View Presentation Video

Patricia Mazwi Maishi^1,2,3, Pheletso Letuka^3,4,5, Daniel Mutithu^3,4,5, Olukayode Aremu^3,4,5, Alladin Speelman⁶, Stephen Jermy^1,2,3, Petronella Samuels^1,2,3, Tasnim Bana^3,4,5, Mpiko Ntsekhe⁵, Morne Kahts^3,4,5, Jason Baker⁷, Hadil Saad⁸, Markella Zanni⁹, Christopher Longenecker¹⁰, and Ntobeko Ntusi^2,3,4,5
1Division of Biomedical Engineering,Department of Human Biology, University of Cape Town, Cape Town, South Africa, ²Cape Universities Body Imaging Centre, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa, ³South African Medical Research Council Extramural Unit on Intersection of Noncommunicable Diseases and Infectious Diseases, University of Cape Town, Cape Town, South Africa, ⁴Cape Heart Institute Department of Medicine, University of Cape Town, Cape Town, South Africa, ⁵Division of Cardiology Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa, ⁶Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Cape Town, South Africa, ⁷Hennepin Healthcare Research Institute and Department of Medicine, University of Minnesota, Minneapolis, MN, United States, ⁸Charite University and Noninvasive Cardiac Imaging, Klinik und Poliklinik fur Kardiolgie und Nephrologie, Charite University, Berlin, Germany, ⁹Metabolism Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, United States, ¹⁰Division of Cardiology and Department of Global Health, University of Washington, Seattle, WA, United States

Cardiovascular disease (CVD) is a major contributor to morbidity and mortality in people living with human immunodeficiency virus (PLHIV). In the general population, increased pericardiac adipose tissue is associated with poor cardiovascular outcomes, but its role in HIV-associated CVD is not well described. Using cardiovascular magnetic resonance (CMR), we report increased pericardial adipose tissue (PAT) and paracardiac adipose tissue (ParaAT) in PLHIV on ART compared to uninfected controls, with untreated PLHIV having an intermediate phenotype. For PLHIV not on ART, myocardial inflammation is associated with more significant impairment in strain and tissue characteristics, but not PAT and ParaAT volume.