Electronic
Posters
: Body (Non-Cancer) Imaging
|
Click on
to view the abstract pdf and click on
to view the video presentation. |
Body Diffusion: Technique & Clinical Applications
Monday May 9th
Exhibition Hall |
14:00 - 16:00 |
Computer 4 |
14:00 |
2978. |
Investigating the
contribution of osteoblastic activity to ADC of bone
metastases by correlating changes in ADC with changes in
T2* and HU
![](play.gif)
Christina Messiou1, David J Collins1,
Matthew Robson2, Veronica A Morgan1,
Catherine Simpkin1, Diletta Bianchini3,
Johann S de Bono3, and Nandita deSouza1
1CRUK & EPSRC Cancer Imaging Centre,
Institute of Cancer Research & Royal Marsden NHS
Foundation Trust, Sutton, Surrey, United Kingdom, 2Dept.
of Cardiovascular Medicine, University of Oxford,
Oxford, United Kingdom, 3Dept.
of Medicine, Institute of Cancer Research & Royal
Marsden NHS Foundation Trust, Sutton, Surrey, United
Kingdom
The aim of this study was to investigate the
contribution of osteoblastic activity to ADC of bone
metastases from prostate carcinoma undergoing
treatment by correlating changes in ADC with changes
in T2* and HU. Percentage changes in ADC did not
correlate with percentage change in HU or T2*. This
may be because intertrabecular distance is beyond
the range interrogated by the DWI technique employed
in this study. Because intertrabecular distance is
so large relative to cell size, a marked sclerotic
response may be required to bring intratrabecular
distances down to a level where it affects
intercellular distances and diminishes ADC.
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14:30 |
2979. |
Improved diagnostic
accuracy of whole body diffusion weighted MRI using
computed imaging. ![](play.gif)
Matthew David Blackledge1, Nina Tunariu1,
David J Collins1, Martin O Leach1,
and Dow Mu Koh1
1CR-UK and EPSRC Cancer Imaging Centre,
Institute of Cancer Research and Royal Marsden
Hospital, Sutton, Surrey, United Kingdom
A recent methodology known as computed diffusion
weighted imaging (cDWI) has demonstrated that
improved SNR may achieved at high b-values by
acquiring images at multiple b-values, calculating
the apparent diffusion coefficient maps and using
the results to simulate the signal at a desired
b-value. In the present study we compare the
diagnostic utility of cDWI, computed at b-values of
1500 and 2000 s/mm2, with conventional DWI, acquired
at 900 s/mm2, in a small cohort of patients
diagnosed with advanced metastatic disease.
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15:00 |
2980. |
Whole-body MR-imaging
allows to differentiate indolent from aggressive
systemic mastocytosis
Henrik J Michaely1, Georgia Metzgeroth2,
Philipp Riffel1, Stefan Haneder1,
W K Hofmann2, Stefan O Schoenberg1,
and Andreas Reiter2
1University Medical Center Mannheim,
Mannheim, BaWue, Germany, 2Oncolocy,
University Medical Center Mannheim, Mannheim, BaWue,
Germany
Systemic mastocytosis is a rare clonal stemm cell
disease occurring in different manifestations:
aggressive systemic mastocytosis, smouldering
mastocytosis and indolent mastocytosis. In this
study wb-MRI was employed to detect the various
manifestations of systemic mastocytosis which
allowed to safely differentiate between the subtypes
of the disease.
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15:30 |
2981. |
Diffusion-Weighted
Imaging of Retroperitoneal Fibrosis and Retroperitoneal
Lymphoma: Can Apparent Diffusion Coefficient Values
Distinguish the Two? ![](play.gif)
Bradley Spieler1, Caludia Reuben Seuss1,
Daniel Sahlein1, and Sooah Kim1
1Radiology, New York University, New
York, NY, United States
27 patients with histopathologically proven
retroperitoneal lymphoma (n=16) and retroperitoneal
fibrosis (RPF, n=11) who underwent MRI including DWI
using b-values of 0, 400, and 800 sec/mm2 at 1.5T
were included. Two readers measured ADCs
independently. ADC values of lymphoma and RPF were
compared by independent sample t-test. There was no
statistical difference in measured ADC between
lymphoma (1.26 *10-3mm2/sec, range 0.54-2.03
*10-3mm2/sec) and RPF (1.35 *10-3mm2/sec, range
0.61-2.45 *10-3mm2/sec) (p=0.57).
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Tuesday May 10th
13:30 |
2982. |
Diffusion-weighted MRI
of normal sized pelvic lymph nodes: how to delineate an
ideal region of interest? ![](play.gif)
Daniel Guo Quae Chong1, Giuseppe Petralia1,2,
Michael Ith1, Johnannes Michael Froehlich1,3,
and Harriet Thoeny1
1Dept. of Diagnostic, Interventional and
Pediatric Radiology (DIPR), Inselspital, Bern,
Switzerland, 2Division
of Radiology, European Institute of Oncology, Milan,
Italy,3Guerbet AG, Zurich, Switzerland
Small structure such as lymph nodes are difficult to
visualized with diffusion weighted imaging. Due to
the lower resolution of DWI and the size of typical
lymph node, it is often the case only 1-4 pixels
contain signal from lymph node with partial volume
effect. This study looks at the effect of this low
pixel count and mediate via image interpolation. No
significant difference was found pre and post image
interpolation for ADC values.
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14:00 |
2983. |
Longitudinal Follow-up
of Kidneys from Living Donors to Their Recipients by
DWI.
Peter Vermathen1, Tobias Binser1,
Harriet C Thoeny2, Chris Boesch1,
Felix J Frey3, and Ute Eisenberger3
1Dept. of Clinical Research, University
of Bern, Bern, Switzerland, 2Dept.
of Radiology, University & Inselspital, Bern,
Switzerland, 3Dept.
of Nephrology, University & Inselspital, Bern,
Switzerland
We performed a prospective longitudinal DWI study in
living kidney donors and their corresponding
recipients before and after transplantation. The
unique situation in living renal allograft donation
allows monitoring DWI changes in the same kidney
before transplantation in the donor and after
transplantation in the recipient. Over one year, all
determined diffusion parameters remained remarkably
stable. This constancy corresponded to GFR, which
also remained stable over one year. Cortical ADC
obtained in recipients after transplantation
correlated significantly with those obtained the
same kidney before transplantation in the donor,
indicating an important impact of the original
kidney status on ADC.
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14:30 |
2984. |
Diffusion-weighted MRI
in the kidney pre- and post-transplantation in
donor-recipient pairs ![](play.gif)
Karl Kristopher Vigen1, Sean B Fain2,
and Elizabeth A Sadowski1
1Radiology, University of
Wisconsin-Madison, Madison, WI, United States, 2Medical
Physics, University of Wisconsin-Madison, Madison,
WI, United States
Water diffusion measured with MR diffusion weighted
imaging (DWI) has been suggested as a means of
studying tissue microstructure changes and can
potentially be estimated using the apparent
diffusion coefficient (ADC). Using donor-recipient
pairs, this study aims to understand the normal
response of water diffusion in kidneys undergoing
transplantation compared to the remaining donor
kidney.
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15:00 |
2985. |
The Effect of Fat
Suppression on ADC Values in Murine Liver with Variable
Degrees of Fibrosis ![](play.gif)
Stephan William Anderson1, Jorge A Soto1,
Elizabeth Tang1, and Hernan Jara1
1Radiology, Boston University Medical
Center, Boston, MA, United States
Purpose: The determine if fat suppression(FS) pulses
influence ADC values and whether effects vary based
on degrees of fibrosis in murine liver. Methods:
3,5-dicarbethoxy-1,4-dihydrocollidine was utilized
to induce hepatic fibrosis. Liver specimens were
imaged using 11.7T MRI; ADC values with and without
fat suppression were compared and differences
correlated with hepatic fibrosis. Results: Slight
differences in ADC values derived with FS were seen;
poor correlation was seen between differences in ADC
and degrees of fibrosis. Conclusion: The difference
in ADC values with and without FS is not a
confounding effect in deriving ADC values of the
liver with variable fibrosis.
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Wednesday May 11th
13:30 |
2986. |
Assesment of liver
blood flow using a navigator echo respiratory gated
parallel imaging technique at 1.5 T
Loredana Sorina Truica1,2, and Ian
Cameron2
1Carleton University, Ottawa, ON, Canada, 2Diagnostic
Imaging - MRI research Lab, Ottawa Hospital- General
Campus
IVIM measurements of normal liver at 1.5 T using a
respiratory triggered DW_SS_EPI as well as a
DW_SS_EPI breath hold protocol are reported.
