MR
of Transgenic Mouse Models (MR Omics)
Daniel H. Turnbull,
Ph.D., Organizer
Sunday, 16 May 2004, 08:00 - 16:30
Last
updated 05 May 2009
Course
Description The past twenty years have seen an explosion in our ability to manipulate the
mouse genome to make an extraordinary variety of animal models to study physiopathology
and disease. In many cases simple changes in the mouse genome lead to complex
changes in tissue function. This complexity combined with the large number of
interesting models being produced has led to a growing interest in efficient ways to
phenotype and measure specific biological processes in the mouse. Over the same time
period there has been an explosion in the range of information that can be obtained by
magnetic resonance (MR) techniques. Due to the wide range of information available
from MR and the large body of work applying MR to rodents, it has been a natural fit to
apply MR to mouse models. The purpose of this course is to
discuss the wide range of applications for the marriage of MR and mouse genomics and to
illustrate the impact MR is having on understanding a wide variety of mouse models.
Audience Description:
MR of Transgenic Mouse Models is designed to impact investigators and
students from almost all areas and thus it is anticipated that this
course will attract a diverse audience. The course is designed for
people who are interested in modeling human disease with mouse models;
assessing mouse models of human disease with MR; using mouse models to
aid development of novel MR techniques to assess tissue structure and
function; molecular imaging; drug development; multi-modality imaging of
the mouse; molecular genetics of the mouse.
Educational
Objectives: The course will give an
understanding of the following topics: Different ways in which molecular biologists are
using mouse models to understand development and disease; Small animal imaging Applications of MR
to mouse models of cancer, neurological and cardiac diseases; Use of MR
and mouse models for drug discovery; different approaches being taken to
obtain functional and molecular information from mouse imaging
techniques.
Different ways in which molecular biologists are
using mouse models to understand development and disease;