| Quantitative MR Analysis
of Articular Cartilage: MSK Applications |
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Monday 20 April 2009 |
| Room 312 |
11:00-13:00 |
Moderators: |
Xiaojuan Li and Hollis G. Potter |
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11:00 |
70. |
Morphological and Biochemical (T2) MR Evaluation and
Comparison of Cartilage Repair Tissue of the Patella
and the Medial Femoral Condyle |
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Goetz Hannes Welsch1,
Tallal Charles Mamisch2, Lukas Zak3,
Sebastian Quirbach1, Stefan Marlovits3,
Siegfried Trattnig1
1MR Center, Department of Radiology, Medical
University of Vienna, Vienna, Austria; 2Department
of Orthopedic Surgery, University of Berne, Berne,
Switzerland; 3Center for Joints and
Cartilage, Department of Trauma Surgery, Medical
University of Vienna, Vienna, Austria |
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The objective of this
study was to use advanced MR techniques to evaluate
and compare cartilage repair tissue after
matrix-associated autologous chondrocyte
transplantation in the patella and in the medial
femoral condyle (MFC). For morphological evaluation,
the MR observation of cartilage repair tissue (MOCART)
score was used, with a 3D-True-FISP sequence. For
biochemical assessment, T2-mapping was prepared by a
multi-echo spin-echo approach with particular
attention to the zonal structure of cartilage. The
assessment of cartilage repair tissue of the patella
and the MFC demonstrated comparable morphological
results, whereas biochemical T2 values showed
differences, possibly due to dissimilar
biomechanical loading conditions. |
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11:12 |
71. |
Effect of Knee Alignment on T2 Relaxation Time of
Articular Cartilage |
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Risto Ojala1,
Riikka Partanen1, Ilkka Hannila1,
Eveliina Lammentausta1, Marianne Haapea1,
Osmo Tervonen1,2, Miika T. Nieminen1,2
1Department of Diagnostic Radiology, Oulu
University Hospital, Oulu, Finland; 2Department
of Radiology, University of Oulu, Oulu, Finland |
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Varus and valgus
malalignment of the knee is known to increase the
risk of medial and lateral osteoarthritis,
respectively. To assess whether knee alignment
influences T2 relaxation time of tibio-femoral
cartilage, T2 was measured at the weight-bearing
cartilages of 30 patients with knee symptoms and 20
asymptomatic volunteers at 1.5T. Varus alignment
resulted in a significant increase in T2 in the
whole medial tibial cartilage and the deep parts of
the femoral cartilage. Valgus alignment caused an
increase only in tibial cartilage, predominantly in
the medial compartment. T2 mapping may provide a
sensitive tool to detect early degenerative
cartilage changes. |
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11:24 |
72. |
Multiexponential T2 Analysis in Cartilage
Degraded Using Different Enzymatic Protocols |
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David A. Reiter1,
Ligaya Roque1, Richard G. Spencer1
1National Institute on Aging, National
Institutes of Health, Baltimore, MD, USA |
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We sought to improve the
specificity for cartilage matrix degradation through
multiexponential analysis of T2
relaxation, which can delineate macromolecular
compartments with varying water fraction and
mobility. Multiexponential T2 analysis of
control cartilage and of cartilage subjected to
three enzymatic degradation protocols showed
distinct patterns, consistent with the known actions
of the degradative enzymes used. In contrast, while
monoexponential T2 values increased with
degradation, there was no enzyme-specificity in this
increase. Therefore, multiexponential T2
analysis demonstrates greatly improved specificity
over standard monoexponential T2 analysis
to changes in cartilage matrix, indicating the
diagnostic potential of such analysis for detecting
cartilage disease. |
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11:36 |
73. |
Evaluation of Cartilage T2 Using Loading in Situ MRI
in Early Osteoarthritis with Hip Dysplasia |
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Takashi Nishii1, Toshiyuki Shiomi2,
Hisashi Tanaka3, Youichi Yamazaki4,
Kenya Murase4, Takashi Sakai2,
Masaki Takao2, Hideki Yoshikawa2,
Nobuhiko Sugano1
1Department of Orthopaedic Medical
Engineering, Osaka University Medical School, Osaka,
Japan; 2Department of Orthopaedic
Surgery, Osaka University Medical School, Osaka,
Japan; 3Department of Radiology, Osaka
University Medical School, Osaka, Japan; 4Department
of Medical Physics & Engineering, Osaka University
Medical School, Osaka, Japan |
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Cartilage T2 with use of
loading in situ MR imaging (50% of body weight) was
evaluated in 9 patients with hip dysplasia and 9
normal volunteers, for evaluation of cartilage
pressure distribution in vivo. There was
significant decrease of T2 by loading at the outer
zone of the acetabular cartilage and inner zone of
the femoral cartilage in dysplastic hips (p<0.05).