Improvements in the acquisition and analysis
techniques used in this study allowed us to obtain
more consistent results for the perfusion fraction,
f, the diffusion coefficient, D, and the
pseudo-diffusion coefficient, D*, than previous
studies. Parameter maps of D and f were reflective
of liver anatomy. Such maps can be useful tools in
identifying tissue differences and give important
insight into the organ hemodynamic system. This
technique could become instrumental in the
assessment and management of normal/diseased tissue
in abdomen.
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14:00 |
2987. |
Diffusion-weighted MRI
for the zonal characterization of liver tumors ![](play.gif)
Mathilde Wagner1,2, Sabrina Doblas2,
Jean-Luc Daire1,2, Helena Leitao1,2,
Philippe Garteiser2, Valérie Vilgrain1,2,
Ralph Sinkus2, and Bernard Edgar Van
Beers1,2
1Radiology, Beaujon University Hospital,
Clichy, France, 2Inserm
U773, Centre de Recherche Biomédicale Bichat
Beaujon, Clichy, France
The aim of this study was to assess if DW-MRI with
separate measurements of ADC mono, ADC slow, and ADC
fast could be used to differentiate between viable,
fibrotic and necrotic regions within liver tumors.
In contrast to ADC mono and ADC fast, ADC slow
differed significantly between the three tumor
regions. These results suggest that when using
DW-MRI for the characterization and follow-up during
treatment of liver tumors, ADC slow rather than ADC
mono should be used.
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14:30 |
2988. |
The effect of Gd-DTPA
on the determination of the Apparent Diffusion
Coefficient in liver metastases and healthy liver tissue
Ulrike Fasol1, Klaus Mross2,
Annette Frost2, Martin Buechert1,
Valerij Kiselev1, and Juergen Hennig1
1MR Development and Application Center,
University Medical Center Freiburg, Freiburg,
Germany, 2Tumor
Biology Center, Albert-Ludwigs-University Freiburg,
Freiburg, Germany
Using the Apparent Diffusion Coefficient (ADC) as a
biomarker for tumors under therapy is currently
under investigation. In most studies contrast
enhanced imaging is included in the protocol, which
poses the problem of the influence of the contrast
agent on the determination of ADC. Studies performed
till now were mainly focused on measurements in the
brain. We present results for the effect of contrast
agent on the ADC measurements in normal liver tissue
and metastasis at 1.5 T.
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15:00 |
2989. |
Correlation of
contrast enhancement speed of hepatic hemangiomas on
gadolinium-enhanced dynamic T1-weighted images with
apparent diffusion coefficient on diffusion-weighted
imaging
Dal-Mo Yang1, Hyun-Cheol Kim1,
and Geon-Ho Jahng1
1Radiology, Kyung Hee University,
East-West Neo Medical Center, Seoul, Korea, Republic
of
Correlation of speed of hepatic hemangiomas on
gadolinium-enhanced dynamic T1-weighted images with
apparent diffusion coefficient on diffusion-weighted
imaging
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Thursday May 12th
13:30 |
2990. |
Motion Correction of
Multiple b-values (MCMB) Diffusion-Weighted Imaging ![](play.gif)
Yousef Mazaheri1, Richard Kinh Gian Do2,
Jingbo Zhang2, Elizabeth Morris2,
Oguz Akin2, and Hedvig Hricak2
1Medical Physics, Memorial Sloan
Kettering Cancer Center, New York, New York, United
States, 2Radiology,
Memorial Sloan Kettering Cancer Center
Diffusion-weighted imaging data were acquired using
at multiple b-values and motion corrected with MCMB
(motion correction of multi b-value). The repeatedly
acquired low-b-value images were used to
prospectively detect and correct for displacement
during extended acquisitions. Co-registration of
higher b-value images was achieved by
nearest-neighbor interpolation of transformation
parameters estimated at lower b-values.
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14:00 |
2991. |
Investigation of the
theoretical background of the IVIM model using flow
compensated DWI ![](play.gif)
Andreas Wetscherek1, Bram Stieltjes2,
Wolfhard Semmler1, and Frederik Bernd
Laun1
1Medical Physics in Radiology, German
Cancer Research Center, Heidelberg, Germany, 2Quantitative
imaging based disease characterization, German
Cancer Research Center, Heidelberg, Germany
To answer the question whether blood flow in
capillaries changes its direction during a typical
diffusion experiment, flow compensated diffusion
weighting gradients were used for the first time in
abdominal DWI of pancreas and liver. In contrast to
the TE-dependent bi-exponential signal decay
observed in strongly perfused organs when using
bipolar gradients, the acquired data can be modeled
by a mono-exponential decay and shows no dependence
on TE or on the total duration of the diffusion
weighting gradients. Since net flow effects are
suppressed, flow compensated diffusion weighting
gradients may prove useful when investigating the
vascularization structure.
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14:30 |
2992. |
Assessment of position
dependent eddy current distortions in DW EPI
measurements: monopolar versus bipolar diffusion
preparation ![](play.gif)
Verena Ballweg1, Petros Martirosian1,
Hansjörg Graf1, Hanne Wojtczyk1,
and Fritz Schick1
1Section on Experimental Radiology,
University Hospital Tübingen, Tübingen, Germany
Eddy currents in DW EPI sequences cause distortions
which negatively influence fibre tracking for
instance. Bipolar gradients reduce those distortions
but lead to a longer echo time and hence to a
decreased signal-to-noise ratio. However, lately
gradient system quality concerning eddy currents
increased making bipolar sequences maybe needless.
Therefore, the distortions of DW EPI sequences with
monopolar and bipolar diffusion preparations were
compared at off-center positions and in the
isocenter, revealing that monopolar sequences can be
applied in the isocenter without considerably
greater distortions. At off-center positions bp
gradients are still needed.
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15:00 |
2993. |
PCATMIP: Enhancing
Signal Intensity in DW-MRI ![](play.gif)
Vinay Manjunath Pai1, Stanislas Rapacchi2,
Peter Kellman1, Pierre Croisille2,
and Han Wen1
1NHLBI, National Institutes of Health,
Bethesda, MD, United States, 2Laboratoire
CREATIS, INSA de Lyon, Lyon, France
Diffusion-weighted MRI (DWI) studies in body imaging
generally lose signal intensity to physiological
motion, which can adversely affect quantification
and diagnosis. While averaging over multiple
repetitions improves signal-to-noise ratio (SNR), it
does not recover the attenuated signal intensity. We
present PCATMIP, a combined Principal Component
Analysis (PCA) and Temporal Maximum Intensity
Projection (TMIP) approach, as a means to resolving
this issue. Numerical simulations and experimental
results using porcine liver data show that PCATMIP
yields higher signal intensity and less variability
than averaging and higher SNR than TMIP, thus
achieving an optimal balance between averaging and
TMIP for processing DWI data.
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Electronic
Posters
: Body (Non-Cancer) Imaging
|
Click on
to view the abstract pdf and click on
to view the video presentation. |
Metabolism/Diabetes
Monday May 9th
Exhibition Hall |
14:00 - 16:00 |
Computer 5 |
14:00 |
2994. |
Volume selective MRS of
the liver for determination of hepatic lipids – is there a
need for cardiac and/or respiratory triggering?
Jürgen Machann1, and Fritz Schick1
1Section on Experimental Radiology,
University Hospital Tübingen, Tübingen, Germany
1H-MRS of the liver for quantification of
hepatic lipid content has evolved to one of the most
applied spectroscopic applications during the past
years, as hepatic lipids are involved in metabolic
diseases. However, as liver is a moving organ, spectral
quality might be influenced by breathing and heartbeat.
There is a discussion about the best acquisition
strategy regarding different triggering modalities
(ECG-triggering, respiratory triggering and combination
of both). This study on 5 volunteers depicts differences
in spectral quality and acquisition times for all
combinations of triggering. Best results regarding
quality and acquisition time are achieved when subjects
breathe flatly during the TR interval and are in
expiration during data acquisition.
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14:30 |
2995. |
Real-time navigator gating
in proton liver spectroscopy at 3T
Andreas Hock1, Ladislav Valkovic2,
Ivan Frollo2, Peter Boesiger1,
Anke Henning1, and Spyros Kollias3
1Institute for Biomedical Engineering,
University and ETH Zurich, Zurich, Switzerland, 2Department
of Imaging Methods, Institute of Measurement Science,
Slovak Academy of Sciences, Bratislava, Slovakia, 3University
Hospital of Zurich, Institute of Neuroradiology, Zurich,
Switzerland
Navigator gated proton MR spectroscopy with inner volume
saturation allows free breathing measurements of liver
molecules while ensuring a precise location of the
measured voxel. It is shown in 5 healthy volunteers that
the spectral quality is improved and the variation of
molecule ratios are decreased compared to measurements
without gating. This technique may thus improve the
quality of the diagnostic procedure of liver disease.
