| Weekend Educational Course:
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| Probing Cancer with MR II: From Animal Models to Clinical Assessment |
| Organizers:
Martin O. Leach, Ph.D. and Anwar R. Padhani, MRCP, FRCR |
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| Skill Level:
Basic - Intermediate |
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| Sunday, 19 April 2009 |
| 08:30 - 17:30 |
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| OVERVIEW |
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This one day course focuses
on clinical imaging biomarker development with a view to
meet current challenges in clinical diagnosis and
management, and drug development. Didactic lectures will
cover the key biological hallmarks of cancers which are
assessable by MRI/MRS techniques that are ready for
clinical translation (hypoxia, proliferation, altered
metabolism and angiogenesis). For each biomarker, the
biological basis, quantification methods, validation and
clinical use will be described by pairs of experts
(scientist with physician) involved in biomarker
development. Emphasis will be placed on biomarker
qualification processes including the integration of
multi-parametric information using statistical methods
and bioinformatics. The approaches demonstrated will be
relevant to other biomarkers and for diagnosis, the
assessment of tumor aggressiveness, therapy response and
resistance and will be relevant to the development of
novel anti-cancer therapeutics. |
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| EDUCATIONAL OBJECTIVES
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Upon completion of this
case based session, participants should be able to:
- Explain the challenges of clinical diagnosis and
management and of drug development;
- Describe how cancer cellular proliferation and
tissue hypoxia and angiogenesis are key biological
markers of the aggressive cancer phenotype;
- Describe biological basis and evidence for MRI
biomarkers that are ready for clinical translation;
- List methods for predictive biomarker
qualification; and
- Discuss insights on how to integrate
multi-parametric, multispectral imaging information
using bioinformatics.
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| Sunday, 19 April 2009 |
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Biomarker Needs
in the Clinic and for Drug Development |
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| 08:30
|
Clinical Bottlenecks
in the Patient Cancer Journey |
Shih-chang
Wang, M.D. |
| 09:00 |
Imaging in Drug
Development (RECIST and Well Beyond) |
Philip
S. Murphy, Ph.D. |
| 09:30
|
Framework for
Clinical Predictive Biomarker Qualification |
Anwar R.
Padhani, MRCP, FRCR |
| 10:00 |
Break - Meet the
Teachers |
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Choline and
Cancer |
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| 10:30 |
Metabolic Changes in
Cancer |
Kristine
Glunde, Ph.D. |
| 11:00 |
Clinical
Applications of Magnetic Resonance Spectroscopy |
Arend
Heerschap, Ph.D. |
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Vascular Targets
|
|
| 11:30 |
Extracting
Physiological Vascular Information Using Contrast
Agents |
David L.
Buckley, Ph.D. |
| 12:00
|
Break - Meet the
Teachers |
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13:30 |
Assessing Anti-Vascular and Anti-Angiogenic
Therapies |
Jeffrey L. Evelhoch,
Ph.D. |
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Hypoxia
Importance and Assessments |
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| 14:00 |
Clinical Importance
of Tumor Hypoxia |
Peter
Vaupel, M.D. |
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14:30 |
Imaging Assessments
of Tumor Oxygenation |
Simon P.
Robinson, Ph.D. |
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Cellular Density
Evaluations |
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| 15:00 |
Diffusion MRI:
Principles & Data Analyses |
Thomas
L. Chenevert, Ph.D. |
| 15:30 |
Break - Meet the
Teachers |
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16:00 |
Diffusion MRI: Utility in Cancer Management
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Dow-Mu Koh, M.D. |
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Statistical Considerations and Bioinformatic
Integration |
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16:30 |
Statistical Analyses of Imaging Trials
|
Brandon J. Whitcher,
Ph.D. |
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17:00 |
CAD
Solutions to Multimodal Data Analyses |
Henkjan Huisman, Ph.D. |
| 17:30 |
Adjournment - Meet the Teachers |
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