TRADITIONAL
POSTERS
MRI Systems
Hall 14.1 Monday 14:00 - 16:00
988.
Accelerated Real-Time MRI with Distributed Computing Using
Standard Scanner Hardware
Ethan K. Brodsky1, Walter F. Block1
1University of Wisconsin - Madison, Madison, Wisconsin, USA
989.
Reducing Data Handling Issues in Large Coil Arrays by ‘If’
Undersampling
Naresh Yallapragada1, Steven M. Wright1
1Texas A&M University, College Station, Texas, USA
990.
Ultra High-Order Global Shimming of the Mouse Brain Using
Diamagnetic and
Paramagnetic Passive Shims
Kevin M. Koch1, Peter B. Brown1, Douglas L. Rothman1, Robin A. de Graaf1
1Yale University, New Haven, Connecticut, USA
991.
Development of a Compact MRI Using a Permanent Magnet for
Trabecular
Bone Microstructure Measurements
Sadanori Tomiha1, Shinya Handa1, Katsumi Kose1, Tomoyuki Haishi2
1University of Tsukuba, Tsukuba, Ibaraki, Japan; 2MRTechnology, Inc., Tsukuba, Ibaraki, Japan
992.
Gradient Coil Array for the Super-Parallel MRI: Experimental
Evaluation
Fumi Okada1, Shinya Handa1, Katsumi Kose1
1University of Tsukuba, Tsukuba, Ibaraki, Japan
993.
Residual Magnetism in an MR Suite After Field-Rampdown of an
8T Superconducting Magnet
Steffen Sammet1, Regina Maria Koch1, Francisco Aguila1, Michael V. Knopp1
1The Ohio State University, Columbus, Ohio, USA
994.
An Efficient Multiple Field of View Gradient Coil Set
Qin Liu1, Anthony Mantone2, Graeme C. McKinnon1, Michael B. Sellers3
1GE Healthcare, Waukesha, Wisconsin, USA; 2GE Healthcare, Florence, South Carolina, USA; 3GE Healthcare, Oxford, UK
995.
Investigation of Dynamic Range Requirement for MRI Signal
Transmission by Optical Fiber Link
Jing Yuan1, Juan Wei1, Chenpeng Du2, Gary X. Shen1
1The University of Hong Kong, Hong Kong, People’s Republic of China; 2MRI Lab, Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, People’s Republic of China
996.
Designing Active Feedback-Based Contrast Enhancement for
In Vivo Imaging
Susie Yi Huang1, Dennis W. Hwang2, Lian-Pin Hwang2, 3, Yung-Ya Lin4
1Harvard Medical School, Boston, Massachusetts, USA; 2National Taiwan University, Taipei, Taiwan; 3Academia Sinica, Taipei, Taiwan; 4University of California, Los Angeles, Los Angeles, California, USA
997.
Ultra-Efficient Shielded Dome Gradient Coils
Michael Poole1, Richard Bowtell1
1University of Nottingham, Nottingham, Nottinghamshire, UK
998.
Radiation Gel Dosimetry Using an Earth Field NMR Relaxometer
Maarten Veevaete1, Oliver Bislich1, Helmut Wiliam Fischer1
1University of Bremen, Bremen, Germany
999.
MRI/PET Insert: Investigations of Eddy Currents on Copper
Shields in the Bore
Bo Joseph Peng1, Jeff Walton1, Ciprian Catana1, Simon R. Cherry1, Jacob Willig-Onwuachi, 12
1University of California, Davis, California, USA; 2Grinnell College, Grinnell, Iowa, USA
1000.
Homogeneity and Shimming Requirements for a Field-Cycled MRI/PET
Scanner
Kyle Michael Gilbert1, William Bradfield Handler1, Timothy James Scholl1, Blaine Alexander Chronik1
1The University of Western Ontario, London, Ontario, Canada
1001.
Digital Wireless Transmission for MRI Signals
Juan Wei1, Guang Zheng Liu2, Jing Yuan1, Yong Pang1, Gary X. Shen1
1The University of Hong Kong, Hong Kong, People’s Republic of China; 2Tianjin University, Tianjin, People’s Republic of China
1002.
A Wide Band Frequency Transverter for High Field MRI
Ralph Oppelt1, Jan Bollenbeck1, Philipp Höcht1, Wilfried Schnell1
1Siemens AG, Erlangen, Germany
1003.
MRI and the Cell Processor
Joseph Czechowski1, Stephen Zingelewicz1, Branden Moore1, Luca Marinelli1, Christopher Hardy1, Mohamed El-Demerdash2
1General Electric Company, Niskayuna, New York, USA; 2General Electric Company, Waukesha, Wisconsin, USA
1004. First Order Dynamic Shimming for 7 Tesla Human Imaging
Saikat Sengupta1, Malcolm J. Avison1, David Foxall2, John Gore1
1Vanderbilt University, Nashville, Tennessee, USA; 2Philips Medical Systems, Cleveland, Ohio, USA
1005. An Independent Spectrometer and Coil Insert for Research on Clinical MR Systems
Martyn NJ Paley1, Eugeny Krjukov1, James M. Wild1, Paul D. Griffiths1, Michael Lamperth2, Ian R. Young2
1University of Sheffield, Sheffield, Yorkshire, UK; 2Imperial College, London, UK
1006. Integrated Low Noise Amplifier and Balun for MRI Receiver-On-Coils
Michael A. de Rooij1, William E. Burdick1
1GE Global Research, Niskayuna, New York, USA
Hall 14.1 Monday 14:00 - 16:00
1007. Fully Integrated Whole Body 3T MRI System for Parallel RF Transmission
Ingmar Graesslin1, Peter Vernickel1, Joachim Schmidt1, Christian Findelklee1, Peter Roeschmann1, Ulrich Katscher1, Christoph Leussler1, Paul Haaker1, Kai-Michael Luedeke1, Jochen Keupp1, Peter Börnert1, Henk Dingemans2, Giel Mens2, Krelis Blom2, Jan vd. Heijden2, Paul Harvey2, Johan Overweg1
1Philips Research Europe, Hamburg, Germany; 2Philips Medical Systems, Best, Netherlands
1008.
Efficient RF Coil Simulations with Curvilinear
Quadrilateral-Element Method of Moments
Shumin Wang1, Patrick J. Ledden2, Jeff H. Duyn1
1LFMI/NINDS/NIH, Bethesda, Maryland, USA; 2Nova Medical, Inc, Wilmington, Massachusetts, USA
1009. Modeling Loaded RF Coils Using the Method of Moments
Aghogho Obi1, Rostislav Lemdiasov2, Reinhold Ludwig1, Gene Bogdanov1
1Worcester Polytechnic Institute, Worcester, Massachusetts, USA; 2Insight Neuroimaging LLC, Worcester, Massachusetts, USA
1010.
Boundary Element Method for Calculation of Induced Electric
Fields Due to Switched
Magnetic Field Gradients and Movement in Strong Static Fields
Clemente Cobos Sanchez1, Paul M. Glover1, Henry Power1, Liviu Marin1, Adib Becker1, Arthur Jones1, Richard W. Bowtell1
1University of Nottingham, Nottingham, UK
1011. Effect of Head Size to B1, SNR and SAR
Jinfeng Tian1, Carl J. Snyder1, Lance Delabarre1, can Akgun1, Wanzhan Liu1, Christopher M. Collins2, Anand Gopinath1, Thomas Vaughan1
1University of Minnesota, Minneapolis, Minnesota, USA; 2Pennsylvania State University, Pennsylvania, USA
1012. The Effect of Shield Proximity on the Mode Distribution of a Birdcage Resonator
Shahed Reza1, Sathya Vijayakumar1, Randy Duensing1, Feng Huang1, Mark Limkeman1, Charles Saylor1
1Invivo Diagnostic Imaging, Gainesville, Florida, USA
1013.
A Whole-Body 7 Tesla RF Excitation Scheme with Much Improved
B1+ Field Homogeneity
and Local/Global SARs Over Quadrature Excitation
Tamer Selim Ibrahim1, 2, Lin Tang2
1University of Pittsburgh, Pittsburgh, Pennsylvania, USA; 2University of Oklahoma, Norman, Oklahoma, USA
1014. FDTD Simulations of RF Inhomogeneities in Ultrahigh-Field MRI Systems of Up to 11.7 T
Masaki Sekino1, Shoogo Ueno2, Hiroyuki Ohsaki1
1The University of Tokyo, Kashiwa, Chiba, Japan; 2Kyushu University, Fukuoka, Japan
1015. Tapered Head Gradient Coil Design Using the Wave Equation Method
Viktor Vegh1, Huawei Zhao1, Graham J. Galloway1, Ian M. Brereton1
1University of Queensland, Brisbane, Queensland, Australia
1016.
Improved Fourier Based Method for Calculating Field
Inhomogeniety from Known
Susceptibility Distribution
Jaladhar Neelavalli1, Yu Chung Norman Cheng2, Ewart Mark Haacke2
1Wayne State University, Detroit, Michigan, USA; 2Wayne State University, Michigan, USA
1017. Simulations of a 3D-Segmented Asymmetric Body Coil for Parallel Transmission
Ingmar Graesslin1, Sven Biederer1, Konstantinos Falaggis1, Dennis Glaesel1, Peter Vernickel1, Ulrich Katscher1, Peter Börnert1
1Philips Research Europe, Hamburg, Germany
1018. A 14.1 Tesla Animal Coil Design for Homogenous and Focused RF Excitation
Tamer Selim Ibrahim1, 2, Vanishree Ranganath2
1University of Pittsburgh, Pittsburgh, Pennsylvania, USA; 2University of Oklahoma, Norman, Oklahoma, USA
1019. A Proposed Ultra High Field RF Coil Design for Axial Human Brain Imaging
Tamer Selim Ibrahim1, 2, Roney Abraham2
1University of Pittsburgh, Pittsburgh, Pennsylvania, USA; 2University of Oklahoma, Norman, Oklahoma, USA
1020.
Decoupling of a Multi Channel Transmit/Receive Coil Array Via
Impedance Inversion
Christian Findeklee1, Jens Eichmann2, Peter Vernickel1
1Philips
Research Europe, Hamburg, Germany; 2Hamburg University of
Technology TUHH, Hamburg, Germany
1021. Field Propagation Phenomena in Ultra High Field NMR: A Maxwell-Bloch Formulation
Andrew JM Kiruluta1
1Harvard University, Cambridge, Massachusetts, USA
1022. RF Shimming Considering Both Excitation Homogeneity and SAR
Zhangwei Wang1, Suk-hoon Oh1, Michael B. Smith1, Christopher M. Collins1
1The Pennsylvania State University, Hershey, Pennsylvania, USA
1023. Simulation of the Effect of Mode Coupling on SAR for a Birdcage Resonator
Shahed Reza1, Randy Duensing1, Sathya Vijayakumar1, Feng Huang1, Mark Limkeman1, Charles Saylor1
1Invivo Diagnostic Imaging, Gainesville, Florida, USA
1024. Composite Shim Coil Design for System-Specific Field Corrections
Parisa Jamali1, Blaine A. Chronik1
1University of Western Ontario, London, Ontario, Canada
Hall 14.1 Monday 14:00 - 16:00
1025.
A Rigid Analysis and Experiments for the Complementary Modes
in the Multi-Port Reception
of a Volume Strip Array
Ray F. Lee1, Rong Xue1
1New York University Medical Center, New York, USA
1026. 4 Channel Mouse Array at 7 Tesla
Marcos Alonso Lopez1, Felix Breuer2, Nicole Seiberlich1, Daniel Gareis1, Sabine Voll1, Peter Michael Jakob1, 2
1University of Würzburg, Würzburg, Bavaria, Germany; 2Research Center Magnetic Resonance Bavaria (MRB), Würzburg, Bavaria, Germany
1027. Parallel Transmission with an 8 Channel Whole Body System at 3 T
Juergen Nistler1, Ulrich Fontius1, Lawrence L. Wald2, Elfar Adalsteinsson3, Kawin Setsompop3, Vijay Anand Alagappan2, Franz Hebrank4, Franz Schmitt1, Wolfgang Renz1
1Siemens Medical Solutions, Erlangen, Germany; 2MGH Martinos Center, Charlestown, Massachusetts, USA; 3MIT, Cambridge, Massachusetts, USA; 4Siemens Medical Solutions, Charlestown, Massachusetts, USA
1028.
A Degenerate Birdcage Coil for Parallel Excitation
Vijayanand Alagappan1, Juergen Nistler2, Elfar Adalsteinsson3, Kawin Setsompop3, Ulrich Fontius2, Adam Zelinski3, Markus Vester2, Graham Wiggins4, Franz Hebrank5, Wolfgang Renz2, Franz Schmitt2, Lawrence Wald4
1Athinoula A. Martinos Center for Biomedical Imaging, MGH, Charlestown, Massachusetts, USA; 2Siemens Medical Solutions, Erlangen, Germany; 3Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; 4Athinoula A. Martinos Center for Biomedical Imaging, MGH, charlestown, Massachusetts, USA; 5Siemens Medical Solutions, Charlestown, Massachusetts, USA
1029.
Towards a Complete Coil Array
Zhiyue J. Wang1, 2
1Texas Children's Hospital, Houston, Texas, USA; 2Baylor College of Medicine, Houston, Texas, USA
1030.
B1+ Region of Interest Localization
Through Convex Optimization
Christopher Carl Olson1, Lance DelaBarre1, John Thomas Vaughan1, Anand Gopinath1
1University of Minnesota, Minneapolis, Minnesota, USA
1031. A Novel RF Head Coil for 7T Homogeneity and Parallel Imaging Applications
Can Eyup Akgun1, Carl J. Snyder1, Lance DelaBarre1, Jinfeng Tian1, Pierre-Francois Van de Moortele1, Steen Moeller1, Kamil Ugurbil1, John Thomas Vaughan1
1University of Minnesota, Minneapolis, Minnesota, USA
1032. Comparison of Array Decoupling Mechanisms on Rat Arrays at 1.5 T
Tobias Wichmann1, 2, Titus Lanz1, Peter M. Jakob3
1Rapid Biomedical GmbH, Rimpar, Germany; 2Magnetic Resonance Bavaria, Würzburg, Germany; 3University of Würzburg, Würzburg, Germany
1033. Comparison Between Broadband Decoupling Methods for Microstirp Array
Bing Wu1, 2, Yong Pang2, Juan Wei2, Peng Qu2, Chunsheng Wang2, Jing Yuan2, Gary X. Shen2
1GE Healthcare, Beijing, People’s Republic of China; 2The University of Hong Kong, Hong Kong, Hong Kong
1034. An Inverse Method for Designing RF Phased Arrays with Optimal Coil Geometry
Peter Thomas While1, Larry K. Forbes1, Stuart Crozier2
1University of Tasmania, Hobart, Tasmania, Australia; 2University of Queensland, Brisbane, Queensland, Australia
1035. The Novel 12 Channel Octahedral Transmit/receive Array for Parallel Imaging of Human Head at 3 T.
Evgeniya Kirilina1, Thomas Riemer2, Wolfgang Driesel3, Harald E. Moeller3, Frank Seifert1
1Physikalisch-Technischen Bundesanstalt, Berlin, Germany; 2IZKF, Leipzig, Germany; 3Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
1036. A 4-Channel Optical Link Transmission for RF Coil Array at 1.5T
Jing Yuan1, Juan Wei1, Guang Cao2, Yong Pang3, Chenpeng Du3, Gary X. Shen1
1The University of Hong Kong, Hong Kong, People’s Republic of China; 2GE Medical System Asia, Hong Kong, People’s Republic of China; 3MRI Lab, Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, People’s Republic of China
1037. Low Noise Preamplifier with Integrated Cable Trap
Martin L. Hergt1, Ralph Oppelt2, Markus D. Vester1, Arne Reykowski3, Klaus M. Huber2, Karsten Jahns1, Hubertus J. Fischer1
1Siemens Medical Solutions, Erlangen, Germany; 2Siemens Cooperate Technology, Erlangen, Germany; 3Invivo Corporation, Gainesville, Florida, USA
1038. A 3D Parallel Imaging Capable Transmit and 16-Channel Receive Array Knee Coil at 3T
Xiaoyu Yang1, 2, Tsinghua Zheng1, 2, Hiroyuki Fujita1, 2
1Case Western Reserve University, Cleveland, Ohio, USA; 2University Hospitals of Cleveland, Cleveland, Ohio, USA
1039. Evaluation of a Degenerated Birdcage Coil for Parallel Imaging
Chunsheng Wang1, Peng Qu1, Jing Yuan1, Gary X. Shen1
1The University of Hong Kong, Hong Kong, Hong Kong
1040.
3D-Orthogonal Phased Array Coil for High-Resolution and
Low-Distortion EPI Imaging
of Monkey Brain at 3.0T
Zhigang You1, Wingchi Edmund Kwok1, Mithun Mukherjee1, Marc Mancarella1
1University of Rochester, Rochester, New York, USA
1041. Comparison of FP, VCSEL and DFB Laser Diode in Optical Transmission for MR RF Coil Array
Chenpeng Du1, Jing Yuan1, Gary Xiong Shen1
1The University of Hong Kong, Hong Kong, People’s Republic of China
1042. A Continuous Capacitance Loop Detector for High Sensitivity 7T MRI
Lucas Carvajal1, Kostas Karpodinis1, Duan Xu1, Daniel B. Vigneron1
1University of California San Francisco, San Francisco, California, USA
1043. SNR and G-Factor Optimized 16-Channel Anterior Cardiac Array for 3T
Mike J. Smith1, 2, Scott B. King1, 2
1National Research Council of Canada, Winnipeg, Manitoba, Canada; 2University of Manitoba, Winnipeg, Manitoba, Canada
1044. Comparison of Transceive Phased Array with TEM Volume Coil for Human Brain Imaging at 4 T.
Nikolai I. Avdievich1, Alexey S. Peshkovsky2, Hoby P. Hetherington1
1Albert Einstein College of Medicine, Bronx, New York, USA; 2RF Sensors, LLC, New York, New York, USA
1045. B1+ Homogeneity and SAR Reduction for Localized Excitation at 7T
Bob van den Bergen1, Cornelis A T van den Berg1, L W. Bartels1, Jan J. W. Lagendijk1
1University Medical Center Utrecht, Utrecht, Netherlands
1046. The Efficiency of 3T Body Transmit Array Coils
Eddy B. Boskamp1, Scott A. Lindsay1, John E. Lorbiecki1, Graeme C. McKinnon1
1GE Healthcare, Waukesha, Wisconsin, USA
1047.
