MRI in Animal Models for Stroke and Traumatic Brain Injury
Room 4E Tuesday 13:30 - 15:30
1451. Early MRI Characterization of Cerebral Edema Following Diffuse Traumatic Brain Injury in Rat
Yohan van de Looij1, 2, Hana Lahrech1, 2, Gilles Francony1, 2, Olivier Carle1, 2, Régine Farion1, 2,
Christoph Segebarth1, 2, Jean-François Payen1, 2
1INSERM U594, Grenoble, France; 2Univ Joseph Fourier, Grenoble, France
1452.
The Effect of Interleukin-1 on Local Brain Temperature During Focal
Cerebral Ischemia in the Rat:
A 1H Magnetic Resonance Spectroscopic
Imaging Study
Adrian Robert Parry-Jones1, Timo Liimatainen2, Nancy Jane Rothwell1, Risto Antero Kauppinen3, Olli H J Grohn2
1University of Manchester, Manchester, UK; 2University of Kuopio, Kuopio, Finland; 3University of Birmingham, Birmingham, UK
1453. Direct Evidence That Activating the Interleukin 1 Type I Receptor Enhances Ischemic Brain Damage
Jelena Lazovic1, Anirban Basu2, Raymond P. Rothstein3, Michael B. Smith4, Steven W. Levison3
1California Institute of Technology, Pasadena, California, USA; 2National Brain Research Center, Gurgaon, India; 3University of Medicine and Dentistry, East Orange, New Jersey, USA; 4The Pennsylvania State University, Hershey, Pennsylvania, USA
1454. In Vivo Measurement of Blood Flow After Traumatic Brain Injury in Rats Using Susceptibility Weighted Imaging
Yimin Shen1, Jiani Hu1, Christian W. Kreipke1, Theodor Petrov1, E Mark Haacke1, 2
1Wayne State University School of Medicine, Detroit, Michigan, USA; 2MRI Institute of Biomedical Research, Detroit, Michigan, USA
1455.
Delayed Thalamic Damage After Stroke: Discriminator for Recovery
Success from Functional
Loss in the Cortex of the Rat
Carlos Justicia1, Pedro Ramos-Cabrer1, Ralph Weber1, Dirk Wiedermann1, Cordula Strecker1, Christiane Sprenger1, Mathias Hoehn1
1Max-Planck-Institute for Neurological Research, Cologne, Germany
1456. The Response of the Fetal Brain to Antenatal Hypoxia-Ischemia Detected by Diffusion-Weighted Imaging
Alexander Drobyshevsky1, Matthew Derrick1, Alice M. Wyrwicz1, Pottumarthi Prasad1, Xinhai Ji1,
Ila Englof2, Sidhartha Tan1
1Evanston Northwestern Healthcare, Evanston, Illinois, USA; 2Evanston Northwestern Healthcare, Evanston,, Illinois, USA
1457. Unilateral Common Carotid Artery Occlusion: A Transient Ischemia Model Well Suited to MR Studies
Jeremy Joseph Flint1, Stephen J. Blackband1, 2, Peter E. Thelwall1
1University of Florida, Gainesville, Florida, USA; 2National High Magnetic Field Laboratory, Tallahassee, Florida, USA
1458. MRI Investigation of Combination Treatment of Embolic Stroke in Rat with Rt-PA and Atorvastatin
Guangliang Ding1, Quan Jiang1, Lian Li1, Li Zhang1, Zheng Gang Zhang1, Swayamprava Panda1, James R. Ewing1, Michael Chopp1
1Henry Ford Health Sciences Center, Detroit, Michigan, USA
1459.
Spatiotemporal Pattern of USPIO Enhancement in Experimental Stroke
Lesions Depends
on the Type of Ischemic Injury: A 9,4 T MRI Study
Michael Schroeter1, Ana M. Oros-Peusquens2, Marko Irkens2, Avdo Celik2, Andreas Saleh1, Nadim J. Shah2,
Sebastian Jander1
1Heinrich Heine-University, Duesseldorf, Germany; 2Research Centre Juelich, Juelich, Germany
1460. MR Imaging of Rat Monocytes Homing Towards an Area of Cerebral Infarction
Raoul David Oude Engberink1, Erik I. Hoff2, Susanne M. van der Pol3, Erwin L. Blezer1, Helga E. de Vries3
1University Medical Center Utrecht, Utrecht, Netherlands; 2Department of Neurology, Maastricht, Netherlands; 3VU Medical Center, Amsterdam, Netherlands
1461.
fMRI of Delayed Albumin Treatment During Stroke Recovery in Rats:
Implication for
Fast Neuronal Habituation in Recovering Brains
Young Ro Kim1, Mauritz P.A. van Meer1, Joseph B. Mandeville1, Emiri Tejima2, George Dai1, Kamil Topalkara3, Jianhua Qui3, Rick M. Dijkhuizen4, Mike A. Moskowitz3, Eng H. Lo2, Bruce R. Rosen1
1Athinoula Martinos Center for Biomedical Imaging/ Massachusetts General Hospital, Charlestown, Massachusetts, USA; 2Neuroprotection Research laboratory/ Massachusetts General Hospital, Charlestown, Massachusetts, USA; 3Stroke and Neurovascular Regulation Laboratory/ Massachusetts General Hospital, Charlestown, Massachusetts, USA; 4Image Sciences Institute, University Medical Center Utrecht, The Netherlands, Charlestown, Massachusetts, USA
1462. Dynamic Tissue Fates Tracking in Acute and Sub-Acute Phase of a Transient Occlusion Rat Model
Qiang Shen1, Hongxia Ren1, Jürgen Bardutzky2, Marc Fisher3, Timothy Q. Duong1
1Emory Unviersity, Atlanta, Georgia, USA; 2University of Heidelberg, Heidelberg, Germany; 3The University of Massachusetts Medical School, Worcester, Massachusetts, USA
1463. Time Course of Water Diffusivity in the Rat Brain After Global Ischemia
Ivan Vorisek1, 2, Helena Neprasova1, Miroslava Anderova1, Daniel Jirak3, Milan Hajek3, Alexandr Chvatal1,
Eva Sykova1, 2
1Institute of Experimental Medicine ASCR, Prague, Czech Republic, Czech Republic; 2Charles University, 2nd Medical Faculty, Prague, Prague, Czech Republic, Czech Republic; 3Institute for Clinical and Experimental Medicine, Prague, Czech Republic, Czech Republic
1464. Brain Tissue Regeneration Following Activation of Endogenous Stem Cells in Animal Model of Stroke
Nancy J. Lobaugh1, Anna Erlandsson2, Hai-Ling Margaret Cheng3, Voytek Gretka1, Cindi Morshead2, Greg J. Stanisz1
1Sunnybrook & Womens' CHSC, Toronto, ON, Canada; 2University of Toronto, Toronto, ON, Canada; 3Hospital for Sick Children, Toronto, ON, Canada
1465.
Application of a Rat Stroke Model for Preclinical Evaluation of
Anti-Stroke Drugs: Noninvasive
Monitoring with Comprehensive Magnetic Resonance Imaging
Feng Chen1, Yicheng Ni1, Nobuo Nagai2, Yasuhiro Suzuki2, Desire Collen2, Guy Marchal2
1Catholic University of Leuven, Leuven, Flamms Brabant, Belgium; 2Catholic University of Leuven, Leuven, Flaams Brabant, Belgium
1466. Correlation of Proton Transfer Ratio and Intracellular PH in Acute Ischaemia
Kimmo T. Jokivarsi1, Heidi I. Gröhn1, Olli H. Gröhn1, Risto A. Kauppinen2
1A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland; 2School of Sport and Exercise Sciences, University of Birmingham, Birmingham, UK
1467.
Comparison of Cerebral Blood Flow Estimates in the Ischemic Area of
Rat Brain Obtained with
Dynamic Susceptibility Contrast and Continuous Arterial Spin Labeling
Ryo Kagaya1, 2, Kazuhiro Nakamura2, 3, Yasushi Kondoh2, Masanobu Ibaraki2, Jeff Kershaw2, 3, Guoyue Chen1,
Iwao Kanno2
1Akita Pref Univ, Ugo-Honjoh, Japan;
2Akita Res Inst of Brain and Vessels, Akita, Japan; 3Akita
Industry Promotion Found, Akita, Japan
Correlation with Blood Gas Analyses
Ulrike Wedegärtner1, Hendrik Kooijman2, Andrew N. Priest1, Mikhail Tchirikov1, Hobe J. Schröder1, Gerhard Adam1
1University Hospital Hamburg-Eppendorf, Hamburg, Germany; 2Philips Medical Systems, Hamburg, Germany
1469. Timecourse of Early CBF Changes After Controlled Cortical Impact in Mice
Lesley M. Foley1, T Kevin Hitchens1, Patrick M. Kochanek2, John A. Melick2, Chien Ho1
1Carnegie Mellon University, Pittsburgh, Pennsylvania, USA; 2University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
1470. Post-Ischaemic Gene Therapy for Stroke: An MRI Study
Romina Aron Badin1, Mark F. Lythgoe1, Martin D. King1, David S. Latchman1, David G. Gadian1
1Institute of Child Health, University
College London, London, UK
1471.
