cartilage,
significant T1ρ/T2 ratio differences were observed
between those with and without ACL lesions; no
significant differences were observed with T1ρ or T2
individually, suggesting heightened sensitivity of the
T1ρ/T2 ratio. Future work is necessary to verify the
applicability of the T1ρ/T2 ratio in other anatomy.
|
4211. |
3 |
MRI evaluation of the
polyethylene tibial insert in total knee arthroplasty
Angela E Li1, Darryl B Sneag1,2,
Alissa J Burge1,2, Shari T Jawetz1,2,
Joseph D Lipman3, and Hollis G Potter1,2
1Radiology, Hospital for Special Surgery, New
York, NY, United States, 2Weill
Cornell Medical College, New York, NY, United States, 3Biomechanics,
Hospital for Special Surgery, New York, NY, United
States
Radiographs have been traditionally used to evaluate the
polyethylene tibial insert in total knee arthroplasty,
although assessment is limited. With the development of
MRI and metal reduction techniques, the polyethylene
tibial insert can be visualized. We review the MRI
scanning considerations to optimize evaluation of the
prosthesis. The expected MRI appearance of polyethylene
tibial inserts will be correlated with corresponding
macroscopic photographs of common total knee
arthroplasty designs. Complications related to the
polyethylene liner including polyethylene wear, fracture
of the polyethylene liner, or dissociation of the
polyethylene component or tibial locking pin will also
be discussed.
|
4212. |
4 |
3T MRI of Arthroplasty
Implants Using Highly Undersampled SEMAC: 3T versus 1.5T
Intra-Subject Comparison
Jan Fritz1, Gaurav Thawait1,
Shadpour Demehri1, Shivani Ahlawat1,
Heiko Meyer2, Wesley Gilson3,
Esther Raithel2, and Mathias Nittka2
1Russell H. Morgan Department of Radiology
and Radiological Science, Johns Hopkins University
School of Medicine, Baltimore, MD, United States, 2Healthcare
Sector, Siemens AG, Bavaria, Germany, 3Siemens
Healthcare USA, Baltimore, United States
Because susceptibility artifacts increase with field
strength, MRI of implants is commonly performed at 1.5T.
However, 3T MRI offers substantially higher SNR and may
be the only available option. SEMAC can achieve
substantial metal artifact reduction at 3T, but the
required increase of SEMAC-encoding steps prolongs scan
times. Capitalizing on the inherent sparsity of SEMAC
data, pseudo-randomized undersampling and iterative
reconstruction can substantially accelerate data
acquisition. We show the clinical feasibility of highly
accelerated 3T MRI of metal-on-metal hip arthroplasty
implants using a highly undersampled TSE SEMAC sequence
with metal artifact reduction capabilities and
acquisition times similar to 1.5T.
|
4213. |
5 |
MR Imaging of Knee Implants
Using SEMAC at 3T
TAO AI1, Panli Zuo2, Yiqi Hu1,
Mathias Nittka3, and Liming Xia1
1Radiology, Tongji Hospital, Tongji Medical
College, Huazhong University of Science and Technology,
Wuhan, Hubei, China, 2Siemens
Healthcare, MR Collaborations NE Asia, Beijing, China, 3Siemens
Healthcare, Germany, Erlangen, Germany
In order to investigate the efficacy of SEMAC and high
bandwidth (high BW) techniques in metal artifact
reduction and clinical applications at 3T MR imaging,
tissue specimens with CoCr/Ti and OxZr/Ti implants and
ten patients with total knee replacements were imaged,
and the artifact size, distortion and image quality were
quantitatively and qualitatively assessed. The results
demonstrated that SEMAC allows for significant metal
artifact reduction and distortion correction at 3T MR
imaging of knee implants, as compared with the
conventional and increased readout bandwidth sequences.
With optimizations, SEMAC would be routinely chosen for
the clinical application of knee prosthesis.
|
4214. |
6 |
Rapid multiparametric
mapping near orthopedic implants at 3T using plug & play
parallel transmission - permission withheld
Martijn A Cloos1, Mary Bruno1,
Tiejun Zhao2, Leeor Alon1,
Riccardo Lattanzi1, and Danial K Sodickson1
1Center for Biomedical Imaging, Department of
Radiology, New York University School of Medicine, New
York, NY, United States, 2Siemens
Medical Solutions USA Inc., Malvern, PA, United States
Under some circumstances, the complex electrodynamic
interactions between the subject and the incident RF
field can distort RF excitation to such an extent that
the diagnostic value of MRI is compromised. Metal
implants, in particular, are a well-known source of MR
artifacts, resulting not only from distortion of the
main magnetic field, but also from distortions of the
excitation RF field. In this work, we explore the
potential of a generalized implementation of the
recently proposed plug & play parallel transmission
framework, to enable rapid multiparamatric mapping (T1,
T2, PD) in the presence of orthopedic implants.
|
4215. |
7 |
Highly Accelerated SEMAC
for MRI of Arthroplasty Implants: Comparison with optimized
TSE and conventional SEMAC
Jan Fritz1, Gaurav Thawait1,
Shadpour Demehri1, Shivani Ahlawat1,
Heiko Meyer2, Wesley Gilson3,
Esther Raithel2, and Mathias Nittka2
1Russell H. Morgan Department of Radiology
and Radiological Science, Johns Hopkins University
School of Medicine, Baltimore, MD, United States, 2Healthcare
Sector, Siemens AG, Bavaria, Germany, 3Siemens
Healthcare USA, Baltimore, United States
Slice-encoding metal artifact correction (SEMAC) affords
powerful metal artifact reduction, but may be considered
impractical due to long acquisition times. The inherent
sparsity of SEMAC data, however, offers potential for
substantial acceleration through the use of
pseudo-randomized k-space undersampling and iterative
reconstruction. We show the clinical usability of a
highly accelerated TSE SEMAC sequence prototype
employing incoherent k-space undersampling and iterative
reconstruction resulting in shortening of the
acquisition time by 50-60% when compared to standard TSE
SEMAC sequences and comparable image quality.