Experimental Phased-Array Excitation Guided Utilizing a
Computational Electromagnetic
Model: Initial Findings
Tamer Selim Ibrahim1, YiK-Kiong Hue1, Fernando Boada1, Juergen Nistler2, Joerg Ulrich Fontius2, Franz Schmitt2
1University of Pittsburgh, Pittsburgh, Pennsylvania, USA; 2Siemens Medical Systems,
1048. Array SNR and Coupling Versus the Input Impedance of the Preamplifiers
Eddy B. Boskamp1, Ke Feng2, Bijay K. Shah2, Steven M. Wright2
1GE Healthcare, Waukesha, Wisconsin, USA; 2Texas A&M University, College Station, Texas, USA
1049. Optimized Quadrature Surface Coils Incorporating Circular, Figure-8 Loops, and Strips
Ananda Kumar1, Paul Arthur Bottomley1
1Johns Hopkins University, Baltimore, Maryland, USA
1050. Simple Digital Tuning System for Large Arrays of Coils
Ke Feng1, Mary Preston McDougall1, Steven M. Wright1
1Texas A&M University, College Station, Texas, USA
1051. Stretchable Coil Arrays
Jurek Antonin Massner1, Nicola De Zanche1, Klaas P. Pruessmann1
1University and ETH Zurich, Zurich, Switzerland
1052. Wavelet-Based Mode-Scanning Excitation (MSE) for Selective Excitation at High Field
Ray F. Lee1, Ting Song2, Rong Xue1, Andrew F. Laine2
1New York University Medical Center, New York, USA; 2Columbia University, New York, USA
1053. An Open 16-Channel Transmission Line Array for 7T
Joshua J. Holwell1, 2, Simon A. Lovell1, Kenneth M. Bradshaw1, Eddie J. Auerbach2, Gregor Adriany2, J Thomas Vaughan2
1MR Instruments Inc., Minneapolis, Minnesota, USA; 2University of Minnesota, Minneapolis, Minnesota, USA
1054. B1 Transmit Field Manipulation at 7 Tesla Using Controlled Decoupling of Array Coil Elements (CODACE)
Graham Charles Wiggins1, Elizabeth Zakszewski2, Christopher John Wiggins1, Lawrence L. Wald1
1Massachusetts General Hospital, Charlestown, Massachusetts, USA; 2MIT, Cambridge, Massachusetts, USA
1055. 20 Channel Coil Array for High Resolution Imaging of the Optic Nerve
J. Rock Hadley1, Emilee Minalga1, Dennis L. Parker1
1University of Utah, Salt Lake City, Utah, USA
Hall 14.1 Monday 14:00 - 16:00
1056. Magnetic Resonance Microimaging of Adult Zebrafish Brain Using Cryoprobe Technology
A. Alia1, S Kabli1, D. Gross2, D. Marek3, T. Oerther2, M. Sacher4, H. P. Spaink5, H. J.M. de Groot1
1Leiden University, Leiden, Netherlands; 2Bruker BioSpin GmbH, Karlsruhe, Germany; 3Bruker BioSpin AG, Fallanden, Switzerland; 4Bruker BioSpin AG, Fallanden, Switzerland; 5Institute of Biology, Leiden, Netherlands
1057. A Circularly Polarized Birdcage Coil with a Single Port
Yoshihisa Soutome1, Hideta Habara1, Hisaaki Ochi1
1Hitachi Ltd., Kokubunji, Tokyo, Japan
1058. A Histological Slice Imaging Coil for 7.0 T MRI
Bu Sik Park1, Mark D. Meadowcroft1, Christopher Michael Collins1, Michael B. Smith1, Qing X. Yang1
1The Pennsylvania State University, Hershey, Pennsylvania, USA
1059. MR-Guided Near-Infrared Spectroscopy System for Rodent Tumor Tomography
Brian W. Pogue1, Scott C. Davis1, Jia Wang1, Subhadra Srinivasan1, Summer L. Gibbs1, Shudong Jiang1, Keith D. Paulsen1, Peter Mazurkewitz2, Daniel Wirtz2, Christoph Leussler2
1Dartmouth College, Hanover, New Hampshire, USA; 2Philips Research Europe, Hamburg, Germany
1060.
Multi Tuned Coupled Microstrip Resonator for High Field
Magnetic Resonance Imaging
at 9.4T Human System
Sasidhar Tadanki1, Gene Bagadanov1, Reinhold Ludwig1, Mathew E. Brevard2, Keith R. Thulborn3, Ian Atkinson3
1Worcester Polytechnic Institute, Worcester, Massachusetts, USA; 2Insight Neuroimaging Systems,LLC, Worcester, Massachusetts, USA; 3University of Illinois at Chicago, Chicago, Illinois, USA
1061.
Comparison of Sensitivity and SNR Between 25mm, 50mm and 75mm
Diameter Round Coils
for Head Imaging on 7T
Akira Nabetani1, 2, Hiroyuki Kabasawa1, 2, Hitoshi Matsuzawa2, Tsutomu Nakada2
1GE Yokogawa Medical Systems, Ltd., Hino-shi, Tokyo, Japan; 2University of Niigata, Niigata, Japan
1062. SAR and B1 Field in a Human Head Model for Birdcage, TEM and Microstrip Coils at 7T
Chunsheng Wang1, Yong Pang1, Bing Wu1, Gary X. Shen1
1The University of Hong Kong, Hong Kong, Hong Kong
1063. Homogeneity Improvement Using a 2 Port Birdcage Coil
Juergen Nistler1, Dirk Diehl2, Wolfgang Renz1, Ludwig Eberler1
1Siemens Medical Solution, Erlangen, Germany; 2Siemens Corporate Technology, Erlangen, Germany
1064. Selective Passive Shielding
Chris P. Bidinosti1, Michael E. Hayden1
1Simon Fraser University, Burnaby, BC, Canada
1065. Quadrature Strip-Line Surface Coil for Ultra-High Field Imaging (7T)
Alexa Jones1, Arthur William Magill1, Paul Glover1
1University of Nottingham, Nottingham, UK
1066. A New Dedicated Coil Setup for In Vivo Measurement of Intramyocellular Lipids by 1H-MRS
Michael Neumaier1, Heiko G. Niessen1, Thomas Kaulisch1, Detlef Stiller1
1Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany
1067. Ultra-Sensitive Micron-Cantilever Detection for MRI
Modhurin Banerjee1, Charles Paulson1, Krishna Kurpad1, Daniel M. Ruf1, Daniel van der Weide1, Thomas M. Grist1
1University of Wisconsin,Madison, Madison, Wisconsin, USA
1068. HTS Surface Coil for MRI of the Patella
Jarek Wosik1, Maged R. Kamel1, Lei-Ming Xie1, Lian Xue1, Krzysztof Nesteruk2, Alexander C. Wright3, Felix W. Wehrli3
1University of Houston, Houston, Texas, USA; 2Institute of Physics of Polish Academy of Sciences, Warsaw, Poland; 3University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
1069. Less Wiggle Room at High-Field: A Segmented Birdcage-Like Example with Excellent Planar Uniformity
Xin Chen1, Timothy P. Eagan1, Tanvir N. Baig1, Robert W. Brown1
1Case Western Reserve University, Cleveland, Ohio, USA
Hall 14.1 Monday 14:00 - 16:00
1070.
Comparison of Measured and Estimated Induced Voltage on
Implanted Cardiac Leads Due to
MRI Gradient Magnetic Fields
Jonathan Edmonson1, Ben Herberg1, Dave Manahan1, Ashish Singal1
1Medtronic Inc., Minneapolis, Minnesota, USA
1071. Performance of the ASTM-Phantom at 3T
Salome Ryf1, Hans Engels2, Peter Boesiger1, Roger Luechinger1
1Institute for Biomedical Engineering, Zurich, Switzerland; 2Philips Medical Systems, Best, Netherlands
1072. SAR and Temperature Rise Within Tissues Near a Medical Implant
Dagang Wu1, Ji Chen1, Shumin Wang2
1University of Houston, Houston, Texas, USA; 2NIH, Bethesda, Maryland, USA
1073. Safety of Localising Intracranial EEG Electrodes Using MRI
David William Carmichael1, John S. Thornton2, Philip J. Allen3, Louis Lemieux1
1UCL Institute of Neurology, London, UK; 2National Hospital for Neurology and Neurosurgery, London, UK; 3National Hospital for Neurology and Neurosurgery, London, UK
1074. Calorimetric Calibration of SAR Estimates Displayed on GE MR Scanners
Krzysztof R. Gorny1, Matt A. Bernstein1, Joel P. Felmlee1, Diana M. Lanners1
1Mayo Clinic College of Medicine, Rochester, Minnesota, USA
1075. MR-Safety and Compatibility of Intrauterine Devices at 3T and 7T
Steffen Sammet1, Regina Maria Koch1, Douglas Arthur Murrey1, Michael V. Knopp1
1The Ohio State University, Columbus, Ohio, USA
1076. RF Heating Model of Active Implants During MRI Examinations
Halise Irak1, Ergin Atalar1, 2
1Bilkent University, Ankara, Turkey; 2Johns Hopkins University, Baltimore, Maryland, USA
1077. Energy Coupling Between RF Electric Fields and Conductive Wires: Image Artifacts and Heating
Todd K. Stevens1, 2, John R. Ives1, Robert Bartha, 12
1University of Western Ontario, London, Ontario, Canada; 2Robarts Research Institute, London, Ontario, Canada
1078. Avoiding Resonant Lengths of Wire with RF Chokes at 4 Tesla
Todd K. Stevens1, 2, John R. Ives1, Robert Bartha, 12
1University of Western Ontario, London, Ontario, Canada; 2Robarts Research Institute, London, Ontario, Canada
1079. Asymmetric Pacemaker Lead Tip Heating Along the X-Axis in 1.5T and 3T Systems
Deborah Anne Langman1, Vibhas S. Desphande2, Feiweier Thorsten3, Gerhard A. Laub2, Paul J. Finn1
1UCLA, Los Angeles, California, USA; 2Siemens, Los Angeles, California, USA; 3Siemens, Erlangen, Germany
1080.
RF Safety Aspects for Hip Implants During MRI: A Comparison
Between Numerical
Calculations and Experimental Measurements
Dan Li1, Jens Stenschke1, Maike Thomann2, Xixi Zhang1, Gregor Schaefers3, Waldemar Zylka4
1University of Applied Sciences Gelsenkirchen; 2University of Applied Sciences Gelsenkirchen, NRW, Germany; 3mr:comp GmbH, Gelsenkirchen, Germany; 4University of Applied Sciences Gelsenkirchen, Gelsenkirchen, NRW, Germany
1081. Safety and Feasibility of Using Implanted Depth Electrodes for Intracranial EEG-fMRI at 3 Tesla
Shannon Boucousis1, Cameron John Bruce Cunningham2, Bradley Goodyear2, Paolo Federico2
1University of Calgary, Calgary, Alberta, Canada; 2University of Calgary, Calgary, Canada
MR Safety, Bioeffects and Acoustic Noise
Hall 14.1 Monday 14:00 - 16:00
1082. Measurement of Visual Evoked Potential During and Following Exposure to Switched Magnetic Fields
Sally Eldeghaidy1, T Mistry1, Paul Glover1, Penny A. Gowland1
1University of Nottingham, Nottingham, UK
1083.
Initial Measurements with an Ambulatory Static and Gradient
Magnetic Field Dosimeter for
Workers in MR Environments
Miguel Angel Fuentes1, Stephen Wilson1, Stuart Crozier1
1University of Queensland, St Lucia, Queensland, Australia
1084. MRI-Based Attenuation Correction for PET Reconstruction
Jeffrey Steinberg1, Jun Zhang1, Guang Jia1, Zarine Shah1, Steffen Sammet1, Deborah Hurley1, Nathan Hall1, Michael V. Knopp1
1The Ohio State University, Columbus, Ohio, USA
1085. RF Shimming and SAR Considerations with an Eight-Element 3T Body Coil
Graeme McKinnon1
1GE Healthcare, Waukesha, Wisconsin, USA
1086. Real-Time SAR Monitoring to Ensure Patient Safety for Parallel Transmission Systems
Ingmar Graesslin1, Sven Biederer1, Konstantinos Falaggis1, Peter Vernickel1, Henk Dingemans2, Giel Mens2, Peter Roeschmann1, Christoph Leussler1, Zhiyong Zhai3, Michael Morich3, Ulrich Katscher1
1Philips Research Europe, Hamburg, Germany; 2Philips Medical Systems, Best, Netherlands; 3Philips Medical Systems, Cleveland, Ohio, USA
1087. RF Safety at 9.4T - Porcine In Vivo Results
Devashish Shrivastava1, Bob Schlentz1, Jeramy Kulesa1, Carl Snyder1, Lance DelaBarre1, Tim Hanson1, Paul Iaizzo1, J. Thomas Vaughan1
1University of Minnesota, Minneapolis, Minnesota, USA
1088. General Method for Acoustic Noise Reduction by Avoiding Resonance Peaks
Jouke Smink1, Geert-Jan Plattel1, Paul R. Harvey1, Patrick Limpens1
1Philips Medical Systems, Best, Netherlands
1089. Modelling Regulatory Compliance of Occupationally Exposed MRI Workers During Gradient Pulsing
Stuart Crozier1, Hua Wang1, Adnan Trakic1, Feng Liu1
1The University of Queensland, Brisbane, Queensland, Australia
1090. SAR Simulations and Experiments for Parallel Transmission
Ingmar Graesslin1, Konstantinos Falaggis1, Sven Biederer1, Dennis Glaesel1, Peter Vernickel1, Peter Roeschmann1, Christoph Leussler1, Axel Thran1, Zhiyong Zhai2, Michael Morich2, Ulrich Katscher1
1Philips Research Europe, Hamburg, Germany; 2Philips Medical Systems, Cleveland, Ohio, USA
1091. RF-Induced Electromagnetic Fields and Implant Heating in MRI
Peter Nordbeck1, Florian Fidler1, Ingo Weiss2, Marcus Warmuth1, Michael T. Friedrich2, Philipp Ehses1, Wolfgang Geistert2, Peter M. Jakob1, Mark E. Ladd3, Harald H. Quick3, Wolfgang R. Bauer1
1University of Würzburg, Würzburg, Germany; 2Biotronik GmbH & Co. KG, Berlin, Germany; 3University of Duisburg-Essen, Essen, Germany
1092. A Conservative Method for Ensuring Safety Within Transmit Arrays
Christopher Michael Collins1, Zhangwei Wang1, Michael Bruce Smith1
1The Pennsylvania State University, Hershey, Pennsylvania, USA
1093. Heating of Metallic Implants and Instruments Induced by Gradient Switching
Hansjörg Graf1, Günter Steidle1, Fritz Schick1
1University Hospital of Tübingen, Tübingen, Germany
1094. The SAR Measurement Phase Transition Method
Rocco Romano1, Fausto Acernese2, Pietro Luigi Indovina3, Fabrizio Barone1
1Università degli Studi di Salerno, Fisciano, Italy; 2Istituto Nazionale di Fisica Nucleare, Napoli, Italy; 3Università degli Studi di Napoli "Federico II", Napoli, Italy
1095.
Contactless Measurements of Liquid Sample Electrical
Conductivity for Estimating Specific
Absorption Rate in MR Applications
Valentina Hartwig1, 2, Giulio Giovannetti2, Nicola Vanello, 12, Luigi Landini2, Antonio Benassi2
1University of Pisa, Pisa, Italy, Italy; 2CNR, Pisa, Italy, Italy
1096.
Four Weeks of Close Proximity to the 4.7T Magnet Does Not
Stimulate Heat Shock Protein
Expression in the Rat Brain
Michal Fiedorowicz1, Kinga Stanczak1, Pawel Grieb1, Urszula Tyrankiewicz2, Tomasz Skorka2, Andrzej Jasinski2, 3
1Medical Research Centre PAN, Warszawa, Poland; 2H. Niewodniczanski Institute of Nuclear Physics PAN, Krakow, Poland; 3Cracow Pedagogical University, Krakow, Poland
1097. FDTD Simulations of Implantable Devices at 3 and 7 Tesla
Tamer Selim Ibrahim1, 2, Alayar Kangarlu3, Roney Abraham2
1University of Pittsburgh, Pittsburgh, Pennsylvania, USA; 2University of Oklahoma, Norman, Oklahoma, USA; 3Columbia University, New York, USA
1098.
Numerical Study of Currents in Occupational Workers Induced
by Body-Motion Around High-Ultrahigh
Field MRI Magnets
Stuart Crozier1, Adnan Trakic1, Hua Wang1, Feng Liu1
1The University of Queensland, Brisbane, Queensland, Australia
1099. Effect of Considering Physiological Response in Temperature Calculations for MRI of the Human Head
Zhangwei Wang1, James C. Lin2, Michael B. Smith1, Christopher M. Collins1
1The Pennsylvania State University, Hershey, Pennsylvania, USA; 2University of Illinois at Chicago, Chicago, Illinois, USA
1100. Effects of Static Magnetic Field Strength on Heart Rate
Adam W. Anderson1, Robin Avison1, John C. Gore1
1Vanderbilt University, Nashville, Tennessee, USA
1101. Acoustic Noise Suppression: Gradient Self-Help?
Timothy Patrick Eagan1, Tanvir Baig1, Jamal J. Derakhshan1, Jeffrey L. Duerk1, 2, Robert Brown1
1Case Western Reserve University, Cleveland, Ohio, USA; 2University Hospitals of Cleveland, Cleveland, Ohio, USA
Safety Regulations and Site Safety Procedure Concerns
Hall 14.1 Monday 14:00 - 16:00
1102. Algorithms for Automatic Calculation of Quality Control Metrics for ACR Accrediatation Compliance
Zhonghao Bao1, Scott O. Stiving1, Joel P. Felmlee1, Kiaran Patrick McGee1
1Mayo Clinic, Rochester, Minnesota, USA
1103. Quality Control for 1HMRS Longitudinal Studies
Roberto Tarducci1, Otello Presciutti2, Gianni Gobbi2
1Azienda Ospedaliera di Perugia, Perugia, Italy; 2SC di Fisica Sanitaria, Azienda Ospedaliera di Perugia, Perugia, Italy
MR-Guided Interventions III (devices, sequences, applications)
Hall 14.1 Monday 14:00 - 16:00
1104. Negative and Positive Contrast Strategies to Track Cell Encapsulation Devices Post Implantation
Barjor Gimi1, 2, Dmitri Artemov2, Timothy Leong3, David Gracias3, Zaver M. Bhujwalla2
1The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA; 2The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; 3Johns Hopkins University, Baltimore, Maryland, USA
1105. MR-Visible and RF-Safe Low Profile Transmission Line for Active Devices
Sascha Krueger1, Karl M. Ruhl2, Elmar Spuentrup2, Sebastian Schmitz3, Steffen Weiss1, Daniel Wirtz1, Arno Buecker4, Oliver Lips1
1Philips Research Europe, Hamburg, Germany; 2University Clinic Aachen, Aachen, Germany; 3Fraunhofer Institute for Production Technology, Aachen, Germany; 4University Clinic Saarland, Homburg, Germany
1106. B0-Field-Driven Capsule Endoscope with Swimming Tails for Propulsion: Design Study
Gabor Kosa1, Peter Jakab2, Nobuhiko Hata2
1Technion, Haifa, Israel; 2Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
1107. A Novel Device for Image-Guided Interventional Breast Procedures Using 3D Access and Geometry
Matthew Smith1, Xu Zhai1, Dharmesh Mahay1, Christopher Westphal1, Ray Harter2, Gale Sisney, MD1, Sean Fain, PhD1
1University of Wisconsin, Madison, Wisconsin, USA; 2Marvel Medtech, LLC, Madison, Wisconsin
1108. Imaging Characteristics of an MRI-Compatible Stent Delivery System
Karl K. Vigen1, Jon Buzzard2, Amish N. Raval1
1University of Wisconsin-Madison, Madison, Wisconsin, USA; 2Cordis Endovascular, Warren, New Jersey, USA
1109. Performance of Inductively Coupled RF Coils as Reference Markers Under Various Conditions at 1.5 T
Robert Trampel1, Harald Busse1, Wilfried Gründer2, Michael Moche1, Thomas Kahn1
1University Hospital Leipzig, Leipzig, Germany; 2University Leipzig, Leipzig, Germany
1110. Development of an Interventional Endo-MRI: Toward the Therapy of Pancreaticobiliary Diseases
Bensheng Qiu1, Joo Ha Hwang1, Jeff Stevenson1, Jenee O'Brien1, Xiaoming Yang1
1University of Washington Medical Center, Seattle, Washington, USA
1111. Development of a Two-Room MR/OR Suite: Concept to Clinical Implementation
Kiaran Patrick McGee1, Kendall H. Lee1, Heidi Ward1, Michael J. Link1, William J. Perkins1, James R. Munis1, Christopher P. Wood1, Robert J. Witte1, John I. Lane1, Fredrick B. Meyer1, John Huston1
1Mayo Clinic, Rochester, Minnesota, USA
1112.