Temporal and Spatial Evolution of MR Derived Cerebral Metabolic Rate
of Oxygen Utilization Index
in Acute Middle Cerebral Artery Occlusion Stroke
Rats
Hongyu An1, Yasheng Chen1, Liansheng Chang1, Weili Lin1
1University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
1472.
Cerebral Edema Induced by Synchrotron Microbeam Radiation Therapy in
the Healthy Mouse Brain.
Characterization by Means of Diffusion Tensor Imaging
Yohan van de Looij1, Raphaël Serduc1, Gilles Francony1, Olivier Verdonck1, Elke Brauer2, Boudewijn van der Sanden1, Christoph Segebarth1, Chantal Remy1, Hana Lahrech1
1UJF/INSERM U594, Grenoble, France;
2European Synchrotron Radiation Facility, Grenoble, France
1473. High Resolution Sodium Imaging of Rat and Mouse Models of Stroke at 17.6 T
Thomas Neuberger1, 2, Andrew Webb1, 2
1Penn State University, University Park,
Pennsylvania, USA; 2University of Würzburg, Würzburg, Germany
Room 4E Tuesday 13:30 - 15:30
1474. Effect of Iron Deficiency on Developing Rat Striatum
Ivan Tkac1, Kay L. Ward1, Barbara Felt2, Betsy Lozoff2, Michael K. Georgieff1, Raghavendra Rao1
1University of Minnesota, Minneapolis, Minnesota, USA; 2University of Michigan, Ann Arbor, Michigan, USA
1475. Water and Metabolite Proton T1 and T2 Relaxation in Rat Brain In Vivo
Robin A. de Graaf1, Peter B. Brown1, Scott McIntyre1, Terence W. Nixon1, Kevin L. Behar1, Douglas L. Rothman1
1Yale University, New Haven, Connecticut, USA
1476. Monitoring De- And Re- Myelination MR Spectroscopy Surrogate Markers in the Mouse Brain at 9.4 T
Wafaa Zaaraoui1, 2, Mathilde Deloire3, Michel Merle2, Gerard Raffard2, Marc Biran2, Maria Inglese1, Klaus G. Petry3, Jean-Michel Franconi2, Oded Gonen1, Vincent Dousset3
1New York University, New York, New York, USA; 2RMSB UMR 5536, Bordeaux, France; 3EA2966 Universite Victor Segalen Bordeaux, Bordeaux, France
1477.
MR Studies of Aging in the Hippocampus of the FBNF1 Rat Show
Correlations with
Behavioral and Structural Degeneration
Ira Driscoll1, 2, Robert S. Sutherland2, Boguslaw Tomanek3, Jeff F. Dunn3, William M. Brooks4
1National Institute on Aging, Baltimore, Maryland, USA; 2University of Lethbridge, Lethbridge, Alberta, Canada; 3University of Calgary, Calgary, Alberta, Canada; 4University of Kansas Medical Center, Kansas City, Kansas, USA
1478. In Vivo Observation of Hypernatremia During Sodium Lactate Infusion
Su Xu1, Wenjun Zhu1, Jun Shen1
1National Institute of Mental Health, Bethesda, Maryland, USA
1479. Acute Administration of Nicotine Reduced Myo-Inositol and GABA Levels in Nucleus Accumbens in Rats
Serguei Liachenko1, Robert Durham1, Lori Badura2, Peter Snyder2
1Pfizer, Inc., Ann Arbor, Michigan, USA;
2Pfizer, Inc., Groton, Connecticut, USA
1480.
Effects of Chronic Morphine Treatment on Metabolism of Glutamate and
GABA in Rat Prefrontal Cortex
Studied by Ex Vivo High Resolution 1H NMR Spectroscopy
Hongchang Gao1, Yun Xiang1, 2, Hang Zhu1, Ninglei Sun3, Yuanye Ma3, Maili Liu1, Hao Lei1
1Wuhan Institute of Physics & Mathematics, Chinese Academy of Sciences, Wuhan, Hubei, People’s Republic of China; 2Jianghan University, Wuhan, Hubei, People’s Republic of China; 3Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, People’s Republic of China
1481.
Morphological and Metabolic Changes in the Brain of 6-Hydroxydopamine
Treated Rats Observed
by MRI and In Vivo 1H MRS
Fang Fang1, Yuanyi Ma2, Shuzhen Kong2, Min He2, Hao Lei1
1Wuhan Institute of Physics & Mathematics, Chinese Academy of Sciences, Wuhan, Hubei, People’s Republic of China; 2Kunming Medical College, Kunming, Yunnan, People’s Republic of China
1482.
Methylphenidate Administration During Adolescence Produces Long-Term
Effects in Adult Rat Brain:
A 1H MRS In Vivo Study
Rossella Canese1, Walter Adriani1, Franca Podo1, Giovanni Laviola1
1Istituto Superiore di Sanità, Rome, Italy
1483. Metabolic Responses in Kanic Acid Induced Lesion in Rat
Hui Mao1, Donna Toufexis2, Xiaoxia Wang1, Shaoxiong Wu2, Agnes Lacreuse2
1Emory University School of Medicine, Atlanta, Georgia, USA; 2Emory University, Atlanta, Georgia, USA
1484. Creatine Uptake Kinetics in Brain and Skeletal Muscle of GAMT Deficient Knockout Mice
Hermien Elise Kan1, Esther Meeuwissen1, Andor Veltien1, Dirk Isbrandt2, Arend Heerschap1
1Radboud University Nijmegen Medical Center, Nijmegen, Netherlands; 2University of Hamburg, Hamburg, Germany
1485. MRI and MRS Study of a Transgenic Mouse Model of D1 Dopamine Receptor Positive Striatal Cell Depletion
Ke Fang1, Ilsa Gantois1, Hong Xin Wang1, Qi Zhu Wu1, Qing Yang1, John Drago1, Gary Francis Egan1
1Howard Flory Institute, Melbourne, Vic, Australia
1486.
Metabolic Interactions Between Glutamatergic and Dopaminergic
Neurotransmiter Systems
Are Mediated Through D1, But Not D2, Dopamine Receptors
Tiago B. Rodrigues1, 2, Ana B. Martin3, Patricia Sanchéz1, Sebastián Cerdán1, Rosario Moratalla3
1Inst. Inv. Biomedicas "Alberto Sols", Madrid, Spain; 2University of Coimbra, Coimbra, Portugal; 3Inst. Cajal, Madrid, Spain
1487.
Aggregation-Induced Reduction in T2 Relaxation Time of MR
Visible Lipids Observed in Ischemic
Rat Brain
Li Wei1, Hao Lei1
1Wuhan Institute of Physics & Mathematics, Chinese Academy of Sciences, Wuhan, Hubei, People’s Republic of China
1488.
Identification of Neural Stem Cells in Rat Brain Using Their Specific
Magnetic Resonance
Spectroscopy Signature
Raphael D. Hazel1, Louis N. Manganas2, Xueying Zhang3, Mei Yu4, Petar M. Djuric3, Helene Benveniste3,
Mark E. Wagshul3, Mirjana Maletic-Savatic, 23
1Stony Brook University, Stony Brook, New Yory, USA; 2Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA; 3Stony Brook University, Stony Brook, New York, USA; 4Brookhaven National Laboratory, Brookhaven, New York, USA
1489. The Effect of Paramagnetic Manganese Cations on 1H MR Spectroscopy of the Brain
Kathrine Skak Madsen1, 2, David Alberg Holm1, 3, Lise Vejby Søgaard1, Gert Rene Christoffersen2, Ian John Rowland1
1Copenhagen University Hospital, Hvidovre, Denmark; 2University of Copenhagen, Copenhagen, Denmark; 3Technical University of Denmark, Copenhagen, Denmark
1490.