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15:00 |
2996. |
Metabolite Cycled
Non-Water-Suppressed Spectroscopy Offers Increased Spectral
Quality In Cases of Physiologic and Subject Motion ![](play.gif)
Erin Leigh MacMillan1, Murielle Bortolotti2,
Andreas Boss1, Chris Boesch1, and
Roland Kreis1
1Dept. of Clinical Research, University of
Bern, Bern, Bern, Switzerland, 2Dept.
of Physiology, University of Lausanne, Lausanne,
Switzerland
Metabolite cycled non-water-suppressed MRS enables
automatic phase, frequency, and eddy-current correction
of individually acquired spectra to improve SNR and
lineshape of metabolite peaks. Examples from deliberate
motion of the head and respiratory motion of the liver
show remarkable improvement in both SNR and linewidth.
The median FWHM of the liver spectra water peak was
improved from 18Hz (range: 13-36Hz) to 15Hz (13-22Hz),
demonstrating how this technique performs particularly
well with decreasing quality of the originally measured
spectra. The improved spectral quality will help make
MRS more applicable in the clinic, especially in cases
of subject or physiologic motion.
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Tuesday May 10th
13:30 |
2997. |
Fast T2 Relaxometry in
1H-MRS of Hepatic Water and Fat using Short TR at 3T
Giulio Gambarota1, Mark Tanner1,
Marinette van der Graaf2, Robert Mulkern3,
and Rexford D Newbould1
1Clinical Imaging Center, GSK, Imperial
College, London, United Kingdom, 2Radboud
University Nijmegen Medical Centre, Nijmegen,
Netherlands, 3Radiology,
Children's Hospital Boston, Boston, United States
Fast measurement of both lipid and water T2 relaxation
time is feasible in a single breath hold, with
acquisition of several echoes and improved lipid SNR.
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14:00 |
2998. |
Quantitative estimation of
the degree of macrosteatosis in living related liver donors
using IDEAL gradient echo imaging
Jeong Min Lee1, Eugene Joe1, and
Joon Koo Han1
1Radiology, Seoul National University
Hospital, Seoul, Seoul, Korea, Republic of
IDEAL can be used as a highly specific modality for the
diagnosis of hepatic macrosteatosis as it does not have
the confounding influence caused by hepatic iron
deposition. IDEAL can accurately depict minimal
macrovesicular hepatic steatosis within the normal
range, thereby avoiding biopsy in potential living liver
donors with an acceptable degree of steatosis for
transplantation.
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14:30 |
2999. |
Noninvasive Quantification
of Hepatic Steatosis in Rats with 1.5 T MRS and MRI:
Feasibility, Early Results and Optimization
Gaspard d'Assignies1,2, Ghislaine Fontés3,4,
Louis Gaboury5, Yvan Boulanger4,6,
Gilles Soulez7, Vincent Poitout3,4,
and An Tang8
1Radiology, Hôpital Saint-Luc, Montreal,
France, 2Beaujon
Hospital, Université Paris VII, Canada, 3Montréal
Diabetes Research Center, Canada, 4CRCHUM,
Canada,5Department of anatomo-pathology,
CHUM, Canada, 6Radiology,
Hôpital Saint-Luc, Canada, 7Radiology,
CRCHUM, Canada, 8Radiology,
University of Montreal, Montreal, Quebec, Canada
The purpose of the study is to validate and optimize a
routine 1.5T MRI method to detect and measure liver
steatosis in an experimental glucolipotoxic rat model by
using 1H-MR spectroscopy as the reference standard. Two
20° and 90° flip angle (FA) were applied on the dual
echo in/out of phase sequence and T2* was calculated.
MRI and 1H-MRS accurately distinguished steatotic from
non steatotic liver. A significant correlation was found
between dual-echo MRI and MRS. This correlation was
higher with 90° (r = 0.749, P < 0.001) than with 20° FA
(r = 0.651, P < 0.001). T2* correction did not improve
the correlation with 1H-MRS.
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15:00 |
3000. |
MRI detection of glycogen
in vivo in diabetic mice at 3 tesla: feasibility and initial
experience
Mina Kim1, Queenie Chan1,2, James
YB Lau3, Sookja K Chung3, and
Pek-Lan Khong1
1Departement of Diagnostic Radiology, The
University of Hong Kong, Hong Kong, Pokfulam, Hong Kong, 2Philips
Healthcare, Hong Kong, 3Department
of Anatomy, The University of Hong Kong
Development of sensitive method to quantify glycogen in
vivo may help to understand the pathophysiology of
type-2 diabetes. In present study, we tested feasibility
of in vivo glycogen detection in diabetic mouse model
using chemical exchange saturation transfer imaging. Our
results suggest that in vivo CEST quantification in
mouse liver is feasible in a clinical scanner.
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Wednesday May 11th
13:30 |
3001. |
Longitudinal Tracking of
Adiposity in a Canine Model of Insulin Resistance ![](play.gif)
Edward Brian Welch1,2, Johan Berglund3,
Joel Kullberg3, Katie Colbert Coate4,
Phil Williams4, Alan Cherrington4,
and Malcolm J Avison1,2
1Vanderbilt University Institute of Imaging
Science, Vanderbilt University, Nashville, TN, United
States, 2Department
of Radiology and Radiological Sciences, Vanderbilt
University, Nashville, TN, United States, 3Department
of Radiology, Uppsala University, Uppsala, Sweden, 4Department
of Molecular Physiology and Biophysics, Vanderbilt
University, Nashville, TN, United States
Animal models in which whole body adiposity can be
manipulated and the size of specific adipose tissue (AT)
depots measured longitudinally and non-invasively, can
help improve our understanding of the role of specific
AT depots in the pathogenesis of obesity-associated
metabolic diseases. In this abstract, we describe the
adaptation of a whole body fat-water MR imaging
acquisition and automated analysis pipeline, initially
validated in human volunteers, for whole-body FWI in
dogs. We demonstrate the utility of this pipeline by
following the changes in lean and AT volume in dogs
placed on an obesogenic high-fat, high-fructose diet
known to increase insulin.
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14:00 |
3002. |
Test-Retest
Reproducibility of Whole-body Fat Water Imaging at 3 Tesla
Compared to DEXA ![](play.gif)
Edward Brian Welch1,2, Malcolm J Avison1,2,
Kevin D Niswender3, Johan Berglund4,
Joel Kullberg4, Lars Johansson4,
Morten Bruvold5, and Heidi J Silver3
1Vanderbilt University Institute of Imaging
Science, Vanderbilt University, Nashville, TN, United
States, 2Department
of Radiology and Radiological Sciences, Vanderbilt
University, Nashville, TN, United States, 3School
of Medicine, Vanderbilt University, Nashville, TN,
United States, 4Department
of Radiology, Uppsala University, Uppsala, Sweden, 5MR
Clinical Science, Philips Healthcare, Best, Netherlands
Whole-body MRI has great potential for quantifying the
amount, type and distribution of adipose tissue to help
better understand its metabolic consequences.
Multi-gradient-echo MR acquisitions have been
successfully used to quickly acquire whole-body
fat-water imaging data sets. Dual energy x-ray
absorptiometry (DEXA) is widely used in studies of body
composition, but few direct comparisons of the
performance of fat-water MR imaging (FWMRI) to DEXA are
available, especially for 3T FWMRI. Here we present
test-retest results of scanning 12 obese female subjects
using a 3T mFFE whole-body FWMRI sequence as well as
DEXA.
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14:30 |
3003. |
Quantitative Analysis of
Fat Distribution using Whole-Body Magnetic Resonance Imaging ![](play.gif)
Julien Dinkel1, Diana Wald2,
Heinz-Peter Schlemmer3, Hans-Peter Meinzer4,
Rudolf Kaaks5, and Stefan Delorme3
1Radiology, German Cancer Research Center,
Heidelberg, Germany, 2Medical
and Biological Informatics, German Cancer Research
Center, 3Radiology,
German Cancer Research Center, 4Medical
and Biological Informatics, 5Cancer
Epidemiology, German Cancer Research Center
The purpose of this study was to evaluate a
semiautomatic method to quantify the distribution of
visceral and non visceral internal fat acquired using
the two point Dixon technique from whole-body MRI data.