|
4216. |
8 |
Spectrum of complications
demonstrated on MRI in patients who undergo revision total
knee arthroplasty
Angela E Li1, Darryl B Sneag1,2,
Alissa J Burge1,2, Shari T Jawetz1,2,
Darius P Melisaratos1,2, and Hollis G Potter1,2
1Radiology, Hospital for Special Surgery, New
York, NY, United States, 2Weill
Cornell Medical College, New York, NY, United States
A proportion of patients will experience long term pain
following total knee arthroplasty (TKA), and some of
these patients ultimately undergo revision TKA. The
purpose of this retrospective study was to determine the
prevalence of complications seen on MRI in cohort of 113
patients who subsequently underwent revision TKA. The
spectrum of complications seen on MRI included the
following: polymeric synovitis in 32%, osteolysis in
27%, loosening in 22%, non-specific synovitis in 20%,
prominent synovial scarring and arthrofibrosis in 13%,
infection in 17%, and periprosthetic fracture in 1% of
patients. We compare our results with the causes for
revision TKA reported in the orthopedic literature.
|
4217. |
9 |
MR Neurography using Robust
Fat and Blood Suppressed Volumetric T2-Weighted Imaging
Xinzeng Wang1, Crystal E Harrison1,
Yogesh K Mariappan2, Karthik Gopalakrishnan2,
Avneesh Chhabra1,3, Robert E Lenkinski1,3,
and Ananth J Madhuranthakam1,3
1Radiology, UT Southwestern Medical Center,
Dallas, Texas, United States, 2Philips
Innovation Campus, Philips Healthcare, Bangalore,
Karnataka, India,3Advanced Imaging Research
Center, UT Southwestern Medical Center, Dallas, Texas,
United States
The visualization of nerves on MRI are often confounded
by surrounding fat and the blood vessels in close
proximity that appear bright on T2-weighted images. Fat
suppression by STIR suffers from reduced SNR and
standard motion sensitized driven equilibrium (MSDE)
based blood suppression suffers from B0 and B1
inhomogeneities, particularly in difficult areas such as
Brachial Plexus. In this work, we implemented an
adiabatic pulse (BIR-4) based MSDE in combination with a
dual-echo 2-point Dixon technique with robust fat and
blood suppression without SNR penalty for volumetric
neurography in clinically feasible scan times.
|
4218. |
10 |
Quantitative Ultrashort TE
(UTE) Imaging Predicts Joint Health in Hemophilic
Arthropathy
Eric Y Chang1, Annette von Drygalski2,
Thomas J Cramer2, Sheronda Statum3,
Jiang Du3, and Christine B Chung1
1Radiology Service, VA San Diego Healthcare
System, San Diego, CA, United States, 2Department
of Hematology/Oncology, University of California, San
Diego Medical Center, San Diego, CA, United States, 3Department
of Radiology, University of California, San Diego
Medical Center, San Diego, CA, United States
21 patients with hemophilic arthropathy were recruited
for this prospective study. Chronically symptomatic
joints (7 knee, 7 ankle, and 7 elbow joints) were
evaluated using clinical pain and Hemophilia Joint
Health scores as well as conventional and quantitative
3D-UTE-Cones images. Semi-quantitative International
Prophylaxis Study Group (IPSG) MRI scales and UTE-T2*
values of weight-bearing cartilage were calculated and
correlated with clinical scores. We found that UTE-T2*
values of cartilage significantly decrease as joint
health declines in patients with hemophilic arthropathy.
|
4219. |
11 |
Quantitative MR Imaging of
the Temporomandibular Joint Disc Using UTE - permission withheld
Karen Chi-Lynn Chen1,2, Reni Biswas2,
Sheronda Statum3, Won Bae2, Eric
Chang1,2, and Christine Chung1
1Radiology, Veterans Administration
Healthcare System San Diego, San Diego, CA, United
States, 2Radiology,
University of California San Diego, San Diego, CA,
United States, 3Radiology,
University of California, San Diego, CA, United States
UTE T2* sequences can be used to assess the
temporomandibular joint disc in vivo with differences in
T2* values in symptomatic patients compared to
asymptomatic volunteers. This study proves feasibility
of in vivo quantitative MR evaluation of TMJ disc using
the UTE T2* technique, which may provide sensitive and
objective measure of TMJ disc degeneration in TMD
patients.
|
4220. |
12 |
Reduced Magic Angle Effects
Using Ultrashort Echo Time Magnetization Transfer (UTE-MT)
for Quantification of Human Rotator Cuff Tendon
Eric Y Chang1, Jiang Du2, Reni
Biswas2, Betty Tran2, Sheronda
Statum2, Won C Bae2, and Christine
B Chung1
1Radiology Service, VA San Diego Healthcare
System, San Diego, CA, United States, 2Department
of Radiology, University of California, San Diego
Medical Center, San Diego, CA, United States
In this study, 7 human cadaveric rotator cuff tendons
were used to compare orientation-dependent value changes
using T2, T2*, and MT techniques. We found that mean
percent change was up to 38% using T2, up to 92% using
T2*, and up to 15% using OSR. OSR measured with the
UTE-MT technique may be more useful than T2 and T2* due
to the strong dipolar-dipolar influence on the latter
two biomarkers.
|
4221. |
13 |
UTE T2* decay analysis of
the rabbit supraspinatus tendon at 7T
Gerd Melkus1,2, Greg O Cron1,2,
Peder E Larson3, Adnan Sheikh1,2,
Ian Cameron1,2, Hakim Louati4,5,
Peter Lapner5, Tim Ramsay6, and
Guy Trudel4,7
1Department of Medical Imaging, The Ottawa
Hospital, Ottawa, ON, Canada, 2Department
of Radiology, University of Ottawa, Ottawa, ON, Canada, 3Radiology
and Biomedical Imaging, University of California San
Francisco, San Francisco, CA, United States, 4Bone
and Joint Laboratory, University of Ottawa, Ottawa, ON,
Canada, 5Division
of Orthopaedic Surgery, The Ottawa Hospital, Ottawa, ON,
Canada, 6Ottawa
Hospital Research Institute, The Ottawa Hospital,
Ottawa, ON, Canada, 7Department
of Medicine, University of Ottawa, ON, Canada
A 3D ultra-short echo time (UTE) sequence was applied to
study the T2* decay of the rabbit supraspinatus tendon
at 7T. Twelve echoes with echo times ranging from 0.09ms
to 10ms were acquired and four different decay models
(mono- and bi-exponential) were applied to fit the T2*
decay. Two ROIs were chosen for their importance in
supraspinatus tendon surgical repair to estimate T2*.