New Devices for Safety and
Usability to Introduce Robot Assistance Into Clinical MR-Guided
Microwave Ablation of Liver Tumors
Shigehiro Morikawa1, Koichiro Murakami1, Sigeyuki Naka1, Yoshimasa Kurumi1, Masahito Morita1, Toshiro Inubushi1, Tsuyoshi Nakakubo2, Kazuo Umihira2, Hasnine A. Haque3, Nobuhiko Hata4
1Shiga University of Medical Science, Ohtsu, Shiga, Japan; 2Umihira Works, Kyoto, Japan; 3GE Yokogawa Medical Systems, Hino, Tokyo, Japan; 4Brigham & Women's Hospital, Boston, Massachusetts, USA
1113. Cardiac Specific Plasmid-VEGF Increases Myocardial Angiogenesis, Perfusion and Infarct Resorption
Maythem Saeed1, Alastair Martin1, Phillip Ursell1, Oliver Weber1, Loi Do1, Alexis Jacquier1, Charles Higgins1, David Saloner1
1University of California San Francisco, San Francisco, California, USA
1114. MRI Based Monitoring of Intervention for Deep Vein Thrombosis
Marcus Katoh1, 2, Andrea J. Wiethoff3, Patrick Haage4, Josef Tacke5, Rolf W. Gunther6, Elmar Spuentrup6
1University Hospital Saarland, Homburg, Germany; 2University Hospital RWTH Aachen, Aachen, Germany; 3Philips Medical Systems, Netherlands; 4Helios Hospital Wuppertal, Germany; 5Hospital Passau, Germany; 6University Hospital RWTH Aachen, Germany
1115. Intraarterial Perfusion to Monitor Endovascular Procedures in MR
Ashley D. Harris1, 2, Jayme C. Kosior1, 2, Linda B. Andersen1, 2, Richard Frayne1, 2
1University of Calgary, Calgary, Alberta, Canada; 2Foothills Medical Centre, Calgary Health Region, Calgary, Alberta, Canada
1116. MR-Guided Electrophysiology Ablations
Richard Philip Mallozzi1, Renee Guhde1, Eric Fiveland1, Robert Darrow1, Charles L. Dumoulin1, Ehud J. Schmidt2, Jeremy Dando3, Scott Petersen3, Vivek Y. Reddy4, Aravinda Thiagalingam4, Gotfried F. Holmvang4
1GE Global Research, Niskayuna, New York, USA; 2GE Healthcare, Waukesha, Wisconsin, USA; 3St. Jude Medical, Inc., Minnetonka, Minnesota, USA; 4Massachusetts General Hospital, Boston, Massachusetts, USA
1117. Phase Refocusing for Improved Visualization of Interventional Guidewires
William Overall1, Greig Scott1, Yoriyasu Suzuki1, Masahiro Terashima1, Fumiaki Ikeno1, Michael McConnell1, John Pauly1
1Stanford University, Stanford, California, USA
1118. Relaxation Properties of Cavitation Induced Tissue Lesions
Timothy L. Hall1, Gregory R. Lee, Charles A. Cain, Luis Hernandez-Garcia
1University of Michigan, Ann Arbor, Michigan, USA
1119.
An Echo-Dephased SPGR Approach to Generate Positive Contrast
Due to Paramagnetic
Marker: An Interventional MRI Application
Sunil Patil1, Oliver Bieri1, Deniz Bilecen2, Klaus Scheffler1
1University of Basel/University Hospital, Basel, Switzerland; 2University Hospital/University of Basel, Basel, Switzerland
1120. Passive Catheter Tracking/Visualization Using Frequency Demodulation and IDEAL
Orhan Unal1, Ethan K. Brodsky1, Scott B. Reeder1
1University of Wisconsin-Madison, Madison, Wisconsin, USA
1121. HYPR MR Fluoroscopy
Orhan Unal1, Chuck A. Mistretta1
1University of Wisconsin-Madison, Madison, Wisconsin, USA
1122. Visualization of the Paramagnetic Markers in Interventional MRI Using Spatial-Spectral Pulses
Sunil Patil1, Christian Boller1, Deniz Bilecen2, Klaus Scheffler1
1University of Basel/University Hospital, Basel, Switzerland; 2University Hospital/University of Basel, Basel, Switzerland
1123. Evaluation of Sub-Pixel Fiducial Tracking Using Image Processing
Marc A. Rea1, Donald W. McRobbie1, Ian Young2, Haytham Elhawary2, Aleksander Zivanovic2, Michael Lamperth2
1Charing Cross Hospital, London, UK; 2Imperial College London, London, UK
1124. Motion Compensated Catheter Tracking
Carsten Oliver Schirra1, Redha Boubertakh1, 2, Reza Razavi1, Tobias Schaeffter1
1King’s College London, London, UK; 2University College London, London, UK
1125. Interactive MR Imaging Using Parallel Acquisition and Parallel Reconstruction
Eigil Samset1, 2, W. Scott Hoge3, Ferenc Jolesz3
1Brigham and Women's Hospital, Boston, Massachusetts, USA; 2University of Oslo, Oslo, Norway; 3Brigham and Women's Hospital, Massachusetts, USA
Hall 14.1 Monday 14:00 - 16:00
1126.
Amide Proton Transfer (APT) Imaging for the Monitoring of
Heating Treatment by High
Intensity Focused Ultrasound (HIFU): Phantom Experiments
Yi-Yu Shih1, Teng-Yi Huang2, Hsu-Hsia Peng1, Hsiao-Wen Chung1, Cheng-Yu Chen3
1National Taiwan University, Taipei, Taiwan; 2National Taiwan University of Science and Technology, Taipei, Taiwan; 3Tri-Service General Hospital, Taipei, Taiwan
1127.
MRI Guided Focused Ultrasound of Moving Organs: Target
Tracking with On-Line
Anticipation of Periodic Displacements
Charles Mougenot1, 2, Baudouin Denis de Senneville1, Mario Ries1, Bruno Quesson1, Chrit Moonen1
1Laboratory for Molecular and Functional Imaging, Bordeaux, Gironde, France; 2Philips Medical Systems, Suresnes, Paris, France
1128.
Three Dimensional Spatial and Temporal Temperature Control
with MR-Thermometry
Guided Focused Ultrasound
Charles Mougenot1, 2, Chrit Moonen1
1Laboratory for Molecular and Functional Imaging, Bordeaux, Gironde, France; 2Philips Medical Systems, Suresnes, Paris, France
1129. Simultaneous Temperature and Motion Tracking Using HARP MRI [T-HARP]
AbdElMonem Mohamed El-Sharkawy1, Khaled Z. Abd-Elmoniem1, Jerry L. Prince1, Paul A. Bottomley1
1Johns Hopkins University, Baltimore, Maryland, USA
1130. Real-Time Temperature Monitoring Using Line-Scan Phase Measurement
Charles L. Dumoulin1, Robert D. Darrow1, Richard P. Mallozzi1
1General Electric Global Research, Niskayuna, New York, USA
1131. Feasibility of Full RF Current-Vector Mapping for MR-Guided RF Ablations
Kim Shultz1, John Pauly1, Greig Scott1
1Stanford
University, Stanford, California, USA
1132.
MRI Guided Focused Ultrasound of Moving Tissues: Accelerated
MR-Thermometry and
Motion Analysis for Subsecond Target Tracking
Mario Ries1, Gregory Maclair1, Baudouin Denis de Senneville1, Philippe Lourenço De Oliviera1, Charles Mougenot2, Erkki Vahala3, Chrit Moonen1
1Laboratory for Molecular and Functional Imaging, Bordeaux, France; 2Philips Medical Systems, Suresnes, France; 3Philips Medical Systems, Helsinki, Finland
1133. PRF Shift Thermometry Using Multiple-Acquisition Phase-Cycled Balanced SSFP
Viola Rieke1, Brian A. Hargreaves1, Kim Butts Pauly1
1Stanford University, Stanford, California, USA
1134. VD K-T Acquisition for Accelerating Temperature Imaging
GuoBin Li1, Yiu-Cho Chung2, Al Zhang1, XiaoDong Zhou1
1Siemens Mindit Magnetic Resonance Ltd., Shen Zhen, Guang Dong, People’s Republic of China; 2Siemens Mediecal Solutions USA, Ohio, USA
1135. PCA-Based Image Registration for On-Line MR Temperature Monitoring of Moving Tissues
Gregory Maclair1, 2, Baudouin Denis de Senneville1, Mario Ries1, Bruno Quesson1, Chrit Moonen1
1Laboratory for Molecular and Functional Imaging, Bordeaux, France; 2LaBRI, Bordeaux, France
1136. A Temporally Constrained Reconstruction Algorithm Applied to MRI Temperature Data
Nick Todd1, Ganesh Adluru, Ed V.R. DiBella, Dennis L. Parker
1University of Utah, Salt Lake City, Utah, USA
1137. Evaluation of Chronic Cryo Prostate Lesions by Diffusion-Weighted MRI
Jing Chen1, Donna Bouley1, M.A.A.J van den Bosch1, Bruce Daniel1, Kim Butts Pauly1
1Stanford University, Stanford, California, USA
1138.
Ice Ball Imaging During Cryoablation of Canine Prostates:
Contrast-Enhanced MRI Provides
Most Accurate Delineation of the Acute Necrotic Zone
Maurice A.A.J. van den Bosch1, Erin H. Liu2, Sonal Josan2, Kim Butts-Pauly2, Donna M. Bouley1, Bruce L. Daniel1
1Stanford University Medical Center, Stanford, California, USA; 2Lucas MRS Imaging Center, Stanford, California, USA
1139.
MRI-Monitoring of Hyperthermia Induced Gadodiamide Release
from Long-Circulating
Thermosensitive Liposomes in Tumors
Michael Peller1, Alenka Schwerdt2, Martin Hossann3, Herbert M. Reinl1, Rolf D. Issels3, 4, Lars Lindner3, 4, M Reiser1
1University Hospital of Munich, Munich, Germany; 2University of Munich, Germany; 3University Hospital of Munich, Germany; 4KKG "Hyperthermia"/GSF-Natl. Research Center for Environment and Health, Germany
1140. Monitoring Prostate Thermal Therapy with Diffusion-Weighted MRI
Jing Chen1, Chris Diederich2, M.A.A.J. van den Bosch1, Bruce Daniel1, Graham Sommer1, Kim Butts Pauly1
1Stanford University, Stanford, California, USA; 2UCSF, San Francisco, California, USA
1141. Multifunctional Plasmonic Nanoparticles for Photothermal Therapy of Cancer with MRI Monitoring
Tim Larson1, Douglas Webb2, James A. Bankson2, Konstantin V. Sokolov1, 2
1The University of Texas, Austin, Texas, USA; 2The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
1142.
Evaluation of Subacute and Chronic Cryotherapy Lesions Using
Histopathology and Contrast
Enhanced MR Images in the Dog Prostate Model
Donna Michelle Bouley1, Erin Liu1, Kim Butts Pauly1, Maurice Van den Bosch1, Bruce Daniel1
1Stanford University, Stanford, California, USA
1143. In Vivo Assessment of Canine Prostate Thermal Ablations with Magnetization Transfer Imaging
Andrew Bruce Holbrook1, Donna M. Bouley1, Marcus Alley1, Bruce Daniel1, Chris Diederich2, Graham Sommer1, Kim Butts Pauly1
1Stanford University, Stanford, California, USA; 2UCSF, San Francisco, California, USA
Hall 14.1 Monday 14:00 - 16:00
1144. Improved Visualization of Intra-Axial Gliomas on Enhanced MR Imaging with Gadobenate
Dimeglumine Compared to Gadopentetate Dimeglumine: Implications for Therapeutic Intervention
Matthew Joseph Kuhn1, Piero Picozzi2, Kenneth Maravilla3, Marco Essig4, Nicoletta Anzalone2, Kalyani Vallurupalli1
1Southern Illinois University, Springfield, Illinois, USA; 2San Raffaele Hospital, Milan, Italy; 3University of Washington, Seattle, Washington, USA; 4German Cancer Research Institute, Heidelberg, Germany
1145. A Highly Sensitive MR Contrast Agent Based on Liposomal Nanocarrier Containing
Superparamagnetic Iron-Oxide
Ketan Ghaghada1, Karl Hagen2, Srinivasan Mukundan1, 3
1Duke University Medical Center, Durham, North Carolina, USA; 2Emory University, Atlanta, Georgia, USA; 3Duke University, Durham, North Carolina, USA
1146. Paramagnetic Dy(III)-Loaded Liposomes as T2 Susceptibility MRI Agents
Enzo Terreno1, Claudia Cabella2, Carla Carrera1, Daniela Delli Castelli1, Stefania Lanzardo1, Roberta Mazzon2, Simona Rollet1, Massimo Visigalli2, Silvio Aime1
1University of Torino, Torino, Italy; 2CRM Bracco Imaging S.p.A., Colleretto Giacosa (TO), Italy
1147. Avidin Induced Clearance of Biotinylated Paramagnetic Liposomes for Improved
Magnetic Resonance Molecular Imaging
Geralda A.F. van Tilborg1, Willem J.M. Mulder2, Nico A.J.M. Sommerdijk1, Gustav J. Strijkers1, Klaas Nicolay1
1Eindhoven University of Technology, Eindhoven, Netherlands; 2Mount Sinai School of Medicine, New York, USA
1148. T1 Relaxivity of Liposomal-Encapsulated Gadolinium Contrast Agents: Effect of
Particle Size and Gadolinium Concentration
Ketan Ghaghada1, Keigo Kawaji2, Catherine Hawley2, Srinivasan Mukundan1, 2
1Duke University Medical Center, Durham, North Carolina, USA; 2Duke University, Durham, North Carolina, USA
1149. The Applications of Nanoshells and Nanocapsules in Magnetic Resonance Molecular Imaging
Chia-Hao Su1, Hwo-Shuenn Sheu2, Yi-Wei Lo3, Jun-Cheng Weng1, Dar-Bin Shieh3, Chen-Sheng Yeh3, Jyh-Horng Chen1
1National Taiwan University, Taipei, Taiwan; 2National Synchrotron Radiation Research Center, Hsinchu, Taiwan; 3National Cheng Kung University, Tainan, Taiwan
1150. SPIO-Loaded Nano Test Tubes as Ultra-Sensitive MRI Contrast Agents
Heather Hillebrenner1, Li Tao2, Chase Kessinger1, Chalermchai Khemtong1, Jimin Ren3, Dean Sherry3, Wenchuang Hu2, Jinming Gao1
1University of Texas Southwestern Medical Center, Dallas, Texas, USA; 2University of Texas at Dallas, Richardson, Texas, USA; 3UT Southwestern Medical Center, Dallas, Texas, USA
1151. Functional Imaging Using Nitroxides - A Feasibility Study at 11.7T
Keerthi Shet1, Gaunglong He2, Jay L. Zweier2
1Ohio State University, Columbus, Ohio, USA; 2Davis Heart and Lung Research Institute, Columbus, Ohio, USA
1152. Relaxivity of Cobalt Nanoparticles, a Novel MR Contrast Agent
Laura Michelle Parkes1, Richard Hodgson1, Le T. Lu2, Ian Robinson2, David Fernig2, Nguyen TK Thanh2
1University of Liverpool, Liverpool, Merseyside, UK; 2University of Liverpool, UK
1153. MRI Characterization of Iron in Soluble (Ferritin-Like) and Particulate (Hemosiderin-Like) Mixtures
Jerry Shing Chung Cheung1, April M. Chow1, Jens H. Jensen2, Haiying Tang3, Truman R. Brown4, Sujit Sheth4, Gary M. Brittenham4, Ed Xuekui Wu1
1The University of Hong Kong, Pokfulam, Hong Kong; 2New York University, New York, USA; 3Merck Research Laboratories, Rahway, New Jersey, USA; 4Columbia University, New York, USA
1154. Controlled Aggregation of Ferritin for MRI of Actin Polymerization
Kevin M. Bennett1, Erik M. Shapiro2, Christopher H. Sotak3, Alan P. Koretsky1
1National Institutes of Neurological Disease and Stroke, Bethesda, Maryland, USA; 2Yale University, New Haven, Connecticut, USA; 3Worcester Polytechnic University, Worcester, Massachusetts, USA
1155. A Novel Class of Vanadium-Based MRI Contrast Agents Specific for Highly Glycolytic Cancer Cells
Devkumar Mustafi1, Walter J. Liszewski1, Reba Mustafi1, Marc B. Bissonnette1, Elizabeth Peng1, Gregory S. Karczmar1, John W. Ejnik2, Heather Martin2
1The University of Chicago, Chicago, Illinois, USA; 2Northern Michigan University, Marquette, Michigan, USA
1156. A Novel Low Molecular Weight Folate Receptor Targeted Contrast Agent for Magnetic
Resonance Tumour Imaging
Tammy Louise Kalber1, Nazila Kamaly, Mahamoud Omar Hussein, Michael Rael Jorgensen, Po-Wah So1, Jimmy David Bell1, Andrew David Miller
1Hammersmith Hospital, Imperial College London, London, UK
1157. Folate Targeted Paramagnetic Liposomes for Magnetic Resonance Tumour Imaging
Nazila Kamaly1, Tammy Louise Kalber2, Maya Thanou1, Po-Wah So2, Jimmy David Bell2, Andrew David Miller1
1Imperial College London, London, UK; 2Hammersmith Hospital, Imperial College London, London, UK
1158. Collagen Binding MR-Detectable Liposomes
H. M.H.F. Sanders1, Maarten Merkx1, Anita Mol1, Willem J. Mulder, 12, Gustav J. Strijkers1, Klaas Nicolay1
1Eindhoven University of Technology, Eindhoven, Netherlands; 2Mount Sinai School of Medicine, New York, USA
1159. Cancer Detection in Mice Using Dendrimeric Gd-Peptide Nucleic Acid-Peptide Molecular Probes
Nariman Amirkhanov1, Mohan Aruva1, Kaijun Zhang1, Ivan Emilov Dimitrov2, Song Lai1, Christopher Cardi1, Mathew Thakur1, Eric Wickstrom1
1Thomas Jefferson University, Philadelphia, Pennsylvania, USA; 2Philips Medical Systems, Best, Netherlands
1160. Targeting Tumor Cells with Gd(III) Chelates by Means of the Glutamine Transporting System
Alessandro Barge1, 2, Lorenzo Tei3, Simonetta Geninatti Crich4, 5, Rachele Stefanìa4, Michaela Forsterova4, Stefania Lanzardo4, Anna Ciampa4, Giancarlo Cravotto1, Silvio Aime4
1University of Torino, Torino, Italy, Italy; 2CIM - Center for Molecular Imaging, Torino, Italy; 3Università del Piemonte Orientale, Alessandria, Italy, Italy; 4University of Torino, Italy; 5CIM -Center for Molecular Imaging,
1161. MR Contrast Agent Coupled to an Antisense Peptide Nucleic Acid - Cell Penetrating Peptide Conjugate
Joern Engelmann1, Wu Su1, Ritu Mishra1, Josef Pfeuffer2, Karl-Heinz Wiesmueller3, Kamil Ugurbil1, 4
1Max Planck Institute for Biological Cybernetics, Tübingen, Germany; 2Siemens Medical Solutions, Erlangen, Germany; 3EMC Microcollections GmbH, Tübingen, Germany; 4University of Minnesota, Minneapolis, Minnesota, USA
1162. In Vitro Mitochondrial Labeling Using Mito-Carboxy Proxyl (Mito-CP) Enhanced
Magnetic Resonance Imaging
Douglas Edward Prah1, Eric Scott Paulson1, Jacek Zielonka1, Micael J. Hardy1, Joy Joseph1, Balaraman Kalyanaraman1, Kathleen Marie Schmainda1
1Medical College of Wisconsin, Milwaukee, Wisconsin, USA
1163. A New Lectin-Targeted Contrast Agent for MR and Optical Molecular Imaging of Vascular Endothelium
Arvind P. Pathak1, Yoshinori Kato1, Jiangyang Zhang1, Melina Jones1
1The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
1164.