Measurement of T1 Relaxation Times of Major Metabolites in
the Mouse Brain at 11.7 and 17.6 Tesla
Using Voxel-Localized Proton Magnetic Resonance Spectroscopy
Thomas Neuberger1, 2, Andrew Webb1, 2, Cornelius Faber2, Volker Christian Behr2, Stefan Neubauer3,
Jürgen E. Schneider3
1Huck Institute Magnetic Resonance Centre, University Park, Pennsylvania, USA; 2University of Würzburg, Würzburg, Germany; 3University of Oxford, Oxford, UK
1491. Quantitative MR Spectroscopic Evaluation of Radiation-Induced Brain Injury in a Rat Model
Todd Atwood1, Mike Robbins1, Jian-Ming Zhu1
1Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
1492. Quantitative 1H MRS in the Rat Hippocampus After Global Ischemia
Daniel Jirak1, 2, Ivan Vorisek3, Eva Sykova4, Milan Hajek1, 2
1IKEM, Prague 4, Czech Republic; 2Charles University, 2nd Faculty of Medicine, Prague, Czech Republic; 3Institute of Experimental Medicine,, Prague, Czech Republic; 4Institute of Experimental Medicine, Prague, Czech Republic
1493. In Vivo Brain NMR Spectroscopy of Alpha-Mannosidosis in a Feline Model
Sergey Magnitsky1, Charles H. Vite2, Stephen Pickup1, David Aleman2, John H. Wolfe2, Harish Poptani3
1The University of Pennsylvania, Philadelphia, Pennsylvania, USA; 2University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, USA; 3The University of Pennsylvania,, Philadelphia, Pennsylvania, USA
1494. 1HMRS in a Monkey Model of AIDS and Opiates
Christine Carol Cloak1, Linda Chang1, Shawn O'Neil2, Thomas M. Ernst1, Dan Anderson3, Robert M. Donahoe4
1University of Hawaii, JABSOM, Honolulu, Hawaii, USA; 2Harvard Medical School, Southborough, Massachusetts, USA; 3Emory University, Atlanta, Georgia, USA; 4University of Utah, School of Medicine, Salt Lake City, Utah, USA
1495.
Genotype Specific Alterations Detected in the Neurochemical Profiles
of Aged Transgenic
Mouse Models of Alzheimer's Disease
Malgorzata Marjanska1, Geoffrey L. Curran2, Thomas M. Wengenack2, Pierre-Gilles Henry1, Robin L. Bliss1,
Joseph F. Poduslo2, Clifford R. Jack, Jr. 2, Kamil Ugurbil1, Michael Garwood1
1University of Minnesota, Minneapolis, Minnesota, USA; 2Mayo Clinic College of Medicine, Rochester, Minnesota, USA
1496.
The Pathophysiogical Basis of Brain Swelling of Grey vs. White Matter
in Acute Liver Failure
Are Different: Lessons from a Study Using MARS
Claudia Zwingmann1, 2, Chris Rose1, Surajit Sen3, Nathan Davies4, Roger Frank Butterworth1, Dieter Leibfritz2,
Lars Marius Ytrebo5, Arthur Revhaug5, Rajiv Jalan6
1Hospital Saint-Luc, Montreal, Quebec, Canada; 2University of Bremen, Bremen, Germany; 3State University of New York, Buffalo, New York, USA; 4University College London, London, UK; 5University Hospital of Northern Norway, Tromso, Norway; 6Royal Free & University College Medical School, London, UK
1497. Effect of Blood Flow on Brain Temperature Distribution
Mingming Zhu1, 2, Joseph J. H. Ackerman1, 2, Alexander L. Sukstanskii2, Dmitriy A. Yablonskiy, 12
1Washington University, St. Louis,
Missouri, USA; 2Washington University School of Medicine, St. Louis,
Missouri, USA
Room 4E Tuesday 13:30 - 15:30
1498.
The Association of Low-Dosage Sex Hormone Replacement Therapy and the
Aging Brain Using 3.0T
MR Scanner
Hu Ling1, Jin Zheng Yu1, Feng Feng1, Ge Qinsheng1, Li Mingli1
1Peking Union Medical College Hospital, Beijing, People’s Republic of China
1499.
Early Experience from the Application of a Noninvasive MRI-Based
Measurement of
Intracranial Pressure in Hydrocephalus
Noam Alperin1, Josh Niebruegge1, Terry Lichtor2, Roberta Glick2
1University of Illinois at Chicago, Chicago, Illinois, USA; 2Cook County Hospital, Chicago, Illinois, USA
1500.
Neuroprotective Effect of Long-Term Low Dose Hormone Replacement
Therapy on
Postmenopausal Women Brain Hippocampus
Hu Ling1, Yue Yun2, Zuo Pingping2, Jin Zheng Yu1, Feng Feng1, Ge Qinsheng1
1Peking Union Medical College Hospital, Beijing, People’s Republic of China; 2Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical Coll, Beijing, People’s Republic of China
1501. Will Piecewise Continuous Echo Spacing Adversely Affect the T2 Distribution?
Thorarin Albert Bjarnason1
1University of Calgary, Calgary, AB, Canada
1502. Magic Echo Imaging of the Brain at 1.5 T
Walter R.T. Witschey II1, Brian K. Bronzo1, Arijitt Borthakur1, Ravinder Reddy1
1University of Pennsylvania,
Philadelphia, Pennsylvania, USA
1503. PET Restoration by Maximization of MRI-PET Mutual Information
Yong Chu1, Min-Ying Su1, Mark Mandelkern1, Orhan Nalcioglu1
1University of California, Irvine, California, USA
1504. Variability of Automated Shape Analyses of Fixed Brain Mouse MRI
Jason Lerch1, Shoshana Tsatskis1, John Sled1, Natasa Kovacevic1, R. Mark Henkelman1
1Mouse Imaging Centre, Toronto, Ontario, Canada
1505. Pre-Processing Strategies to Improve Longitudinal MRI Repeatability
Kelvin Wong1, 2, Xiaoyin Xu2, Geoffrey Young2, Stephen Wong1, 2
1Harvard Medical School, Boston, Massachusetts, USA; 2Brigham and Women's Hospital, Boston, Massachusetts, USA
1506. Biocompatibility of Sapphire and Borosilicate Glass for Neural Prosthesis Using MRI and Histopathology
Kaushik Saranath Parthasarathy1, Yimin Shen1, Kelley Brabant1, Jie Li1, Yu Cheng1, Gregory William Auner1,
James Pat McAllister II1, Ewart Mark Haacke1
1Wayne State University, Detroit, Michigan, USA
1507. Using MRI Images for Determination of Near-Infrared Regions of Sensitivity in Rodent Brain
Hamid Dehghani1, Jeff Frank Dunn2
1University of Exeter, Exeter, UK; 2University of Calgary, Calgary, AB, Canada
1508.
SWI Filtered Phase Images Demonstrate That Tissue Iron in the
Midbrain Correlates
with Local Capillary Density
Ewart Mark Haacke, Ph.D. 1, 2, Elena Svilenova Manova1, Muhammed Ayaz2, Asadullah Khan2, Daniel K. Kido3,
Wolff Kirsch3
1Wayne State University, Detroit, Michigan, USA; 2The MRI Institute for Biomedical Research, Detroit, Michigan, USA; 3Loma Linda University, Loma Linda, California, USA
1509.