The study demonstrated that T2* of the rabbit tendon can
be quantified using 3D UTE imaging and that a
3-parameter mono-exponential signal decay model shows
the best fit results for the tendon T2* decay.
|
4222. |
14 |
Evaluation of the
glycosaminoglycan content in healthy and degenerated menisci
with gagCEST at 3T
Benedikt Hager1, Vladimir Juras1,2,
Olgica Zaric1, Vladimir Mlynarik1,
Stefan Zbyn1, Pavol Szomolanyi1,2,
and Siegfried Trattnig1
1High Field MR Centre, Department of
Biomedical Imaging and Image-guided Therapy, Medical
University of Vienna, Vienna, Austria, 2Department
of Imaging Methods, Institute of Measurement Science,
Slovak Academy of Sciences, Dubravska cesta 9,
Bratislava, Slovakia
The purpose of this study was to demonstrate the
feasibility of Glycosaminoglycan Chemical Exchange
Saturation Transfer (gagCEST) imaging for the detection
of degenerated menisci. The results show that the
average of asymmetries in gagCEST z-spectra summed over
all offsets from 0.6 to 1.8 ppm was significantly lower
(p < 0.02) in degenerated meniscal horns (2.2 ± 5.5 %)
compared to healthy meniscal horns (8.4 ± 3.9%), which
indicates a decrease in GAG content in the degenerated
menisci. This study demonstrates that gagCEST imaging
holds great potential as a biomarker to differentiate
between healthy and degenerated menisci.
|
4223. |
15 |
Rapid, High-Resolution, and
Multi-Contrast Knee MRI of Short T2 Tissues
with Ultrashort TE Double-Echo Steady-State
Akshay S Chaudhari1,2, Catherine J Moran2,
Emily J McWalter2, Garry E Gold1,2,
and Brian A Hargreaves1,2
1Bioengineering, Stanford University, Palo
Alto, California, United States, 2Radiology,
Stanford University, Palo Alto, California, United
States
In this study, we have developed a multi-echo UTE-DESS
pulse sequence. UTE-DESS offers rapid and
high-resolution imaging of short T2 tissues with
proton-density, T2, and diffusion contrasts, along with
fat-water separation and a very high overall scan
efficiency. We present our initial results of scanning
the knees of healthy volunteers with multi-echo
UTE-DESS. Our preliminary data shows that the contrasts
generated by this sequence and its ability for fast
imaging, makes the sequence potentially attractive for
routine clinical study of the morphology of the
connective tissues in the knee.
|
4224. |
16 |
Assessment of degenerative
changes in disc endplates using DCEMRI and T1
Volkan Emre Arpinar1 and
L Tugan Muftuler1,2
1Department of Neurosurgery, Medical College
of Wisconsin, Milwaukee, Wisconsin, United States, 2Center
for Imaging Research, Medical College of Wisconsin,
Wisconsin, United States
Degenerating intervertebral discs sometimes lead to
degenerative changes in adjacent vertebral bodies, which
are classified based on the appearance of vertebral
marrow in T1 and T2 weighted MRI. Although this
classification is widely accepted, those images may not
be sufficiently sensitive to early or transitional
changes. Initial changes associated with vascularization
and edema can be studied by Dynamic contrast enhanced
MRI (DCEMRI). Additional information can be obtained
from T1 ,
which is reported to increase in various inflamed
tissues. Our findings show significant increases in both
DCEMRI and T1 with
degeneration in disc endplates.
|
4225. |
17 |
Evaluation of the
applicability of iGagCESL and gagCEST on both cartilage and
disc at 3T - permission withheld
Wen Ling1, Nam Vo2, Gwendolyn A.
Sowa2, James Kang3, and Kyongtae
Ty Bae1
1Radiology Department, University of
Pittsburgh Medical Center, Pittsburgh, PA, United
States, 2Department
of Orthopedic Surgery, University of Pittsburgh Medical
Center, PA, United States, 3Department
of Orthopedic Surgery, University of Pittsburgh Medical
Center, Pittsburgh, PA, United States
The applicability of recently proposed iGagCESL on both
cartilage and intervertebral disc at 3T has been
evaluated by 3-pool Bloch simulation and in vivo human
data (n=3), along with gagCEST. iGagCESL and gagCEST
give rise to similar contrast, ~1% for cartilage and ~5%
for disc, at 3T; but preserve more than10 times higher
signal intensity than gagCEST. For comparison, same
metrics are used for both simulation and data
acquisition. Along with its additional advantages,
iGagCESL is a much superior method on 3T scanner with
3~5 minutes of scan time.
|
4226. |
18 |
Triple-echo steady state T2
mapping and high resolution axonal bundle assessment of the
median nerve in healthy volunteers and patients with carpal
tunnel syndrome at 7Tesla
Georg Riegler1, Gregor Drlicek1,
Claudia Kronnerwetter1, Rahel Heule2,
Oliver Bieri2, Benedikt Hager1,
Peter Bär1, and Siegfried Trattnig1
1MR Centre of Excellence, Dept. of Biomedical
Imaging and Image-Guided Therapy, Medical University
Vienna, Vienna, Vienna, Austria, 2Department
of Radiology, Division of Radiological Physics,
University of Basel Hospital, Basel, Switzerland
To determine T2 values of the median nerve with TESS and
the numbers of fascicles with a PD-TSE-fat-sat in
healthy volunteers and patients with
carpal-tunnel-syndrome at 7-Tesla. Six volunteers and
three patients were included. Axial-PD-TSE-fat-sat and
axial-3D-TESS were performed. Two reader assessed T2
values and fascicles. Mean T2 values of patients were
significantly higher for the median nerve in comparison
to healthy subjects (P = 0.008) with an ICC of 0.97.
Median of fascicle count was 19 in all subjects with an
ICC of 0.81. Axial-PD-TSE-fat-sat and axial-3D-TESS
provides fast and reliable morphological and biochemical
assessment of the median nerve.
|
4227. |
19 |
A fast scanning technique
of MR micro-neurography using the 3-Point-Dixon method at 3T - permission withheld
Paolo F Felisaz1, Eric Y Chang2,
Irene Carne3, Polesel Marco1,
Stefano Montagna4, Maugeri Giulia1,
Baldi Maurizia4, Fabrizio Calliada1,
and Stefano Bastianello5
1Radiology Department, University of Pavia,
Pavia, Italy, 2Radiology
Service, VA San Diego Healthcare System, San Diego, CA,
United States, 3Medical
Physics Department, IRCCS Salvatore Maugeri Foundation,
Scientific Institute of Pavia, Italy, 4Radiology
Department, IRCCS Salvatore Maugeri Foundation,
Scientific Institute of Pavia, Italy, 5Department
of Brain and Behavioral Sciences, University of Pavia,
Pavia, Italy
The aim of this study is to present a fast and
high-resolution MRI scanning technique focused on the
study of peripheral nerves. We used a 3T MRI scanner
with a readily available coil, optimized for clinical
peripheral nerve evaluation. Sequences were based on 3D
spoiled gradient echo combined with the 3-point-Dixon
technique. This protocol provides a combination of high
spatial resolution and adequate SNR with robust and
consistent fluid-fat separation in a single acquisition,
thereby microscopic nerve components can be visualized.