Feasibility of cNGR Labeled Paramagnetic Quantum Dots for
Molecular Magnetic
Resonance Imaging and Two Photon Laser Scanning Microscopy of
Neovascularization
Marlies Oostendorp1, 2, Kim Douma2, Bram J. Stelt2, Tilman M. Hackeng2, Anouk Dirksen2, Marc A. van Zandvoort2, Mark J. Post2, Walter H. Backes1, 2
1Maastricht University Hospital, Maastricht, Netherlands; 2Maastricht University, Maastricht, Netherlands
1165. A Novel Gd-Based MRI Contrast Agent Responsive to the Factor XIII Transglutaminase Activity
Lorenzo Tei1, 2, Alessandro Barge, 2, Dario Longo, 2, Linda Chaabane3, Luigi Miragoli3, Vito Lorusso3, Giancarlo Cravotto, Silvio Aime, 2
1University of Eastern Piedmont, Alessandria, Italy; 2CIM – Center for Molecular Imaging, University of Torino, Torino, Italy; 3Bracco Imaging S.p.A., Milano, Italy
1166. A New Bio-Activated Paramagnetic Gadolinium(III) Complex [Gd(DOTA-FPG)] for Tracing Gene Expression
Yun-Ming Wang1, Yu-Ton Chang1, Yu-Zheng Su1, Tian-Lu Cheng1, Jui-Sheng Hsu2, Gin-Chung Liu, 13
1Kaohsiung Medical University, Kaohsiung, Taiwan; 2Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan; 3Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
1167. Novel Solubility Switch Contrast Agents: In Vivo Detection of MMP-7 Activity
Martin Lepage1, William C. Dow2, Marco Melchior2, Ying You2, Barbara Fingleton3, C Chad Quarles4, John C. Gore4, Lynn M. Matrisian3, J Oliver McIntyre3
1Université de Sherbrooke, Sherbrooke, Québec, Canada; 2Alerion Biomedical Inc., San Diego, California, USA; 3Vanderbilt University, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA; 4Vanderbilt University, Nashville, Tennessee, USA
1168. Quantification of Release of Thermosensitive Liposome-Encapsulated Gadodiamide
Tungte Wang1, Martin Hossann1, Herbert M. Reinl1, Michael Peller1, Maximilian Reiser1, Rolf D. Issels1, Lars H. Lindner1
1University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Bavaria, Germany
1169. A Novel Generation of Concentration Independent Gd(III)-Based MRI Responsive Agents
Enzo Terreno1, Alberto Bert1, Mauro Botta2, Walter Dastrù1, Alberto Sanino1, Silvio Aime1
1University of Torino, Torino, Italy; 2University Eastern Piedmont, Alessandria, Italy
1170. Towards the Detection of Hepatocellular Carcinoma with a pH-Responsive Dendritic MRI Contrast Agent
Md. Meser Ali1, Mark D. Pagel1
1Case Western Reserve University, Cleveland, Ohio, USA
1171. Increased Sensitivity of 19F MR of Perfluoro-Emulsions Using Lanthanide Chelates for T1 Shortening
Rolf Lamerichs1, René Wegh1, Dirk Burdinski1, Sander Langereis1, Holger Grüll1
1Philips Research, Eindhoven, Netherlands
1172. Selectively Dissolvable Manganese/Alginate Microcapsules for Novel Drug Delivery
Strategies and Positive Contrast Imaging at 3T
Partha Hota1, Brad P. Barnett1, Yahel Har-el1, Pitor Walczak1, D Qian1, H B. Na2, J. H. Lee3, K An2, T. Hyeon2, George Sgouros1, Jeff W. Bulte1, Philippe Gailloud1, Aravind Arepally1
1The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; 2Seoul National University, Republic of Korea; 3Sungkyunkwan University School of Medicine, Republic of Korea
1173. In Vivo Molecular MRI of Mouse Embryonic Stem Cell Viability
Phillip C. Yang1, Esther Xie1, Pratima Kundu1, William Stein1, Micha Drukker1, Irving Weissman1, Joseph Wu1, Robert Robbins1
1Stanford University, Stanford, California, USA
1174. A New Route to Cellular Labelling
Eliana Gianolio1, Silvio Aime1, Giovan Battista Giovenzana2, Simonetta Geninatti Crich1, Anna Ciampa1
1University of Torino, Torino, Italy, Italy; 2Università del Piemonte Orientale “A. Avogadro”,
1175. Manganese Oxide (MnO) Nanoparticles as a New T1 Contrast Agent for MRI
Hyon Bin Na1, Jung Hee Lee2, Kwangjin An1, In Su Lee3, Yong Il Park1, Sung Tae Kim2, Sun-Ok Kim4, Taeghwan Hyeon1
1School of Chemical and Biological Engineering, Seoul, Republic of Korea; 2Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; 3Kyunghee University, Yongin, Republic of Korea; 4Samynag R&D Center, Daejeon, Republic of Korea
1176. A Novel Generation of Improved LIPOCEST MRI Agents with Highly Shifted Intraliposomal Water Protons
Daniela Delli Castelli1, Claudia Cabella2, Carla Carrera1, Roberta Mazzon2, Simona Rollet1, Joseph Stancanello2, Enzo Terreno1, Massimo Visigalli2, Silvio Aime1
1University of Torino, Torino, Italy; 2CRM Bracco Imaging S.p.A., Colleretto Giacosa (TO), Italy
1177. pH Measurement with a MRI-PARACEST Contrast Agent: Nd-DOTAM-Gly-Lys
Alex Xuexin Li1, 2, Craig K. Jones1, Mojmir Suchy2, Filip Wojciechowski2, Robert H.E. Hudson2, Ravi S. Menon1, 2, Robert Bartha1, 2
1Robarts Research Institute, London, Ontario, Canada; 2The University of Western Ontario, London, Ontario, Canada
1178. A New MRI PARACEST Agent for Sensing Glucose
Jimin Ren1, Eul Hyun Suh1, Zoltan Kovacs1, 2, Allen Dean Sherry1, 2
1University of Texas, Southwestern Medical Center, Dallas, Texas, USA; 2University of Texas at Dallas, Richardson, Texas, USA
1179. Detection of MRI Contrast Based on Chemical Exchange Saturation Transfer (CEST) in the
Presence of the T2/T2* Contrast Agent Feridex
Assaf A. Gilad1, Hanneke W.M. van Laarhoven2, Michael T. McMahon1, 3, Piotr Walczak1, Arend Heerschap2, Michal Neeman4, Peter C.M. van Zijl1, 3, Jeff W.M. Bulte1
1Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; 2Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 3Kennedy Krieger Institute, Baltimore, Maryland, USA; 4The Weizmann Institute of Science, Rehovot, Israel
1180. Multi-Colored Nano-CEST MRI Contrast Particles for Cell Imaging
Michael T. McMahon1, 2, Yahel Har-el1, Assaf A. Gilad1, Jason M. Zhao1, George Sgouros1, Jeff W.M. Bulte1, Peter C.M. vanZijl1, 2
1Johns Hopkins School of Medicine, Baltimore, Maryland, USA; 2Kennedy Krieger Institute, Baltimore, Maryland, USA
1181. A PARACEST MRI Contrast Agent That Detects Esterase Enzymes
Yuguo Li1, Guanshu Liu1, Mark D. Pagel1
1Case Western Reserve University, Cleveland, Ohio, USA
1182. Towards ParaCEST MRI Contrast Agents Without Coordinated Water: Lanthanide
Complexes of Novel Acetamido-Substituted Diethylenetriamine- And Triethylenetetramine Ligands
Dirk Burdinski1, Johan Lub1, Jeroen A. Pikkemaat1, René T. Wegh1, Holger Grüll1, Lidia Nieto Garrido1, Séverine G. Girard1, Sophie Martial1, Carolina Del Pozo Ochoa1, Diana Moreno Jalón1, Thomas Weyhermüller2
1Philips Research Europe, Eindhoven, Netherlands; 2Max Planck Institute for Bioinorganic Chemistry, Mülheim a. d. Ruhr, Germany
Molecular Imaging Applications
Hall 14.1 Monday 14:00 - 16:00
1183. T2* Quantification Can Differentiate Alzheimer’s Plaques Burden Following Anti-Amyloid Therapy
Youssef Zaim Wadghiri1, Moustafa Douadi1, Henrieta Scholtzova1, Thomas Wisniewski1
1NYU School of Medicine, New York, USA
1184. In Vivo MR Imaging of Human Glioblastoma Cell Derived Tumor by Using Anti MT1-MMP
Antibody Conjugated Ultrasmall Superparamagnetic Iron Oxides (USPIOs)
Bo-Hyung Park1, Jae-Chang Chung1, Man-Il Huh1, Young-Ju Lee1, In-Seong Kim1, Joo-Hyun Kim1, Yongmin Chang, 12
1Kyungpook National University, Daegu, Republic of Korea; 2Kyungpook National University Hospital, Daegu, Republic of Korea
1185. Targeted Imaging of Breast Cancer Brain Metastasis Using Antibody Labeled Manganese
Oxide (MnO) Nanoparticles
Yoo Jeong Yim1, Hyon Bin Na2, Ji-Sun Baek1, Yong Il Park2, Kwangjin An2, Do-Hyun Nam1, Sung Tae Kim1, Keun-Ho Lim3, Jung Hee Lee1, Taeghwan Hyeon2
1Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; 2School of Chemical and Biological Engineering, Seoul, Republic of Korea; 3Asan Institutes for Life Science, University of Ulsan, Seoul, Republic of Korea
1186. In Vivo Characterization of the Pharmacokinetics of Perfluorocarbon Nanoparticles in a Mouse
Model Using 19F MRS
Jacob Wheatley Myerson1, Xiaoxia Yang1, Anne Morawski Neubauer1, Emily Alex Waters1, Greg M. Lanza1, Samuel A. Wickline1, Junjie Chen1
1Washinton University, Saint Louis, Missouri, USA
1187. High-Resolution 3D MRI Mapping of Tumor Angiogenesis Using α 5β 1-Targeted
Perfluorocarbon Nanoparticles
Anne H. Schmieder1, Todd A. Williams1, John S. Allen1, Grace Hu1, Huiying Zhang1, Shelton D. Caruthers1, 2, Samuel A. Wickline1, Gregory M. Lanza1
1Washington University Medical School, St. Louis, Missouri, USA; 2Philips Medical Systems, Cleveland, Ohio, USA
1188. Use of Highly Sensitive Dual Probes Gd-Liposome and Gd-Loaded Apoferritin for
Targeting Tumor Angiogenesis for MR-Visualization and Drug Delivery
Lorenzo Tei1, 2, Simonetta Geninatti Crich, 2, Benedetta Bussolati, Anna Ciampa, 2, Cristina Grange, Diego Alberti, 2, Stefania Lanzardo, 2, Giovanni Camussi, Silvio Aime, 2
1University of Eastern Piedmont, Alessandria, Italy; 2CIM – Center for Molecular Imaging, University of Torino, Torino, Italy
1189. Investigation of a Carcinoma-Specific SPIO-Antibody Conjugate for MR Visualisation of Epithelial Tumours
Panagiotis Kyrtatos1, Kim Vigor2, Jack Wells1, Kenneth Cheung1, David G. Gadian1, Kerry Chester2, Mark Lythgoe1
1UCL Institute of Child Health, London, UK; 2Royal Free and University College Medical School, London, UK
1190. Magnetic Resonance Imaging of Delivery Multifunctional Liposomes with Novel Peptide
Ligand Targeted to Breast Cancer Vasculature
Maria Mikhaylova1, Amin Hajitou2, Saraswati Sukumar3, Yoshinori Kato1, Dmitri Artemov1, Wadih Arap2, Renata Pasqualini2, Zaver M. Bhujwalla1
1JHU ICMIC Program, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; 2The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA; 3Johns Hopkins University, Breast Cancer Program, Baltimore, Maryland, USA
1191. Molecular Magnetic Resonance Imaging (MRI) of Surface-Epithelial-Derived Protein
CA125 in Human Ovarian Carcinoma Cells Using Superparamagnetic Immunomicelles
Brian A. Larsen1, Kristen M. Scaff2, Michael A. Haag1, Natalie J. Serkova2, Kenneth R. Shroyer2, Conrad R. Stoldt1
1University of Colorado, Boulder, Colorado, USA; 2University of Colorado Health Science Center, Denver, Colorado, USA
Molecular Imaging: Imaging of Cell Migration
Hall 14.1 Monday 14:00 - 16:00
1192. Iron Oxide Labeling of Primary Rat Monocytes Using Magneto Electroporation
Raoul David Oude Engberink1, Piotr Walczak2, H E. de Vries3, Erwin L. Blezer1, Jeff Bulte2
1University Medical Center Utrecht, Utrecht, Netherlands; 2Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; 3VU Medical center, Amsterdam, Netherlands
1193. Magnetofection Accelerates the Loading of SPIO Nanoparticles for MRI Cell Tracking
Amit S. Marwah1, Richard G. Spencer1, Kenneth W. Fishbein1
1National Institutes of Health, Baltimore, Maryland, USA
1194. Cancer Cells Induce Lymphatic Endothelial Cell Migration
Maria Mikhaylova1, Noriko Mori1, Barjor Gimi2, Piotr Walczak3, Jeff W. M. Bulte3, Arvind P. Pathak1, Zaver M. Bhujwalla1
1JHU ICMIC Program, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; 2University of Texas Southwestern Medical Center, Dallas, Texas, USA; 3Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
1195. MRI Quantification of USPIO-Labeled Cell Density and Number
Jerry Shing Chung Cheung1, April M. Chow1, Hung Fat Tse1, Ed Xuekui Wu1
1The University of Hong Kong, Pokfulam, Hong Kong
1196. Electrophysiological Properties of the Effect of USPIO-Labeling on Embryonic Stem Cells
April Mei Kwan Chow1, Yau-Chi Chan2, Yee-Man Lau2, Jerry Shing Chung Cheung1, Tracy Yee Mau Chow1, Hung-Fat Tse2, Ed Xuekui Wu1
1The University of Hong Kong, Pokfulam, Hong Kong; 2The University of Hong Kong, Hong Kong
1197. Efficiency of Cell Labeling with Different Perfluoro-15-Crown-5 Ether Nanoparticles for 19F MRI
Jesus Ruiz-Cabello1, 2, Piotr Walczak3, Vadappuram P. Chacko3, Dorota A. Kedzioreck3, Anne H. Schmieder4, Sam A. Wickline4, Gregory M. Lanza4, Jeff W.M. Bulte3
1Johns Hopkins University Medical School, Baltimore, Maryland, USA; 2Universidad Complutense Madrid, Spain; 3Johns Hopkins University Medical School, Maryland, USA; 4Washington University Medical School, Missouri, USA
1198. Manganese Guided Cellular MRI of Human Embryonic Stem Cell Viability
Mayumi Yamada1, Pratima Kundu1, Micha Drukker1, Irving L. Weissman1, Robert C. Robbins1, Phillip C. Yang1
1Stanford University, Stanford, California, USA
1199. Migration of SPIO Labled EPCs and Angiogenic Factors
Ali S. Arbab1, Robert A. Knight2, ASM Iskander1, Ali M. Rad1, Stasia A. Anderson3, Sunil D. Pandit3, Elizabeth J. Read3, Joseph A. Frank3
1Henry Ford health System, Detroit, Michigan, USA; 2Henry Ford Health System; 3National Institutes of Health,
1200. Microcapsules Used in Cell Based Therapy Were Designed for Post Implantation Tracking
Barjor Gimi1, 2, Timothy Leong3, David Gracias3, Zaver M. Bhujwalla2
1The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA; 2The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; 3Johns Hopkins University, Baltimore, Maryland, USA
1201. Fluorine-19 MRI for Visualization and Quantification of Cell Migration in a Diabetes Model
Mangala Srinivas1, Penelope A. Morel2, Lauren A. Ernst1, Jelena Janjic1, Deepak Kadayakkara1, David H. Laidlaw3, Eric T. Ahrens1
1Carnegie Mellon University, Pittsburgh, Pennsylvania, USA; 2University of Pittsburgh, Pittsburgh, Pennsylvania, USA; 3Brown University, Providence, Rhode Island, USA
1202. Magnetically Labeled Sensitized Splenocytes to Identify Glioma by MRI
Ali S. Arbab1, Ali M. Rad1, ASM Iskander1, Kourosh Jafari-Khouzani1, Stephen L. Brown1, Guangliang Ding1, Jiang Quan1, Hamid Soltanian-Zadeh1, Donald J. Peck1
1Henry Ford Health System, Detroit, Michigan, USA
1203. In Vivo Cell Tracking Using Micron-Sized Iron Oxide Particle (MPIO) Labeling in Rat Model of
Liver Tumor Metastasis
Jerry Shing Chung Cheung1, April M. Chow1, Kwan Man1, S F. Fan1, Ed Xuekui Wu1
1The University of Hong Kong, Pokfulam, Hong Kong
1204. Cellular MRI of Monocyte Infiltration: In Vitro Vs In Vivo Labeling
Raoul David Oude Engberink1, Erwin L. Blezer1, Erik I. Hoff2, Susanne van der Pol3, H E. de Vries3
1University Medical Center Utrecht, Utrecht, Netherlands; 2Department of Neurology, Maastricht, Netherlands; 3VU Medical center, Amsterdam, Netherlands
1205. In Vivo Identification of Iron-Marked Cells in the Heart by Gadolinium-Enhanced MRI in a
Single Breath-Hold
Dirk Cleppien1, Georg Horstick1, Angelica Karpi1, Marion Bug1, Nico Abegunewardene1, Marcus Vosseler1, Wolfgang Schreiber1
1Mainz University Medical School, Mainz, Germany
1206. Track Brain Tumor Growth by MRI and Planar Bioluminescence Imaging
Kemi Cui1, Xiaoyin Xu1, Kelvin Wong1, Hong Zhao2, Jinmin Zhu3, Santosh Kesari2, Stephen TC Wong2, 4
1Brigham and Women's Hospital, Boston, Massachusetts, USA; 2Brigham and Women's Hospital, Massachusetts, USA; 3Harvard Medical School, Boston, Massachusetts, USA; 4Harvard Medical School, Massachusetts, USA
1207. Longitudinal Detection of Neuronal Stem Cells Labeled with Two Types of Iron Oxide Particles
Sergey Magnitsky1, Evangelia I. Zacharaki1, Ragini Verma1, Raquel M. Walton1, John H. Wolfe1, 2, Harish Poptani1
1University of Pennsylvania, Philadelphia, Pennsylvania, USA; 2Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
1208. Pancreatic Islet Graft Monitoring by Magnetic Resonance Imaging in Non-Human Primates
Prashanth Vallabhajosyula1, Zdravka Medarova1, Bruce Jenkins1, Natalia Evgenov1, Atsushi Hirakata1, Kazuhiko Yamada1, David Sachs1, Anna Moore1
1Massachusetts General Hospital, Charlestown, Massachusetts, USA
1209. Clinical Field-Strength MRI of Transplanted Pancreatic Islets in a Large Animal Model
Zdravka Medarova1, Prashanth Vallabhajosyula1, Bruce Jenkins1, Natalia Evgenov1, Atsushi Hirakata1, Kazuhiko Yamada1, David Sachs1, Anna Moore1
1Massachusetts General Hospital, Charlestown, Massachusetts, USA
1210. MRI and PET Dual Detection of Embryonic Stem Cells Grafted in the Myocardium
Hualei Zhang1, Hui Qiao1, Datta Ponde1, Fabao Gao1, Hank Kung1, Victor Ferrari1, Rong Zhou1
1University of Pennsylvania, Philadelphia, Pennsylvania, USA
1211. In Vivo Labeling of Adult Neural Progenitors with Micron Sized Particles of Iron Oxide:
Quantitation of Labeled Cell Type
James P. Sumner1, Erik M. Shapiro2, Dragan Maric1, Alan P. Koretsky1
1NINDS, Bethesda, Maryland, USA; 2Yale University School of Medicine, New Haven, Connecticut, USA
1212. Longitudinal Tracking of Recipient Macrophages in Chronic Cardiac Rejection with
Non-Invasive In Vivo MRI Using Micrometer-Sized Paramagnetic Iron Oxide (MPIO) Particles
Qing Ye1, Yijen Lin Wu1, Lesley M. Foley1, T Kevin Hitchens1, Haval Shirwan2, Chien Ho1
1Carnegie Mellon University, Pittsburgh, Pennsylvania, USA; 2University of Louisville, Louisville, Kentucky, USA
1213. Novel Radiopaque and MR-Visible Intracellular Contrast Agents for Cell-Tracking and
Viability Enhancement of Human Pancreatic β-Islets
Partha Hota1, Brad P. Barnett1, Jesus Ruiz-Cabello1, Cal Lauzon1, Piotr Walczak1, Vadappuram P. Chacko1, Aravind Arepally1, Jeff WM Bulte1
1The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
1214. IIn Vivo Cell Tracking 19F MRI using Perfluorocrown Ether Nanoparticles
Jesus Ruiz-Cabello1, 2, Piotr Walczak1, Vadappuram P. Chacko1, Dorota A. Kedzioreck1, Anne H. Schmieder3, Sam A. Wickline3, Gregory M. Lanza3, Jeff W.M. Bulte1
1Johns Hopkins University Medical School, Baltimore, Maryland, USA; 2Universidad Complutense Madrid, Madrid, Spain; 3Washington University Medical School, Missouri, USA
1215. Detection of Reactive Gliosis Using Manganese-Enhanced MRI (MEMRI)
Yuko Kawai1, Ichio Aoki2, Noriko Matsumoto1, Masahiro Umeda1, Toshihiro Higuchi1, Jeff Kershaw2, Afonso C. Silva3, Chuzo Tanaka1
1Meiji University of Oriental Medicine, Kyoto, Japan; 2National Institute of Radiological Sciences, Chiba, Japan; 3NIH,
1216. Positive Contrast MRI of Magnetically Labeled Human Cervical Carcinoma Cells and Tumor Monitoring
Young Beom Kim1, Ki Hyun Bae1, Seung-Schik Yoo2, Tae Gwan Park1, HyunWook Park1
1Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea; 2Harvard Medical School, Boston, Massachusetts, USA
1217. In Vivo Tracking of Solitary Cells as a Tool for Comparing the Behaviour of Two
Metastatically-Distinct Cell Lines in a Mouse Model of Breast Cancer Metastasis to the Brain
Soha Said Ramadan1, 2, Lisa T. MacKenzie2, 3, Diane Palmieri4, Patricia S. Steeg4, Ann F. Chambers2, 3, Brian K.