Loading in situ MR imaging with T2 assessment may
allow biomechanical assessment of pathological
conditions related to localized stress concentration
and have prognostic significance for osteoarthritic
changes in hip dysplasia. |
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11:48 |
74. |
Localised
Cartilage Assessment with Three-Dimensional DGEMRIC
in Subjects with Normal and Cam-Type Abnormal Hip
Joint Morphology. an Assay of Early Disease. |
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Tom
C.B. Pollard1, Eugene G. McNally1,
Derek C. Wilson2, Burkhard Maedler3,
David R. Wilson2, Marion Watson1,
Andrew J. Carr1
1Nuffield Department of Orthopaedic Surgery,
University of Oxford, Oxford, UK; 2Department
of Orthopaedics, University of British Columbia,
Vancouver, BC, Canada; 3Philips
Healthcare, Vancouver, BC, Canada |
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The majority of cases of
hip osteoarthritis are caused by morphological
abnormalities, such as the cam deformity. Treating
such deformity may prevent disease progression. A
sensitive, responsive assay of chondral damage is
needed to assess treatment efficacy.
dGEMRIC was performed on
subjects without radiographic osteoarthritis, with
and without cam deformities. The ratio of the
T1-index in the anterosuperior acetabular cartilage,
divided by the T1-index for the whole joint
cartilage, was significantly different between the
two groups.
Using dGEMRIC to map
chondral damage may have advantages over a single
measure of whole joint cartilage in OA. dGEMRIC
offers promise as an assay of early hip
osteoarthritis. |
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12:00 |
75. |
Factors
Affecting Accuracy of T1 Estimates in Vivo by
Variable Flip Angle Approach for DGEMRIC |
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Angela Manuel1,
Wei Li1, Vladimir Jellus2,
Timothy Hughes2, Pottumarthi V. Prasad1
1NorthShore
University HealthSystem, Evanston, IL, USA; 2Healthcare
Sector, Siemens AG, Erlangen, Germany |
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Previous experience with
phantoms has shown good agreement in T1s obtained by
standard 2D IR-TSE and 3D VFA techniques. However,
the level of agreement in vivo was less. In
order to determine the reason behind this
inaccuracy, we investigated a number of potential
factors, such as number of flip angles used, fitting
routines, and effects of B1 inhomogeneity. Our
results suggest that increasing the number of flip
angles had minimal or no effect on improving the
agreement between the techniques and that B1
inhomogeneity may be most responsible for the
apparent poor agreement between 3D VFA and 2D IR-TSE
estimates. |
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12:12 |
76. |
Longitudinal Evaluation of Cartilage Degeneration in
ACL-Injured Knees Using MR T1ρ Quantification and
Laminar Analysis |
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Daniel Kuo1,
Alekos A. Theologis1,2, Radu I. Bolbos1,
Julio Carballido-Gamio1, ChunBong
Benjamin Ma3, Xiaojuan Li1
1Musculoskeletal Quantitative Imaging Research
(MQIR), Department of Radiology, University of
California, San Francisco, San Francisco, CA, USA;
2School of Medicine, University of
California, San Francisco, San Francisco, CA, USA;
3Department of Orthopaedic Surgery,
University of California, San Francisco, San
Francisco, CA, USA |
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Patients with ACL
injuries have a high risk of developing
osteoarthritis (OA) despite ACL reconstruction.
