| Weekend Educational Course:
|
| Cellular and Molecular Imaging |
| Organizer: Patrick Winter,
Ph.D. |
| |
| Skill Level:
Basic |
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| Saturday, 18 April 2009 |
| 08:00 - 17:30 |
|
| OVERVIEW |
|
The first part of this
one day course will focus on technological aspects of
cellular and molecular imaging, covering the underlying
physical principals and design criteria for three
primary classes of MRI contrast agents (paramagnetic,
super-paramagnetic and activatable agents). Part 2 will
focus on biological labeling techniques, including in
vivo targeting of MRI contrast agents to biomarkers,
labeling strategies for tracking cellular migration and
homing, and cell tracking using methods that produce
positive image contrast. Part 3 will outline diverse
applications of cellular and molecular imaging
techniques, demonstrating specific contrast agent
designs to meet the unique needs of each: ultra-high
field imaging, nanotechnology and detection of
angiogenesis. The final portion covers the use of
molecular and cellular MRI for detecting and monitoring
the response to therapy. In particular, three broad
applications will be presented, including two of the
most prevalent and debilitating diseases (cancer d
cardiovascular disease) and the newly emerging field of
gene therapy. Apart from the technological aspects, most
of the lectures in the course will highlight recent
applications of cellular and molecular imaging in
biomedical research. |
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| EDUCATIONAL OBJECTIVES
|
Upon completion of this
case based session, participants should be able to:
- Explain basic concepts and the potential of
cellular and molecular imaging as a basic research
tool, for diagnostics of disease processes and for
monitoring therapeutic interventions, and explain
the role of imaging cellular and molecular markers
versus structural and physiological readouts;
- Explain image contrast principles of the various
reporter moieties (paramagnetic, superparamagnetic
and activatable MRI contrast agents) and recognize
the strengths and weaknesses of each;
- Describe the techniques utilized to
functionalize contrast agents for the purpose of
binding or interacting with biological targets and
the resulting imaging procedures to detect cellular
or molecular biomarkers;
- List design criteria for contrast agents
specifically developed for various biomedical
applications;
- Assess the potential of cellular and molecular
imaging concepts for combining therapeutic
interventions and diagnostics.
|
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|
| Saturday, 18 April 2009 |
| |
|
|
| 08:00 |
Introduction |
Patrick
M. Winter, Ph.D. |
| 08:35 |
Paramagnetic Agents
|
Eva
Jakab Toth, Ph.D. |
| 09:10 |
Iron Oxide Particles
|
Marlène
Wiart, Ph.D. |
| 09:45 |
Activatable Agents
|
A. Dean
Sherry, Ph.D. |
| 10:20 |
Break - Meet the
Teachers |
|
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Labeling
Strategies |
|
| 10:40 |
In vivo
Targeting |
Dmitri
Artemov, Ph.D. |
| 11:15 |
Cell Labeling
|
Olivier
Clément, M.D., Ph.D. |
| 11:50 |
Cell Tracking with
Positive Contrast |
Michael
T. McMahon, Ph.D. |
| 12:25 |
Break - Meet the
Teachers |
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|
Applications |
|
|
13:30 |
Ultra High Field
|
Glenn A.
Walter, Ph.D. |
| 14:05 |
Nanotechnology
|
Lon J.
Wilson, Ph.D. |
|
14:40 |
Imaging Angiogenesis
|
Michal
Neeman, Ph.D. |
| 15:15 |
Break - Meet the
Teachers |
|
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Therapy
Monitoring |
|
| 15:45 |
Cancer
|
Kevin M.
Brindle, D.Phil. |
|
16:20 |
Cardiovascular
Disease |
Dara L.
Kraitchman, V.M.D., Ph.D. |
| 16:55 |
Gene Therapy
|
Ann-Marie Broome, Ph.D. |
| 17:30 |
Adjournment - Meet the Teachers |
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