Rutt1, 2, Paula J. Foster1, 2
1Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada; 2Medical Biophysics, University of Western Ontario, London, Ontario, Canada; 3London Regional Cancer Centre, London, Ontario, Canada; 4Women’s Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, Bethesda, Maryland, USA
1218. In Vivo MR Imaging of the Evolution of the Immune Response in Type 1 Diabetes Progression
Zdravka Medarova1, Bingue Han2, Pere Santamaria2, Natalia Evgenov1, Anna Moore1
1Massachusetts General Hospital, Charlestown, Massachusetts, USA; 2Julia McFarlane Diabetes Research Center, Calgary, Alberta, Canada
1219. In Vivo Detection, Tracking and Quantitation of SPIO-Labeled Dendritic Cells in the
Mouse Lymphatic System
Jonatan Snir1, Brad Shrum1, Elizabeth Dunn1, Brian K. Rutt1, Greg Dekaban1, Peta O'Connell1, Paula J. Foster1
1Robarts Research Institute, London, Ontario, Canada
1220. Stroma Fibroblasts are Recruited Systemically to Contribute to the Tumor Angiogenic Rim:
Cell Tracking by MRI and Two Photon Microscopy
Dorit Granot1, Yoseph Addadi1, Vyacheslav Kalchenko1, Michal Neeman1
1Weizmann Institute of Science, Rehovot, Israel
1221. Iron Oxide Incorporation for Cell Tracking Does Not Prevent Osteogenic, Chondrogenic or
Adipogenic Differentiation of Mesenchymal Stem Cells But Does Affect Extracellular
Matrix Patterns and Gene Expression
Eric Farrell1, 2, Piotr A. Wielopolski1, Holger Jahr1, Jan Verhaar1, Harrie Weinans1, Gabriel P. Krestin1, Fergal J. O'Brien3, Patrick J. Prendergast2, Gerjo J.V.M. van Osch1, Monique R. Bernsen1
1Erasmus MC, Rotterdam, Netherlands; 2Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Ireland; 3Royal College of Surgeons in Ireland, Dublin, Ireland
1222. Cellular MRI of Neural Stem Cell Therapy in a Rat Glioma Model
Cecilie Brekke1, 2, Jasdeep Sandhu2, Andrew Lowe2, Thomas Meade3, Jack Price2, Steven Williams2, Michel Modo2
1University of Bergen, Bergen, Norway; 2King's College London, London, UK; 3Northwestern University, Chicago, Illinois, USA
1223. In Vivo Morphological and Parametric Analysis of Stem Cell Migration on MRI: Investigation of
Viable and Non-Viable Behavior
Jennifer A. Flexman1, Donna J. Cross1, 2, Takahiro Sasaki1, Yongmin Kim1, Satoshi Minoshima1
1University of Washington, Seattle, Washington, USA; 2University of Michigan, Ann Arbor, Michigan, USA
1224. Optimized MRI Parameters for Positive Contrast Detection of Iron-Oxide Labeled Cells Using
Double-Echo Ultra-Short Echo Time (D-UTE) Sequences
Bram F. Coolen1, 2, Philip Lee1, Borys Shuter3, Xavier Golay1, 4
1Singapore Bioimaging Consortium, Singapore, Singapore; 2Eindhoven University of Technology, Eindhoven, Netherlands; 3National University Hospital, Singapore, Singapore; 4National Neuroscience Institute, Singapore, Singapore
1225. Positive Contrast Imaging of Micron-Sized Iron Oxide Particles
Angus Zoen Lau1, Charles Henry Cunningham1
1University of Toronto, Toronto, Ontario, Canada
1226. Off-Resonance Saturation Method to Enhance SPIO Contrast in Molecular Imaging of Cancer
Jinming Gao1, Chase Kessinger1, Chalermchai Khemtong1, Jimin Ren1, Dean Sherry1
1UT Southwestern Medical Center, Dallas, Texas, USA
1227. Fast Low Angle Positive Contrast Steady-State Free Precession (FLAPS) Imaging: Theory and Experiment
Rohan Dharmakumar1, Ioannis Koktzoglou1, Debiao Li1
1Northwestern University, Chicago, Illinois, USA
1228. Suppression of Large Scale Susceptibility Artifacts in Positive Contrast Images
Hannes Dahnke1, Wei Liu2, Jospeh A. Frank3, Tobias Schaeffter4
1Philips Research Europe, Hamburg, Germany; 2Philips Research North America, Briarcliff, New York, USA; 3National Institutes of Health, Bethesda, Maryland, USA; 4King's College, London, UK
1229. Monitoring the Fate of Iron-Labeled Metastatic Melanoma Cells within the Mouse Lymphatic System
Paula J. Foster1, Elizabeth Dunn1, Alfred Harvey2, Kristina Karl2, Colleen M. Nycz2, Ron J. Pettis2
1Robarts Research Institute, London, Ontario, Canada; 2Becton Dickinson Technologies, Research Triangle Park, North Carolina, USA
Hall 14.1 Monday 14:00 - 16:00
1230. Spatio-Spectral Non-Linear Filtering of Spectroscopic Imaging: Increasing Signal-To-Noise
Ratio While Preserving Spatial and Spectral Structures
Yoshitaka Bito1, Satoshi Hirata1, Yo Taniguchi1, Toru Shirai1, Hisaaki Ochi1
1Hitachi, Ltd., Kokubunji-shi, Tokyo, Japan
1231. High-Resolution Spectroscopic Imaging with Statistical Reconstruction
Justin P. Haldar1, Diego Hernando1, Matthew D. Budde2, Qing Wang2, Sheng-Kwei Song2, Zhi-Pei Liang1
1University of Illinois at Urbana-Champaign, Urbana, Illinois, USA; 2Washington University, St. Louis, Missouri, USA
1232. Self Rewinding Trajectories for Spectroscopic Imaging
Claudiu Schirda1, 2, Fernando Boada2
1University of Pittsburgh, Pittsburgh, Pennsylvania, USA; 2UPMC, Pittsburgh, Pennsylvania, USA
1233. Correcting for Center Frequency Variations in MRSI Data Using the Partially Suppressed Water Signal
Lawrence P. Panych1, 2, Joseph R. Roebuck1, 2, Nan-Kuei Chen1, 2
1Brigham and Women's Hospital, Boston, Massachusetts, USA; 2Harvard Medical School, Boston, Massachusetts, USA
1234. Fast Nosological Imaging of 2DTSI Brain Data Using Canonical Correlation Analysis
Teresa Laudadio1, M. Carmen Martinez-Bisbal2, Bernardo Celda2, Sabine Van Huffel3
1Consiglio Nazionale delle Ricerche, Bari, Italy; 2Universitat de Valencia, Valencia, Spain; 3Katholieke Universiteit Leuven, Leuven, Belgium
1235. A High Spatial Resolution 1H Magnetic Resonance Spectroscopic Imaging Technique for
Breast Cancer with a Short Echo Time
Jiani Hu1, Yingjian Yu1, Quan Jiang2, Yang Xuan1, Tao Li1, vivek Sehgal1, Cassann Blake1, Renate Soulen1
1Wayne State University, Detroit, Michigan, USA; 2Henry Ford Hospital, Detroit, Michigan, USA
1236. Acquisition-Weighted CSI with a Small Number of Scans
Rolf Pohmann1, Kamil Ugurbil1, 2
1Max-Planck-Institute for Biological Cybernetics, Tübingen, Germany; 2University of Minnesota, Minneapolis, Minnesota, USA
1237. Spatially Resolved Measurement of Bone Marrow Fat Content and Unsaturation Index Via
Spectroscopic MR Imaging
Catherine Jones1, Suzanne L. Wehrli2, Jeremy Magland1, Felix W. Wehrli1
1University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA; 2Children's Hospital of Philadelphia, Pennsylvania, USA
1238. Mapping T2 Relaxation Time of Cerebral Metabolites Using Proton-Echo Planar Spectroscopic
Imaging (PEPSI)
Shang-Yueh Tsai1, Stefan Posse2, 3, Yi-Ru Lin4, Cheng-Wen Ko5, Ricardo Otazo3, Hsiao-Wen Chung1, Fa-Hsuan Lin6, 7
1National Taiwan University, Taipei, Taiwan; 2University of New Mexico School of Medicine, Albuquerque, New Mexico, USA; 3University of New Mexico, Albuquerque, New Mexico, USA; 4National Taiwan University of Science and Technology, Taipei, Taiwan; 5National Sun Yat-Sen University, Kaohsiung, Taiwan; 6MGH-HMS-MIT Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA; 7Massachusetts General Hospital, Boston, Massachusetts, USA
1239. Improved Coverage of Brain Tumors with 1H MRSI Using Cosine Modulated Very Selective
Suppression Pulses at 3T
Joseph Anthony Osorio1, Duan Xu1, Charles H. Cunningham2, Albert P. Chen1, John M. Pauly3, Daniel B. Vigneron1, Sarah J. Nelson1
1University of California, San Francisco, San Francisco, California, USA; 2University of Toronto, Toronto, Ontario, Canada; 3Stanford University, Palo Alto, California, USA
1240. Spectroscopic Imaging of the Knee Using an Interleaved Ultrashort TE (UTE) Sequence
Jiang Du1, Gavin Hamilton1, Atsushi Takahashi2, Sinha Shantanu1, Christine B. Chung1
1University of California, San Diego, San Diego, California, USA; 2GE Healthcare Technologies, Meno Park, California, USA
1241. 3-D MRSI of Patients with Gliomas Using a 7T Whole Body MR Scanner
Sarah J. Nelson1, Duan Xu1, Kathryn E. Hammond1, Janine M. Lupo1, Albert P. Chen1, Charles H. Cunningham2, Douglas A C Kelley3, Susan M. Chang1, John M. Pauly4, Daniel B. Vigneron1
1University of California, San Francisco, California, USA; 2University of Toronto, Toronto, Ontario, Canada; 3GE Healthcare, San Francisco, California, USA; 4Stanford University, Palo Alto, California, USA
1242. A Magnetic Resonance Spectroscopic Imaging (MRSI) Mapping Technique for Radiotherapy Planning
Roberto Garcia-Alvarez1, 2, Gary Liney1, David Manton1, Lindsay Turnbull1
1University of Hull, Hull, UK; 2GE Healthcare, Madrid, Spain
1243. Fast 3D Proton MR Spectroscopic Imaging of the Human Prostate In Vivo at 3 Tesla Using
"Spectroscopic Missing Pulse – SSFP"
Christian Schuster1, 2, Tom Scheenen3, Wolfgang Dreher1, 2, Thomas Hambrock3, Arend Heerschap3,
Dieter Leibfritz1, 2
1University of Bremen, FB 2 (Chemistry), Bremen, Germany; 2Center of Advanced Imaging (CAI), Bremen, Germany; 3Radiology (667), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
1244. Removal of Lipid Nuisance Signals in MRSI Using Spatial-Spectral Constraints
Diego Hernando1, Justin Haldar1, Bradley Sutton1, Zhi-Pei Liang1
1University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
1245. Fat Suppression for 1H MRSI at 7T Using a Spectrally Selective Adiabatic Inversion Pulse
Priti Balchandani1, Daniel Spielman1
1Stanford University, Stanford, California, USA
1246. Simultaneous Acquisition of Short and Long Echo Time Spectra of the Mouse Brain Using
Proton Magnetic Resonance Spectroscopic Imaging at 11.75 T
Pierre Larvaron1, Yann Le Fur1, Sylviane Confort-Gouny1, Patrick J Cozzone1, Angèle Viola1
1Centre de Résonance Magnétique Biologique et Médicale, UMR CNRS 6612, Marseille, France
1247. Short-TE Proton Spectroscopic Imaging of the Neurochemical Profile in the Rat Brain at 1 μl Resolution
Vladimir Mlynarik1, Giulio Gambarota1, Ingrid Kohler1, Rolf Gruetter1, 2
1Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; 2Universities of Lausanne and Geneva, Switzerland
1248. High-Resolution LASER-Localized Chemical Shift Imaging in the Rat Brain at 9.4 T
Julien Valette1, Christopher Nelson1, Isabelle Iltis1, Kamil Ugurbil1, Pierre-Gilles Henry1
1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA
1249. Chemical Shift Independent Imaging of 19F Contrast Agents Using Ultrafast MRSI (F-uTSI)
Muhammed Yildirim1, 2, Jochen Keupp3, Klaas Nicolay2, Rolf Lamerichs1
1Philips Research, Eindhoven, Netherlands; 2Eindhoven University of Technology, Eindhoven, Netherlands; 3Philips Research, Hamburg, Germany
1250. Fast Spatial-Spectral Imaging of Hyperpolarized 13C Compounds Using Partial-Fourier
Multiple Echo 3DFIESTA
William H. Perman, Ph.D. 1, Pratip Bhattacharya2, 3, Alex Lin2, Jan Hovener, 24, Kent Harris2, Eduard Chekmenev2, Valerie A. Norton3, Daniel P. Weitekamp3, Brian D. Ross2
1Saint Louis University School of Medicine, St. Louis, Missouri, USA; 2Huntington Medical Research Institutes, Pasadena, California, USA; 3California Institute of Technology, Pasadena, California, USA; 4German Cancer Research Institute (DKFZ), Heidelberg, Germany
1251. Combination of Proton MRSI of the Brain Acquired Using a Multichannel Coil Without Water Suppression
Zhengchao Dong1, 2, Bradley Peterson1, 2
1Columbia University, New York, New York, USA; 2New York State Psychiatric Institute, New York, New York, USA
1252. Fast Chemical Shift Imaging with Ultra Short Echo Time
Yingli Yang1, Qi Zhao1, Srirama V. Swaminathan, 12, Stefan Fischer2, Truman R. Brown1
1Columbia University, New York, New York, USA; 2Philips Medical Systems, Cleveland, Ohio, USA
Hall 14.1 Monday 14:00 - 16:00
1253. Comparison of Spin Echo and Balanced Steady State Free Precession in MR-Elastography -
A First Step to Cardiac MR-Elastography
Benjamin Robert1, Ralph Sinkus1, Mickael Tanter1, Mathias Fink1
1Laboratoire Ondes et Acoustique, Paris, France
1254. In Vivo and In Vitro 7T MR Elastography with Parallel Imaging
Stefan Maderwald1, 2, Oliver Kraff, 12, Armin de Greiff, 12, Michael O. Zenge, 12, Frank Stock2, Titus Lanz3, Mark E. Ladd, 12
1University Duisburg-Essen, Essen, Germany; 2University Hospital Essen, Essen, Germany; 3RAPID Biomedical GmbH, Würzburg, Germany
1255. High Resolution MR-Elastography of In-Vivo Rat Brain – Understanding the
Scaling Behaviour of the Structures
Benoit Larrat1, Ralph Sinkus1, Mickael Tanter1, Mathias Fink1
1Laboratoire Ondes et Acoustique, Paris, France
1256. Direction Dependent Overestimation of Local Wavelengths in MR Elastography by Discretized
Helmholtz Inversion
Uwe Hamhaber1, Sebastian Papazoglou2, Ingolf Sack2, Dieter Klatt2, Jens Rump2, Jürgen Braun1
1Charité -Universitätsmedizin Berlin, Berlin, Germany; 2Charité - Universitätsmedizin Berlin, Berlin, Germany
1257. Vibration Safety Limits for Magnetic Resonance Elastography
Eric Ehman1, Phillip Rossman, Scott Kruse2
1Mayo Clinic, Rochester, Minnesota, USA; 2Mayo Clinic, Minnesota
1258. Position Dependent Shear Wave Group Velocities in In Vivo Human Biceps Muscle
Sebastian Papazoglou1, Uwe Hamhaber2, Jens Rump1, Dieter Klatt1, Jürgen Braun2, Ingolf Sack1
1Charité Berlin, Berlin, Germany; 2Charité, Berlin, Berlin, Germany
1259. Assessing the Mass Effect of Tumors on Adjacent Tissue: Initial Feasibility Study in a Phantom Model
Kevin Glaser1, Jose Pulido1, Richard Ehman1
1Mayo Clinic, Rochester, Minnesota, USA
1260. Reproducibility of Shear Modulus Estimates in Clinical Steady State MR Elastography
John Weaver1, Timothy Miller2, Phillip Perrinez2, Marvin Doyley2, Huifang Wang2, Yvonne Cheung1, Francis Kennedy2, Keith Paulsen2
1Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA; 2Dartmouth College, Hanover, New Hampshire, USA
1261. A Preliminary MR Elastography Database of In Vivo Human Brain Viscoelasticity
Bernd Beierbach1, Jens Würfel1, Jens Rump1, Sebastian Papazoglou1, Dieter Klatt1, Uwe Hamhaber1, Jürgen Braun1, Ingolf Sack1
1Charité - Universitätsmedizin Berlin, Berlin, Germany
1262. MR Elastography of the Eye: Initial Feasibility
Daniel V. Litwiller1, Jose S. Pulido2, Scott A. Kruse2, Kevin J. Glaser2, Richard L. Ehman2
1Mayo Clinic College of Medicine, Rochester, Minnesota, USA; 2Mayo Clinic, Rochester, Minnesota, USA
Hyperpolarized Noble Gas Imaging
Hall 14.1 Monday 14:00 - 16:00
1263. 129Xe Polarizer Commercial Prototype
Stephen Ketel1, Jeffrey Ketel2, Jan Distelbrink2, Walt Porter2, Korac MacArthur1, John Brackett2, Dianna Muth1, Aaron Hope2, F William Hersman1, 2
1University of New Hampshire, Durham, New Hampshire, USA; 2Xemed LLC., Durham, New Hampshire, USA
1264. Automated Hyperpolarized 129Xe Gas Generator for Biomedical MRI/MRS Applications
