fMRI: Basics to Cutting Edge Skill level: Basic - Intermediate Risto A. Kauppinen, M.D.,Ph.D., James J. Pekar, Ph.D., Lawrence L. Wald, Ph.D., Organizers   Saturday, 19 May   Overview This one-day course will give an overview of basic brain function, and approaches to evaluation of brain activity using the hemodynamic and metabolic adaptations to energy requirements by increased neuronal workload. It will provide a thorough description in physiology of BOLD as well as of MRI methods used to detect brain activation, including CBF, CBV and blood oxygenation. The program includes several components dealing with paradigm design as well as advanced fMRI data analysis methods. The combined use of fMRI with other functional imaging techniques (such as EEG, MEG, optical imaging) will be demonstrated, and highlights of latest technical developments for fMRI applications will be given. Educational Objectives Upon completion of this course, participants should be able to: • Interpret BOLD response in terms of physiological substrates, and evaluate relationships between BOLD and brain activity; • Describe analysis methods for functional brain imaging; • Describe MRI methods for detection of cerebral blood flow and blood volume and • Evaluate their use for functional brain imaging; • Interpret published fMRI studies; • Design fMRI paradigms; and • Design and execute fMRI experiments using rodent models. Audience Description This course is designed for: • Scientists from cognitive psychology, neurophysiology, MRI physics, image analysis field. and radiology. • It will be suitable for graduate students, post-docs and clinical residents. 08:30 Physiology, Hemodynamics, and BOLD Signals Risto A.Kauppinen, M.D., Ph.D. 09:05 Instrumentation for fMRI: More Coils, Less Distortion Lawrence L. Wald, Ph.D. 09:40 fMRI Paradigm Design Nick F. Ramsey, Ph.D. 10:15 Break - Meet the Teachers         10:45 Pre-processing of BOLD fMRI Mark Jenkinson, Ph.D. 11:20 General Linear Model for BOLD fMRI Analysis Robert W. Cox, Ph.D. 11:55 Independent Component Analysis of BOLD fMRI Data Vince D. Calhoun, Ph.D. 12:30 Break     12:30 - 12:45 - Meet the Teachers           13:45 Low Frequency BOLD Fluctuations and Brain Functional Connectivity Vesa J. Kiviniemi, Ph.D. 14:20 Perfusion-based fMRI Thomas T. Liu, Ph.D. 15:00 Break - Meet the Teachers           15:30 Blood Volume Based fMRI Hanzhang Lu, Ph.D. 16:05 Relationship Between fMRI Signals And The Underlying Neurophysiological Activity Studied In Animal Models Amir Shmuel, Ph.D.     16:40 Combining Functional Imaging Modalities Rainer Goebel, Ph.D. 17:15 BOLD Crimes: Frequently-committed fMRI Offenses James J. Pekar, Ph.D.  17:50 - 18:00 - Meet the Teachers     17:50 Adjournment