ISMRM 24th Annual Meeting & Exhibition • 07-13 May 2016 • Singapore |
Sunrise Educational Session:
Hyperpolarisation & MR Applications
Skill Level: Intermediate to Advanced
Organizers: Thomas K. F. Foo, Ph.D. & N. Jon Shah, Ph.D.
Tuesday 10 May 2016
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Overview
This course is designed for physicists and engineers to provide an introduction to new or emerging MR methods and applications that are gaining interest. The session provides a description of the underlying physics principles, image acquisition and reconstruction methods, pitfalls and challenges associated with hyperpolarized MR imaging. The clinical potential of this new MR imaging method will be discussed.
Target Audience
Those with an interest in: 1) understanding principles of hyperpolarization, including the operation of commercially available dynamic nuclear polarization methods and alternative hyperpolarization methods, 2) understanding the optimal acquisition methods for rapid data acquisition of short-lived hyperpolarized nuclei, including image reconstruction methods, and 3) understanding the potential clinical applications and implementation of hyperpolarized MRI in a clinical setting.
Educational Objectives
Upon completion of this course, participants should be able to:
- Understand and implement the
optimum acquisition methods for rapid image acquisition for
hyperpolarized nuclei with different chemical shift species;
- Better design experiments
that utilize hyperpolaried MR for specific applications, with
improved understanding of the limitations and pitfalls associated
with hyperpolarized MRI; and
- Better appreciate the added
functional information and the clinical impact of metabolic imaging
that is enabled by hyperpolarized MRI, and how this can be used in a
clinical setting.
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PROGRAM |
Moderators: Sean Fain, Philip Lee |
07:00
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Hyperpolarisation - Description, Overview & Method ![](play.gif)
Rolf F Schulte1
1GE Global Research, Munich, Germany
Metabolic imaging using hyperpolarised substances is a
relatively new research field looking at metabolic
processes in the body minimally invasive. In this
educational talk, the basic principles of dissolution
dynamic nuclear polarisation are introduced. The most
commonly used substance is [1-13C]pyruvate, which gets
taken up into the cells and converted enzymatically into
lactate, alanine and bicarbonate. Five dimensional MR
encoding is required to capture spectral, temporal and
3D spatial information.
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07:25
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Hyperpolarisation - Clinical Potential & Relevance ![](play.gif)
Ferdia Aidan Gallagher1
1Radiology, University of Cambridge,
Cambridge, United Kingdom
Hyperpolarized carbon-13 MRI is a new method for imaging
tissue metabolism. [1-13C]Pyruvate is the leading probe
used with the technique and is converted into lactate
under the action of lactate dehydrogenase (LDH).
Hyperpolarized carbon imaging has recently been
translated into humans and there are a number of sites
now undertaking clinical studies. Potential applications
may be found in oncology, cardiology and neurology; for
example, it has the potential to aid diagnosis, identify
disease heterogeneity, predict disease outcome, help
target biopsies and determine treatment response
non-invasively.
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07:50
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Adjournment & Meet the
Teachers |
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The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for physicians. |