Voxel-Based Morphometry Analysis of Structural Gray Matter Volume
Variations Across
Idiopathic and Cryptogenic Epilepsy Syndromes
Heath Pardoe1, Gaby S. Pell1, Anne T. Berg2, David F. Abbott1, Graeme D. Jackson1
1Brain Research Institute, Melbourne, Victoria, Australia; 2Northern Illinois University, DeKalb, Illinois, USA
1510. Cerebrospinal Fluid Pulsatility Model and Its Validation
Jieun Kim1, Neil A. Thacker1, Paul A. Bromiley1, Stephen J. Payne2, Alan Jackson1
1University of Manchester, Manchester, UK; 2University of Oxford, Oxford, UK
1511. Perfusion Weighted MR in NPSLE
Bart Jeroen Emmer1, M J. van Osch1, D van As1, O Wu2, G M. Steup-Beekman1, S C. Steens1, T W. Huizinga1,
M A. van Buchem1, J van der Grond1
1Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands; 2Massachusetts General Hospital, Charlestown, Massachusetts, USA
1512. Contrast-Enhanced First Pass Perfusion MR Imaging in Patients with Subclinical Hepatic Encephalopathy
Li Tao1, Ma Lin1, Li Tao1
1PLA General Hospital, Beijing, People’s Republic of China China
1513. Central Pontine Myelinolysis After Liver Transplantation: MR Diffusion, Spectroscopy, and Perfusion Findings
Yong Guo1, Jinhua Hu2, Wei Lin1, Kuihong Zheng1
1General navy Hospital, Beijing,
People’s Republic of China; 2302 Hospital of PLA, Beijing, People’s
Republic of China
Room 4E Tuesday 13:30 - 15:30
1514. Characteristic MRI Findings of Metastatic Neuroblastomas and Chloromas in the Orbit in Children
Junfang Xian1, Zhenchang Wang1, Liyan He1
1Beijing Tongren Hospital, Beijing, People’s Republic of China
1515. Assessment of Orbital Masses Using Dynamic Contrast-Enhanced MR Imaging
Liyan He1, Jun Fang Xian1, Zhen Chang Wang1, Zhong Lin Liu1, Fei Yan1, Yan Tao Niu1, Bo Zhao1
1Beijing tongren Hospital, Beijing, People’s Republic of China
1516. Study of Ocular Drug Delivery Using Contrast-Enhanced Magnetic Resonance Imaging
Stephanie Kim1, 2, Craig J. Galban1, Michael R. Robinson1, Karl G. Csaky1, Martin J. Lizak1, Ginger Tansey1,
Nam Sun Wang2, Robert J. Lutz1
1NIH, Bethesda, Maryland, USA; 2University of Maryland, College Park, Maryland, US
1517. In Vivo Echo Planar Diffusion Tensor Imaging of the Optic Nerve in Rats
Marte Thuen1, Anders Kristoffersen2, Torgil Riise Vandberg2, Trond Erling Singstad2, Olav Haraldseth1,
Christian Brekken1
1Norwegian University for Science and Technology, Trondheim, Norway; 2St. Olavs Hospital HF, Trondheim, Norway
1518. First Report of Diffusion Tensor Imaging of the Murine Eye
Saurav Chandra1, Kyle Padgett1, John R. Forder2
1University of Florida, Gainesville, Florida, USA; 2McKnight Brain Institute, University of Florida, Gainesville, Florida, USA
1519. Does the Use of Passive Occlusion Combined with a Sialogogue Improve MR Sialography ?
Jo Ann Hugill1, Kieren Grant Hollingsworth2, Evis Sala2, David J. Lomas2
1Addenbrookes Hospital, Cambridge, Cambridgeshire, UK; 2University of Cambridge, Cambridge, Cambridgeshire, UK
1520. Differentiating Squamous Cell Carcinoma from Other Types of Tumors in the Head and Neck Region by 1H MRS
Tedros Bezabeh1, Olva Odlum1, 2, Richard Nason1, 3, Paul Kerr3, Donna Sutherland3, Rakesh Patel1, Ian C.P. Smith1
1National Research Council, Institute for Biodiagnostics, Winnipeg, Manitoba, Canada; 2University of Manitoba, Winnipeg, Manitoba, Canada; 3CancerCare Manitoba, Winnipeg, Manitoba, Canada
1521. Dynamic Magnetic Resonance Imaging of Swallowing Using a Synchronized Sampling Method
Yasutoshi Honda1, Yoshinobu Yanagi1, Noriko Kawai1, Kanji Kishi1, Dang Jianwu2
1Graduate school of Medicine, Dentistry
and Pharmaceutical Sciences, Okayama University, Okayama-shi, Okayama, Japan;
2Japan Advanced Institute of Science and Technology, Nomi, Ishikawa,
Japan
1522.
Apparent Diffusion Coefficient in Malignant Lymphoma and Carcinoma
Involving Cavernous Sinus
Evaluated by Line Scan Diffusion-Weighted Imaging
Masayuki Maeda1, Hajime Sakuma1, Kan Takeda1
1Mie University School of Medicine, Tsu, Mie, Japan
1523. Dynamic MRI of Vocal Cords Using Carotid Phased Array Coils
Marc Uwe Schlamann1, Stefan Maderwald1, Goetz Lehnerdt1, Isabel Wanke1, Roya Jeyrani1, Susanne Ladd1
1University of Essen Medical School, Essen, Germany
1524.
Characterization of a MRI Compatible Head / Neck Immobilization and
Repositioning Device for
Longitudinal Studies of the Carotid Artery
Emilee S. Minalga1, J. Rock Hadley1, Dennis L. Parker1
1University of Utah, Salt Lake City, Utah, USA
1525. Technique for Acquiring MR Images of CSF Flow During a Valsalva Maneuver
Andrew L. Wentland1, Oliver Wieben1, Charles A. Mistretta1, Frank R. Korosec1, Victor M. Haughton1
1University of Wisconsin, Madison, Wisconsin, USA
1526. Evaluation of Aneurysm Hemodynamics Using Phase Contrast Vastly Undersampled Isotropic Projection Imaging
Kevin Michael Johnson1, Roham Moftakhar1, Beverly Aagaard1, Chuck Mistretta1
1University of Wisconsin-Madison, Madison, Wisconsin, USA
1527. Anatomic Imaging of the Soft Palate During Phonation as an Aid in Cleft Palate Presurgical Planning
James S. Hyde1, David A. Soltysik1, Andrzej Jesmanowicz1, Arun K. Gosain2
1Medical College of Wisconsin, Milwaukee, Wisconsin, USA; 2Children's Hospital of Wisconsin, Milwaukee, Wisconsin, USA
1528. Dynamic MRI of the Orbit
Marco Piccirelli1, 2, Roger Luechinger1, Oliver Bergamin2, Michaela Soellinger1, Andrea Rutz1, Christof Baltes1,
Peter Boesiger1
1Swiss Federal Institute of Technology &
University of Zürich, Zürich, ZH, Switzerland; 2University Hospital
of Zürich, Zürich, ZH, Switzerland
Cerebral Blood Flow and Dynamic Contrast Perfusion
Room 4E Tuesday 13:30 - 15:30
1529. Relaxivity of Blood Pool Contrast Agent Depends on the Host Tissue as Suggested by Semianalytical Simulations
Birgitte Fuglsang Jensen1, Leif Østergaard1, Valerij G. Kiselev2
1Aarhus University Hospital, Aarhus, Denmark, Denmark; 2University Hospital Freiburg, Freiburg, Germany, Germany
1530. Intercompartmental Water Exchange Effects in DCE MRI
Xin Li1, William Rooney1, Charles Springer1
1Oregon Health & Science University, Portland, Oregon, USA
1531.
Investigations on the Non-Mono Exponential Signal Decay in Presence
of a Single Vessel; Simulations,
Phantom and In Vivo Measurements
Jan Sedlacik1, Alexander Rauscher1, Jürgen Rainer Reichenbach1
1Friedrich Schiller Universität, Jena, Thüringen, Germany
1532. A Re-Examination of the Impact of Dispersion on Quantitative Cerebral Blood Flow Measurements
Linda Ko1, Marina Salluzzi1, Richard Frayne1, Michael Smith1
1University of Calgary, Calgary, Alberta, Canada
1533. The Effects of Background Micro-Circulation in the AIF Measured from DSC MRI of the Brain
Zhiyue J. Wang1, 2, Robert J. Thornton1, 2, Jeremy Y. Jones1, 2
1Baylor College of Medicine, Houston, Texas, USA; 2Texas Children's Hospital, Houston, Texas, USA
1534. Automated Selection of Arterial Input Function (AIF) Pixels in DCE-MRI
Andreas Pohlmann1, Katja Oberholzer1, Wolfgang G. Schreiber1
1Johannes Gutenberg University Medical School, Mainz, Germany
1535. Automated Computation of the Vascular Input Function for Dynamic Contrast-Enhanced MRI of the Brain
Sandeep Narendra Gupta1, John A. Butman2
1GE Healthcare, Hanover, Maryland, USA; 2Clinical Center, NIH, Bethesda, Maryland, USA
1536. Visualization of Distinct Collateral Flow Territories in Patients with Symptomatic Carotid Artery Occlusion
Peter Jan van Laar1, Jeroen Hendrikse1, Willem Mali1, Karin Klijn1, Jaap Kappelle1, Matthias van Osch2,
Jeroen van der Grond2
1University Medical Center, Utrecht, Netherlands; 2Leiden University Medical Center, Leiden, Netherlands
1537.