MR micro-neurography may complement standard MR
neurography protocols, for focused evaluation of a
selected nerve tract.
|
4228. |
20 |
The Magic Angle Effect on
Ultrashort Echo Time MRI for analysis of T2* and
Magnetization Transfer Ratio
Hongda Shao1, Michael Carl2, Eric
Chang1, Christine B Chung1, Graeme
M Bydder1, and Jiang Du1
1Radiology, University of California, San
Diego, CA, United States, 2GE
Healthcare, San Diego, CA, United States
We investigate the magic angle effect in ultrashort echo
time MRI of cadaveric specimens of the human Achilles'
tendon on bi-component analysis of T2* decay and
magnetization transfer ratio using a clinical 3T
scanner.
|
4229. |
21 |
Clinical Evaluation of IVIM
and DCE in Sarcoma
Jing Zhang1, Pan-Li Zuo2, Thorsten
Feiweier3, and Xiaoguang Cheng4
1Beijing Jishuitan Hospital, Beijing,
Beijing, China, 2Siemens
Healthcare, MR Collaborations NE Asia, Beijing, China, 3Siemens
Healthcare, Erlangen, Germany,4Beijing
Jishuitan Hospital, Beijing, China
The purpose of this study was to assess the clinical
value of IVIM and DCE in sarcoma. 7 patients with
pathologically proven sarcoma were involved in this
study. For IVIM, D-slow was lower in tumor masses than
in healthy muscle, but D-fast and PF had no statistic
difference between them. For DCE, Ktrans, Kep and Ve
were higher in the tumor masses than in healthy muscles
. In sarcoma, ADC and D-slow were able to provide
information about cell growth, and Ktrans provided
information about tumor angiogenesis.
|
4230. |
22 |
Optimized
refocusing-flip-angle-train design for small peripheral
nerve imaging with 3D TSE
Barbara Cervantes1, Jan S. Bauer2,
Hendrik Kooijman3, Marcus Settles1,
Axel Haase4, Ernst J. Rummeny1,
Klaus Wörtler1, and Dimitrios C. Karampinos1
1Diagnostic and Interventional Radiology,
Technische Universität München, Munich, Germany, 2Neuroradiology,
Technische Universität München, Munich, Germany, 3Philips
Healthcare, Hamburg, Germany, 4Zentralinstitut
für Medizintechnik, Technische Universität München,
Garching, Germany
3D TSE imaging has been emerging for high-resolution MR
neurography. 3D TSE refocusing-flip-angle-train design
traditionally considers only the signal of a target
tissue. Peripheral-nerve branches can have diameters
down to a couple of millimeters and can therefore be
affected not only by their own signal behavior but also
by that of the surrounding tissue. The present work
proposes flip-angle schemes that consider the interface
between fine nerve structures and the enveloping tissue.
The optimized flip-angle design is compared to cases
considering only the signal behavior of nerve (standard
approach) and is demonstrated in
vivo in
the lumbar plexus.
|
4231. |
23 |
An improved saturation
scheme for measuring gagCEST in human knee at 7 T
Vladimir Mlynarik1, Stefan Zbyn1,
Vladimir Juras1, Pavol Szomolanyi1,
Martin Brix1, Benjamin Schmitt2,
and Siegfried Trattnig1
1High Field MR Center, Medical University of
Vienna, Vienna, Austria, 2Siemens
Ltd, Macquarie Park, Australia
Application of the gagCEST mapping technique on human
knee is complicated by technical limitations of
scanners, safety regulations and by an inhomogeneous B0 field
over the knee cartilage. Measurements on human
volunteers using either Gaussian or adiabatic full
passage hs2 saturation pulses showed unexpected regional
variations in MTRasym values
in femoral cartilage. By varying frequency of the
saturation pulses in a range of ±60 Hz, increased
intensity and improved homogeneity of the MTRasym maps
was achieved.
|
4232. |
24 |
Quantitative MRI of
Triangular Fibrocartilage (TFC): Correlation with
Biomechanical Properties. - permission withheld
Mohammed Aakef1, Tania Kumar1,
Reni Biswas1, Betty Tran1,
Sheronda Statum1, Eric Y Chang2,
Won C Bae1, and Christine B Chung2,3
1Radiology, Univeristy of California, San
Diego, San Diego, CA, United States, 2Veterans
Affairs San Diego Healthcare System, CA, United States, 3Radiology,
Univeristy of California, San Diego, CA, United States
Triangular Fibrocartilage (TFC) serves important
biomechanical function and its injury is a common cause
of wrist pain. This study evaluated quantitative MR
properties of TFC using two T1rho sequences tailored for
long (MAPSS T1rho) and short (UTE T1rho) T2 components,
and correlated the values with local indentation modulus
of the TFC. While significant negative correlations were
found, the strength of correlation was greater for UTE
T1rho measurements.
