14:50
|
Advanced Tumor Tutorial: Post-Treatment Response Assessment 
Benjamin M Ellingson1
1Radiology, University of California Los
Angeles, Los Angeles, CA, United States
The current lecture will discuss the current standard of
care in glioblastoma and malignant glioma as well as new
therapies and how they are integrated and may change
into this therapeutic landscape. We will then introduce
a brief history of response assessment from the WHO and
Levin Criteria through Macdonald and classical response
assessment in neuro-oncology (RANO) criteria. We will
briefly discuss new RANO initiatives including RANO for
low grade gliomas, RANO for immunotherapies (iRANO), and
updates on classical RANO criteria being developed for
the new GBM AGILE global adaptive trial. In addition to
classic response assessment we will discuss new
perfusion MR approaches including quantification of
hypervascular tumor volume by comparison to a
large-scale radiographic atlas, new leakage correction
algorithms for improved quantification of cerebral blood
volume, and the use of new multi-echo perfusion
techniques including vascular size imaging (VSI) to
characterize changes malignant glioma vasculature during
therapy. Lastly we will discuss promising new clinical
imaging techniques including pH- and hypoxia-weighted
multi-echo amine chemical exchange saturation transfer
echoplanar imaging (CEST EPI) of malignant gliomas under
a variety of therapeutic conditions in both human and
preclinical models.
|