We performed MR imaging on 30 subjects using a 1.5T
system using a 3d-Dixon-VIBE sequence. Signal strength
changes within the 3D volume due to variation in coil
sensitivity were corrected with a normalization
algorithm. Full automated correction of the
Dixon-mismatch artifacts were performed successfully.
Automated segmentation quantifying the distribution of
visceral and non visceral fat were done and assessed as
successful by an experienced radiologist.
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15:00 |
3004. |
Correlation of lipid
profile and insulin sensitivity with body fat evaluated
using MRI, Dual Energy X-ray Absorptiometry and Bioimpedance ![](play.gif)
Ankur Poddar1, and Rama Jayasundar1
1NMR, All India Institute of Medical
Sciences, New Delhi, Delhi, India
Correlation of lipid profile and insulin sensitivity
with body fat evaluated using MRI, Dual Energy X-ray
Absorptiometry and Bioimpedance A.Poddar 1, R.
Jayasundar 2, A.C. Ammini 3, A. K. Mukhopadhyaya 4
Departments of Biotechnology1, NMR2, Endocrinology3, Lab
Medicine4, All India Institute of Medical Sciences, New
Delhi, India. In this study, body fat assessed using
MRI, Dual energy x-ray absorptiometry (DEXA) and
Bio-impedance analysis (BIA) methods are correlated
individually with biochemical parameters such as lipid
profile, insulin sensitivity, BMI & BMR and compared.
These biochemical parameters are considered risk factors
for diabetes, obesity, etc. The data indicates that fat
mass evaluated using all the three techniques (MRI, DEXA
and BIA) correlated well with insulin sensitivity and
BMI and can be used interchangeably. However, only MRI
evaluated fat mass correlated well with cholesterol and
MRI had the additional advantage of giving information
on fat distribution in the whole body.
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Thursday May 12th
13:30 |
3005. |
Determination of ATP
synthesis exchange rates in human liver and skeletal muscle
using 31P
magnetization transfer ![](play.gif)
Tania Buehler1, Andreas Boss1,
Roland Kreis1, and Chris Boesch1
1Dept. of Clinical Research, University of
Bern, Bern, Switzerland
The metabolic syndrome, which includes insulin
resistance (IR), is a risk factor for cardiovascular
diseases with epidemic dimensions. It is hypothesized
that impaired mitochondrial activity could be a cause of
IR. ATP synthesis exchange rates determined by 31P
MRS allow a non-invasive estimation of mitochondrial
activity. Several human studies exist for skeletal
muscle, but only one for liver. Two methods (31P
saturation (ST) and inversion transfer (IT)) have been
implemented in combination with volume selection based
on saturation bands. In this study the two methods for a
determination of ATP synthesis exchange rates are
compared in skeletal muscle and liver.
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14:00 |
3006. |
Regional variability in
triglyceride composition of adipose tissue measured by 1H
MRS ![](play.gif)
Gavin Hamilton1, Michael S Middleton1,
Takeshi Yokoo1, and Claude B Sirlin1
1Department of Radiology, University of
California, San Diego, San Diego, California, United
States
The multi-peak structure of the fat 1H
MR Spectrum allows non-invasive estimation of
triglyceride composition in adipose tissue in
vivo. The study compares variability in triglyceride
composition of three different abdominal adipose tissue
depots. We see statistically different triglyceride
compositions in the three abdominal adipose tissue
depots.
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14:30 |
3007. |
Influence of Type 2
Diabetes on Intramyocellular Lipids among Patients with
Chronic Kidney Disease ![](play.gif)
Jimin Ren1, Manisha Shah2, Maram
Museitif2, Lynne Roetzer2, A Dean
Sherry1,3, Craig R Malloy1,2, and
Devasmita Choudhury2
1Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, Texas,
United States, 2VA
North Texas Health Care System, 3Department
of Chemistry, University of Texas at Dallas, Richardson,
Texas
Chronic kidney disease (CKD) and type 2 diabetes (T2D)
are both highly prevalent and complex disorders. While
T2D may cause CKD; CKD also independently causes insulin
resistance. Increased intramyocellular lipids (IMCL)
have been associated with insulin resistance and
diabetes but the role of the compartmental distribution
of lipids in normal physiology and disease is still
debated. This study was designed to test the hypothesis
that patients with T2D and CKD have higher levels of
IMCL compared to patients with CKD but without overt
T2D. Surprisingly, the results showed that IMCL was not
significantly different in diabetic vs. nondiabetic CKD
patients.
|
15:00 |
3008. |
Look-Locker MRI
measurements of relaxation rate after manganese labeling of
pancreatic β cells detect increments in disease progression
in a mouse model of type 1 diabetes ![](play.gif)
Patrick Antkowiak1, Brian Stevens2,
Marcia McDuffie2, and Frederick H Epstein3
1Biomedical Engineering, University of
Virginia, Charlottesville, Virginia, United States, 2Microbiology,
University of Virginia, 3Radiology,
University of Virginia
Pancreatic β cells secrete insulin and maintain blood
glucose homeostasis; in type 1 diabetes mellitus (T1D),
β cell function and mass decline, with potentially
severe complications. Noninvasive imaging to detect this
decline would be important for both pre-clinical and
clinical studies. We used Look-Locker MRI to measure the
pancreatic relaxation rate R1 after injection of MnCl2,
which labels functional β cells, and applied this to a
mouse model of T1D characterized by a graded loss of
functional β cell mass. We measured a decline in
pancreatic R1 concurrent with the incidence of T1D and
decline in functional β cell mass.
|
|
|
Electronic
Posters
: Body (Non-Cancer) Imaging
|
Click on
to view the abstract pdf and click on
to view the video presentation.
|
Body Applications of Contrast Media & Bowel MRI
Monday May 9th
Exhibition Hall |
14:00 - 16:00 |
Computer 6 |
14:00 |
3009. |
Evaluation of positive
contrast around SPIO-loaded polymer threads for surgical
mesh delineation by MRI ![](play.gif)
Hank C.W. Donker1, Nils A. Krämer1,
Jens Otto2, Ioana Slabu3, Martin
Baumann3, Uwe Klinge2, and
Christiane K. Kuhl1
1Department of Diagnostic Radiology, RWTH
Aachen University, Aachen, NRW, Germany, 2Department
of Chirurgy, RWTH Aachen University, Aachen, NRW,
Germany,3Helmholtz Institute for Applied
Medical Engineering, RWTH Aachen University, Aachen,
NRW, Germany
Surgical textile mesh implants for abdominal hernia
repair are hard to delineate in MRI. To improve
MR-visualization, superparamagnetic iron oxides (SPIO)
were implanted in the mesh polymer base material. SPIO
generate magnetic susceptibility gradients. To
discriminate SPIO induced voids from proton-free
structures positive contrast susceptibility imaging was
developed. Here 4 ways to generate positive contrast
from susceptibility gradients were compared: IRON,
FLAPS, white-marker imaging and SGM. The acquisition of
a gradient echo image with a calculated Short Term
Fourier Transform Susceptibility Gradient Map image is
to be preferred for positive contrast imaging of SPIO
loaded hernia meshes.
|
14:30 |
3010. |
High-resolution
interstitial MR lymphography for the diagnosis of sentinel
lymph nodes: Inhomogeneous distribution of SPIO within
non-malignant lymph nodes
Daisuke Suzuki1,2, Masayuki Yamaguchi1,
Toshihiro Furuta1,3, Kohki Yoshikawa2,
and Hirofumi Fujii1
1Functional Imaging Division, National Cancer
Center Hospital East, Kashiwa, Chiba, Japan, 2Graduate
Division of Health Sciences, Komazawa University,
Setagaya, Tokyo, Japan, 3Department
of Radiology, The Tokyo University Hospital, Tokyo,
Japan
Since the presence of sentinel lymph nodes (SLNs)
metastasis predicts a poor prognosis, the diagnosis of
SLN metastasis is clinically important. MR lymphography
by means of the interstitial administration of
superparamagnetic iron oxide (SPIO) is one of the
techniques that can sensitively detect SLNs based on the
signal reduction by SPIO trapped by macrophages. To our
knowledge, the intra-lymph node distribution of
subcutaneously administered SPIO has not been fully
understood. In this study, we demonstrated the
inhomogeneous distribution of interstitially
administered SPIO within regional lymph nodes of mice
using high-resolution MRI and Prussian blue-stained
specimens
|
15:00 |
3011. |
Fitting DCE-MRI data in
the liver with a dual-inlet model: choice of venous and
arterial delay parameters ![](play.gif)
Steven Sourbron1, Wieland Sommer2,
Christoph J Zech2, Maximilian F Reiser2,
and Karin A Herrmann2
1Division of Medical Physics, University of
Leeds, Leeds, United Kingdom, 2Department
of Clinical Radiology, University of Munich, Munich,
Germany
The choice of arterial and venous delay times in DCE-MRI
of the liver has a strong effect on the measured
parameters. In this study a number of alternative
methods are applied to patient data and compared.