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Wednesday, 3 June 2015
Exhibition Hall |
14:30 - 15:30 |
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Computer # |
|
4233. |
25 |
Reproducibility of
carnosine quantification in the calf muscle by 1H MRS at 7T
and detection of its concentration changes following acute
physical activity
Ivica Just Kukurova1, Barbara Ukropcová2,3,
Marjeta Tušek Jelenc1, Milan Sedliak4,
Marek Chmelik1, Jozef Ukropec2,
Martin Krššák1,5, Siegfried Trattnig1,
and Ladislav Valkovič1,6
1High Field MR Centre, Department of
Biomedical Imaging and Image-guided Therapy, Medical
University of Vienna, Vienna, Austria, 2Institute
of Experimental Endocrinology, Slovak Academy of
Sciences, Bratislava, Slovakia, 3Faculty
of Medicine, Comenius University, Bratislava, Slovakia, 4Faculty
of Physical Education and Sport, Comenius University,
Bratislava, Slovakia, 5Department
of Internal Medicine III, Medical University of Vienna,
Vienna, Austria, 6Institute
of Measurement Science, Slovak Academy of Sciences,
Bratislava, Slovakia
Reproducibility of carnosine measurement in the calf
muscles was tested on 5 volunteers by STEAM sequence
with very good results of CV (6.3% for SOL, 9.1% for
GM). Effect of one hour running on carnosine
concentration was examined on 7 volunteers, which did
not prove to be significant. However, changes in the
shape of the carnosine peak appeared, in form of its
widening or splitting and also its shift. As carnosine
is pH sensitive, we suppose it is a consequence of
different use of carnosine buffering capacity in
oxidative and glycolytic muscle fibres leading to
different pH in these compartments.
|
4234. |
26 |
Myoglobin Contribution to
the Near Infrared Signal in Exercising Skeletal Muscle - permission withheld
David Bendahan1, Benjamin Chatel1,
and Thomas Jue2
1CNRS, CRMBM, Aix-Marseille University,
Marseille, France, 2Biochem
& Mol Medicine, University of California, Davis, CA,
United States
To be entered
|
4235. |
27 |
Spinal fusion induced
increase of energy demand in lower back muscles - A
functional 31P-MRS
study
Alexander Gussew1, Philipp Schenk2,3,
Heiko Stark4, Bernhard Ullrich3,
Christoph Anders2, Patrick Hiepe1,
Reinhard Rzanny1, Kai Wohlfahrt5,
Gunther Hofmann2,3, Hans-Christoph Scholle2,
and Jürgen R. Reichenbach1
1Medical Physics Group, Institute of
Diagnostic and Interventional Radiology, Jena University
Hospital - Friedrich Schiller University Jena, Jena,
Thuringia, Germany, 2Clinic
for Trauma, Hand and Reconstructive Surgery, Division of
Motor Research, Pathophysiology, Jena University
Hospital - Friedrich Schiller University Jena, Jena,
Thuringia, Germany, 3Department
of Trauma Surgery, BG Clinics Bergmannstrost, Halle
(Saale), Saxony-Anhalt, Germany,4Institute of
Systematic Zoology and Evolutionary Biology,
Friedrich-Schiller-University Jena, Jena, Thuringia,
Germany, 5Clinic
for Neurology, BG Clinics Bergmannstrost, Halle (Saale),
Saxony-Anhalt, Germany
Functional 31P-MRS
was performed in five patients after spinal fusion
during a standardized isometric exercise to evaluate
differences of load induced high energy metabolic
alterations in back muscles close to the fused vertebrae
segments. Compared to healthy subjects, patients showed
stronger PCr depletions during exercise indicating
higher energy demand and thus higher muscle stress
(patients: 61 ± 17 % vs. controls: 37 ± 11 %).
|
4236. |
28 |
Functional 2D 31P MRSI in
the leg during exercise, using a dual-tuned 1H/31P volume
coil
Claudiu Schirda1, Tiejun Zhao2,
Shailesh Raval3, SoJung Lee4,
Silva Arslanian4, Hoby Hetherington1,
and Tamer Ibrahim1,3
1Radiology, University of Pittsburgh School
of Medicine, Pittsburgh, PA, United States, 2Siemens
Medical Solutions, Pittsburgh, PA, United States,3Bioengineering,
University of Pittsburgh, Pittsburgh, PA, United States, 4Division
of Weight Management and Wellness, University of
Pittsburgh School of Medicine, Pittsburgh, PA, United
States
Monitoring 31P metabolism during exercise and recovery
has typically been done using non-localized functional
31P MRS and a surface coil. By employing a
high-sensitivity dual-tuned 1H/31P volume coil,
functional 2D 31P spectroscopic imaging (thus, 4D) is
demonstrated.
|
4237. |
29 |
Fat to Water Ratio and T2
Value Variations Measured in Lumbar, Thoracic, and Cervical
Spinal Bone Marrow at 3 T
Quinn M. Barber1 and
Atiyah Yahya1,2
1Department of Oncology, University of
Alberta, Edmonton, Alberta, Canada, 2Department
of Medical Physics, Cross Cancer Institute, Edmonton,
Alberta, Canada
Fat to water levels and their transverse relaxation (T2)
times measured with magnetic resonance in spinal bone
marrow have been relevant to the study of a number of
diseases. Previous measurements characterizing fat to
water ratios and T2 values have been limited to the
lumbar region of the spine. In this work, fat to water
ratios and fat and water T2 values are determined for
the L3 and T7 vertebrae of 20 healthy volunteers;
measurements were also obtained from the C4 vertebra in
19 of the volunteers. Measurements were performed with a
Point RESolved Spectroscopy (PRESS) sequence at 3 T.
|
4238. |
30 |
Fat assessment in shoulder
muscle: A comparison between spectroscopic and imaging
techniques.
Gaëlle Diserens1, Helen Anwander2,
Fabian Fuhrer2, Chris Boesch1,
Mattias A Zumstein2, and Peter Vermathen1
1Depts. Radiology and Clinical Research,
University Bern, Bern, Switzerland, 2Dept.
of Orthopaedic Surgery and Traumatology, University
Bern, Bern, Switzerland
The aim of this study was to compare Dixon imaging and
single voxel spectroscopy (SVS) for determination of low
fat contents in muscles that are not prone to motion, as
shoulder muscles (infraspinatus and supraspinatus). The
results clearly demonstrate that also for low contents
below 10%, the lipid content can be determined reliably
by both, Dixon and SVS methods. This was shown by strong
correlations between results from SVS and Dixon and
between independent measures of right and left shoulders
and between the two different muscles investigated.
|
4239. |
31 |
Towards a Whole-Joint MR
Evaluation of the Knee: Cartilage, Bone and Marrow.