Mineyuki Hattori1, Tomokazu Numano1, Kazuhiro Homma1, Takashi Hiraga2, Morio Murayama3, Norio Ohtake3
1National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan; 2National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan; 3Toyoko Kagaku Co. Ltd., Kawasaki, Kanagawa, Japan
1265. Scaling Up 129Xe Hyperpolarization - A Diagnostic Tools System
Isabel Maria Anna Dregely1, Iulian C. Ruset1, Edward J. Kotkowski1, F. William Hersman1
1University of New Hampshire, Durham, New Hampshire, USA
1266. Scaling-Up 129Xe Hyperpolarization - Theoretical Modeling
Iulian C. Ruset1, 2, F. W. Hersman1, 2, Robert Carrier1, Silviu Doru Covrig1, Adrian Sindile1, Jan Distelbrink2
1University of New Hampshire, Durham, New Hampshire, USA; 2XEMED, Durham, New Hampshire, USA
1267. An Economical Laboratory-Scale System for Purifying 3He
Robert Cadman1, Stephen Kadlecek1, James Baumgardner2, Chris Cox1, John MacDuffie Woodburn1, Sheeva Rajaei1, Vahid Vahdat1, Kiarash Emami1, Jiangsheng Yu1, Masaru C. Ishii3, Rahim Rizi1
1University of Pennsylvania, Philadelphia, Pennsylvania, USA; 2Oscillogy LLC, Folsom, Pennsylvania, USA; 3Johns Hopkins University, Baltimore, Maryland, USA
1268. A Robust Transmitter Calibration Procedure for NMR of Hyperpolarized Nuclei
G Wilson Miller1, Michael Carl2, Eduard E. de Lange1, Talissa A. Altes1, Gordon D. Cates, 12, William Alexander Tobias2, John P. Mugler III1
1University of Virginia School of Medicine, Charlottesville, Virginia, USA; 2University of Virginia, Charlottesville, Virginia, USA
1269. Direct Molecular Solution of Hyperpolarized 129Xe Through Hollow Fiber Membranes
Jörg Schmiedeskamp1, Paul Philipp Zänker1, Rodolfo Hector Acosta2, Luis Agulles Pedros1, Peter Blümler3, Horst Dieter Lemke4, Florian M. Meise5, Wolfgang G. Schreiber5, Hans Wolfgang Spiess1
1Max Planck Institute for Polymer Research, Mainz, Germany; 2 Universidad Nacional de Cordoba, Cordoba, Argentina; 3Research Centre Jülich, Jülich, Germany; 4Membrana GmbH, Obernburg, Germany; 5Mainz University Medical School, Mainz, Germany
1270. Optimum Ventilation Mixture Ratio for Maximizing Hyperpolarized 129Xe MR Brain Signal
Xin Zhou1, Yang-Sheng Tzeng1, 2, Joey K. Mansour1, Mary L. Mazzanti1, Yanping Sun1, Mitchell S. Albert1
1Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; 2Boston University, Boston, Massachusetts, USA
1271. Comparison of 129Xe Pulmonary Gas Exchange Measured by Two Techniques: XTC and CSSR
Iga Muradian1, 2, Mirko Hrovat3, James Butler4, Christina Johnson1, 2, F. William Hersman1, Samuel Patz2
1University of New Hampshire, Durham, New Hampshire, USA; 2Brigham and Women's Hospital, Boston, Massachusetts, USA; 3Mirtech, Inc., Brockton, Massachusetts, USA; 4Harvard School of Public Health, Boston, Massachusetts, USA
1272. Detecting Emphysematous Lung in a Rabbit Model Using XTC MRI
Kai Ruppert1, Jaime F. Mata2, Jing Cai2, Talissa A. Altes3, Hsuan-Tsung J. Wang2, William A. Tobias2, Gordon D. Cates2, James R. Brookeman2, Klaus D. Hagspiel2, John P. Mugler III2
1The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; 2University of Virginia, Virginia, USA; 3The Children's Hospital of Philadelphia, Pennsylvania, USA
1273. Development of Novel Parameter That Reflects Xe Transfer Rate in Mouse Lung from
Hyperpolarized 129Xe Dynamic Study Under Spontaneous Respiration: Definition and Application
to Murine Tumor B16BL6 Melanoma
Hirohiko Imai1, Tsuyoshi Ito1, Atsuomi Kimura1, Shinsaku Nakagawa1, Hideaki Fujiwara1
1Osaka University, Suita, Osaka 565-0871, Japan
1274. Hyperpolarized Xe-129 as a Non-Invasive Biosensor to Characterize Atherosclerotic Plaques
Zhaohui Han1, Nicholas N. Kuzma1
1University of Rochester, Rochester, New York, USA
1275. Imaging Stroke with Hyperpolarized 129Xe MRI
Xin Zhou1, Yanping Sun1, Mary L. Mazzanti1, Nils Henninger2, Jessica D. Gereige1, Joey K. Mansour1, Marc Fisher2, Mitchell S. Albert1
1Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; 2University of Massachusetts Medical School, Worcester, Massachusetts, USA
1276. Phase Contrast Imaging of Flow Dynamics in the Lungs Using Hyperpolarized Helium
Vinay Manjunath Pai1, Igor Kamenetskiy1, Davide Santoro1, Jean Reid1, Glyn Johnson1
1New York University School of Medicine, New York, New York, USA
1277. Hyperpolarized Helium3 Phase-Contrast Velocimetry on Human Paranasal Sinus Ostial Patency
John M. Woodburn1, Masaru Ishii2, Jiangsheng Yu1, Kiarash Emami1, Chris Cox1, Stephen Kadlecek1, Vahid Vahdat1, Robert Cadman1, Sheeva Rajaei1, Takeshi Nakayama1, Richard Guyer1, David A. Lipson1, Warren Gefter1, Rahim Rizi1
1University of Pennsylvania, Philadelphia, Pennsylvania, USA; 2Johns Hopkins University, Baltimore, Maryland, USA
1278. Validation of Phase-Contras MR Velocimetry of Hyperpolarized Rare Gases Via Particle Image Velocimetry
Wolfgang Kilian1, Tomasz Lindel1, M. Strowig1, André Brunn2, Frank Seifert1
1Physikalisch-Technische Bundesanstalt, Berlin, Germany; 2TU-Berlin, Berlin, Germany
1279. Voxel-Based Measurment of Flow and Volume Using Regional Motion-Tracking in the
Lung with Hyperpolarized 3He MRI
Davide Santoro1, Abram Voorhees2, Vinay Pai1, Igor Kamenetskiy1, Jean Reid1, Glyn Johnson1
1New York University, New York, New York, USA; 2Siemens Medical Solutions, Malvern, Pennsylvania, USA
1280. Hyperpolarized Helium-3 Spiral Ventilation Imaging: Implementation and Validation of a
Free-Breathing Protocol on a Clinical MR Scanner
Elise Bannier1, Katarzyna Cieslar2, Vasile Stupar1, Robin M. Heidemann3, Sophie Gaillard1, Abdulrazzaq Sulaiman1, Emmanuelle Canet-Soulas1, Yannick Cremillieux1
1CNRS, UMR 5012, Laboratoire RMN-MIB, ESCPE, Villeurbanne, France; 2Jagiellonian University, Kraków, Poland; 3Siemens Medical Solutions, Erlangen, Germany
1281. Assessment of In-Vitro Lung Structure Using Hyperpolarized He-3 ADC MRI:
Comparison with In-Vivo Measurements and Repeatability
Jaime Mata1, Talissa Altes2, Kai Ruppert2, Klaus Hagspiel1, James Brookeman1, John Mugler III1
1University of Virginia, Charlottesville, Virginia, USA; 2University of Pennsylvania, Philadelphia, Pennsylvania, USA
1282. New Sequence for a Fast and Accurate Measurement of Hyperpolarized Helium-3 Diffusion
Dayane Habib1, Geneviève Guillot1
1Université Paris-Sud, Orsay, France
1283. Probing Lung Geometry: Measurement of Time-Dependent Diffusion of Hyperpolarized
129Xe in Healthy Mice
Tetsuya Wakayama1, Masakazu Kitamoto1, Atsuomi Kimura1, Hideaki Fujiwaka1
1Osaka University Graduate School of Medicine, Suita, Osaka, Japan
1284. Measurement of the Diffusion of Hyperpolarized 3He in Human Lungs Over Short and
Long Time Scales During One Breath Hold
Chengbo Wang1, Grady W. Miller1, Tallisa A. Altes1, 2, Eduard E. de Lange1, James R. Brookeman1, Gordon D. Cates, Jr1, John P. Mugler, III1
1University of Virginia, Charlottesville, Virginia, USA; 2Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
1285. Measurement of Hyperpolarized Gas Diffusion at Very Short Time Scales
Michael Carl1, Grady Wilson Miller1, John P. Mugler III1, Scott Rohrbaugh1, William Al Tobias1, Gordon D. Cates1
1University of Virginia, Charlottesville, Virginia, USA
1286. SNR Performance of Q-Space Formalism and Multi-Exponential Modelling for Hyperpolarized
3He Gas Diffusion Spectroscopy in Human Lungs
Dattesh D. Shanbhag1, 2, Talissa A. Altes3, Jaime F. Mata1, G.Wilson Miller1, Jack Knight-Scott4
1University of Virginia, Charlottesville, Virginia, USA; 2GE JFWTC, Bangalore, Karnataka, India; 3The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; 4Children's Healthcare of Atlanta at Egleston, Atlanta, Georgia, USA
1287. A Rapid Hyperpolarized 3He Q-Space Diffusion Spectroscopy Sequence for Sub-Second
Breath Hold In Vivo
Dattesh D. Shanbhag1, 2, Talissa A. Altes3, Jaime F. Mata1, G.Wilson Miller1, Jack Knight-Scott4
1University of Virginia, Charlottesville, Virginia, USA; 2GE JFWTC, Bangalore, Karnataka, India; 3The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; 4Children's Healthcare of Atlanta at Egleston, Atlanta, Georgia, USA
1288. Finite Element Modeling and Experimental Validation of Transverse Relaxation and
Apparent Diffusion Coefficients of Hyperpolarized Noble Gases in Rodent Lung
Juan Parra-Robles1, Peggy Xu2, Wilfred Lam1, Alexei Ouriadov1, David McCormack2, Giles E. Santyr1
1Robarts Research Institute, London, Ontario, Canada; 2University of Western Ontario, London, Ontario, Canada
1289. Measurements of Hyperpolarized He-3 T2* and ADC in the Lungs Using Multi-Echo VIPR
James Holmes1, Rafael O'Halloran1, Ethan Brodsky1, Walter Block1, Sean Fain1
1University of Wisconsin-Madison, Madison, Wisconsin, USA
1290. Human Pulmonary Diffusion Weighted Imaging at 0.2T with Hyperpolarized 129Xe
Adrian Sindile1, Iga Muradian1, 2, Mirko Hrovat3, Christina Johnson1, 2, F. William Hersman1, Samuel Patz2
1University of New Hampshire, Durham, New Hampshire, USA; 2Brigham and Women's Hospital, Boston, Massachusetts, USA; 3Mirtech, Inc., Brockton, Massachusetts, USA
1291. Progression of Emphysema Evaluated by Hyperpolarized 3He ADC Measurements
Lise Vejby Søgaard1, Trine Stavngaard1, Marion Batz2, Wolfgang G. Schreiber3, Asger Dirksen4
1Copenhagen University Hospital, Hvidovre, Denmark; 2Johannes Gutenberg-University, Mainz, Germany; 3Johannes Gutenberg-University Medical School, Mainz, Germany; 4Gentofte University Hospital, Hellerup, Denmark
1292. Evaluation of Radiation Lung Injury from Tomotherapy Using Hyperpolarized Helium-3 Diffusion MRI
Jaime Mata1, Jing Cai1, Ke Sheng1, Kai Ruppert2, 3, Paul Read1, Klaus Hagspiel1, Talissa Altes2, 4, James Brookeman1, John Mugler III1
1University of Virginia, Charlottesville, Virginia, USA; 2University of Pennsylvania, Philadelphia, Pennsylvania, USA; 3Children's Hospital of Philadelphia, Philadelphia, Virginia, USA; 4Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
1293. Hyperpolarized 3He MRI at 3.0 Telsa: Anatomic Bias of Apparent Diffusion Coefficients in
Chronic Obstructive Pulmonary Disease
Andrea Evans1, 2, David McCormack2, Shayna McKay1, Roya Etemad-Rezai2, Giles Santyr1, 2, Grace Parraga1, 2
1Robarts Research Institute, London, Ontario, Canada; 2The University of Western Ontario, London, Ontario, Canada
1294. Ventilation and Perfusion Ratio Obtained by Polarized Carbon-13 and Polarized Gas MRI
Masaru Ishii1, Jiangsheng Yu2, Stephen Kadlecek2, Kiarash Emami2, John M. Woodburn2, Vahid Vahdat2, Takeshi Nakayama2, Robert Cadman2, Sheeva Rajaei2, Chris Cox2, Richard Guyer2, Michelle Law2, Michael Stephen3, David A. Lipson2, Warren Gefter2, Rahim Rizi2
1Johns Hopkins University, Baltimore, Maryland, USA; 2University of Pennsylvania, Philadelphia, Pennsylvania, USA; 3University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
1295. Optimization of Steady State Free Precession Sequences for Hyperpolarized 3He Lung MRI
Jim M. Wild1, Kevin Teh1, Neil Woodhouse1, Martyn NJ Paley1, Nicola de Zanche2, Larry Kasuboski3
1University of Sheffield, Sheffield, Yorkshire, UK; 2ETH, Zurich, Switzerland; 3Philips Medical Systems, Ohio
1296. Multiple Regression Method for Optimizing Scan Parameters in Pulmonary Partial Pressure
Oxygen Measurement by Hyperpolarized 3He MRI
Jiangsheng Yu1, David Lipson1, Masaru C. Ishii2, Stephen Kadlecek1, Kiarash Emami1, Vahid Vahdat1, John MacDuffie Woodburn1, Robert Cadman1, Sheeva Rajaei1, Warren Gefter1, Rahim Rizi1
1University of Pennsylvania, Philadelphia, Pennsylvania, USA; 2Johns Hopkins University, Baltimore, Maryland, USA
1297. Slice Profile Effects in Variable Flip Angle Hyperpolarized 3He MRI
Kevin Teh1, Kuan J. Lee1, Jim M. Wild1
1University of Sheffield, Sheffield, Yorkshire, UK
1298. Automated Algorithm for Calculation of Lung Defect Volume Using Hyperpolarized He-3 MRI
and Proton Magnetic Resonance Imaging
Guillermo Gonzalez-Fernandez1, Eric Peterson1, Rafael O'Halloran1, Sean Fain1
1University of Wisconsin-Madison, Madison, Wisconsin, USA
1299. Airway Segmentation in 3D Using Dynamic Hyperpolarized He-3 Multi-Echo VIPR
Eric Peterson1, Jim Holmes1, Guillermo Gonzalez-Fernandez1, Rafael O'Halloran1, Ethan Brodsky1, Wally Block1, Sean Fain1
1University of Wisconsin - Madison, Madison, Wisconsin, USA
1300. Reproducibility of Partial Pressure of Oxygen and Oxygen Depletion Rate in Animal Model
Masaru Ishii1, Jiangsheng Yu2, Stephen Kadlecek2, Kiarash Emami2, John M. Woodburn2, Vahid Vahdat2, Takeshi Nakayama2, Robert Cadman2, Sheeva Rajaei2, Chris Cox2, Richard Guyer2, Michelle Law2, Michael Stephen3, David A. Lipson2, Warren Gefter2, Rahim Rizi2
1Johns Hopkins University, Baltimore, Maryland, USA; 2University of Pennsylvania, Philadelphia, Pennsylvania, USA; 3University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
1301. Longitudinal Helium-3 and Proton Imaging of Magnetite Biodistribution in a Rat Model of
Instilled Nanoparticles
Achraf Al Faraj1, Ghislaine Lacroix2, hasan Al Said1, Dan Elgrabi2, Vasile Stupar1, Franck Robidel2, Sophie Gaillard1, Emmanuelle Canet-Soulas1, Yannick Crémillieux1
1Université Lyon 1, Villeurbanne, France; 2INERIS, Verneuil-en-Halatte, France
1302. Quantitative Analysis of MCh Induced Ventilation Changes in Mouse Lungs
Nilesh Navnitlal Mistry1, 2, Bastiaan Driehuys2, G. Allan Johnson2
1Duke University, Durham, North Carolina, USA; 2Duke University Medical Center, Durham, North Carolina, USA
1303. Assessment of Lung Volumes Using Hyperpolarized 3He MR Imaging in Rodents: Comparison
with Xenon-Enhanced X-Ray CT
M Reza Akhavan Sharif1, 2, Wilfred W. Lam1, Alexei V. Ouriadov1, David W. Holdsworth1, 2, David G. McCormack3, Giles E. Santyr1, 2
1Robarts Research Institute, London, Ontario, Canada; 2University of Western Ontario, London, Ontario, Canada; 3London Health Sciences Centre, London, Ontario, Canada
1304. Hyperpolarized 3He Magnetic Resonance Imaging of Ventilation Defect Volume Variability in COPD
Lindsay Mathew1, 2, Jade Fenster1, Shayna McKay1, Giles Santyr1, 2, Roya Etemad-Rezai2, David McCormack2, Grace Parraga1, 2
1Robarts Research Institute, London, Ontario, Canada; 2The University of Western Ontario, London, Ontario, Canada
1305. Evaluation of the Safety of Hyperpolarized Helium-3 Gas as an Inhaled Contrast Agent for MRI
Talissa A. Altes1, 2, Joanne C. Gersbach1, Jaime F. Mata1, John P. Mugler III1, James R. Brookeman1, Eduard E. de Lange1
1University of Virginia, Charlottesville, Virginia, USA; 2Children's Hiaospital of Philadelph, Philadelphia, Pennsylvania, USA