Results show that an arterial delay time is necessary to
obtain a good fit to the data, but including an
additional venous delay causes unstable and
overestimated perfusion values. It is concluded that
DCE-MRI data in the liver are best analysed by fitting
an arterial delay, and assuming that the venous delay is
zero.
|
15:30 |
3012. |
Initial experiences
evaluating the hepatic arterial buffer response with DCE-MRI
in healthy rats at 9.4T ![](play.gif)
Manil Chouhan1, Shonit Punwani1,
Alan Bainbridge2, Nathan Davies3,
Raj Mookerjee3, Rajiv Jalan3, and
Stuart Taylor1
1Centre for Medical Imaging, University
College London, London, London, United Kingdom, 2Department
of Medical Physics, University College London Hospitals
NHS Trust,3Institute of Hepatology,
University College London
Feasibility of DCE-MRI for liver haemodynamic assessment
before and after modulation of portal venous flow is
demonstrated, with presentation of preliminary data.
|
Tuesday May 10th
13:30 |
3013. |
Clinical Feasibility of
High-Resolution Navigator-Gated 3D T1w Hepatobiliary MRI
with Gd-EOB-DTPA Enhancement
Alan De Lun Xu1, Anja C Brau2,
Yuji Iwadate2, Jarrett Rosenberg1,
Shreyas Vasanawala1, and Robert Herfkens1
1Radiology, Stanford University, Stanford,
CA, United States, 2GE
Healthcare
Conventional contrast-enhanced 3D T1w hepatic imaging
requires serial breath-hold acquisitions to capture the
contrast dynamics, inherently limiting spatial
resolution and image quality. The hepatobiliary-specific
contrast agent Gd-EOB-DTPA offers a prolonged time
window of contrast-enhancement over which data can be
acquired. This work evaluates the clinical feasibility
of using a navigator-gated 3D T1w sequence to improve
the spatial resolution and image quality of
Gd-EOB-DTPA-enhanced hepatobiliary imaging compared to
conventional breath-hold imaging.
|
14:00 |
3014. |
Balanced MR
Cholangiopancreatography with Motion-Sensitized
Driven-Equilibrium: Feasibility of Post-contrast Biliary
Examination with Gadolinium Ethoxybenzyl Diethylene Triamine
Pentaacetic Acid (Gd-EOB-DTPA) ![](play.gif)
Tomohiro Nakayama1, Akihiro Nishie1,
Takashi Yoshiura1, Yoshiki Asayama1,
Kousei Ishigami1, Daisuke Kakihara1,
Yukihisa Takayama1, Makoto Obara2,
and Hiroshi Honda1
1Clinical Radiology, Graduate School of
Medical Sciences, Kyushu University, Fukuoka, Fukuoka,
Japan, 2Philips
Electronics Japan
In this study, a balanced steady-state free precession
(SSFP) sequence with motion-sensitized
driven-equilibrium (MSDE) preparation was used as an
alternative technique for magnetic resonance
cholangiopancreatography (MRCP).@@T2-weighted MRCP was
associated with poor visualization of the biliary
systems due to excreted Gd-EOB-DTPA, as previously
reported. Use of MSDE-balanced MRCP resulted in higher
CNR and better visualization of biliary structures than
T2-weighted MRCP. Moreover, problematic vesselfs
signals, such as PV and HV, were sufficiently suppressed
by MSDE technique.@@In conclusion, we demonstrated the
usefulness of MSDE-balanced MRCP sequenced in
Gd-EOB-DTPA post-contrast study.
|
14:30 |
3015. |
Diagnosis of FNH:
Comparison of Gd-EOB-DTPA with Gd-BOPTA, Preliminary Results
from a Multicentric US Study. ![](play.gif)
Christine Iseman1, Bachir Taouli1,
Rajan T Gupta2, John Leyendecker3,
and Elmar Merkle2
1Mount Sinai School of Medicine, New York,
NY, United States, 2Duke
University, Durham, NC, United States, 3Wake
Forest University, Winston-Salem, NC, United States
In this study, we report preliminary results from a US
multicentric study, comparing qualitatively and
quantitatively Gd-EOB-DTPA and Gd-BOPTA for diagnosis of
FNH. 23 FNHs were assessed in 11 preliminary patients.
Lesion conspicuity was equivalent for both contrast
agents at all phases. Quantitative enhancement was
significantly higher at the arterial and portal venous
phases for Gd-BOPTA, and higher at the hepatobiliary
phase for Gd-EOB-DTPA. These preliminary results
indicate advantage for BOPTA at the dynamic phase, and
advantage for EOB at the hepatobiliary phase.
|
15:00 |
3016. |
The First Human Whole Body
Pharmacokinetic Minimal Model for the Liver Specific
Contrast Agent Gd-EOB-DTPA ![](play.gif)
Mikael Fredrik Forsgren1,2, Olof Dahlqvist
Leinhard1,3, Gunnar Cedersund2,4,
Nils Dahlström1,3, Örjan Smedby1,3,
Torkel B Brismar5, and Peter Lundberg3,6
1Department of Medical and Health Sciences,
Division of Radiological Sciences, Linköping University,
Linköping, Sweden, 2Department
of Clinical and Experimental Medicine, Diabetes and
Integrated Systems Biology, Linköping University,
Linköping, Sweden, 3Center
for Medical Image Science and Visualization (CMIV),
Linköping University, Linköping, Sweden, 4School
of Life Sciences, Freiburg Institute of Advanced
Sciences, Freiburg, Germany, 5Department
of Radiology, Karolinska University Hospital, Stockholm,
Sweden, 6Department
of Radiation Physics, CKOC, University Hospital of
Linköping, Linköping, Sweden
Clinical dynamic contrast-enhanced MRI examinations of
the human liver can be analyzed in detail using tissue
models. Our aim was to devise the first physiologically
correct minimal model that describes the most important
routes of contrast agent flux. Based on established
pharmacokinetic equations incorporated into a system of
ordinary differential equations, the model has a
significant potential for gaining a better understanding
of the contrast agent behaviour in the human body. We
believe that it is possible, in a Bayesian modeling
framework, to use the model on individual patient data,
thereby increasing the information obtained from
clinical examinations.
|
Wednesday May 11th
13:30 |
3017. |
Magnetization Transfer
Detects Changes in Intestinal Fibrosis after Anti-TNF![lower case Greek alpha](http://submissions.miracd.com/ISMRM2011/Images/LCGreek/alpha.gif) ![](play.gif)
Scott D Swanson1, Jeremy Adler2,
Phyllissa Schmiedlin-Ren3, Kinan Rahal3,
Laura Reingold3, and Ellen M Zimmermann3
1Department of Radiology, University of
Michigan, Ann Arbor, MI, United States, 2Department
of Pediatrics and Communicable Diseases, University of
Michigan, Ann Arbor, MI, United States, 3Department
of Internal Medicine-Gastroenterology, University of
Michigan, Ann Arbor, MI, United States
synopsis
|
14:00 |
3018. |
T2 relaxometry
to assess inflammation and fibrosis in an acute and chronic
murine model of inflammatory bowel diseases
Tom Dresselaers1, Christine Breynaert2,
Gert Van Assche2, and Uwe Himmelreich1
1Biomedical NMR Unit/ MoSAIC, K.U.Leuven,
Leuven, Brabant, Belgium, 2Division
of Gastroenterology, K.U.Leuven, leuven, Brabant,
Belgium
In human colon disease, the value of MRI and CT
enterography as a non-invasive assessment tool of
transmural inflammation and extraluminal complications
is increasingly recognized. However, data on MR imaging
as a screening tool to study murine ileitis or colitis
are limited. In this study the feasibility of using
T2-weighted imaging and T2 maps to distinguishing
between a DSS induced acute and chronic murine colitis
model was evaluated. T2 values are markedly different
between the control, acute and chronic group. This is
confirmed by histology which shows more fibrosis in the
chronic versus acute model.
