| Weekday Educational
Course: |
| Tools and Tips for Mouse Imaging and Spectroscopy |
| Organizers: Carles Arús, Ph.D.,
and Klaas Nicolay,
Ph.D. |
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| Skill Level: Basic |
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| Monday, 20 April 2009 |
| 14:00 - 16:00 |
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| OVERVIEW |
This two hour course deals
with the practicalities of MR imaging and spectroscopy
of mice. A significant fraction of the biomedical MR
research that is done worldwide involves studies on
small animal models (predominantly mice). Working with
such small animals often requires very specific
solutions in terms of MR hardware (RF and gradient
coils), shimming procedures, physiological monitoring
approaches, etc. Topics to be covered are:
- Anesthesia and physiological monitoring procedures;
- Wild-type and genetically modified animal models;
- High-resolution whole-body imaging;
- Ultra-small voxel spectroscopy;
- The use of whole-body MRI scanners for studies on
mice;
- The design of dedicated mouse RF coils.
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| EDUCATIONAL OBJECTIVES
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Upon completion of this
case-based session, participants should be able to:
- Explain the main acquisitions protocols that are
used for in vivo high-resolution MR imaging and
spectroscopy of alive mice;
- Recognize the specific requirements of
physiological monitoring of anesthetized mice;
- Indicate the opportunities and the limitations
of the use of clinical MR scanners for research on
mice;
- Recognize the strength and the limitations of
the use of genetically modified animal models of
human disease for translational research; and
- Describe the main design concepts of RF coils
for MR studies on mouse models.
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