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CLINICAL SCIENCE FOCUS SESSION: MR as a Predictive of Response Biomarkers to
Cancer Treatment
Room 618 - 620
13:30 - 15:30
Chairs: Peter L. Choyke and Frederik L. Giesel
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Time |
Prog # |
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13:30 |
755. |
Prognostic Power of
DCE-MRI Heterogeneity Analysis in Patients with Advanced Solid Tumours
Yvonne Watson1,
Sue Cheung1, Caleb Roberts1, Gio A. Buonaccorsi1,
Karen E. Davies1, Alan Jackson1, Chan Ton2,
Lynn
Broughton2,
Fiona Power2, Gordon C. Jayson2, Zhihui Lang3,
Saifee Mullamitha2, Robert Beckman3, Geoff J M
Parker1
1University
of Manchester, Manchester, UK; 2Christie Hospital,
Manchester, UK; 3Centocor, Malvern, Pennsylvania, USA |
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13:40 |
756. |
Predicting Recurrence
Patterns of Gliomas Using Diffusion Tensor Imaging
Stephen John Price1,
Rajesh Jena1, Neil Gunn Burnet1, T. Adrian Carpenter1,
John D. Pickard1, Jonathan H. Gillard1
1University
of Cambridge, Cambridge, UK |
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13:50 |
757. |
Predicting Grade of Cerebral
Glioma Using Vascular-Space-Occupancy (VASO) MRI
Hanzhang Lu1, Erica
Pollack1, Robert Young1, James S. Babb1, Glyn
Johnson1, Jens H. Jensen1, Joseph A. Helpern1,
Meng Law1
1New York University,
New York, USA |
|
14:00 |
758. |
Pre-Surgery Lactate, Lipid,
and ADC Predict Survival for Patients with Glioblastoma Multiforme
Forrest W. Crawford1,
Inas S. Khayal1, Kathleen R. Lamborn1, Rebeca Choy1,
Suja Saraswathy1, Ilwoo Park1,
Joonmi Oh1, Soonmee
Cha1, Susan Chang1, Sarah J. Nelson1
1University
of California, San Francisco, California, USA |
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14:10 |
759. |
Dynamic Tumor Regression
During Radiation Therapy Predicts Treatment Outcome in Cervical Cancer
Jian Zhong Wang1,
Nina A. Mayr1, William TC Yuh1, Joseph F. Montebello1,
John C. Grecula1, Dee H. Wu2,
Kenneth F. Wegner2,
Susan M. Edwards2, Nilendu Gupta1, Michael V. Knopp1
1The
Ohio State University, Columbus, Ohio, USA; 2University of Oklahoma
Health Science Center, Oklahoma City, Oklahoma, USA |
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14:20 |
760. |
Use of Dynamic
Contrast-Enhanced MRI to Predict Drug Uptake in Patients
Alain Oregioni1,
Simon Walker-Samuel1, James Darcy1, David J. Collins1,
Chooi P. Lee1, Michael Tracey2, Maeli J. Campbell3,
Ian R.
Judson1, Paul Workman1,
Martin O. Leach1, Geoffrey S. Payne1
1Institute
of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, UK; 2SRI
International, Menlo Park, California, USA; 3Cancer Research UK,
London, UK |
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14:30 |
761. |
The Effect of Heterogeneous
Tumour Enhancement on the Assessment of Response to Treatment
Simon Walker-Samuel1,
N. Jane Taylor2, Anwar R. Padhani2, Martin O. Leach1,
David J. Collins1
1Institute
of Cancer Research, Sutton, Surrey, UK; 2Mount Vernon Hospital,
Northwood, Middlesex, UK |
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14:40 |
762. |
MRI Measures of Tumor
Perfusion and T2 Relaxation in Response to Radiotherapy for Prostate
Cancer
David L. Buckley1,
Lucy E. Kershaw1, John P. Logue2, Charles E. Hutchinson1
1University
of Manchester, Manchester, Greater Manchester, UK; 2Christie
Hospital, Manchester, Greater Manchester, UK |
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14:50 |
763. |
Parametric DCE-MRI HPI Maps -
A Qualitative and Quantitative Analysis in Phase I Clinical Trial Patients with
Liver
Metastases
Keiko Miyazaki1,
Simon Walker-Samuel1, Benjamin Richard Knowles1, N J.
Taylor2, A R. Padhani2, Tony Wallace1, Adrian
Tang1,
Mark White3, David
Hawkes3, David Atkinson3, David J. Collins1,
Martin O. Leach1, D M. Koh1
1The
Institute of Cancer Research and The Royal Marsden NHS Trust, Sutton, Surrey,
UK; 2Mount Vernon Hospital, Northwood, Middlesex, UK; 3University
College of London, London, UK |
| 15:00 |
764. |
Evaluation of the Effects of
the Triple Angiokinase Inhibitor BIBF 1120 on Tumor Vasculature in a Phase I
Clinical Trial
Using Dynamic
Contrast-Enhanced MRI (DCE-MRI)
Ralph Strecker1,
Klaus Mross2, Martin Stefanic3, Lothar de Rossi3,
Jürgen Hennig1
1University
Hospital, Freiburg, Germany; 2Tumorbiology Center, Freiburg, Germany;
3Boehringer-Ingelheim Pharma GmbH & CO KG, Biberach, Germany |
| 15:10 |
765. |
Dynamic MRI Evaluation of the
Triple Receptor Tyrosine Kinase Inhibitor BIBF 1120 in Patients with Advanced
Solid
Tumours
Anwar R. Padhani1, N
Jane Taylor1, James A. d'Arcy2, Simon Walker-Samuel2,
David J. Collins2, Benjamin Knowles2, J. James
Stirling1, Toni
Wallace2, Dow-Mu Koh2, Adrian Tang2, Chooi Lee2,
Graham Temple3, Gordon J S Rustin1, Martin O. Leach2
1Mount
Vernon Hospital, Northwood, Middlesex HA6 2RN, UK; 2Royal Marsden
Hospital, Sutton, Surrey SM2 5PT, UK; 3Boehringer Ingelheim,
Bracknell, Berkshire RG12 8YS, UK |
| 15:20 |
766. |
Single and Multi-Centre
DCE-MRI Reproducibility in Phase I Clinical Trials
N. Jane Taylor1,
James A. d'Arcy2, Simon Walker-Samuel2, Katharine J.
Lankester3, David J. Collins2, Benjamin Knowles2,
David L.
White4, Yves Miaux4,
Joyce Suhy4, Ali Guermazi4, J James Stirling1,
Toni Wallace2, Dow-Mu Koh2, Adrian Tang2, Chooi
Lee2,
Gordon J S Rustin1,
Martin O. Leach2, Anwar R. Padhani1
1Mount
Vernon Hospital, Northwood, Middlesex HA6 2RN, UK; 2Royal Marsden
Hospital, Sutton, Surrey SM2 5PT, UK; 3Royal Marsden Hospital,
London, SW3 6JJ, UK; 4Synarc, Inc., San Francisco, CA 94105, USA |
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