|
14:30 |
3019. |
Optimising oral contrast
agents for interactive neonatal gut imaging ![](play.gif)
Owen John Arthurs1, Martin John Graves1,
Ilse Joubert1, and David John Lomas1
1Radiology, University of Cambridge,
Cambridge, Cambridgeshire, United Kingdom
The optimal contrast medium for neonatal gut MR imaging
is unclear. Here, we investigate the relative T1
properties of several different potential agents to
provide optimal signal. We then tested a variable IR
pulse during interactive SSFSE imaging to null existing
bowel fluid and demonstrate feasibility. An optimal
in-vitro TI of 500 - 800ms gave maximal signal
difference between pineapple juices and milk, but
in-vivo this was 1000 ms. Application of an optimally
timed IR pulse can allow for improved contrast medium
imaging in this sensitive population.
|
15:00 |
3020. |
Contrast-enhanced MR
enterography as a stand-alone tool to evaluate Crohn’s
disease in pediatric population. ![](play.gif)
Bradley Spieler1, Nicole Hindman1,
Caludia Reuben Seuss1, Alec J Megibow1,
Joseph Levy2, Kerry Zabriskie2,
Daniel Sahlein1, Rafael Rivera1,
and Sooah Kim1
1Radiology, New York University, New York,
NY, United States, 2Pediatric
Gastroenterology, New York University, New York, NY,
United States
MR imaging of the pediatric abdomen can be challenging,
often secondary to inability to tolerate long scan
times. Twenty five pediatric patients (mean age 11.2
years) with Crohn’s disease referred for MR enterography
at 1.5 T were evaluated. Two radiologists reviewed post
contrast images of MRI during the first session and all
images including pre- and post contrast sequences during
the second session. The intestine was divided into 10
segments. The readers evaluated the presence or absence
of disease in regard to the presence of active
inflammation using a five-point grading system.
Sensitivity, specificity, PPV, NPV, and accuracy for
diagnosing definite active inflammation using post
contrast images alone were 83.3%, 86.9%, 89.3%, 80%, and
84.9%, respectively. In all five of the false negative
cases there was a disagreement in at least one bowel
segment with respect to the presence or absence of
abscess and/or sinus tracts which was confirmed on
non-contrast images (HASTE without fat suppression).
|
Thursday May 12th
13:30 |
3021. |
Simultaneous assessment of
gastric secretion, mixing and emptying during free breathing ![](play.gif)
Jelena Curcic1, Matthias Sauter2,
Werner Schwizer2, Peter Boesiger1,
and Andreas Steingoetter1,2
1Institute for Biomedical Engineering,
University and ETH, Zurich, Zurich, Switzerland, 2Division
of Gastroenterology and Hepatology, University Hospital
Zurich, Zurich, Switzerland
Gastric emptying, distention, intragastric secretion and
mixing are important factors in pathogenesis of
gastro-intestinal (GI) diseases such as
gastro-esophageal reflux disease (GERD). A formerly
described method, for simultaneous T1 mapping and
imaging was optimized and validated for free breathing
gastric imaging. The optimized sequence (GOLD) was used
in-vivo to simultaneously detect intragastric secretion
and mixing as well as gastric emptying during free
breathing. This pilot study shows the feasibility of the
GOLD sequence to detect multiple gastric parameters in
one single free breathing period of maximally 2 min and
emerges as a versatile tool for diagnostic GI MRI.
|
14:00 |
3022. |
Quantitative assessment of
small bowel motility by nonrigid registration of dynamic MR
images ![](play.gif)
Freddy Odille1, Alex Menys2, Asia
Ahmed2, Shonit Punwani2, Stuart
Taylor2, and David Atkinson1
1Centre for Medical Image Computing,
University College London, London, United Kingdom, 2Centre
for Medical Imaging, University College London, London,
United Kingdom
Small bowel motility assessment by dynamic MRI is of
increasing interest for the clinical management of
enteric disorders such as Crohn’s disease. A
postprocessing technique is described for the automated
assessment of bowel motility. The technique jointly
registers 2D dynamic images (nonrigidly) and models
local intensity changes due to through-plane motion or
flow. Validation was performed by drawing various small
bowel regions in 10 patients with known or suspected
Crohn’s disease. We assessed the performance of the
registration (manual versus automatically propagated
markers) as well as the agreement between automated
motility measures with expert grading of the motility.
|
14:30 |
3023. |
Defining the mode of
action of Loperamide and Loperamide plus Simethicone using
an MRI model of acute diarrhoea ![](play.gif)
Elisa Placidi1, Luca Marciani2,
Caroline L Hoad1, Klara C Garsed2,
Susan E Pritchard1, Eleanor F Cox1,
Carolyn Costigan3, Robin C Spiller2,
and Penny A Gowland1
1SPMMRC, University of Nottingham,
Nottingham, United Kingdom, 2Nottingham
Digestive Diseases Centre Biomedical Research Unit,
Nottingham, United Kingdom, 3Brain
and Body Centre, University of Nottingham, Nottingham,
United Kingdom
MRI was used to investigate the mode of action of
anti-diarrheal drugs, loperamide and loperamide +
simethicone, using a model of acute diarrhoea based on a
mannitol drink. 18 healthy volunteers were imaged on a
1.5 T Philips Achieva scanner with several sequences up
to 5 hours after the mannitol drink, to assess changes
in the gut in terms of water content, volume, T2 and
image signal intensity. Differences between the three
conditions have been quantified, proving that the MRI
technique optimised is efficient to investigate the
response of the gut to drugs.
|
15:00 |
3024. |
Real-time Imaging and
Reconstruction of the Small Bowels Based on Golden Ratio
Radial and Regularized SENSE MRI ![](play.gif)
Lau Brix1,2, Steffen Ringgaard2,
Brian Stausbøl-Grøn2, Bodil Ginnerup Pedersen2,
Yasmina Berber3, Mario Ries3, and
Thomas Sangild Sørensen4,5
1Department of Clinical Engineering, Aarhus
N, Region Midt, Denmark, 2MR-Centre,
Aarhus University Hospital, Skejby, Aarhus N, Region
Midt, Denmark, 3Laboratoire
IMF, Centre National de la Recherche Scientifique/Universite
Bordeaux 2, France, 4Department
of Computer Science, Aarhus University, Denmark, 5Institute
of Clinical Medicine, Aarhus University, Denmark
The aim of this project was to implement a real-time
data and reconstruction system for imaging of the bowel
by using a constant azimuthal profile based on the
Golden Ratio. The reconstruction gave the operator a
unique possibility to interactively reconstruct images
with an optimal compromise between a true temporal
resolution and a sliding window reconstruction in
real-time. This study demonstrates that real-time images
of the bowel may improve the diagnosis and documentation
of patients with Crohn’s disease, bowel stenosis or
altered bowel motility and is a step toward using MRI
for imaging moving organs on-line in real-time.
|
|
|
Electronic
Posters
: Body (Non-Cancer) Imaging
|
Click on
to view the abstract pdf and click on
to view the video presentation. |
Pulmonary Structure & Function with Hyperpolarized Gas & Proton
MRI
Monday May 9th
Exhibition Hall |
14:00 - 16:00 |
Computer 7 |
14:00 |
3025. |
Modeling Hyperpolarized 129Xe
Bolus Passage for Quantification of Pulmonary Blood Flow ![](play.gif)
Harald E. Möller1,2, Zackary I. Cleveland2,
Laurence W. Hedlund2, John Nouls2,
Matthew Freeman2,3, Yi Qi2, and
Bastiaan Driehuys2
1Max Planck Institute for Human Cognitive and
Brain Sciences, Leipzig, Germany, 2Center
for In Vivo Microscopy, Duke University Medical Center,
Durham, NC, United States, 3Graduate
Program in Medical Physics, Duke University, Durham, NC,
United States
Information on pulmonary perfusion can be obtained by
from experiments involving intravenous injection of
hyperpolarized (HP) 129Xe.
Signal curves recorded in rats during bolus transport
through the gas-exchange region can be fitted to a model
that assumes delayed bolus arrival and an exponential
transport function to account for dispersion effects.
