Alzheimer's Disease

Alzheimer's Disease: From Animal Models to Man

Dachgarten 16:00 - 18:00 Chairs: Kelvin Lim and Markus Von Kienlin

Time	Prog #
16:00	*639.*	Functional MRI Reveals Strong Hemodynamic Impairment in arcAβ Mice Modeling Vascular Pathology of Alzheimer’s Disease Felicitas Laura Kranz¹,², Marlen Knobloch², Thomas Mueggler¹,², Roger Nitsch², Markus Rudin¹,² ¹University & ETH Zurich, Zurich, Switzerland; ²University Zurich, Zurich, Switzerland
16:12	*640.*	Phenotyping the APP/PS2 Mouse Model for Alzheimer's Disease: Cerebral Perfusion, Blood Volume, and Vessel Density Claudia Weidensteiner¹, Friedrich Metzger¹, Johann R. Frey¹, Thomas Bielser¹, Andreas Bruns¹, Basil Kuennecke¹, Markus von Kienlin¹ ¹F. Hoffmann-La Roche Ltd, Basel, Switzerland
16:24	*641.*	Integrated MRS and Neuropathological Analysis of Alzheimer Mouse Brain in Response to Anti-Inflammatory Treatment Bruce G. Jenkins¹, Ji-Kyung Choi¹, Isabel Carreras², Neil W. Kowall², Alpaslan Dedeoglu² ¹Massachusetts General Hospital, Charlestown, Massachusetts, USA; ²Boston University, Bedford, Massachusetts, USA
16:36	*642.*	Tau Hyperphosphorylation in the Hippocampus of Alzheimer-Like Rat Is Associated with Reduction of Total Choline Xiaoxia Du¹, Xiaochuan Wang², Jianzhi Wang², Hao Lei¹ ¹Wuhan Institute of Physics & Mathematics, Chinese Academy of Sciences, Wuhan, Hubei, People’s Republic of China; ²Huazhong University of Science and Techology, Wuhan, Hubei, People’s Republic of China
16:48	*643.*	In Vivo MRI Investigation of Decreased Neuronal Transport with Aging and in Brains Expressing Alzheimer’s Pathology Donna J. Cross¹, Jennifer A. Flexman², Yoshimi Anzai², Jeffrey Stevenson², Kenneth R. Maravilla², Satoshi Minoshima² ¹University of Washington, WaNPRC, Seattle, Washington, USA; ²University of Washington, Seattle, Washington, USA
17:00	644.	Ventricular Shape Biomarkers for Alzheimer's Disease in Clinical MR Images Luca Ferrarini¹, Hans Olofsen¹, Walter Miguel Palm, Mark A. van Buchem, Johan H.C. Reiber¹, Faiza Admiraal-Behloul¹ ¹LKEB - Leiden University Medical Center, Leiden, Netherlands
17:12	*645.*	Functional Hippocampal Connectivity Identifies AD Risks in Mild Cognitive Impairment Subjects Zhilin Wu¹, Guofan Xu¹, Piero Antuono¹, Shi-Jiang Li¹ ¹Medical College of Wisconsin, Milwaukee, Wisconsin, USA
17:24	*646.*	Regional Hippocampal Connectivity Index: Evaluation of an fMRI Marker for Alzheimer’s Disease Zhilin Wu¹, Yin Xu¹, Guofan Xu¹, Shi-Jiang Li¹ ¹Medical College of Wisconsin, Milwaukee, Wisconsin, USA
17:36	*647.*	DTI in Alzheimer’s Disease (AD) and Mild Cognitive Impairment (MCI): Rapid Reproducible Analysis of Corpus Callosum Fiber Integrity Can Predict Conversion from MCI to AD Bram Stieltjes¹, Philipp Thomann², Frederik Lars Giesel¹, Mathias Schlüter³, Horst Karl Hahn³, Johannes Schröder², Marco Essig¹ ¹DKFZ, Heidelberg, Baden-Württemberg, Germany; ²University of Heidelberg, Heidelberg, Baden-Württemberg, Germany; ³MeVis, Bremen, Germany
17:48	*648.*	Assessment of Abnormalities in the Cerebral Microstructure of Schizophrenia Patients: A Diffusional Kurtosis Imaging Study Anita Ramani¹, Jens H. Jensen¹, Kamila U. Szulc¹, Osman Ali, Caixia Hu¹, Hanzhang Lu², Jonathan D. Brodie, Joseph A. Helpern¹ ¹Center for Biomedical Imaging, New York University School of Medicine, New York, New York, USA; ²Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, Texas, USA