Won C Bae1, Kyu-Sung Kwack2, Gavin
Hamilton1, Reni Biswas1, Betty
Tran1, Robert Healey3, Sheronda
Statum1, Eric Y Chang4, and
Christine B Chung4,5
1Radiology, Univeristy of California, San
Diego, San Diego, CA, United States, 2Radiology,
Ajou University Medical Center, Korea, 3Orthopedic
Surgery, Univeristy of California, San Diego, CA, United
States, 4Veterans
Affairs San Diego Healthcare System, CA, United States, 5Radiology,
Univeristy of California, San Diego, CA, United States
Current knee MR evaluation focuses on specific parts of
the knee. This abstract shows feasibility and usefulness
of a whole-joint quantitative MR evaluation paradigm,
achieved using currently available techniques, to
evaluate articular cartilage, trabecular bone, and bone
marrow simultaneously.
|
4240.
|
32 |
Creatine concentration in
human calf muscle at 7T with AREX
Eugenia Rerich1, Moritz Zaiss1,
Johannes Windschuh1, Patrick Schünke1,
and Peter Bachert1
1German Cancer Research Center, Heidelberg,
Baden-Württemberg, Germany
Pulsed steady-state in
vitro CEST
measurements of creatine followed by spillover, MT and
T1 compensated evaluation - AREX - yield creatine
concentration calibration. This method is applicable in
vivo and
allows quantification of creatine in human calf muscle.
|
4241. |
33 |
Progression of Skeletal
Muscle Dysfunction Assessed by 31P MRS and BOLD MRI in
Non-obese Type 2 Diabetic Rats
Yuchi Liu1, Xunbai Mei1, Andrew
Slabic1, Nicola Lai1, and Xin Yu1,2
1Biomedical Engineering, Case Western Reserve
University, Cleveland, Ohio, United States, 2Radiology,
Case Western Reserve University, Cleveland, Ohio, United
States
This study investigated changes in mitochondrial
response to ischemia in skeletal muscle of non-obese
type 2 diabetic rats. Mitochondrial function and tissue
oxygenation was evaluated in vivo using interleaved 31P
Magnetic Resonance Spectroscopy (MRS) and Blood Oxygen
Level-Dependent (BOLD) imaging. Results from 12- and
18-week rats showed a progression of mitochondrial
dysfunction.
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4242. |
34 |
Dystrophic Skeletal Muscle 1H2O
T2 Analyzed
for Multiple Components
Sean C Forbes1, William T Triplett1,
Rebecca Willcocks1, Abhinandan Batra1,
Ravneet Vohra1, James Pollaro2,
Dah-Jyuu Wang3, Richard Finkel4,
Barry J Byrne5, Barry S Russman6,
Erika Finanger6, Michael Daniels7,
William Rooney2, Glenn A Walter1,
H Lee Sweeney8, and Krista Vandenborne1
1University of Florida, Gainesvillle,
Florida, United States, 2Oregon
Health & Science University, Oregon, United States, 3The
Children's Hospital of Philadelphia, Pennsylvania,
United States, 4Nemours
Children's Hospital, Florida, United States, 5University
of Florida, Gainesville, Florida, United States,6Shriners
Hospital, Oregon, United States, 7University
of Texas at Austin, Texas, United States, 8University
of Pennsylvania, Pennsylvania, United States
This study evaluated 1H2O
T2 of
skeletal muscle in boys with Duchenne muscular dystrophy
(DMD) and unaffected controls, and in dystrophic mice
before and after downhill running. Data were acquired
using single voxel 1H-MRS
and analyzed for multiple components using non-negative
least squares analyses (NNLS). NNLS revealed differences
between dystrophic muscle and controls, including DMD
having a more predominant long component. The long
component was affected by corticosteroid treatment and
downhill running in dystrophic muscle and was consistent
with muscle damage/inflammation contributing to this
component. Overall, NNLS analyses may provide valuable
insight when interpreting 1H2O
T2 changes
in dystrophic muscle.
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4243. |
35 |
Diffusion-Weighted,Triple-Fat-Suppressed Echo-Planar Imaging
Provides 'Anomalous' Diffusion Metrics for Assessment of
Muscle Quality in the Human Thigh
Donnie Cameron1, Mustapha Bouhrara1,
David A. Reiter1, Kenneth W. Fishbein1,
Christopher M. Bergeron1, and Richard G.
Spencer1
1National Institute on Aging, National
Institutes of Health, Baltimore, Maryland, United States
In diffusion-weighted imaging (DWI) of the thigh,
‘anomalous’ diffusion models may better reflect muscle
architecture than conventional Gaussian models. In this
work, four models were investigated—monoexponential,
intravoxel incoherent motion, diffusional kurtosis, and
stretched exponential—and a triple-fat-suppressed
sequence was developed to mitigate fat contributions.
Eight volunteers were scanned at 3T, with sixteen
b-values applied in the slice and read directions, and
diffusion parameter maps were generated. In the read
direction, kurtosis and the stretching parameter were
non-Gaussian (>0 and <1), and the stretched exponential
fit the data best—suggesting some merit for non-Gaussian
models in assessment of muscle quality.
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4244. |
36 |
Importance of Supine Rest
Period before Imaging for Thigh Muscle Volume Quantification
Vijay Shah1, Therese Crilly1,
Larry Molinelli1, William Badger2,
and Jon Riek1
1VirtualScopics, Inc., Rochester, NY, United
States, 2Univerisity
of Rochester Medical Center, Rochester, NY, United
States
This study aimed to evaluate the influence of supine
rest on thigh muscle volume in a healthy volunteer.
Dynamic T1-weighted MR images were acquired in the
mid-thigh region for 30 minutes. On average, muscle
volume in the mid-thigh region decreased by 1.21%. The
average coefficient-of-variation of two consecutive
acquisitions was 0.15%, indicating that the measurement
technique should be sensitive to changes in volume of
less than 1%. At least 15 minutes of supine rest prior
to positioning on the table may help to detect smaller
changes in the thigh muscle volume by eliminating
variability that could be introduced by redistribution
of fluid in the muscles when posture is changed.
|
4245. |
37 |
MSK hemodynamics at
quadriceps using blood-oxygen level dependent (BOLD) MRI at
3T; Volitional exercise VS Neuromuscular Electrical
Stimulation (NMES) - permission withheld
Junghwan Kim1,2, Serter Gumus2,
Piva Sara Regina3, Tae Kim2, Tamer
Ibrahim1,2, and Kyongtae Ty Bae1,2
1Bioengineering, University of Pittsburgh,
Pittsburgh, PA, United States, 2Radiology,
University of Pittsburgh, Pittsburgh, PA, United States, 3Physical
Therapy, University of Pittsburgh, Pittsburgh, PA,
United States
The BOLD MR imaging was performed at quadriceps to
understand the hemodynamics at volitional exercise (VE)
and neuromuscular electrical stimulation (NMES).
Near-infrared spectroscopy (NIRS) was used to measure
the total, deoxy- and oxy- hemoglobin concentrations to
understand the mechanism of muscle hemodynamics.