Quantitative results are consistent with expected values
for the cardiac output and transit times in the lung.
|
14:30 |
3026. |
A simple model of gas
exchange in the lung for hyperpolarized Xe129 ![](play.gif)
Yulin V Chang1
1Mechanical Engineering, Washington
University, St. Louis, MO, United States
We present in this a work a simple model of gas exchange
in the lung for hyperpolarized Xe129. This model
expresses the two dissolved-xenon signal amplitudes in
the lung in terms of several important pulmonary
parameters, including surface area-to-volume ratio,
air-blood barrier thickness, capillary blood transit
time, etc. It provides a means to quantify not only the
microstructure, but the physiology and function of the
lung. It can potentially be used in diagnosing a variety
of related pulmonary diseases.
|
15:00 |
3027. |
Optimized diffusion time
for long-time-scale Helium-3 diffusion MRI ![](play.gif)
Chengbo Wang1, John P Mugler, III1,2,
Eduard E de Lange1, and Talissa A Altes1
1Radiology, University of Virginia,
Charlottesville, VA, United States, 2Biomedical
Engineering, University of Virginia, Charlottesville,
VA, United States
Global long-time-scale helium-3 ADC values as a function
of diffusion time were measured in 29 healthy volunteers
and 14 subjects with COPD. The percentage difference in
group mean ADC versus diffusion time had a well-defined
maximum at a diffusion time of approximately 1 s,
suggesting that this diffusion time affords the best
ability to discriminate COPD and healthy subjects.
Furthermore, the percentage difference between the two
groups at the long-time scale (110%-150%) was much
greater than that found at the short-time-scale
(commonly, 20%-100%), which supports the premise that
long-time-scale diffusion is more sensitive to COPD than
short-time-scale diffusion.
|
15:30 |
3028. |
Non-linear image
registration of 3He
lung diffusion MRI acquired at different inflation states,
exemplified by alveolar ventilation maps ![](play.gif)
Torsten Dorniok1, Peter Magnusson1,
Frederik Hengstenberg1,2, Sergei Karpuk3,
Jorgen Vestbo2, Per Åkeson1, and
Lise Vejby Søgaard1
1Danish Research Centre for Magnetic
Resonance, Copenhagen University Hospital, Hvidovre,
Denmark, 2Department
of Cardiology and Respiratory Medicine, Copenhagen
University Hospital, Hvidovre, Denmark, 3Institute
of Physics, University of Mainz, Mainz, Germany
A non-linear image registration method was used to
co-register hyperpolarized 3He diffusion MRI data
acquired at different stages of inflation. The method
was validated using synthetic data and data from healthy
volunteers. ADC values in the original and registered
maps were compared regionally to assess if the
transformation had any considerable effect on the
values.
|
Tuesday May 10th
13:30 |
3029. |
Functional mapping of
regional airway obstruction and gas trapping in 3D using
dynamic HP He-3 MRI ![](play.gif)
Jionghan Dai1, Eric T Peterson2,
James H Holmes3, Robert V Cadman1,
Ronald L Sorkness4, and Sean B Fain1,5
1Medical Physics, University of Wisconsin -
Madison, Madison, Wisconsin, United States, 2Biomedical
Engineering, University of Wisconsin - Madison, Madison,
Wisconsin, United States, 3Global
Applied Science Laboratory, GE Healthcare, Madison,
Wisconsin, United States, 4pharmacy,
University of Wisconsin - Madison, Madison, Wisconsin,
United States, 5Radiology,
University of Wisconsin - Madison, Madison, Wisconsin,
United States
Noble gas MRI enables high contrast to noise dynamic
imaging during respiratory maneuvers. A model of gas
in-flow using linear system theory to deconvolve the
dispersion at the trachea provides maps that are
analogous to gas flow, while washout delay during forced
exhalation provides maps of gas trapping. In this work
the feasibility of these modeling approaches is
evaluated in adults and children with known obstructive
lung disease.
|
14:00 |
3030. |
Validation of
Hyperpolarized 3Helium
MRI in probing Regional Ventilation: A quantitative
assessment against MDCT based local air volume changes (AVC) ![](play.gif)
Ahmed Fathi Halaweish1,2, Youbing Yin3,
Daniel R. Thedens1, Ching-Long Lin3,
Edwin JR vanBeek4, and Eric A Hoffman1,2
1Department of Radiology, University of Iowa,
Iowa City, IA, United States, 2Department
of Biomedical Engineering, University of Iowa, Iowa
City, IA, United States,3Department of
Mechanical & Industrial Engineering, University of Iowa,
Iowa City, IA, United States, 4Queen's
Medical Research Institute, University of Edinburgh,
Edinburgh, Scotland
Hyperpolarized 3Helium
MRI has enabled probing of ventilation distribution
(static ventilation) and the underlying microstructure
(apparent diffusion coefficients). We have successfully
evaluated these techniques against regional ventilation
measures based on local air volume changes, obtained
from matching FRC to TLC MDCT scans. A strong positive
correlation between the techniques was observed, as well
as a strong fit of the regression line between the two,
when assessed on a whole or left & right lung basis.
Differences arise as a function of gas density, such
that 3Helium
distributions are higher in the ventral portions when
compared against the MDCT estimates.
|
14:30 |
3031. |
Development of a
Three-Dimensional Visualization and Atlasing Tool for
Pulmonary Gas Distribution from Hyperpolarized 3He
Magnetic Resonance Imaging ![](play.gif)
Andrew Wheatley1, Usaf Aladl1,
Igor Gyacskov1, Aaron Fenster1,2,
and Grace Parraga1,2
1Imaging, Robarts Research Institute, London,
Ontario, Canada, 2Department
of Medical Biophysics, The University of Western
Ontario, London, Ontario, Canada
Until the emergence of hyperpolarized 3He MRI, it has
been difficult to quantify and visualize the
structure/function relationships of the lung with high
spatial and temporal resolution. Our objective was to
generate, from static ventilation 3He MRI images of
COPD, three-dimensional volumetric lung models that
incorporate k-means clustering of differential pixel
intensities across the lung that represent partial,
fully and non-ventilated regions. We developed software
and a visualization environment to generate a set of
fully rotational 3D surfaces of the regional ventilation
patterns for individual COPD subjects and an image-based
lung atlas that combines the functional features of 55
COPD subjects.
|
15:00 |
3032. |
Improved Compressed
Sensing reconstruction and optimised sampling patterns for
very fast acquisition of Hyperpolarised 3He images ![](play.gif)
Salma Ajraoui1, Steven Parnell1,
Juan Parra-Robles1, Robert Ireland1,
and Jim Wild1
1University of Sheffield, Sheffield, United
Kingdom
Compressed Sening reconstruction of lung 3He images is
improved through the introduction of prior knowldge.
Here coregistered 1H MRI image and the knowledge of the
hyperpolarised gas depolarisation through the k-space
filter are used for a more accurate reconstruction at
higher reduction factor.
|
Wednesday May 11th
13:30 |
3033. |
T2* Measurements of 3.0 T
MRI with Ultra-Short TE: Capabilities of Pulmonary
Functional Assessment and Clinical Stage Classification in
Smokers ![](play.gif)
Yoshiharu Ohno1,2, Hisanobu Koyama1,
Takeshi Yoshikawa1, Nobukazu Aoyama2,
Daisuke Takenaka1, Keiko Matsumoto3,
Masaya Takahashi4, Makoto Obara5,
Marc van Cauteren5, and Kazuro Sugimura1
1Radiology, Kobe University Graduate School
of Medicine, Kobe, Hyogo, Japan, 2Radiology,
Kobe University Hospital, Kobe, Hyogo, Japan, 3Radiology,
Yamanashi Hospital of Social Insurance, Kofu, Yamanashi,
Japan, 4Advanced
Imaging Research Center, University of Texas
Southwestern Medical Center, Houston, TX, United States, 5Philips
Healthcare, Tokyo, Japan
Recently, several investigators have tried to determine
the utility of regional T2* measurement in the lung for
assessment of pulmonary diseases in animal studies. We
hypothesized that direct T2* measurement in the lung at
3.0 T MR system has a potential role to play as a method
for pulmonary functional loss assessment and clinical
stage classification as well as thin-section MDCT. The
purpose of this study was to determine the capability of
pulmonary MR imaging with ultra-short TEs (UTEs) in a
3.0 T system for pulmonary functional assessment and
clinical stage classification in smokers.