Improved Contrast in Dynamic Contrast Enhanced MRI by Combining
Complex In-Phase and
Opposed-Phase Data: Simulations and Phantom Experiment
Karl-Heinz Herrmann1, Alexander Rauscher1, Werner A. Kaiser1, Jürgen R. Reichenbach1
1IDIR, Friedrich-Schiller University, Jena, Germany
1538.
Voxel-Wise Exact T1 Estimation for Accurate Quantitation of Perfusion
Indices Using Fast
3D-SPGR in Intracranial Mass Lesion
RKS Rathore1, Anup Singh1, RK Gupta2, P Mohan2, Md Haris2, Getaneh Bayu1, Divya KS Rathore1, Ankur Purwar1, Manoj K. Sarma1
1Indian Institute of Technology, Kanpur, UP, India; 2Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, UP, India
1539. Extraction of the Contribution of the First Bolus Passage to the Signal in Dynamic Perfusion Measurements
Peter Gall1, Oliver Speck1, Ralph Strecker1, Valerij G. Kiselev1
1University Hospital Freiburg, Freiburg, Germany
1540.
Accurate Dynamic Susceptibility Contrast MR Perfusion Quantification
Using Spatiotemporal
Noise Filtering Algorithms
Jayme C. Kosior1, 2, Richard Frayne, 12
1University of Calgary, Calgary, Alberta, Canada; 2Foothills Medical Centre, Calgary Health Region, Calgary, Alberta, Canada
1541.
Adaptive SVD Thresholding is Shown to Be More Appropriate for Partial
Brain Scans (TR = 1 S)
Rather Than Full Brain Scans (TR = 2 S)
Michael Smith1, Marina Salluzzi1, Richard Frayne1
1University of Calgary, Calgary, Alberta, Canada
1542. Thresholding Artefacts in SSVD and OSVD Deconvolution
Louise Gyldensted1, Kim Mouridsen1, Leif Østergaard1
1Aarhus University Hospital, Aarhus, Denmark
1543. Estimation of Red Blood Cell Flow Using Microbubbles as a Contrast Agent for DSC-MRI
Christopher Chad Quarles1, Ronald R. Price1, John Christopher Gore1
1Vanderbilt University, Nashville, Tennessee, USA
1544. Quantitative Cerebral Blood Flow Measurement at 3.0T : The Comparison of GE-EPI and SE-EPI
Wanyong Shin1, Ty Allen Cashen1, Jeffrey Miller2, Matthew T. Walker2, Medhi Rohany2, Timothy J. Carroll1, 2
1Northwestern University, Chicago, Illinois, USA; 2Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
1545. High Resolution Dynamic-Susceptibility Contrast Perfusion Imaging Using Multi-Echo Parallel EPI
Thies Halvor Jochimsen1, Rexford Newbould1, Stefan Skare1, David B. Clayton1, Michael E. Moseley1,
Roland Bammer1
1Stanford University, Palo Alto, California, USA
1546. T2* Perfusion Imaging at 7.0 Tesla Using 3D PRESTO: Initial Results
Christoph A. Manka1, Christiane K. Kuhl1, Lukas Scheef1, Carsten Meyer1, Michael R. Thompson2, John Duraj2,
Frank Gerardus Hoogenraad3, Jürgen Gieseke4, Hans H. Schild1
1University of Bonn, Bonn, Germany; 2Philips Medical Systems, Cleveland, Ohio, USA; 3Philips Medical Systems, Best, Netherlands; 4Philips Medical Systems, Bonn, NRW, Germany
1547. The Age Dependence of QCBF Measure with the Bookend Technique
Timothy J. Carroll1, Wanyong Shin2, Hyun Jeong1, Matthew Walker1, Ali Shaibani1, Medhi Rohany1, James Carr1,
Ty Cashen1
1Northwestern University, Chicago, Illinois, USA; 2Northwestern, Chicago, Illinois, USA
1548. Variability in QCBF Obtained from Deconvolution-Based Perfusion-Weighted MR Techniques
Daniel James Niven1, Jayme C. Kosior1, 2, Peter J. Dickhoff3, Imanuel Dzialowski4, 5, Suresh Subramaniam4, 5
Andrew M. Demchuk4, 5, Richard Frayne1, 6
1Seaman Family MR Centre, Foothills Medical Centre, Calgary Health Region, Calgary, Alberta, Canada; 2Electrical and Computer Engineering, University of Calgary, Calgary, Alberta, Canada; 3Diagnostic Imaging, Rockyview General Hospital, Calgary Health Region, Calgary, Alberta, Canada; 4Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada; 5Calgary Stroke Program, Foothills Medical Centre, Calgary Health Region, Calgary, Alberta, Canada; 6Radiology, University of Calgary, Calgary, Alberta, Canada
1549. Assessment of the Computational Efficiency of Perfusion Deconvolution Algorithms for Application to Acute Stroke
Sylvia Drabycz1, J Ross Mitchell1
1University of Calgary, Calgary, Alberta, Canada
1550. Digital Anthropomorphic Perfusion Phantom for the Evaluation of DSC-MR Perfusion Algorithms
Jayme C. Kosior1, 2, Richard Frayne, 12
1University of Calgary, Calgary, Alberta, Canada; 2Foothills Medical Centre, Calgary Health Region, Calgary, Alberta, Canada
1551. Improving the Sensitivity of Total Cerebral Blood Flow Measurement by Cine Phase Contrast MRI
Noam Alperin1, Sang H. Lee1
1University of Illinois at Chicago, Chicago, Illinois, USA
1552.
Demonstration of Direct and Complete Collateral Compensation During
Carotid Artery Compression
by MR Flow Monitoring
Jan-Henry Seppenwoolde1, Jeroen Hendrikse1, Henk Johan Nanang Streefkerk2, Berend Hillen2, Chris J.G. Bakker1
1University Medical Center Utrecht, Utrecht, Netherlands; 2University Medical Center St Radboud, Nijmegen, Netherlands
Room 4E Tuesday 13:30 - 15:30
1553.
Association Between MR Changes Early in Therapy and Later
Neurocognitive Performance
in Children Treated for Acute Lymphoblastic Leukemia
Wilburn E. Reddick1, Courtney L. Dirksen1, John O. Glass1, Cheng Cheng1, Ching-Hon Pui1
1St. Jude Children's Research Hospital, Memphis, Tennessee, USA
1554.
Relationship of Temporal Lobe Volume to Neuropsychological Test
Performance in Healthy Children
and Adolescents
Carolyn Theresa Wells1, Ernest Mark Mahone1, Melissa Matson1, Wendy R. Kates1, 2, Trisha Hay2, Alena Horska3
1Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; 2SUNY Upstate Medical University, Syracuse, New York, USA; 3Johns Hopkins University, Baltimore, Maryland, USA
1555.