However, the mechanism of OA development in
ACL-injured knees remains elusive. Nine ACL-injured
patients were studied over 2 years to evaluate
changes in bone marrow edema-like lesions (BMEL) and
cartilage degeneration. Degenerative changes were
evaluated using MR T1ρ relaxation time
quantification and laminar analysis. Although BMEL
resolved significantly over time, T1ρ values in BMEL-overlying
cartilage were elevated at both baseline and
follow-ups, suggesting irreversible damage in those
regions. T1ρ values were also elevated in
superficial layers of the weight-bearing cartilage
sub-compartments of the medial knee. |
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12:24 |
77. |
Demonstration of the Pre-Clinical Efficacy of
Aggrecanase Selective Inhibitor by T1p MRI |
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Reddy Beesam Shashank1,
Ashwini Anumandla2, Eric Albert Mellon2,
Jennifer H. Lee3, Jingsong Wang3,
Ravinder Reddy2
1MMRRCC,Radiology, University of Pennsylvania,
Philadelphia, PA, USA; 2MMRRCC,Radiology,
University of Pennsylvania, USA; 3Wyeth
Research, Collegeville, USA |
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To demonstrate the
effectiveness of T1p MRI as a pre-clinical tool in
drug development. |
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12:36 |
78. |
Ultrashort TE MRI of the Osteochondral Junction of
the Knee at 3T:Identification of Anatomic Structures
Contributing to Signal Intensity |
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Won C. Bae1, Jerry R. Dwek2,
Richard Znamirowski1, Sheronda Statum1,
Juan C. Hermida3, Darryl D. D’Lima4,
Robert L. Sah5, Jiang Du1,
Christine B. Chung1
1Radiology, UC San Diego, San Diego, CA, USA;
2Children’s Hospital and Health Center,
UC San Diego, San Diego, CA, USA; 3Scripps
Clinic; 4Scripps Clinic, La Jolla, CA,
USA; 5Bioengineering, UC San Diego, La
Jolla, CA, USA |
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Joint diseases may
involve abnormalities in the junction between
cartilage and bone. Using Ultrashort Time-to-Echo
(UTE) MRI techniques, tissues with short T2
properties at this junction become visible, unlike
when conventional sequences are used. UTE MR
signature of human osteochondral tissues near the
junction (uncalcified cartilage, calcified cartilage
and subchondral bone) was determined, using
experimental treatments to isolate specific
components. Both calcified cartilage and the deepest
layer of uncalcified cartilage were identified as
tissues contributing to the UTE signal. This study
has implications for clinical evaluation of the
osteochondral junction and introduces new
opportunities for assessing joint disease using MRI. |
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12:48 |
79. |
Evaluation
of Articular Cartilage of Lumbar Facet Joints with
UTE MR Imaging and Multi-Echo SE T2 Mapping
Techniques |
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Hatice Tuba Sanal1, Tobias Mett2,
Sheronda Statum1, Jiang Du1,
Richard Znamirowski1, Graeme Bydder1,
Christine Chung1
1Radiology, UCSD, San Diego, CA, USA; 2THE
VIENNA SCHOOLS OF MEDICINE, Vienna, Austria |
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Evaluation of articular
cartilage (AC) of lumbar facet joints (LFJS) with
UTE/Multi-Echo SE T2 Mapping. Objective:
Qualitatively/quantitatively evaluate morphology and
biochemical integrity of AC of LFJs. Materials and
methods: A cadaveric lumbar spine was evaluated with
standard clinical, UTE sequences, multi-echo SE T2
mapping and T1/T2* measurement. Results: Mean T2
value of superficial layer of cartilage was 53 ms on
abnormal side and 40ms on normal side. T2* value of
calcified layer of cartilage on abnormal side and
normal side were calculated 6.8 ms and 2.1
respectively.
Conclusion/Discussion:
Quantitative evaluation of FJ’s cartilage might be
useful for lower back pain. |
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