Pre-Clinical Evaluation of Tumor Response

Dachgarten 10:30 - 12:30 Chairs: Simon P. Robinson and Nada Al-Saffar

Time	Prog #
10:30	*463.*	Evaluating Carboxypeptidase G2 (CPG2) Based Gene-Directed Enzyme Prodrug Therapy Using¹⁹F Magnetic *Resonance Spectroscopy: 3,5-Difluorobenzoyl-Glutamic Acid as a Potential In Vivo* reporter of CPG2 Activity** Yann Jamin¹, Thomas R. Eykyn¹, Simon P. Robinson¹, Caroline J. Springer², Martin O. Leach¹, Geoffrey S. Payne¹ ¹The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, UK; ²The Institute of Cancer Research, Sutton, Surrey, UK
10:42	*464.*	Evaluation of Vector Mediated Gene Therapy of Experimental Gliomas Using Multi-Modal Imaging Techniques Uwe Himmelreich¹, Hrvoje Miletic², Yannic Waerzeggers¹, Martina Deckert², Alexandra Winkeler¹, Mathias Hoehn¹, Andreas Jacobs¹ ¹Max-Planck-Institute for Neurological Research, Cologne, Germany; ²University of Cologne, Cologne, Germany
10:54	*465.*	Molecular Imaging of Lentiviral-Mediated Silencing of Choline Kinase as Gene Therapy in a Human Breast Cancer Xenograft Kristine Glunde¹, Balaji Krishnamachary¹, Flonne Wildes¹, Venu Raman¹, Zaver M. Bhujwalla¹ ¹The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
11:06	*466.*	Correlation Between Single Quantum and Triple-Quantum-Filtered ²³Na MRI Signal Intensities, Water ADC and Histology Changes in Control and 5-Fluorouracil Treated RIF-1 Tumors A Babsky¹, H Zhang¹, SK K. Hekmatyar¹, N Bansal¹ ¹Indiana University, Indianapolis, Indiana, USA
11:18	*467.*	MRI Evaluation of Tumor Physiological Response to Combretastatin A4 Phosphate: Correlation with a Combined Radiation Response Dawen Zhao¹, Lan Jiang¹, Ralph P. Mason¹ ¹University of Texas Southwestern Medical Center, Dallas, Texas, USA
11:30	*468.*	Validation of EPSI Angiography by Image Co-Registration Chad R. Haney¹, Charles A. Pelizzari¹, Sean Foxley¹, Marta Zamora¹, Devkumar Mustafi¹, Maria Tretiakova¹, Terry S. Li¹, Xiaobing Fan¹, Gregory S. Karczmar¹ ¹University of Chicago, Chicago, Illinois, USA
11:42	*469.*	Treatment with the Novel PI3K Inhibitor PX-866 Results in ¹H MRS Detectable Changes in a Glioma Model In Vivo Sabrina M. Ronen¹, Jim Banskon¹, Dimpy Koul¹, Madhuri Sankaranarayanapillai¹, Douglas Webb¹, Charles Kingsley¹, Jorge Delacerda¹, Jennifer Edge¹, Alfred Yung¹, Garth Powis² ¹U.T. M.D. Anderson Cancer Center, Houston, Texas, USA; ²U.T. M.D. Anderson Cancer, Houston, Texas, USA
11:54	*470.*	*Imaging Immune Response In Vivo: Cytolytic Action of Genetically Altered T-Cells Directed to Glioblastoma Multiforme* Jelena Lazovic¹, Evette Ferkassian², Brenda Aguilar², Michael C. Jensen², Andrew Raubitschek², Russell E. Jacobs¹ ¹California Institute of Technology, Pasadena, California, USA; ²City of Hope National Medical Center, Duarte, California, USA
12:06	*471.*	Metabolite Profiling Using ¹H-HRMAS NMR Spectroscopy of the Response to Methionine Stress in a Malignant Melanoma Model Samuel Guénin¹, Aicha Demidem¹, Jean Claude Claude Madelmont¹, Daniel Morvan¹,² ¹Inserm 484, Clermont-Ferrand, France; ²Centre Jean Perrin, Clermont-Ferrand, France
12:18	*472.*	Disorders in Methylated Species in Response to Nitrosourea in a Melanoma Tumor Model: Demonstration *Using ¹H-¹³C HRMAS NMR Spectroscopy and L-[methyl-¹³C]methionine* Aicha Demidem¹, Samuel Guénin¹, Jean-Claude Madelmont¹, Daniel Morvan¹,² ¹Inserm 484, Clermont-Ferrand, France; ²Centre Jean Perrin, Clermont-Ferrand, France