Pre-Clinical Assessment of Vascular Function

Room 618 - 620 11:00 - 13:00 Chairs: Natarajan Raghunand and Simon P. Robinson

Time	Prog #
11:00	*464.*	Vascular Tortuosity is Culprit to Abnormal Perfusion in 9L Gliosarcoma Tumor Moses Morakortoi Darpolor¹, Robert C. Molthen², Francisca C. Wu³, Kathleen M. Schmainda³ ¹Marquette University, Milwaukee, Wisconsin, USA; ²Dept. of Veterans Affair, Zablocki VAMC, Milwaukee, Wisconsin, USA; ³Medical College of Wisconsin, Milwaukee, Wisconsin, USA
11:12	*465.*	Assessment of Mouse Glioma Vasculature Using SPIO and Small Molecule Contrast Agents: Sequential Implementation of Alternate Perfusion MRI Methodologies Martin Mugar Pike¹, Catherine P. Langford¹, Cristine D. Neumann¹, L Burt Nabors¹, G Yancey Gillespie¹ ¹University of Alabama at Birmingham, Birmingham, Alabama, USA
11:24	*466.*	The Role of VEGF in Growth of Brain Metastases from Single Cells as Visualized by Contrast Enhanced MRI Kirsten Tracy¹, Juan Juan Yin¹, Jeeva Munasinghe¹, Erik Shaprio¹, Alan Koretsky¹, Kathleen Kelly¹ ¹National Institutes of Health, Bethesda, Maryland, USA
11:36	*467.*	*The Role of Platelet-Derived Growth Factor on Tumour Vascular Function and Morphology In Vivo* Assessed by Susceptibility Magnetic Resonance Imaging** Simon P. Robinson¹, Christian Ludwig², Janna Paulsson³, John R. Griffiths¹, Arne Ostman³ ¹St. George's, University of London, London, UK; ²University of Birmingham, Birmingham, UK; ³Karolinska Institute, Stockholm, Sweden
11:48	*468.*	Vascular Targeting Photodynamic Therapy (VTP): Correlations Between Hemodynamic and Photosensitized fMRI Response Parameters in the Mouse Ear Tumor Model Noa Madar¹, Catherine Brami¹, Vyacheslav Kalchenko¹, Avigdor Scherz¹, Michal Neeman¹, Yoram Salomon¹ ¹The Weizmann Institute of Sciences, Rehovot, Israel
12:00	*469.*	Assessment of Spin Echo BOLD FMR Imaging as a Prognostic Tool for Determining Chemotherapeutic Efficacy Arup Bhattacharya¹, Richard Mazurchuk¹, Joseph A. Spernyak¹, Shousong Cao¹, Farukh A. Durrani¹, Youcef M. Rustum¹ ¹Roswell Park Cancer Institute, Buffalo, New York, USA
12:12	*470.*	*Characterizing Hypoxia-Induced Alterations in ECM Integrity of Solid Tumors In Vivo* Using MRI and Fluorescent Microscopy** Arvind P. Pathak¹, Venu Raman¹, Dmitri Artemov¹, Zaver M. Bhujwalla¹ ¹Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
12:24	*471.*	Molecular Imaging and Targeted Anti-Angiogenic Therapy in Cancer with Alpha_nubeta₃-Targeted Nanoparticles Patrick M. Winter¹, Shelton D. Caruthers¹,², Todd A. Williams¹, John S. Allen¹, Thomas D. Harris³, Samuel A. Wickline¹, Gregory M. Lanza¹ ¹Washington University, St. Louis, Missouri, USA; ²2Philips Medical Systems, Cleveland, Ohio, USA; ³Bristol-Myers Squibb Medical Imaging, Billerica, Massachusetts, USA
12:36	*472.*	Multi Parameter High-Resolution Magnetic Resonance Imaging and Spectroscopy of Tumors Philipp Moerchel¹, Gerd Melkus¹, Volker Christian Behr¹, Markus Kotas¹, Peter Jakob¹, Michael Flentje¹ ¹University of Würzburg, Würzburg, Germany
12:48	473.	HRMAS 1H Spectroscopy of the Novel VEGF-RTK Inhibitor AG013736 in a Breast Cancer Model Lisa J. Wilmes¹, Samson Jarso¹, Maria G. Pallavicini², David R. Shalinsky³, John Kurhanewicz¹, Nola M. Hylton¹ ¹University of California San Francisco, San Francisco, California, USA; ²University of California Merced, Merced, California, USA; ³Pfizer Global Research and Development, La Jolla, California, USA