Non-Invasive Imaging of Endogenous Magnetic Particle Deposits in
Biological Tissue Using
Magnetic Resonance Imaging
Heath Pardoe1, Gaby S. Pell1, Graeme D. Jackson1
1Brain Research Institute, Melbourne, Victoria, Australia
1556. Cerebral Gray and White Matter T2 in Autism Spectrum Disorder
Helen Petropoulos1, Seth D. Friedman1, Dennis W. Shaw1, Alan A. Artru1, Geraldine Dawson1, Stephen R. Dager1
1University of Washington, Seattle, Washington, USA
1557. Diffusion Tensor Imaging Findings in Rett Syndrome Patients
Izlem Izbudak1, Luciano Farage1, David Bonekamp1, Weihong Zhang1, Genila Bibat2, Sussumu Mori1,
SakkuBai Naidu2, Alena Horska1
1Jonhs Hopkins Medical Institutions, Baltimore, Maryland, USA; 2Kennedy Krieger Institute, Baltimore, Maryland, USA
1558. Faster Quantitative Brain Imaging in Pediatric Patients by Using IR-TrueFISP
Claudia Maria Hillenbrand1, Ralf Berthold Loeffler1, John O. Glass1, Wilburn Eugene Reddick1
1St. Jude Children's Research Hospital, Memphis, Tennessee, USA
1559. In Vivo Detection of Age-Related Brain Iron Differences with MFC
Anita Ramani1, Jens H. Jensen1, Amy L. Krain1, Jing Yang1, Caixia Hu1, Hanzhang Lu1, Joseph A. Helpern1
1New York University School of Medicine, New York, New York, USA
1560. Comparison of BOLD Signal Changes in the Fetal Brain at 3T with Local PO2 Measurements
Ulrike Wedegärtner1, Andrew N. Priest1, Hendrik Kooijman2, Mikhail Tchirikov1, Hobe J. Schröder1, Gerhard Adam1
1University Hospital Hamburg-Eppendorf, Hamburg, Germany; 2Philips Medical Systems, Hamburg, Germany
1561. Quantitative MR Imaging and Spectroscopy in Childhood White Matter Disorders
Patrick van der Voorn1, Petra J.W. Pouwels1, Augustinus A.M. Hart2, Frederik Barkhof1, Marjo S. van der Knaap1
1VU University Medical Center, Amsterdam, Netherlands; 2Academic Medical Center, Amsterdam, Netherlands
1562. Fast 3D Pediatric Brain MRSI
Dong-Hyun Kim1, Meng Gu2, Charles Cunningham2, Albert Chen1, Fiona Baumer1, Orit Glenn1, Daniel Vigneron1, Daniel Spielman2, Anthony James Barkovich1
1University of California, San
Francisco, California, USA; 2Stanford University, Stanford,
California, USA
Room 4E Tuesday 13:30 - 15:30
1563. Evaluating the Impact of Cancer Therapy on the Developing Brain
Wilburn E. Reddick1, John O. Glass1, Jinesh J. Jain1, Nicholas S. Phillips1, Qing Ji1, Robert J. Ogg1,
Thomas E. Merchant1, Amar Gajjar1
1St. Jude Children's Research Hospital, Memphis, Tennessee, USA
1564. Longitudinal Evaluation of HSV Brain Tumor Therapy Using Diffusion Tensor MR Imaging
Wei Bian1, Narasimha Shastry Akella1, Steven T. Moore1, William T. Evanochko1, Matthias Karrasch2, Axel Mescheder2, James M. Markert1, Louis B. Nabors1
1University of Alabama at Birmingham, Birmingham, Alabama, USA; 2Medigene AG, Munich, Germany
1565. Computer-Aided Detection of Brain Tumor Invasion Using Morphological and Diffusion-Weighted MR
Todd Robert Jensen1, 2, Xin Feng1, John L. Ulmer2, Kathleen M. Schmainda2
1Marquette University, Milwaukee, Wisconsin, USA; 2Medical College of Wisconsin, Milwaukee, Wisconsin, USA
1566. The Added Value of MRS in Brain Tumor Diagnosis
Margarida Julià-Sapé1, Indira E. Coronel1, Marta Serrallonga2, Carles Majós2, Ana Paula Candiota1, Mònica Cos2, Oscar Godino3, Juan-José Acebes3, Carles Aguilera2, Carles Arús1
1Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain; 2IDI-Bellvitge, Institut de Diagnòstic per la Imatge, L'Hospitalet del Llobregat, Barcelona, Spain; 3Hospital Universitari de Bellvitge, L'Hospitalet del Llobregat, Barcelona, Spain
1567.
Supervised Pattern Recognition for Predicting the Appearance of
Contrast-Enhancement in
High-Grade Gliomas Using Multimodality MRI and MRSI
Michael C. Lee1, Susan M. Chang1, Sarah J. Nelson1
1University of California, San Francisco, California, USA
1568.
Lessons from Functional Brain Mapping in Pre- And Intra- Operation
for Low-Grade Glioma:
Insights Into Associations Between Tumour and Brain
Plasticity
Zi Xiao Li1, Jian Ping Dai1, Tao Jiang2, Shao Wu Li1, Zhong Zhang2, Cai Jie Duan3, Yi Lin Sun4, Pei Yi Gao1, Jun Ma1
1The Capital University of Medical Science Affiliated Beijing Tian Tan Hospital, Beijing, People’s Republic of China; 2The Capital University of Medical Science Affiliated Beijing Tian Tan Hospital, Beijing, Chile; 3Beijing University, Beijing, People’s Republic of China; 4Beijing Neurosurgery Institute, Beijing, People’s Republic of China
1569. Comparison of MRI Contrast Enhancement by Motexafin Gadolinium and Omniscan in Glioblastoma Multiforme
Genevieve Ning Wu1, Judith M. Ford1, Robert B. Lufkin1, Jeffry R. Alger1
1Univ. of California at Los Angeles, Los Angeles, California, USA
1570.
Imaging Blood Vessel Volume in High Grade Gliomas at 3T Using
Susceptibility-Weighted
Imaging and Dynamic Susceptibility Contrast Perfusion MRI
Janine M. Lupo1, Michael C. Lee1, Soonmee Cha1, Susan M. Chang1, Sarah J. Nelson1
1University of California, San Francisco, California, USA
1571. Multi-Parametric Composite Maps in Recurrent Brain Tumor Patients
Kathryn M. McMillan1, Baxter P. Rogers1, Cheng Guan Koay2, M Elizabeth Meyerand3
1Vanderbilt University, Nashville, Tennessee, USA; 2NIH, Bethesda, Maryland, USA; 3University of Wisconsin, Madison, Wisconsin, USA
1572.
Quantitative Characterization of Functional and Morphological
Properties of
Tumor Vasculature in High-Grade Gliomas
Vijaya Nagesh1, Thomas L. Chenevert1, Larry Junck1, Christina I. Tsien1, Brian D. Ross1, Theodore S. Lawrence1,
Yue Cao1
1University of Michigan, Ann Arbor, Michigan, USA
1573.
Accuracy Evaluation of a First-Pass Pharmacokinetic Model (FPPM) for
Simultaneous Mapping
of Blood Volume and Microvascular Permeability in Brain Tumors
Hua-Shan Liu1, 2, Hsiao-Wen Chung1, 2, Ming-Chung Chou1, 2, Chun-Jung Juan1, 2, Cheng-Yu Chen2
1National Taiwan University, Taipei, Taiwan, Taiwan; 2Tri-Service General Hospital, Taipei, Taiwan, Taiwan
1574. Permeability Fitting of DSC Perfusion Data Through Constrained Optimization
Talin Tasciyan1
1Medical Numerics Inc, Sterling, Virginia, USA
1575. Comparison of T1 to T2* Derived Parametric Maps in Brain Tumor Patients
Matthew L. Zierhut1, 2, Soonmee Cha2, Michael C. Lee2, Mary Katherine Mayo2, Sarah J. Nelson1, 2
1UCSF/UCB Joint Graduate Group in Bioengineering, San Francisco, California, USA; 2UCSF, San Francisco, California, USA
1576. rCBV Estimates in Tumor vs. Normal Brain Depend on Acquisition and Analysis Methods
Eric Scott Paulson1, Douglas Edward Prah1, Kathleen M. Schmainda1
1Medical College of Wisconsin,
Milwaukee, Wisconsin, USA
Metabolic and White Matter MRS
Room 4E Tuesday 13:30 - 15:30
1577. Reproducibility of 1H-MR Spectroscopic Imaging in the Centrum Semi-Ovale in Patients with Multiple Sclerosis
Jop Mostert1, Jeroen van der Grond2, Jacques De Keyser1, Hans Hoogduin1
1University Medical Center Groningen, University of Groningen, Groningen, Netherlands; 2University Medical Center Leiden, Leiden, Netherlands
1578. Whole Brain N-Acetylaspartate Concentration as a Surrogate Marker for Benign Multiple Sclerosis
Daniel Rigotti1, Tyson Oberndorfer1, James Babb1, Clyde Markowitz2, Joseph Herbert1, Oded Gonen1
1NYU School of Medicine, New York, New York, USA; 2UPenn Medical Center, Philadelphia, Pennsylvania, USA
1579.
Brain Metabolism in Primary Progressive Multiple Sclerosis:A
Three-Dimensional Proton
MR Spectroscopy Study at 3T
Meredith Spindler1, Sarah Brown1, Joseph Herbert1, Hina Jaggi1, Matilde Inglese1, Oded Gonen1
1New York University, New York, New York, USA
1580. Temporal Lobe Biochemistry and Non-Verbal Neurocognitive Function in Myotonic Dystrophy
Type I
Deidre J. Devier1, Charles Gasparovic, 12, Rex E. Jung1, 2, Richard Campbell1, Alejandro Tobon1, Leslie Morrison1
1University of New Mexico, Albuquerque, New Mexico, USA; 2MIND Institute, Albuquerque, New Mexico, USA
1581. Metabolic Changes in Juvenile Myoclonic and Frontal Lobe Epilepsy by 1H MR Spectroscopy
Hyun-Man Baik1, Barbara Swartz2, Long Vu1, Hui Liu1, O. Nalcioglu1, Min-Ying Su1
1University of California-Irvine, Irvine, California, USA; 2Haog Hospital, Newport Beach, California, USA
1582. Quantitative MR Spectroscopy for Monitoring Treatment of Cerebrotendinous Xanthomatosis
Eva H. Baker1, Jennifer L. McKeon1, Robert D. Shamburek1
1NIH, Bethesda, Maryland, USA
1583. Blind Recovery of 1H MRSI Spectral Signatures of Batten Disease and Melas
Shuyan Du1, Xiangling Mao2, Paul Sajda1, Dikoma C. Shungu2
1Columbia University, New York, New York, USA; 2Weill Medical College of Cornell University, New York, New York, USA
1584.
