Special Notice
Last updated Wednesday, 04 February 2009
 
The following information is being provided by the International Society for Magnetic Resonance in Medicine (ISMRM) as a courtesy to the MR community.  If you have additional articles or publications regarding this which you feel would be of interest and assistance, please send the citations to the ISMRM, and we will add these resources to this page.  Send them to the attention of Roberta A. Kravitz, ISMRM Executive Director, at roberta@ismrm.org.
 
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 Special Symposium on  NSF/NSD from the Joint Annual Meeting ISMRM-ESMRMB 2007 available online


The FDA (United States Food & Drug Administration) has received additional information about a new disease, known as Nephrogenic Systemic Fibrosis or Nephrogenic Fibrosing Dermopathy (NSF/NFD), which may occur in patients with moderate to end-stage kidney disease after they have had a Magnetic Resonance Imaging (MRI) or Magnetic Resonance Angiography (MRA) scan with a gadolinium-based contrast agent.

The FDA has released the following:

In addition, the EMEA (European Agency for the Evaluation of Medicinal Products) has released the following information:

Additional resources:

The Radiological Society of North America (RSNA) has made two articles available free of charge on the Radiology Web site:
 
  • New information on the link between gadolinium-based contrast agents and the rare disease nephrogenic systemic fibrosis is available in the RSNA peer-reviewed journal RADIOLOGY. “Nephrogenic Systemic Fibrosis: Risk Factors and Incidence Estimation,” by Elizabeth A. Sadowski, M.D., and colleagues will appear in the April print issue and is available now online at http://radiology.rsnajnls.org/cgi/content/full/2431062144v1.
     
  • An editorial, “Gadolinium-based MR Contrast Agents and Nephrogenic Systemic Fibrosis,” by Phillip H. Kuo, M.D., Ph.D., and colleagues is available in the March print issue or online at http://radiology.rsnajnls.org/cgi/content/full/2423061640v1.

In addition, the February issue of RSNA News includes an article on this topic at http://www.rsna.org/Publications/rsnanews/feb07/upload/RSNANews_Feb07_Gadolinium.pdf
 
  • NSF Registry - Cowper SE. Nephrogenic Fibrosing Dermopathy [NFD/NSF Website]. 2001-2007
  • Gadolinium - a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis?  T. Grobner; Oxford University Press on behalf of ERA-EDTA, Nephrol Dial Transplant 2006; 21:1104–1108 and Response to letter to the Editor, Nephrol Dial Transplant 2006; 21:3604-5
  • Nephrogenic Systemic Fibrosis:  Suspected Causative Role of Gadodiamide Used for Contrast-Enhanced Magnetic Resonance Imaging, P. Marckmann, L. Skov, K. Rossen, A. Dupont, M. Damholt, J. Heaf, and H. Thomsen; American Society of Nephrology, 2006; JAmSocNephrol17:2359–2362,2006.doi:10.1681/ASN.2006060601
  • Editorial:  Is there a causal relation between the administration of gadolinium based contrast media and the development of nephrogenic systemic fibrosis (NSF)?  H. Thomsen, S.K. Morcos, and P. Dawson; Clinical Radiology (2006) 905-906
  • Gadolinium deposition in nephrogenic fibrosing dermopathy, A. Boyd, J. Zic, and J. Abraham; J Am Acad Dermatol, Articles in press, 2007 American Academy of Dermatology, Inc.
  • Letter to the Editors:  Gadolinium and nephrogenic fibrosing demopathy in pediatric patients, V. Dharnidharka, S. Wesson, and R. Fennell; Pediatric Nephrology, DOI 10.1007/s00467-006-0384-z (Springer)