Measured NIRS data was then used for calculation of BOLD
signal and compared to the BOLD MRI.
|
4246. |
38 |
Quantifying perfusion in
conditions of rapidly changing blood flow and vascular
volume: A novel tracer kinetic model
Jeff L Zhang1, Christopher J Hanrahan1,
and Vivian S Lee1
1Radiology, University of Utah, Salt Lake
City, Utah, United States
DCE MRI is widely used for assessing tissue perfusion
noninvasively, using indicator dilution theory, which
models tissue enhancement as a convolution between the
arterial input function and impulse response function.
This approach requires that the system of interest is
time-invariant during data acquisition, which is
fulfilled in most situations. However, the convolution
approach does not work when perfusion changes
dramatically during the measurement period, such as
skeletal muscle perfusion during exercise-recovery. In
this study, we propose a new tracer kinetic model where
both blood inflow and vascular volume can vary during
the measurement.
|
4247. |
39 |
Multi parametric MRI
evaluation of muscle development
Kerryanne V. Winters1,2, Olivier Reynaud1,2,
Dmitry S. Novikov1,2, Els Fieremans1,2,
and Sungheon G. Kim1,2
1Department of Radiology, Bernard and Irene
Schwartz Center for Biomedical Imaging - NYU School of
Medicine, New York, NY, United States, 2Center
for Advanced Imaging Innovation and Research, NYU
Langone Medical Center, New York, NY, United States
We quantified changes in normal skeletal muscle growth
using time dependent DTI combined with the random
permeable barrier model (RPBM), the conventional
IDEAL-Dixon imaging and T2 mapping. Muscle development
was assessed by using different age of mice and
comparing the parameters of each modality. DTI-RPBM was
used to monitor changes in muscle fiber size and
sarcolemma permeability, and showed that younger mice
had higher surface-to-volume ratio and higher membrane
permeability. Dixon imaging proved that with
development, fatty deposits develop and therefore
increase the fat fraction of the tissue. In addition,
our preliminary results also showed that T2 values
decrease with age. These results demonstrate that the
microstructural changes measured using DTI-RPBM during
muscle development are in line with the literature and
can serve as a useful tool in assessment of disease
progress or treatment response in various myopathies.
|
4248. |
40 |
Muscle perfusion reserve
(MPR) measured from exercise-recovery MRI: a new functional
index for diagnosing PAD
Jeff L Zhang1, Christopher J Hanrahan1,
Jason Mendes1, Gwenael Layec2,
Corey Hart2, Kristi Carlston1,
Michelle Mueller3, Russell S Richardson2,
and Vivian S Lee1
1Radiology, University of Utah, Salt Lake
City, Utah, United States, 2Division
of Geriatrics, Department of Internal Medicine,
University of Utah, Salt Lake City, Utah, United States, 3Vascular
Surgery, University of Utah, Salt Lake City, Utah,
United States
Without a reliable way of assessing calf muscle
function, therapeutic management of PAD is highly
controversial. None existing imaging is capable of
quantifying exercise-induced capillary recruitment. We
have applied a validated plantar-flexion exercise
protocol within MRI scanner together with ASL
measurements at exercise recovery to measure
exercise-induced capillary recruitment, which we term
Muscle Perfusion Reserve (MPR). We examined MPR in
healthy subjects. MPR increased as workloads.
Significant differences in MPR were found between the
two healthy subjects with different body mass index. The
proposed MPR has great potential of evaluating calf
muscle function of PAD and improving their therapeutic
management.
|
4249. |
41 |
Evaluation of skeletal
muscle DTI in Duchenne Muscular Dystrophy
Melissa Hooijmans1, Martijn Froeling2,
Maarten Versluis3, Andrew Webb1,
Erik Niks4, Jan Verschuuren4, and
Hermien Kan1
1Radiology, Leiden University Medical Center,
Leiden, Zuid-holland, Netherlands, 2Radiology,
Utrecht Medical Center, Utrecht, Netherlands, 3Philips,
Netherlands, 4Neurology,
Leiden University Medical Center, Leiden, Zuid-holland,
Netherlands
Skeletal muscle DTI can potentially serve as a surrogate
measure of fiber architecture. This intrinsically
T2-weighted sequence is susceptible to SNR and fat
percentage. In muscles of Duchenne muscular dystrophy
(DMD) patients, increased %fat and higher T2 relaxation
times could obscure pathophysiological effects on DTI
parameter estimation. Our data show that the proposed
quality criteria from simulation-based work are suited
to reliably determine mean diffusivity (MD) in DMD
patients and controls and that multi-parametric MRI is
essential to distinguish between confounding effects and
pathophysiological processes in skeletal muscle DTI.
|
4250. |
42 |
Advanced pathology in aged
mdx muscle characterized by quantitative multi-parametric
MRI
Nathan David Bryant1,2, Ke Li1,2,
and Bruce Damon1,2
1Vanderbilt University Institute of Imaging
Science, Vanderbilt University, Nashville, TN, United
States, 2Department
of Radiology and Radiological Sciences, Vanderbilt
University, Nashville, TN, United States
Dystrophic skeletal muscles, from mdx mice of advanced
age and stages of myopathy, were characterized using an
array of quantitative metrics derived from a
multi-parametric MRI approach including: T2, DTI and
qMT-MRI data that were collected in a single imaging
session. These observations were compared to age matched
healthy control mice. Compared to healthy control
muscle, old mdx gastroc muscles were observed to have in
increased T2, but were not different in terms of the
diffusion indices investigated. However, the qMT
parameters R1f, PSR, and kmf were all decreased in the
histologically-verified fibrotic and advanced dystrophic
pathology mdx muscle.
|
4251. |
43 |
Simultaneous acquisition of
transverse relaxation, perfusion, and diffusion information
of lower-leg muscle using diffusion EPI with different TE
Makoto Terazono1, Tosiaki Miyati1,
Naoki Ohno1, Shuya Fujihara1,2,
Natsumi Makino3, Satoshi Kobayashi4,
and Toshifumi Gabata4
1Division of health sciences, Graduate school
of Medical Sciences, Kanazawa University, Kanazawa,
Ishikawa, Japan, 2Department
of Radiology, Shinshu University Hospital, Nagano,
Nagano, Japan, 3School
of Health Sciences, College of Medical, Pharmaceutical
and Health Sciences, Kanazawa, Ishikawa, Japan, 4Department
of Radiology, Kanazawa University Hospital, Kanazawa,
Ishikawa, Japan
To simultaneously acquire information on R2, MBF, and
restricted water diffusion in lower-leg, we devised a
method using SE-diffusion-EPI imaging with different
echo times, and compared these values before and after
the exercise. R2, ADCr, ADCP, and Fp of the tibialis
anterior (TA) of the lower-leg muscle after the exercise
were significantly higher than those before the
exercise. On the other hand, there was no significant
correlation between R2, ADCr, ADCP, and Fp of the TA.