Serial Proton MRS of Neurometabolic Alterations in Hereditary Spastic
Paraplegia with Thin Corpus
Callosum (HSP-TCC)
Steffi F. Dreha-Kulaczeski1, Knut Brockmann1, Gunther Helms1, Jens Frahm2, Jutta Gärtner1, Peter Dechent1
1Georg-August-University, Goettingen, Lower Saxony, Germany; 2Biomedizinische Forschungs GmbH am MPI für biophysikalische Chemie, Goettingen, Lower Saxony, Germany
1585. Assessment of the Metabolic Changes in Type 2 Diabetes Mellitus Using Magnetic Resonance Spectroscopy
Shilpi Modi1, Manisha Bhattacharya1, S S. Kumaran1, T Sekhri1, S Khushu1
1INMAS, Delhi, India
1586. Use of Opioids in Asphyxiated Term Neonates: Effect on Brain Metabolites and Outcomes
Barbara Holshouser1, Danilyn M. Angeles2, Nathaniel D. Wycliffe1, Douglas Deming1, Carrie Carr2,
Lawrence C. Sowers2, Stephen Ashwal1
1Loma Linda University Medical Center, Loma Linda, California, USA; 2Loma Linda University, Loma Linda, California, USA
1587. Anti-TNF-Alpha Does Not Cause Acute Demyelination
Bart Jeroen Emmer1, A E. van der Bijl1, F C. Breedveld1, T W. Huizinga1, M A. van Buchem1, J van der Grond1
1Leiden University Medical Center,
Leiden, Zuid-Holland, Netherlands
Brain Registration and Normalization Techniques
Room 4E Tuesday 13:30 - 15:30
1588. Robust Anatomy Recognition for Automated MR Neuro Scan Planning
Stewart Young1, Daniel Bystrov1, Thomas Netsch1, Rene Bergmans2, Arianne van Muiswinkel2, Fredy Visser2,
Rudolf Springorum2, Frank Hoogenraad2, Jürgen Gieseke3
1Philips Research, Hamburg, Germany; 2Philips Medical Systems, Best, Netherlands; 3University of Bonn, Bonn, Germany
1589. Iterative Tensor-Based Registration
Ravichandran Rajaram1, Carlo Ciulla1, E Mark Haacke1
1The MRI Institute for Biomedical Research, Detroit, Michigan, USA
1590. Comparison of Two Spatial Normalization Methods in the Elderly Brain
Weiying Dai1, Owen T. Carmichael, 12, Oscar L. Lopez1, H. Michael Gach, 13
1University of Pittsburgh, Pittsburgh, Pennsylvania, USA; 2Carnegie Mellon University, Pittsburgh, Pennsylvania, USA; 3Nevada Cancer Institute, Las Vegas, Nevada, USA
1591. Evaluation of a Symmetric Diffeomorphic Registration Algorithm for Analyzing Neurodegenerative Disease
Brian Avants1, James Gee1, Murray Grossman1
1University of Pennsylvania, Philadelphia, Pennsylvania, USA
1592. Non-Rigid Registration of Functional to Anatomical Brain MR Images Using Constrained Optimization
Ali Gholipour1, Nasser Kehtarnavaz1, Kaundinya Gopinath2, Richard Briggs2, Michael Devous2, Robert Haley2
1University of Texas at Dallas, Richardson, Texas, USA; 2University of Texas Southwestern Medical Center, Dallas, Texas, USA
1593. Automated Versus Manual Scan Positioning: A Quantitative Analysi
Rudolf Springorum1, Frank Hoogenraad1, Rene Bergmans1, Stewart Young2, Daniel Bystrov2, Clemens Bos1
1Philips Medical Systems, Best, Netherlands; 2Philips Research, Hamburg, Germany
1594. Measurement of Subpixel Motion of the Lateral Ventricular Walls
Mark E. Wagshul1, Michael R. Egnor1, James Manzione1, Erin J. McCormack1, Abram Voorhees2, Timothy Wei3
1Stony Brook University, Stony Brook, New York, USA; 2New York University, New York, New York, USA; 3Rutgers University, New Brunswick, New Jersey, USA
1595. Realignment Strategies in ASL Timeseries
Karam Sidaros1, Anders Jespersen2, Torben E. Lund1
1Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; 2Copenhagen University Hospital Frederiksberg, Copenhagen, Denmark
1596. Measurement of Pulsatile Brain Motion in a Patient with a Meningioma
Michaela Soellinger1, Andrea Kaspar Rutz1, Sebastian Kozerke1, Miroslava Bjeljac2, Peter Boesiger1
1University and ETH Zurich, Zurich,
Switzerland; 2University Hospital Zurich, Zurich, Switzerland
Room 4E Tuesday 13:30 - 15:30
1597. Improved Segmentation of Intracranial Volumes Using a Combination of T1- And T2-Weighted 3D MRI
Gunther Helms1, Kai Kallenberg1, 2, Peter Dechent1
1Göttingen University, Faculty of Medicine, Göttingen, Germany; 2Göttingen University, Göttingen, Germany
1598. Reproducibility of Automated Brain Morphometric Estimates Derived from Multi-Site Structural MRI Studies
Jorge Jovicich1, Silvester Czanner1, Xiao Han1, Douglas Greve1, Jenni Pacheco1, Evelina Busa1,
Andre van der Kouwe1, Bruce Fischl1, 2, Anders Dale3
11MGH/MIT/HMS Athinoula Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA; 2Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; 3University of California San Diego, San Diego, California, USA
1599. Segmentation of Gray- And White Matter on MR Brain Images in Multiple Sclerosis
Sushmita Datta1, Balasrinivasa Rao Sajja1, Renjie He1, Jerry S. Wolinsky1, Ponnada A. Narayana1
1Medical School, The University of Texas at Houston, Houston, Texas, USA
1600.
Histogram-Based Acceleration on EM Algorithm for Segmentation of
Multi-Spectral MRI with
Contextual Constrains
Renjie He1, Sushmita Datta1, Balasrinivasa Rao Sajja1, Ponnada A. Narayana1
1University of Texas Medical School at Houston, houston, texas, USA
1601. Virtual Definition of Tissue by Cluster Analysis of Multi-Parametric MR Imaging (Virtual-Dot-Com Imaging)
Yossi Yovel1, Yaniv Assaf1, 2
1Tel Aviv University, Tel Aviv, Israel; 2Tel Aviv Sourasky Medical Cener, Tel Aviv, Israel
1602. Optimum Template Selection for Atlas-Based Segmentation
Minjie Wu1, Jessica LoSurdo1, Pilar Lopez-Garcia2, Cameron Stuart Carter2, Howard Jay Aizenstein1
1University of Pittsburgh, Pittsburgh, Pennsylvania, USA; 2University of California at Davis, Sacramento, California, USA
1603. Significant Local Shape Differences of the Brain Ventricles in Alzheimer’s Patients Compared to Healthy Elderly
Luca Ferrarini1, Walter Miguel Palm1, Hans Olofsen1, Mark A. van Buchem1, Johan H C Reiber1,
Faiza Amiraal-Behloul1
1Leiden University Medical Center, Leiden, Netherlands
1604. Segmentation of Age-Related White-Matter Changes in a Large-Scale, Multi-Centre Study
Tim Dyrby1, Egill Rostrup1, Elisabeth Catherine Wilhelmina van Straaten2, Frederik Barkhof2, Stefan Ropele3,
Lars Kai Hansen4, Gunhild Waldemar5
1Copenhagen University Hospital, Hvidovre, Copenhagen, Denmark; 2VU Medical Center, Amsterdam, Netherlands; 3Karl Franzens University, Graz, Austria; 4Danish Technical University, Copenhagen, Denmark; 5Copenhagen Univ. Hospital, Rigshospitalet, Copenhagen, Denmark
1605.
