Diffusion MRI: The Methods
Skill level: Intermediate - Advanced
Jeffry R. Alger, Ph.D., Alan Connelly, Ph.D., and Derek K.
Jones, Ph.D., Organizers
Saturday, 19th May
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Overview
This one-day course covers intermediate to advanced topics in
diffusion MRI. The underlying theory and biophysical
underpinnings will be discussed. Techniques for encoding and
acquiring MR data suitable for diffusion quantification will be
described, together with comparisons/critiques of methods for
subsequent post-acquisition analysis. Pitfalls and artifacts
will be covered and emerging research areas/cutting edge
techniques highlighted and explained.
Educational Objectives
Upon completion of this course, participants should be able to:
• Explain the theoretical basis and biophysical underpinnings of
diffusion-based MR techniques;
• Compare and contrast the different approaches to encoding and
acquiring MR data for quantification of diffusion in vivo;
• Select the appropriate imaging sequence for a diffusion-based
imaging study;
• Recognize the influence of exchange on diffusion measurements;
• List the types of artifacts found in diffusion image data and
recognize limitations of diffusion imaging techniques;
• Describe the current approaches to fiber tracking, including the
problems associated with resolving multiple fiber directions and
their potential solutions;
• Understand the issues associated with parametric and
non-parametric approaches to voxel based analysis of diffusion
data; and
• Evaluate the potential role of diffusion imaging in detecting
neuronal activation.
Audience Description
This course is designed for:
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Anyone who wants to develop a solid
understanding of diffusion MR imaging techniques.
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It is
especially designed for Ph.D. candidates, postdoctoral students,
and residents who have knowledge of MR physics that includes
basic
concepts such as phase, k-space, etc., and who are facile
with basic calculus.
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It would also benefit researchers who have
expertise in limited aspects of diffusion imaging, and who wish
to develop a more rounded
knowledge base in this area.
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08:30 |
Theory of diffusion |
Peter J. Basser, PhD. |
09:00 |
Biophysical underpinnings of diffusion |
Christian Beaulieu, Ph.D. |
09:30 |
Exchange - and its effect on diffusion measurements |
Charles Springer, Jr., Ph.D. |
10:00 |
Pulse sequences |
James G. Pipe, Ph.D. |
10:30 |
Break - Meet The Teachers |
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11:00 |
Tensor encoding / decoding |
Derek K. Jones, Ph.D. |
11:30 |
Extracting statistical distributions of diffusion parameters |
Brandon J. Whitcher, Ph.D. |
12:00 |
Artefacts and their remediation |
Carlo Pierpaoli, M.D. |
12:30 |
Break |
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12:30 - 12:45 - Meet the Teachers |
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14:00 |
Q-space: Restricted diffusion and tissue microstructure |
Yaniv Assaf, Ph.D. |
14:30 |
Resolving crossing fibers (HARDI) |
Jacques-Donald Tournier, M.Sc. |
15:00 |
Fiber tracking |
Geoffrey J.M. Parker, Ph.D. |
15:30 |
Break - Meet The Teachers |
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16:00 |
Clustering of tracts |
Alexander Leemans, M.Sc. |
16:30 |
Tracking based segmentation |
Timothy E.J. Behrens, D.Phil. |
17:00 |
Voxel based analyses of diffusion data |
Stephen M. Smith, D. Phil. |
17:30 |
Functional diffusion imaging |
Denis Le Bihan, M.D., Ph.D. |
18:00 |
Adjournment |
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18:00 - 18:15 Meet the Teachers |
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