Hyperpolarization: C-13 and Other Nuclei
Hall 14.1 Monday 14:00 - 16:00
1306. A Shielded NMR System Suitable for Parahydrogen-Induced Polarization
Takeshi Nakayama1, Kiarash Emami1, Stephen Kadlecek1, Stephen Pickup1, John M. Woodburn1, Jianliang Zhu1, Jiangsheng Yu1, Vahid Vahdat1, Masaru Ishii2, Robert Cadman1, Sheeva Rajaei1, Chris Cox1, Richard Guyer1, Michelle Law1, Michael Stephen3, Joseph Shrager1, David A. Lipson1, Warren Gefter1, Rahim Rizi1, sheeva rajaei4
1University of Pennsylvania, Philadelphia, Pennsylvania, USA; 2Johns Hopkins University, Baltimore, Maryland, USA; 3University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA; 4university of pennsylvania, philadelphia, Pennsylvania, USA
1307. Precise Flip Angle Calibration for Hyperpolarized 13C Scans
Ileana Hancu1, Ronald Watkins1, Susan Kohler2, Richard Mallozzi1
1GE Global Research Center, Niskayuna, New York, USA; 2GE Healthcare, Niskayuna, New York, USA
1308. Selective Homonuclear Hartmann-Hahn for 13C-13C Polarization Transfer in Solution State NMR
Thomas Roger Eykyn1, Martin O. Leach1
1Institute of Cancer Research, Sutton, Surrey, UK
1309. How Low Can We Go? Limits of Detection in PASADENA 13C Hyperpolarization
Pratip Bhattacharya1, 2, Kent Christopher Harris1, 2, Eduard Y. Chekmenev, 23, Alexander Peter Lin1, 2, Valerie Ann Norton2, Jan Hovener, 23, William H. Perman4, Brian David Ross1, Daniel P. Weitekamp2
1Huntington Medical Research Institute, Pasadena, California, USA; 2California Institute of Technology, Pasadena, California, USA; 3Rudi Schulte Research Institute, Santa Barbara, California, USA; 4St. Louis University School of Medicine, Saint Louis, Michigan, USA
1310. Off-Resonance Behaviour of RARE and TrueFISP in Imaging of Hyperpolarized 13C
Jochen Leupold1, Sven Månsson2, Oliver Wieben3, Klaus Scheffler4, Jürgen Hennig1
1University Hospital Freiburg, Freiburg, Germany; 2GE Healthcare, Malmö, Sweden; 3University of Wisconsin-Madison, Madison, Wisconsin, USA; 4University Hospital of Basel, Basel, Switzerland
1311. Reproducibility and Quality Assurance in Hyperpolarized 13C MRI and MRS
Jan B. Hövener1, 2, Pratip Bhattacharya1, 2, Eduard Y. Chekmenev1, 2, Valerie Norton2, William H. Perman3, Alexander Lin1, Kent Harris1, Daniel P. Weitekamp2, Brian D. Ross1
1Huntington Medical Research Institute, Pasadena, California, USA; 2California Institute of Technology, Pasadena, California, USA; 3St. Louis University, School of Medicine, St. Louis, Michigan, USA
1312. Generating 1H- And 13C-Hyperpolarized Molecular Probes of Variable Size from Parahydrogen to
Explore the Lung Via MRI
Joachim Bargon1, Matthias Stephan2, Rahim Rizi3
1University of Bonn, Bonn, Germany; 2University of Bonn, Germany; 3University of Pennsylvania, Philadelphia, Pennsylvania, USA
1313. PASADENA: A Novel Tool to Image Atherosclerotic Plaque
Eduard Y. Chekmenev1, 2, Pratip Bhattacharya1, 2, Siu K. Chow3, Alexander P. Lin1, 4, Daniel P. Weitekamp2, Brian D. Ross1, 4
1Huntington Medical Research Institutes, Pasadena, California, USA; 2California Institute of Technology, Pasadena, California, USA; 3UCSD, San Diego, California, USA; 4Rudi Schulte Research Institutes, Santa Barbara, California, USA
1314. Kinetic Data from Cellular Assay Using Hyperpolarized 13C-DNP-NMR
Magnus Karlsson1, Linda Andersson1, Pernille Jensen1, Georg Hansson1, Anna Gisselsson1, Sven Månsson1, Rene in 't Zandt1, Mathilde Lerche1
1Imagnia AB, Malmö, Sweden
1315. Freely Diffusible Contrast Agents for Hyperpolarized 13C Perfusion Imaging
Aaron K. Grant1, Elena Vinogradov1, David Alsop1
1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
1316. Parahydrogen Induced Polarization of Drug Compounds for MRI
Achim Koch1, Jörg Schmiedeskamp1, Joachim Bargon2, Hans Wolfgang Spiess1
1Max Planck Institute for Polymer Research, Mainz, Germany; 2University of Bonn, Bonn, Germany
1317. Parahydrogen-Induced Hyperpolarization of 15N
Joachim Bargon1, Achim Koch2, Johannes Natterer3, Rahim Rizi4, Jorg Schmiedeskamp2
1University of Bonn, Bonn, Germany; 2Max Planck Institute for Polymer Research , Mainz, Germany; 3University of Bonn, Germany; 4University of Pennsylvania, Philadelphia, Pennsylvania, USA
1318. Towards Detection of Sub-Micromolar Contrast Agent Concentration with Hyperpolarized 6-Lithium
Ruud B. van Heeswijk1, Kai Uffmann1, Fiodar Kurdzesau2, 3, Sami Jannin3, Arnaud Comment3, Ton Konter2, Patrick Hautle2, Ben van den Brandt2, Jacques J. van der Klink3, Gil Navon4, Rolf Gruetter1, 5
1Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; 2Paul Scherrer Institute, Villigen, Switzerland; 3Ecole Polytechnique Fédérale de Lausanne, Lausanne, VD, Switzerland; 4Tel Aviv University, Tel-Aviv, Israel; 5Universities of Lausanne and Geneva, Switzerland
1319. Hyperpolarized N-15 of Choline - Potential for Observing Phospholipid Metabolism in Cancer
Thomas Roger Eykyn1, Steven Reynolds2, Cristina Gabellieri1, Martin O. Leach1
1Institute of Cancer Research, Sutton, Surrey, UK; 2Oxford Instruments Molecular Biotools Ltd., Tubney Woods, Abingdon, Oxon, UK
1320. Characterization of Solid State Dynamic Nuclear Polarization for Metabolic Imaging
Marie Allen Schroeder1, Lowri Elizabeth Cochlin1, George K. Radda1, Kieran Clarke1, Damian J. Tyler1
1University of Oxford, Oxford, Oxon, UK
Hall 14.1 Monday 14:00 - 16:00
1321. Development of Micro-Pellets Holding EPR Oxygen Sensors
Mustapha Dinguizli1, Bernard Gallez1
1Université catholique de
Louvain, Brussels, B, Belgium
1322. High Resolution 2D and 3D EPR Imaging of Melanin in Biological Samples
Emilia Sabina Vanea1, Nicolas Charlier1, Mustapha Dinguizli1, Bernard Gallez1
1Université Catholique de Louvain, Brussels, B, Belgium
1323. Changes in Serum Albumin Measured by Electron Spin Resonance: In Vitro Diagnostic EPR Test
Andrey Gurachevsky1, Gert Matthes, 12, Vladimir Muravsky1
1MedInnovation GmbH, Wildau, Germany; 2University Hospital Leipzig, Germany
1324. Strategies for Improved Temporal and Spatial Resolution: In Vivo Oxymetric Imaging Using
Time-Domain EPR
Nallathamby Devasahayam1, Sankaran Subramanian1, Ramachandran Murugesan2, Fuminori Hyodo1, Ken-Ichiro Matsumoto3, James B. Mitchell1, Murali C. Krishna1
1National Institutes of Health, Bethesda, Maryland, USA; 2Madurai Kamaraj University, Madurai, Tamil Nadu, India; 3National Institute of Radiological Science, Chiba-shi, Chiba 263-8555, Japan
1325. Evaluation of Radiation Dose Distribution in Lithium Formate Pellets Using EPR Imaging
Emilia Sabina Vanea1, Jean-Marc Denis2, Stefaan Vynckier2, Bernard Gallez1
1Université Catholique de Louvain, Brussels, Belgium; 2Université catholique de Louvain, Brussels, Belgium
1326. Sequential Imaging of Tissue pO2 by Electron Paramagnetic Resonance Imaging and Anatomy
by MRI at 300 MHz
Shingo Matsumoto1, Fuminori Hyodo1, Nallathamby Devasahayam1, Sankaran Subramanian1, Jeeva P. Munasinghe2, James B. Mitchell1, Murali C. Krishna1
1National Cancer Institute, NIH, Bethesda, Maryland, USA; 2National Institute of Neurological Disorder and Stroke, NIH, Bethesda, Maryland, USA
Hall 14.1 Monday 14:00 - 16:00
1327. High Resolution Sodium Imaging of Isolated Neurons
Samuel Colles Grant1, 2
1The National High Magnetic Field Laboratory, Tallahassee, Florida, USA; 2The Florida State University, Tallahassee, Florida, USA
1328. Sodium Chemical Shift Imaging of Induced Diuresis in a Mouse Renal Model
Thomas Neuberger1, 2, Vikas Gulani2, 3, Andrew Webb1, 2
1Huck Institute Magnetic Resonance Centre, Penn State University, University Park, Pennsylvania, USA; 2University of Würzburg, Würzburg, Germany; 3Case Western Reserve University, Cleveland, Ohio, USA
1329. In Vivo Sodium MRI Relaxometry of Normal and Pathological Mouse Liver at 4.7 T
Mihaela Lupu1, 2, Carole D. Thomas1, 2, Andreas Volk1, 2, Joel Mispelter1, 2
1Institut Curie, Orsay, France; 2INSERM U759, Orsay, France
1330. Performance Comparison of Direct Fourier Sum and Regridding Reconstructions of Sodium TPI
Serge Minin1, Ian Atkinson2, Fred Damen2, Farzad Kamalabadi1, Keith R. Thulborn2
1University of Illinois, Urbana, Illinois, USA; 2University of Illinois Medical Center, Chicago, Illinois, USA
1331. MR Imaging of Sodium Using a 3D Cones Acquisition
Jeff A. Stainsby1, Paul T. Gurney2, Belinda S. Li3, Fred C. Damen4, Keith R. Thulborn4
1GE Healthcare, Toronto, Ontario, Canada; 2Stanford University, California, USA; 3GE Healthcare, Chicago, Illinois, USA; 4University of Illinois at Chicago, Chicago, Illinois, USA
1332. Optimization of Acquisition and Post-Processing Strategies for Na-23 Imaging of the Human Kidney
Yael Rosen1, 2, Ananth Madhuranthakam3, Alexander Ivanishev1, Robert E. Lenkinski1, 2
1Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA; 2Harvard Medical School, Boston, Massachusetts, USA; 3GE Healthcare, Boston, Massachusetts, USA
1333. Method for Electronically Setting Transmit Gain for Non-1H Imaging and Spectroscopy
Susan J. Kohler1, W Thomas Dixon1
1General Electric Company, Niskayuna, New York, USA
1334. Simultaneous 19F/1H Imaging for Quantification : Calibration and Sensitivity Assessment
Jochen Keupp1, Peter Caesar Mazurkewitz1
1Philips Research Europe, Hamburg, Germany
1335. Relationship Between 3He Gas ADCs and Lung Microstructure. Computer Simulations
Alexander L. Sukstanskii1, Mark S. Conradi1, Dmitriy A. Yablonskiy1
1Washington University, St. Louis, Missouri, USA
1336. Rapid In-Vivo MRI Measurement of Fluorinated Gas Concentration in Lungs Using T1- Mapping
Maxim V. Terekhov1, Ursula A. Wolf1, Alexander W. Scholz1, Wolfgang Guenther Schreiber1
1Mainz University Medical School, Mainz, Germany
1337. Variable Flip Angle MR Imaging of Regional Ventilation Using Hyperpolarized Helium in Rodent Lungs
Giles Santyr1, Wilfred Lam1, Alexei Ouriadov1, David McCormack2
1Robarts Research Institute, London, Ontario, Canada; 2London Health Sciences Centre, London, Ontario, Canada
1338. Dynamical 17O Imaging in Tumor Bearing Mice at 7T
Michiko Narazaki1, Yoko Kanazawa1, Sachiko Koike1, Koichi Ando1, Hiroo Ikehira1
1National Institute of Radiological Sciences, Chiba, Japan
New & Emerging Applications for MR Microscopy
Hall 14.1 Monday 14:00 - 16:00
1339. Assessment of Cellular Growth in a Double Microbead Alginate Construct Via MR Microscopy
Parastou Foroutan1, 2, Nicholas Edward Simpson3, Jose A. Oca-Cossio3, Carol A. Sweeney3, Stephen John Blackband, 14, Samuel Colles Grant1, 2, Ioannis Constantinidis, 13
1The National High Magnetic Field Laboratory, Tallahassee, Florida, USA; 2The Florida State University, Tallahassee, Florida, USA; 3University of Florida, Gainesville, Florida, USA; 4The McKnight Brain Institute, Gainesville, Florida, USA
1340. High-Field MR Microscopy as a Tool for Comparative Morphological Studies: Soft Tissue
Discrimination in Sea Urchins
Alexander Ziegler1, Cornelius Faber2, Susanne Mueller3, Thomas Bartolomaeus1
1Freie Universität, Berlin, Germany; 2Universität Würzburg, Germany; 3Charité-Universitätsmedizin, Germany
1341. Experimental Investigation of One-Dimensional "DESIRE" for NMR Microscopy
Markus Weiger1, Yi Zeng1, Michael Fey1
1Bruker BioSpin AG, Faellanden, Switzerland
1342. MR Microscopy Can Resolve Differences in the Behaviour of Implantable Drug Delivery Biomaterials
Joshua M. Bray1, 2, Mark Filiaggi2, Steven D. Beyea1, 2
1National Research Council of Canada, Halifax, Nova Scotia, Canada; 2Dalhousie University, Halifax, Nova Scotia, Canada
1343. 3D-MR-Based Polymer Gel Dosimetry of Proton Needle Beams
Andreas Georg Berg1, Christian Bayreder1, Jens Heufelder2, 3
1Medical University of Vienna, Vienna, Austria; 2Hahn-Meitner-Institut, Berlin, Germany; 3Paul Scherrer Institut, Switzerland
1344. Corresponding Non-Invasive 1H and 23Na MRI of Ancient Mummified Human Tissue
Kerstin Münnemann1, 2, Thomas Boeni3, Bernhard Blümich1, Giovanni Colacicco4, Frank Rühli3
1RWTH Aachen University, Aachen, Germany; 2Mainz University Medical School, Mainz, Germany; 3University of Zurich, Zürich, Switzerland; 4University of Zurich, Zurich, Switzerland
1345. Retrospective Gating for Whole Body Mouse MRI
Jonathan Bishop1, Lorinda Davidson1, Jun Dazai1, Mark Henkelman1, 2
1Hospital for Sick Children, Toronto, Ontario, Canada; 2University of Toronto, Toronto, Ontario, Canada
1346. Rapid MR Microscopy of the Mouse Inner Ear Structures in Vitro Using True-FISP at 7.0T
H. Douglas Morris1, Byung Yoon Choi1, Andrew J. Griffith1, John A. Butman1
1NIH, Bethesda, Maryland, USA
1347. In Vivo Magnetic Resonance Microimaging in Adult Zebrafish
Samira Kabli1, Herman Spaink1, Huub J. M. de Groot1, Alia Alia1
1Leiden University, Leiden, Netherlands
1348. Internal Motions of Manduca Sexta Pupae Studied Using Magnetic Resonance Microscopy
Kevin J. Hallock1
1Boston Medical Center, Boston, Massachusetts, USA
Hall 14.1 Monday 14:00 - 16:00
1349. In Vivo Single Voxel 1H MR Spectroscopy with Segmented 2D-Selective RF Excitations
Wolfgang Weber-Fahr1, 2, Jürgen Finsterbusch1, 2
1University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 2Neuroimage Nord, Hamburg-Kiel-Lübeck, Germany
1350. Spatial Localization with Pulsed Second-Order Shims
Robin A. de Graaf1, Douglas L. Rothman1, Terence W. Nixon1
1MRRC, Yale University, New Haven, Connecticut, USA
1351. Full Signal Intensity for Short Echo Time Localized Spectroscopy on a Clinical Scanner
Ralf Mekle1, 2, Vladimir Mlynarik1, Giulio Gambarota1, Rolf Gruetter1, 3
1Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland; 2University of Lausanne, Lausanne, Switzerland; 3Universities of Lausanne and Geneva, Lausanne/Geneva, Switzerland
1352. Short Echo Time Proton Spectroscopy of the Human Brain at 3 Tesla Using an Optimized
PRESS Sequence Without Water Suppression
Wolfgang Dreher1, 2, Christian Schuster1, 2, Dieter Leibfritz1, 2
1University of Bremen, FB 2 (Chemistry), Bremen, Germany; 2Center of Advanced Imaging (CAI), Bremen, Germany
1353. Extension of 8 Step Phase Cycling Scheme for Improved Lipid Suppression Using Four-Pulse
PRESS MRS Sequences
Shiloh Sison1, Michael H. Buonocore1, Richard J. Maddock1
1UC Davis Imaging Research Center, Sacramento, California, USA
1354. High-Resolution MRS in Inhomogeneous Fields Via Double-Quantum-Filtered Intermolecular
Zero-Quantum Coherences
Xi Chen1, Meijin Lin1, Zhong Chen1, 2, Jianhui Zhong2
1Xiamen University, Xiamen, Fujian, People’s Republic of China; 2University of Rochester Medical Center, Rochester, New York, USA