Our method makes it possible to simultaneously obtain
R2, MBF, and restricted water diffusion in lower-leg,
and increase amount of the muscle functional
information.
|
4252. |
44 |
Deformation-Induced Damage
in Rat Skeletal Muscle: role of the vascular system
Jules Nelissen1,2, Willeke Traa3,
Kevin Moerman4, Cees Oomens3, Aart
Nederveen4, Klaas Nicolay1, and
Gustav Strijkers1,2
1Biomedical NMR, Department of Biomedical
Engineering, Eindhoven University of Technology,
Eindhoven, Netherlands, 2Biomedical
Engineering and Physics, Academic Medical Center,
Amsterdam, Netherlands, 3Soft
Tissue Biomechanics and Engineering, Department of
Biomedical Engineering, Eindhoven University of
Technology, Eindhoven, Netherlands, 4Department
of Radiology, Academic Medical Center, Amsterdam,
Netherlands
To investigate the response of the vascular system on
sustained mechanical loading of skeletal muscle and
subsequent skeletal muscle damage after end of period of
deformation a study was performed in a rat model for
skeletal muscle damage. During application of sustained
mechanical loading to skeletal muscle and subsequent
collapse of main supplying artery the body tries to keep
up blood supply. After end of indentation a hyperemic
response is observed. In case of combination of skeletal
muscle deformation and occlusion of main supplying
vessel, more edema formation is observed, which was
further confirmed by T2 ROI analysis. T2 enhancement due
to skeletal muscle damage appears highly structured and
matches the peri, and endomysium organization of
skeletal muscle.
|
4253. |
45 |
Muscle Oxygenation Changes
in Different Bone Mineral Density Subjects - a BOLD Based
Study
Heather T. Ma1,2, James F. Griffith3,
Yang Chen1, Shoulin Huang1, Davd
K. Yeung3, Xu Xing1, and Li Liang1
1Harbin Institute of Technology Shenzhen
Graduate School, Shenzhen, Guangdong, China, 2Johns
Hopkins University, Baltimore, MD, United States, 3The
Chinese University of Hong Kong, Hong Kong, China
This study examined the BOLD effect on calf muscles in
different bone mineral density (BMD) elderly females to
investigate the oxygenation characteristics in
osteoporotic patients. An air-cuff was used to induce
ischemia and BOLD-MRI data was curve fitted to derive
quantitative parameters. A significant decreased Slope
during hyperemia and longer Half-life in ischemic stage
were shown in the BOLD signal of subjects with lower
BMD, indicating a different vascular reactivity and
oxygen utilization strategy in osteoporotic patients. No
significant changes of minimum ischemic value among
subjects may indicate a normal oxygen utilization in
total for osteoporotic patients.
|
4254. |
46 |
Significance of Perfusion
Parameters and Muscle Performance in the Rotator Cuff
Muscles of Young Badminton Athletes: Assessment by Dynamic
Contrast-Enhanced MR Imaging
Chih-Wei Yu1, Tiffany Ting-Fang Shih1,
Hsing-Kuo Wang2, Chao-Yu Hsu1,
Bang-Bin Chen1, and Xin-Jia Chen3
1Radiology and Medical Imaging, National
Taiwan University College of Medicine and Hospital,
Taipei, Taiwan, 2School
and Graduate Institute of Physical Therapy, National
Taiwan University College of Medicine, Taipei, Taiwan, 3Medical
Imaging, National Taiwan University Hospital, Taipei,
Taiwan
Perfusion parameters of DCE-MRI and muscle performance
in rotator cuff muscles were evaluated in the 20 young
badminton athletes. Perfusion parameters of MRI in the
rotator cuff muscles may correlate with muscle strength
and significant difference was observed in perfusion
parameters between the anterior and the posterior
bellies of supraspinatus muscle.
|
4255. |
47 |
Dynamic analysis of T2 and
proton density of exercise-induced muscle using SE-EPI
Noriyuki Tawara1, Takahiro Ohnishi2,
and Toru Yamamoto1
1Faculty of Health Sciences, Hokkaido
University, Hokkaido, Japan, 2Siemens
Japan, Japan
Understanding of exercised muscle activity has been the
essences in sports medicine and rehabilitation medicine.
Although MRI is a useful technique to obtain
quantitative values of T2 and
proton density, most of the previous MRI studies
discussed changes of MR signal. Changes of T2 in
the exercised muscle are speculated based on the results
of the NIRS, and various physiologic mechanisms are
proposed. However, physiologic understanding of
exercised muscle activity is still controversial. In
this study, we first tried to obtain dynamic changes of
T2 and
proton density quantitatively after the muscle exercise.
In conclusion, using SE-EPI, temporal resolution of
dynamic study of exercise-induced muscle can be
shortened to 30 s and dynamic changes of R2 and
M0 were
quantitatively obtained for the new understanding of
exercised muscle activity.
|
4256. |
48 |
Correlation between
quantitative MRI features and functional assessment of
myopathy
Hon J. Yu1,2, Manaswitha Khare3,
Mathew Gargus3, Marie Wencel3,
Abhilasha Surampalli3, Vince Caiozzo4,
and Virginia Kimonis3
1Radiological Sciences, University of
California, Irvine, CA, United States, 2Tu
& Yuen Center for Functional Onco-Imaging, University of
California, Irvine, CA, United States, 3Pediatrics,
University of California, Irvine, CA, United States, 4Orthopaedic
Surgery, University of California, Irvine, CA, United
States
MRI and biophysical evaluation were performed on eight
subjects consisting of control and patients with varying
degrees of myopathy. Despite small sample size, the
potential for quantitative MRI features based on texture
analysis is demonstrated as a functional means for
muscle function in comparison with dynamometer-based
muscle strength measurements, which could be an
invaluable tool in study of the disease progression
and/or treatment intervention in both clinical and
research setting.
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