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14:00 |
3034. |
3D Pulmonary Perfusion MRI
with Whole-Chest Coverage, High Temporal and Isotropic
Spatial Resolution ![](play.gif)
Kang Wang1, Frank Korosec1,2, Mark
Schiebler2, Christopher Francois2,
Scott Reeder2,3, Thomas Grist2,
Reed Busse4, James Holmes4, Jean
Brittain4, Nathan Artz1, Sean Fain1,3,
and Scott Nagle2
1Medical Physics, University of
Wisconsin-Madison, Madison, WI, United States, 2Radiology,
University of Wisconsin-Madison, Madison, WI, United
States, 3Biomedical
Engineering, University of Wisconsin-Madison, Madison,
WI, United States, 4Applied
Science Lab, GE Healthcare, Madison, WI, United States
MR pulmonary perfusion is well suited for studying the
pulmonary circulation and understanding the physiology
and pathology of the lung. However, MR pulmonary
perfusion has been challenging due to the requirements
for large spatial coverage, high temporal resolution,
and high spatial resolution. The purpose of this study
is to demonstrate the feasibility of obtaining high
isotropic spatial resolution 3D dynamic pulmonary
perfusion images of the whole chest with very high
temporal resolution. The technique combines a previously
developed Interleaved Variable Density sampling method
with parallel imaging and Cartesian HYPR reconstruction.
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14:30 |
3035. |
Automated Airway Lumen
Segmentation and Characterization in Patients with
Tracheomalacia: a Feasibility Study ![](play.gif)
Piotr A Wielopolski1, Pierluigi Ciet2,3,
Rashindra Manniesing4, Sandra Lever2,
Martin Lequin1, Gabriel Krestin1,
and Harm A.W.M. Tiddens1,2
1Radiology, Erasmus Medical Center,
Rotterdam, Netherlands, 2Pulmonology,
Erasmus Medical Center, Sophia Children Hospital,
Rotterdam, Netherlands, 3Radiology,
Department of Medical-Diagnostic Sciences and Therapies,
University of Padua, Padua, Italy, 4Department
of Informatics and Radiology, Erasmus Medical Center,
Rotterdam, Netherlands
Tracheomalacia is an excessive narrowing of the
intra-thoracic part of the trachea such that the airway
is softer and more susceptible to collapse. We
demonstrate a suitable acquisition scenario using static
and dynamic 3D MRI sequences with sufficient temporal
and spatial resolution to provide good morphological
information and visualization of dynamic events in the
central airways. We evaluate a segmentation and dynamic
analysis tool to compute the cross-sectional areas of
the central airways down to the 2nd generation branching
and detect airway narrowing during the respiratory
manouvers. We conclude that cine-MRI is a feasible
non-invasive radiation free alternative for
bronchoscopy.
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15:00 |
3036. |
Comparative Study of SSFP
lung MRI at 1.5T with High Resolution Computed Tomography in
patients with Interstitial Lung Fibrosis
Smitha Rajaram1, Andy James Swift1,2,
David Capener1, Robin Condliffe3,
Charlie Elliot3, Judith Hurdman3,
Christine Davies4, Catherine Hill4,
David G Kiely3, and Jim M Wild1
1Academic unit of Radiology, University of
Sheffield, Sheffield, yorkshire, United Kingdom, 2NIHR
Cardiovascular Biomedical Research Unit, Sheffield,
United Kingdom,3Pulmonary Vascular Disease
Unit, Royal Hallamshire Hospital, Sheffield, 4Department
of Radiology, Royal Hallamshire Hospital, Sheffield
Interstitial lung disease is characterised by
inflammation and scarring of the pulmonary interstitium
leading to increased signal from the diseased lung
tissue. The purpose of our study was to compare 1.5 SSFP
MRI of the lung parenchyma with high resolution computed
tomography (HRCT), which is considered as the ‘gold
standard’ imaging modality in assessment of patients
with interstitial lung disease. MR lung imaging has good
specificity and sensitivity for diagnosing pulmonary
fibrosis. However our results show that lung MRI has a
poor sensitivity (78.5%) for identifying mild degree of
pulmonary fibrosis but high sensitivity for severe
disease.
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Thursday May 12th
13:30 |
3037. |
Accelerated Whole-Lung
Specific Ventilation Imaging in Large Species with
Hyperpolarized Gas MRI ![](play.gif)
Kiarash Emami1, Hooman Hamedani1,
Yinan Xu1, Stephen J. Kadlecek1,
Yi Xin1, Puttisarn Mongkolwisetwara1,
Harrila Profka2, Masaru Ishii3,
and Rahim R. Rizi1
1Radiology, University of Pennsylvania,
Philadelphia, PA, United States, 2Department
of Radiology, University of Pennsylvania, Philadelphia,
PA, United States,3Otolaryngology–Head & Neck
Surgery, Johns Hopkins University, Baltimore, MD, United
States
The accelerated acquisition scheme for imaging specific
ventilation effectively reduced the total imaging time
by a factor of two as implemented in mechanically
ventilated Yorkshire pigs. In addition to retaining the
breathing pattern closer to normal conditions, this
technique is less sensitive to the accumulative RF
effect, as well as O2-induced depolarization of 3He,
which collectively improve the accuracy of r
measurements, and encourages transition to voluntarily
breathing human subjects.
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14:00 |
3038. |
Quantification of Regional
Lung Microstructure Response to Positive End-Expiratory
Pressure by Hyperpolarized Gas MRI in Surfactant-Deficient
Rats ![](play.gif)
Maurizio F. Cereda1, Kiarash Emami2,
Stephen J. Kadlecek2, Yi Xin2,
Puttisarn Mongkolwisetwara2, Harilla Profka2,
Amy Barulic2, Stephen Pickup2,
Nicholas N. Kuzma2, Masaru Ishii3,
Hooman Hamedani2, Benjamin M Pullinger2,
Rajat Ghosh2, Jennia Rajaei2,
Clifford S. Deutschman1, and Rahim R. Rizi2
1Anesthesiology and Critical Care, University
of Pennsylvania, Philadelphia, Pennsylvania, United
States, 2Radiology,
University of Pennsylvania, Philadelphia, Pennsylvania,
United States, 3Otolaryngology–Head
& Neck Surgery, Johns Hopkins University, Baltimore,
Maryland, United States
Positive end expiratory pressure (PEEP) protects
surfactant deficient lungs from lung injury during
mechanical ventilation. The mechanisms of this effect
have not been established at the alveolar level. We used
hyperpolarized gas MRI to quantify the effects of PEEP
on lung microstructure on the alveolar and distal
airspace level in surfactant deficient lungs. We show
that, in spite of the increase in inspiratory pressures,
PEEP alleviates airspace overdistension caused by
surfactant deficiency. This technique can provide unique
pathophysiological insight in the mechanisms of
ventilator-associated lung injury.
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14:30 |
3039. |
Detection of Pulmonary
Ischemia using the Oxygen Sensitivity of Hyperpolarized
Helium MRI in a Rodent Model of Pulmonary Embolism ![](play.gif)
Ronn P Walvick1,2, Austin L Reno2,
Mathew J Gounis2, and Mitchell S. Albert2
1Radiology, New York University Langone
Medical Center, New York, NY, United States, 2Radiology,
University of Massachusetts Medical School, Worcester,
MA, United States
Synopsis: In this work, we present data on the
application of the measurement of measuring the time
course of the partial pressure of oxygen in the lungs
using hyperpolarized helium to detect ischemia in a
novel rodent model of pulmonary ischemia. We show that
both the initial partial pressure of oxygen is higher,
and oxygen uptake rate in the ischemic lung is lower, in
the ischemic then in the contralateral lung of embolized
animals, and in both lungs of control animals. This work
may be useful for the non-invasive evaluation of
experimental treatment options for pulmonary embolism.
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15:00 |
3040. |
Free vs Forced : Gas
Transport Differences in 3He MRI Dynamic Ventilation
Measurements of Lungs Induced by Gas Mixture Application
Regime. ![](play.gif)
Maxim Terekhov1, Manuela Gueldner2,
Klaus Gast3, Julien Rivoire1,
Ursula Wolf3, Janet Friedrich1,
Sergei Karpuk2, Zahir Salhi2, and
Laura Maria Schreiber1
1Department of Diagnostic and Interventional
Radiology. Section of Medical Physics, Johannes
Gutenberg University Medical Center Mainz, Mainz,
Germany, 2Institute
of Physics, Johannes Gutenberg University Mainz, 3Department
of Diagnostic and Interventional Radiology, Johannes
Gutenberg University Medical Center Mainz, Mainz,
Germany
Dynamic ventilation (DV) of lung measured with 3He MRI
is an efficient tool to visualize the intrapulmonary gas
inflow. In current work we performed comparison 3He
application with two different form of gas bolus: short
bolus delivered by Application Unit (AU) in
Free-Breathing mode and Forced Inspiration from Tedlar
bag (TB) via fine tube with high resistance and
prolonged bolus shape. The discrepancy between
application modes was considered in terms of first
orders Linear Transfer Function. The results show that
TB-application changes significantly the gas transport
in parenchyma and higher order derivations of “input
bolus function” should be accounted.
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