Cell Tracking and Targeted Contrast Agents in Cancer

Room 618 - 620         10:30 - 12:30                 Chairs: Alexei A. Bogdanov and Joseph A. Frank

Time

Prog #

 
10:30 677.

In Vivo Tracking of Growth and Dormancy of Solitary Cells in a Mouse Model of Breast Cancer Metastasis

to Brain Using MRI

Chris Heyn1, 2, John A. Ronald1, 3, Soha S. Ramadan1, 3, Jonatan A. Snir1, Andrea M. Barry1, Lisa T. MacKenzie3, 4,

David J. Mikulis2, 5, Diane Palmieri6, Julie L. Bronder6, Patricia S. Steeg6, Toshiyuki Yoneda7, Ian C. MacDonald3,

Ann F. Chambers3, 4, Brian K. Rutt1, 3, Paula J. Foster1, 3

1Robarts Research Institute, London, ON, Canada; 2University of Toronto, Toronto, ON, Canada; 3University of Western Ontario, London, ON, Canada; 4London Regional Cancer Program, London, ON, Canada; 5Toronto Western Hospital of The University Health Network, Toronto, ON, Canada; 6Center for Cancer Research, NCI, Bethesda, Maryland, USA; 7The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
10:42 678.

Expression of Transferrin Receptor and Ferritin Following Ferumoxides - Protamine Sulfate Labeling of Cells: Implications

for Cellular Magnetic Resonance Imaging

Edyta Pawelczyk1, Ali S. Arbab2, Sunil Pandit3, Elbert Hu1, Joseph A. Frank1

1National Institutes of Health, Bethesda, Maryland, USA; 2Henry Ford Health System, Detroit, Michigan, USA; 3Clinical Center, Bethesda, Maryland, USA
10:54 679.

Sentinel Node Imaging of the Breast in Mice Using a Dual-Labeled Nano-Sized MRI/near Infrared (NIR) Optical Hybrid

Contrast Agent, G6 Cy5.5

Hisataka Kobayashi1, Vladimir S. Talanov1, Marcelino Bernardo2, Celeste A. Regino1, Yoshinori Koyama1,

Yukihiro Hama1, Martin W. Brechbiel1, Peter L. Choyke1

1NCI/NIH, Bethesda, Maryland, USA; 2SAIC-Frederick, NCI/NIH, Bethesda, Maryland, USA
11:06 680.

Noninvasive MR Quantification of Magnetically Labeled Tumor Cells in Rats

Wei Liu1, Daniel Herzka1, Hannes Dahnke2, Bobbi K. Lewis3, E. Kay Jordan3, Naheed Banu3, Tobias Schaeffter2, Joseph A. Frank3

1Philips Research North America, Briarcliff Manor, New York, USA; 2Philips Research Germany, Hamburg, Germany; 3National Insititue of Health, Bethesda, Maryland, USA
11:18 681.

High-Resolution Fluorescence Microscopy and MRI Reveals Mechanism of Lymphatic Metastasis

Maya Dadiani1, Dalia Seger1, Vyacheslav Kalchenko1, Ady Yosepovich2, Yaron Hassid1, Raanan Margalit1,

Hadassa Degani1

1Weizmann Institute of Science, Rehovot, Israel; 2Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv, Israel
11:30 682.

Tracking Recruitment of Fibroblasts to Ovarian Carcinoma Tumors by MRI

Dorit Granot1, Michal Neeman1

1Weizmann Institute of Science, Rehovot, Israel
11:42 683.

Internalization of Annexin A5-USPIOs by Apoptotic Cells

Geralda A.F. van Tilborg1, Gustav J. Strijkers1, H. Duimel2, Paul Bomans2, Peter M. Frederik2,

Chris P.M. Reutelingsperger3, Klaas Nicolay1

1Eindhoven University of Technology, Eindhoven, Netherlands; 2University of Maastricht, Maastricht, Netherlands; 3Maastricht University, Maastricht, Netherlands
11:54 684.

New Vanadium-Based MRI Probes for Early Detection of Cancer

Devkumar Mustafi1, Sean Foxley1, Marta Zamora1, Marvin W. Makinen1, Gregory S. Karczmar1

1The University of Chicago, Chicago, Illinois, USA
11:06 685.

Tumor-Targeted Enzyme Mediated MR Signal Amplification Using Paramagnetic Substrates

Alexei A. Bogdanov1, Hye-Won Kang1, David Gordon Bennett2, Manuel Querol1, Anna Y. Yudina1, Iris Verel3,

Christopher H. Sotak,12

1UMASS Medical School, Worcester, Massachusetts, USA; 2Worcester Polytechnic Institute, Worcester, Massachusetts, USA;

3Phillips Research, Eindhoven, Netherlands

11:18 686.

Polyamine-Substituted Gd-DTPA: Intracellular, Tumor-Selective, High-Retention MRI Contrast Agents

William E. Hull1, Markus Wolf1, Sabine Heiland2, Ulrike Bauder-Wuest1, Michael Eisenhut1

1German Cancer Research Center (DKFZ), Heidelberg, Germany; 2University of Heidelberg, Heidelberg, Germany