1355. Proton Spectroscopy Without Water Suppression Using a High Dynamic Range A/D Converter
Andrzej Jesmanowicz1, Robert Prost1, James S. Hyde1
1Medical College of Wisconsin, Milwaukee, Wisconsin, USA
1356. Robust Water and Lipid Suppression Using Multiple Dualband Frequency-Selective
RF Pulses for 1H Spectroscopic Imaging at 3T
Meng Gu1, Daniel Mark Spielman1
1Stanford University, Stanford, California, USA
1357. Single Voxel Spectroscopy of the Pons: Shimming, Quantitation, and Reproducibility Issues at 3T
Sergey Cheshkov1, Audrey Chang1, Subhendra Sarkar1, Evelyn Babcock1, Kaundinya Gopinath1, Richard Briggs1
1University of Texas Southwestern Medical Center, Dallas, Texas, USA
1358. Optimization of PRESS-Localized Metabolite Measurements in the Frontal Lobes In Vivo at 3T
Mary McLean1, James Stone2, David Lythgoe2, Gareth Barker2, John Duncan1
1UCL Institute of Neurology, London, England, UK; 2Kings College London, London, England, UK
1359. Localized H1-MRS of the Human Frontal White Matter at 3 T: Metabolite Concentrations and
Relaxation Times
Nuran Tunc-Skarka1, Tim Wokrina1, Marco Ulrich1, Gabi Ende1
1Central Institute of Mental Health, Mannheim, Germany
1360. Negligible Dehydroascorbate and GSSG Signal Contributions to Human Brain 1H NMR Spectra In Vivo
Melissa Terpstra1, Marjanska Malgorzata1, Pierre-Gilles Henry1, Ivan Tkac1
1University of Minnesota, Minneapolis, Minnesota, USA
1361. Quantitative Time-Domain Analysis of Intermolecular Multiple-Quantum Coherences (iMQC)
and Effects of Radiation Damping
Stefan Kirsch1, William Edmund Hull1
1German Cancer Research Center (DKFZ), Heidelberg, Germany
1362. Accurate Measurements of Small J Coupling Constants in Inhomogeneous Fields
Yanqin Lin1, Congbo Cai1, Shuhui Cai1, Zhong Chen1, 2, Jianhui Zhong2
1Xiamen University, Xiamen, Fujian, People’s Republic of China; 2University of Rochester Medical Center, Rochester, New York, USA
1363. Three-Dimensional, J-Resolved H-1 MRSI of Volunteers and Patients with Brain Tumors at 3 T
Yan Li1, Albert P. Chen1, Jason C. Crane1, Susan M. Chang1, Daniel B. Vigneron1, Sarah J. Nelson1
1University of California, San Francisco, California, USA
1364. Controlling J-Coupling Evolution During Selective RF Pulses
Lorenz Mitschang1
1Physikalisch-Technische Bundesanstalt, Berlin, Germany
1365. 2D J-Resolved Spectroscopy at 7T
Duan Xu1, Yan Li1, 2, Albert P. Chen1, Ralph Hurd3, Jason Crane1, Sarah J. Nelson1, 2, Daniel B. Vigneron1, 2
1UCSF, San Francisco, California, USA; 2UCSF/UC Berkeley, San Francisco, Berkeley, California, USA; 3GE Healthcare, Menlo Park, California, USA
1366. Fast Acquisition of High-Resolution MRS in Inhomogeneous Fields Via Intermolecular
Single-Quantum Coherences
Zhong Chen1, 2, Xi Chen1, Shuhui Cai1, Jianhui Zhong2
1Xiamen University, Xiamen, Fujian, People’s Republic of China; 2University of Rochester Medical Center, Rochester, New York, USA
1367. Improved High-Resolution MRS in Inhomogeneous Fields Via Intermolecular Zero-Quantum Coherences
Shuhui Cai1, Song Chen1, Zhong Chen1, 2, Jianhui Zhong2
1Xiamen University, Xiamen, Fujian, People’s Republic of China; 2University of Rochester Medical Center, Rochester, New York, USA
1368. Prospects of Resolution and Senstivity Enhancement Using In Vivo iZQC MR Spectroscopy
David Zsolt Balla1, Cornelius Faber1
1University of Würzburg, Würzburg, Bavaria, Germany
1369. A Modified PRESS Sequence Designed for Lactate Editing
Atiyah Yahya1, B. Gino Fallone1
1Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada
1370. Optimized Detection of Glutathione in the Human Brain at 3T Using MEGA-PRESS
Richard Anthony Edward Edden1, 2, Peter B. Barker1, 2
1The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; 2Kennedy Krieger Institute, Baltimore, Maryland, USA
1371. Detection of Resolved Glutamate and/or Glutamine Using Optimized STEAM at 3T – a Verification
Study by Phantom Experiments
Shaolin Yang1, Jiani Hu2, Yihong Yang1
1National Institute on Drug Abuse, Baltimore, Maryland, USA; 2Wayne State University, Detroit, Michigan, USA
1372. In-Vivo Detection of Human Brain GABA* in Frontal Cortex, Thalamus and Hippocampus by
J-Difference Spectroscopy at 3T
Kevin Wayne Waddell1, James Michael Joers1, Eiman Shafa2, Parham Zhanjanipour1, Malcolm James Avison1, John C. Gore1
1Vanderbilt University, Nashville, Tennessee, USA; 2Temple University School of Medicine,
1373. In Vivo Measurements of Brain Serine with 1H-MRS
Jean Théberge1, 2, Perry F. Renshaw3
1St. Joseph's Health Care, London, Ontario, Canada; 2University of Western Ontario, London, Ontario, Canada; 3McLean Hospital, Belmont, Massachusetts, USA
1374. Simulation Study for Suppression of Myo-Inositol for Glycine Measurement by PRESS at
Various Field Strengths
Changho Choi1, Nicholas J. Coupland1, Paramjit P. Bhardwaj1, Sanjay Kalra1, Peter S. Allen1
1University of Alberta, Edmonton, Alberta, Canada
1375. Dynamics of Lactate Concentration and BOLD Effect Upon Repeated Identical Visual Stimuli
Silvia Mangia1, Ivan Tkac1, Nikos Logothetis2, Pierre-Francois Van de Moortele1, Rolf Gruetter3, Kamil Ugurbil1, 2
1University of Minnesota, Minneapolis, Minnesota, USA; 2Max Planck Institute for Biological Cybernetics, Tubingen, Germany; 3Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
1376. T1 Measurement of Brain Metabolites at 3T with a Saturated-Inversion Recovery Method
Albert P. Chen1, Charles H. Cunningham2, Duan Xu1, Yan Li1, 3, Sarah J. Nelson1, 3, Daniel B. Vigneron1, 3
1UCSF, San Francisco, California, USA; 2University of Toronto, Toronto, Ontario, Canada; 3UCSF/UCB, San Francisco, California, USA
1377. Stand-Alone GUI of Analyzing and Displaying Proton 2D/3D MRSI Data Sets with LCModel
Meng-Hsueh Yu1, Cheng-Wen Ko1, Shang-Yueh Tsai2, Martin Buechert3, Ping-Hong Lai4
1National Sun Yat-sen University, Kaohsiung, Taiwan; 2National Taiwan University, Taipei, Taiwan; 3University Hospital Freiburg, Freiburg, Germany; 4Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
1378. A New Post-Processing Method to Remove Ringing Artifacts in Clinical MR Spectra
Yuxi Pang1, Thomas L. Chenevert1, Marko Ivancevic2, Pia C. Sundgren1
1University of Michigan, Ann Arbor, Michigan, USA; 2Philips Medical Systems, Cleveland,
1379. 13C Multi-Spectral 2D Rosette Imaging
Elizabeth Kathleen Bucholz1, Susan Kohler2, Ileana Hancu3
1Duke University, Durham, North Carolina, USA; 2GE, Niskayuna, New York, USA; 3GE, Niskyuna, New York, USA
1380. In Vivo Metabolite Compartmentalization Probed Using Intracellular GdDTPA
David Alberg Holm1, 2, Ian John Rowland1
1Hvidovre Hospital, Hvidovre, Denmark; 2Technical University of Denmark, Lyngby, Denmark
1381. 1H MRS During Creatine Supplementation in GAMT Deficient Knockout Mice Elucidates an Early
Difference in Creatine Uptake Between Muscle and Brain
Hermien E. Kan1, Esther Meeuwissen1, Jack van Asten1, Andor Veltien1, Dirk Isbrandt2, Arend Heerschap1
1Radboud University Nijmegen Medical Center, Nijmegen, Netherlands; 2Center for Molecular Neurobiology Hamburg, Hamburg, Germany
1382. Effect of Ischemia on Muscle Metabolites Assessed with Functional Magnetic Resonance
Spectroscopy (fMRS) During Electrically Imposed Exercise
Johannes Slotboom1, Werner J. Z'Graggen1, Arto C. Nirkko1
1University Hospital, Bern, Switzerland
1383. Age Effect on Intramyocellular Lipid Composition in Db/db Mice Using In Vivo 1H-MR Spectroscopy
Rachida Fissoune1, Marc Janier2, André Briguet1, Bassem Hiba3
1Université Lyon1, Laboratoire de RMN CNRS UMR 5012, Lyon, France; 2Platform ANIMAGE, Rhone-Alpes Genopole, Lyon, France; 3Platform ANIMAGE, Rhone-Alpes Genopole, Lyon, France
1384. In Vivo Proton Magnetic Resonance Spectroscopy of Human Adipose Tissue Fatty Acids: A Feasibility Study
Jesper Lundbom1, Antti Hakkarainen1, Marja-Riitta Taskinen1, Nina Lundbom1
1Hospital District of Helsinki and Uusimaa, Helsinki, Finland
1385. RF Pulse Design for Adiabatic Spin Decoupling
Lorenz Mitschang1
1Physikalisch-Technische Bundesanstalt, Berlin, Germany
1386. Providing 1H- And 13C-Hyperpolarized Gamma-Aminobutyric Acid (GABA) for Parahydrogen-Enhanced
MRI and MRS
Joachim Bargon1, Achim Koch2, Rahim Rizi3, Jorg Schmiedeskamp2
1University of Bonn, Bonn, Germany; 2Max Planck Institute for Polymer Research , Mainz, Germany; 3University of Pennsylvania, Philadelphia, Pennsylvania, USA
Hall 14.1 Monday 14:00 - 16:00
1387. Improved Tissue Metabolite Quantification in 1H HR-MAS Spectroscopy Using the ERETIC Method
Thomas Nordling Butler1, Mark Julius Albers1, 2, Kayvan Keshari1, Mark Gunnard Swanson1, 2, John Kurhanewicz1, 2
1University of California San Francisco, San Francisco, California, USA; 2UC Berkeley / UC San Francisco, San Francisco, California, USA
1388. (1)H-HRMAS for Quantitative Measurement of Choline Concentration in Amniotic Fluid as a Marker
of Fetal Lung Maturity: Inter- And Intra-Observer Reproducibility Study
Bonnie N. Joe1, Mark G. Swanson1, Kiarash Vahidi1, Andrew Zektzer1, Mei-Hsiu Chen2, Matthew Clifton1, Thomas Butler1, Kayvan Keshari1, John Kurhanewicz1
1UCSF, San Francisco, California, USA; 2Brown University, Providence, Rhode Island, USA
1389. Quantitative Measurement of Neurotransmitters in Rat Brain Tissue Using HR MAS 13C NMR
Spectroscopy and the ERETIC Method
Øystein Risa1, Torun Margareta Melø1, Ursula Sonnewald1
1Norwegian University of Science and Technology (NTNU), Trondheim, Norway
1390. Measurement of Citrate Chemical Shift Changes in HR-MAS NMR Spectra of Prostate Biopsies
Paul Allen DiCamillo1, Mark Gunnard Swanson1, Zoe Laura Tabatabai, 12, John Kurhanewicz1, Sarah Jane Nelson1
1University of California, San Francisco, California, USA; 2VA Medical Center, San Francisco, California, USA
1391. Evaluation of Anatomic Variation in Macromolecule Contribution to the GABA Signal
Using Metabolite Nulling and the J-Editing Technique at 3.0 T
Lawrence S. Kegeles1, Xiangling Mao2, Robyn Gonsalez1, Dikoma C. Shungu2
1Columbia University, New York, New York, USA; 2Weill Medical College of Cornell University, New York, New York, USA
1392. Is Spending Extra Scan Time on Measuring a `Macromolecules-Only' Signal Worthwhile?
Hérald Rabeson1, Hélène Ratiney1, Enrico Capobianco2, Ron de Beer3, Dirk van Ormondt3, Danielle Graveron-Demilly1
1CNRS UMR5012, Villeurbanne, France; 2Consorzio 21 & CRS4, Pula (Cagliari), Italy; 3Delft University of Technology, Delft, Netherlands
1393. Pitfalls and Advantages of Different T2 Correction Strategies for the Absolute Quantification of
Choline, Creatine, N-Acetil Aspartate in Human Grey Matter by 1H-MRS
Emil Malucelli1, Claudia Testa1, Caterina Tonon1, Raffaele Lodi1, Bruno Barbiroli1, Stefano Iotti2
1Università di Bologna, Italy; 2Università di Bologna, Bologna, Italy, Italy
1394. Resampling Strategies to Estimate Mean Concentrations from Low SNR In Vivo MR Spectra
Gunther Helms1, Ivanka Savic2, Peter Dechent1
1University of Göttingen, Faculty of Medicine, Göttingen, Germany; 2Karolinska Institutet, Stockholm, Sweden
1395. Comparison of Quantification of Clinical MR Spectra by LCModel and the Scanner System Software
Zili Chu1, 2, Zhiyue Jerry Wang1, 2, Jon Chia3, Jill V. Hunter1, 2
1Texas Children's Hospital, Houston, Texas, USA; 2Baylor College of Medicine, Houston, Texas, USA; 3Philips Medical Systems, Cleveland, Ohio, USA
1396. Lower Glutamate Levels in the Anterior Cingulate Cortex of Chronic Cocaine Users:
A Proton MRS Study Using TE-Averaged PRESS at 3T with a Modified Glutamate Quantification Strategy
Shaolin Yang1, Betty Jo Salmeron1, Thomas J. Ross1, Zheng-Xiong Xi1, Elliot A. Stein1, Yihong Yang1
1National Institute on Drug Abuse, Baltimore, Maryland, USA
1397. Improved Procedure for Automatic Alignment of Strongly Overlapping Peak-Regions in
High-Resolution 1H NMR Spectra
Qi Zhao1, Radka Stoyanova2, Nicole Clarke3, István Pelczer3, Truman R. Brown1
1Columbia University, New York, New York, USA; 2Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA; 3Princeton University, Princeton, New Jersey, USA
1398. Reproducibility of In Vivo GABA Quantification in Anterior Cingulate at 3 Tesla
Malgorzata Marjanska1, Pierre-Gilles Henry1, Edward J. Auerbach1, Daniel Franc1, Bryon Mueller1, Kamil Ugurbil1, Kelvin O. Lim1
1Unviersity of Minnesota, Minneapolis, Minnesota, USA
1399. Quantification of Co-Edited Macromolecules in GABA J-Editing
Jan Willem C van der Veen1, Noriaki Hattori2, Jun Shen1
1NIH, NIMH, Magnetic Resonance Spectroscopy Core, Bethesda, Maryland, USA; 2NIH, NINDS, Bethesda, Maryland, USA
1400. Improved MR Spectral Analysis for a PFC-Filled Endorectal Prostate Surface Coil Compared to
an Air-Filled Coil
Gavin Hamilton1, Michael S. Middleton1, Sang-Hee Choi1, Nouha Salibi2, Robert F. Mattrey1
1University of California, San Diego, San Diego, California, USA; 2Siemens Medical Solutions, Malvern, Pennsylvania, USA
1401. Quantitative J-Resolved Prostate Spectroscopy Using Two-Dimensional Prior-Knowledge Fitting
Thomas Lange1, Rolf Feodor Schulte1, Peter Boesiger1
1University and ETH Zurich, Zurich, Switzerland
1402. Bootstrap in MRSI: A Non-Parametric Way to Assess Quantification Standard Error
Hélène Ratiney1, SungWon Chung1, Roland G. Henry1, Radhika Srinivasan1, Sarah J. Nelson1, Daniel Pelletier1
1University of California San Francisco, San Francisco, California, USA
1403. Improved Proton NMR Thermometry by Field Inhomogeneity Correction Post-Processing
Mingming Zhu1, 2, Adil Bashir2, Joseph J. H. Ackerman1, 2, Dmitriy A. Yablonskiy, 12
1Washington University in St Louis, Saint Louis, Missouri, USA; 2Washington University School of Medicine, Saint Louis, Missouri, USA
1404. Classification of the Quality of In Vivo 1H Spectra from Human Brain Tumours Using ICA
Alan R. Wright1, John R. Griffiths2, Franklyn A. Howe1
1St George's, University of London, London, UK; 2Cancer Research UK Cambridge Reseach Institute, Cambridge, UK
1405. Fast Absolute Quantitation Using FID Echo Planar Chemical Shift Imaging (FID EP-CSI)
Melvyn Boon King Ooi1, Yingli Yang1, Srirama V. Swaminathan, 12, Truman R. Brown1
1Columbia University, NYC, New York, USA; 2Philips Medical Systems, Cleveland, Ohio, USA
1406. Feasibility of Using Predicted Cramer Rao Lower Bounds for the Design of
Optimized In Vivo MR Spectroscopy Sequences Targeting Multiple Metabolites
Daniel GQ Chong1, Johannes Slotboom2, Roland Kreis1
1University Berne, Berne, Switzerland; 2Inselspital Berne, Berne, Switzerland