Automatic Cortex Extraction and Gray/White Matter Segmentation from
T1-Weighted MRI
with Geodesic Active Contours
Albert Huang1, Rafeef Abugharbieh1, Roger Tam1, Anthony Traboulsee1
1The University of British Columbia, Vancouver, BC, Canada
1606.
The Size of Corpus Callosum Normalized by the Intracranial or Brain
Parenchymal Volume Exhibits
a Significant Difference Between Male and Female
Brains
Nobuhiro Takaya1, Hidehiro Watanabe1, Fumiyuki Mitsumori1
1National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
1607. De-Scalping of the Brain in Echo Planar DT-MRI
Ankur Purwar1, RK Gupta2, Manoj Kumar Sarma1, Getaneh Bayu1, Anup Singh1, Divya KS Rathore1, Sona Saksena2, Richa Trivedi2, Ashtmangal Mishra2, Mohammad Haris2, P Mohan2, RKS Rathore1
1Indian Institute of Technology, Kanpur, UP, India; 2Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, UP, India
1608. A Simple Method for the Automatic Measurement of Cortical Thickness
Don C. Bigler1, Qing X. Yang1, Michael B. Smith1
1Penn State College of Medicine, Hershey, Pennsylvania, USA
1609. Semi-Automated Segmentation of Brain Tumor Lesions in MR Images
Suja Saraswathy1, Forrest Crawford1, Sarah J. Nelson1
1University of California, San Francisco, California, USA
1610. Brain Tumor Image Segmentation Using Neural Networks
Miguel Martín-Landrove1, Raúl Villalta1
1Centro
de Resonancia Magnética, Facultad de Ciencias, Universidad Central de Venezuela,
Caracas, District of Columbia, Venezuela
Diffusion Modeling and its Application to Microstructure
Room 4E Tuesday 13:30 - 15:30
1611.
A Model of Diffusion Weighted MRI in Grey Matter - A Multiparametric
Approach Using Global Solutions
Peter Vestergaard-Poulsen1, 2, Brian Hansen1
1Aarhus University, Aarhus, Denmark; 2Aarhus University Hospital, Aarhus, Denmark
1612.
A Finite Difference Model of Diffusion Applied to Ischemia
Kevin D. Harkins1, Jean-Philippe Galons1, Timothy W. Secomb1, Joe L. Divijak1, Theodore P. Trouard1
1University of Arizona, Tucson, Arizona, USA
1613. Diffusion Weighted Signal at Short Times in the Presence of Impermeable Interfaces
Astrid From Frøhlich1, 2, Leif Østergaard1, Valerij G. Kiselev2
1Aarhus University Hospital, Aarhus, Denmark; 2University Hospital Freiburg, Freiburg, Germany
1614. Analysis of Water Diffusion and Magnetization Transfer Ratio in Optic Nerves After Crush Injury
Masaya Takahashi1, Timothy K. Vartanian1, David B. Hackney1
1Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
1615.
Decreased Diffusion Coefficients in Suspected Prostate Cancer Regions
in Peripheral Zone:
A Comparison with Increased (Cho + Cr)/Cit Ratios from
Magnetic Resonance Spectroscopy
Agnieszka Szot Barnes1, Steven J. Haker1, Stephan E. Maier1, Clare m. Tempany1, Robert V. Mulkern1
1Brigham and Women's Hospital, Boston, Massachusetts, USA
1616. Q-Space Analysis of Intracellular Water Diffusion in Cultured Cells
Jean-Philippe Galons1, Joseph L. Divijak1, Silvia Lope-Piedrafita1, Kevin Harkins1, Robert J. Gillies1,
Theodore Trouard1
1University of Arizona, Tucson, Arizona, USA
1617.
Separating Intra- And Extracellular Water Signals in Rat Brain Using
Gd-DPTA-Enhanced
Diffusion-Weighted MRI
Timothy Michael Shepherd1, Peter Edward Thelwall1, Christopher M. Sotak2, Stephen John Blackband1
1University of Florida, Gainesville, Florida, USA; 2Worcester Polytechnic Institute, Worcester, Massachusetts, USA
1618. Multi-Component Apparent Diffusion Coefficients in the Rabbit VX2 Tumor Model
Jie Deng1, Thomas K. Rhee1, Gayle E. Woloschak1, Tatjana Paunesku1, Reed A. Omary1, Andrew C. Larson1
1Northwestern University, Chicago, Illinois, USA
1619. The Intracellular Water Diffusion Coefficient of Cultured Microbead-Adherent HeLa Cells is ≥ 1 µm2/ms
Lin Zhao1, Christopher D. Kroenke1, Joseph J. H. Ackerman1, Jeffrey J. Neil1
1Washington University in St. Louis, St. Louis, Missouri, USA
1620. Subcompartmental Cesium Diffusion in Healthy and Globally Ischemic Rat Brain
James A. Goodman1, Joseph J.H. Ackerman1, Jeffrey J. Neil1
1Washington University in St. Louis, St. Louis, Missouri, USA
1621. Diffusion Exchange Weighted (DEW) Imaging
Saadallah Ramadan1, Carolyn Mountford1
1Institute for Magnetic Resonance Research, Sydney, NSW, Australia
1622. Accuracy of Q-Space Derived Parameters in MRI - A Phantom Study of System-Induced Limitations
Jimmy Lätt1, Daniel Topgaard1, Ronnie Wirestam1, Carin Malmborg1, Olle Söderman1, Freddy Ståhlberg1, Sara Brockstedt1
1Lund University, Lund, Sweden
1623. Diffusion Weighted µMRI of Isolated Human Pancreatic Islets
Muhammad E. Haque1, Suraj D. Serai2, Lara Leoni1, Robert V. Honeychuck3, Jose Oberholzer4, Brian B. Roman1
1University of Chicago, Chicago, Illinois, USA; 2University of Illinois at Chicago, Chicago, Illinois, USA; 3George Mason University, Fairfax, Virginia, USA; 4University of Illinois, Chicago, Illinois, USA
1624. Localization Regime of Restricted Diffusion in a Model Pulmonary Acinus
Denis S. Grebenkov1, Geneviève Guillot1
1C.N.R.S. UMR8081 Université Paris-Sud, Orsay, France
1625. Dependence of Apparent Diffusion Coefficient on Cellular Structure
Dmitry S. Novikov1, Valerij G. Kiselev2
1Princeton University, Princeton, New Jersey, USA; 2University Hospital Freiburg, Freiburg, Germany
1626. Microscopic MRI Assessment of Human Articular Cartilage Degeneration Using Q-Space Analysis
Shadi F. Othman1, Osama Abdullah1, Richard L. Magin1, Xiaohong Joe Zhou1
1University of Illinois at Chicago, Chicago, Illinois, USA
1627. Diffusive Diffraction Measured with MRI at 7T
Egbert Gedat1, Susanne Müller2, Thomas Tolxdorff1, Jürgen Braun1
1Institut für Medizinische Informatik, Berlin, Germany; 2Klinik für Neurologie, Berlin, Germany
1628. The Variance of DTI-Derived Parameters Via First-Order Perturbation Methods
Lin-Ching Chang1, Carlo Pierpaoli1, Peter J. Basser1
1NIH, Bethesda, Maryland, USA
1629. Modelling Uncertainty in Two Fibre-Orientation Estimates Within a Voxel
Philip A. Cook1, Daniel C. Alexander1
1University College London, London, UK
1630. Sensitivity of Diffusion-Weighted-Steady State Free Precession to Diffusion Anisotropy
Jennifer Andrea McNab1, Karla L. Miller1
1University of Oxford, Oxford, UK
1631. Numerical Simulation of Double Wave Vector Diffusion Experiments
Martin A. Koch1, Jürgen Finsterbusch1
1University Medical Center Hamburg-Eppendorf, Hamburg, Germany
1632.
Isoflurane Strongly Affects the Diffusion of Intracellular
Metabolites in the Brain, Revealing the
Contribution of Subcellular Restriction
to Metabolite ADC
Julien Valette1, Martine Guillermier2, Philippe Hantraye, 12, Gilles Bloch1, Vincent Lebon1
1CEA-SHFJ, Orsay, France; 2URA CEA-CNRS 2210, Orsay, France
1633. Effects of Cellular Mitosis on the Apparent Diffusion Coefficient of Synchronized HeLa Cells
Daniel C. Colvin1, Natasha Deane1, Coe Foutch1, Mark D. Does1, John C. Gore1
1Vanderbilt University, Nashville,
Tennessee, USA