Overview:
Each session of this four-hour course will focus on one topic:
angiogenesis and permeability; white matter dysfunction; gray matter
dysfunction; and cerebral hemodynamics. Current state of knowledge and
topics of interest in clinical research fMRI, DT-MRI, tractography and
perfusion MRI (bolus tracking and arterial spin labeling) will be
illustrated in the context of depicting underlying pathophysiology of
neoangiogenesis, axonal injury, demyelination and ischemia. Emphasis
will be on how to perform studies in the clinical environment with the
cooperation of patients. Limitations and Quality Assurance (QA)
procedure will be described.
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Educational Objectives:
Upon completion of this session, participants should be able to: |
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Describe the main applications and contributions
of fMRI, DTI and tractography and bolus tracking and arterial
spin labeling perfusion MR imaging in clinical neuroscience; |
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Describe the technical requirements necessary to
implement robust, accurate and repeatable clinical advanced MR
studies in patients with neurological diseases; |
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· |
List the potential contribution of PWI, DTI and
fMRI to formulate diagnosis, prognosis and evaluate different
therapeutic strategies in the neurological diseases focus of
this course; |
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• |
Discuss the basic MR principles involved in the
quantification of angiogenesis and permeability using perfusion
MR imaging; |
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• |
Implement new quantitative MR methods that may
quantify cumulative brain damage that better correlate with the
disability score; |
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· |
Recognize challenges, limitations and pitfalls of
performing advanced MR studies to answer clinical questions in
neurological patients; and |
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• |
Implement Quality Assurance (QA) procedures
necessary to run a reliable and successful advanced MRI clinic. |
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Audience
Description:
This course is designed for students in EE/BME/Physics/Medicine who are
interested in learning when and how advanced MRI techniques may answer
clinical questions; neuroscientists/engineers who are working with
advanced MRI methods and are interested in learning which are the
relevant clinical questions to address with fMRI/DTI/PWI in
neuroscience; physicians/neuroscientists who are interested in learning
about achievements and limitations of using advanced MRI techniques to
answer clinical questions in neuroscience; and
physicians/neuroscientists/engineers who are planning to perform
state-of-the-art advanced MRI studies in their clinical practice. |
Program |
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Tuesday, 9 May |
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Angiogenesis and
Permeability: Perfusion MRI |
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| 07:00 |
What Can
Quantitative DCE T1-Weighted MR Imaging Tell Us? |
Paul S. Tofts,
D.Phil. |
| 07:30 |
Grading, Therapy
Monitoring, and Predicting Outcome of Glioma |
Soonmee Cha,
M.D. |
| Wednesday,
10 May |
|
Measuring Extent of White
Matter Disease: Diffusion MRI |
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| 07:00 |
Diffusion Tensor
Imaging of Traumatic Brain Injury |
Pratik Mukherjee,
M.D., Ph.D. |
| 07:30 |
Clinical Output
of DTI Measurements in Multiple Sclerosis |
Olga Ciccarelli,
Ph.D. |
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Thursday, 11 May |
|
Brain Function and
Cortical Reorganization: Functional MRI |
|
| 07:00 |
Functional
Connectivity |
Mark J. Lowe,
Ph.D. |
| 07:30 |
Combining fMRI and DTI Applications |
Andrei I.
Holodny, M.D. |
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Friday, 12 May |
|
Advanced Imaging of the
Pediatric Brain |
|
| 07:00 |
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Diffusion MRI in the Fetus and Newborn |
|
Andrea Righini,
M.D. |
| 07:30 |
Measuring Brain Perfusion in
the Pediatric Brain |
Michela Tosetti,
Ph.D. |
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