Electronic Posters
: Cardiovascular Imaging
|
Click on
to view the abstract pdf and click on
to view the video presentation. |
Myocardial Function: Experimental Models & Human
Studies I
Monday May 9th
Exhibition Hall |
14:00 - 16:00 |
Computer 36 |
14:00 |
3353. |
Quantitative
Evaluation of Regional RF shimming on a Wide
Aperture Dual-Channel Multi-Transmit 3.0T:
Implications for cardiac MRI
![](play.gif)
Ramkumar Krishnamurthy1, Amol
Pednekar2, Marc Kouwenhoven3,
Paul Harvey3, Claudio Arena4,
Benjamin Cheong4, and Raja
Muthupillai4
1Bioengineering, Rice University,
Houston, Texas, United States, 2Philips
Healthcare, Houston, Texas, United States, 3Philips
Healthcare, Best, Netherlands, 4Diagnostic
and Interventional Radiology, St. Luke's
Episcopal Hospital, Houston, Texas, United
States
In this prospective study we quantitatively
evaluated the performance of a regional RF
shimming approach that exploits the ability
to independently modulate the amplitudes and
phases of two RF transmit channels at 3.0T
for cardiovascular MR applications. The
results from this study of 11 subjects show
that: (a) greater than 20% variations in
flip angle exist even in as small a region
as the heart and can cause substantial
shading artifact; (b) RF shimming using a
multi-channel RF transmit system is
feasible, and quantitative metrics show a
robust improvement in B1 homogeneity across
the region of interest.
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14:30 |
3354. |
Quantification
of Left Bundle Branch Block on Left Ventricular
Regional Wall Motion Using Six-Segment Center
Point Trajectory Mapping ![](play.gif)
Ting Song1,2, Jeffrey A Stainsby3,
Maureen N Hood2,4, and Vincent B
Ho2,4
1Global Applied Science
Laboratory, GE Healthcare, Bethesda, MD,
United States, 2Radiology,
Uniformed Services University of the Health
Sciences, Bethesda, MD, United States, 3Global
Applied Science Laboratory, GE Healthcare,
Toronto, ON, Canada, 4Radiology,
National Naval Medical Center, Bethesda, MD,
United States
Left Bundle Branch Block (or LBBB) is a
common cardiac electrical conduction
abnormality. It is important to quantify the
degree of LBBB using cardiac MR. We propose
a six-segment center point trajectory (CPT)
approach for LBBB quantification. The
proposed method was implemented on a total
of nine healthy and LBBB subjects. A
quantitative metric generated by CPT showed
statistically significant distinction
between normal and LBBB regions.
|
15:00 |
3355. |
FUNCTIONAL
CHARACTERIZATION OF THE MICRO-RNA DEFICIENT
ADULT MURINE HEART ![](play.gif)
Surya C Gnyawali1, Sashwati Roy1,
Jaideep Banerjee1, Savita Khanna1,
and Chandan K Sen1
1Surgery, Ohio State University,
Columbus, OH, United States
MiRNAs are capable of post-transcriptional
gene regulation by binding to their target
messenger RNAs (mRNAs), leading to mRNA
degradation or suppression of translation.
MiRNAs have recently been shown to play
pivotal roles in cardiovascular biology.
Dicer, a RNAse III endonuclease, plays a key
role in processing of miRNA into their
functional mature form. A number of recent
reports point towards a central role of
miRNA in cardiac development and function.
We have developed cardiomyocyte-specific
conditional dicer knockout mice. Dicer
knockout of adult mice resulted in a overt
phenotype featuring ventricular enlargement,
myocyte hypertrophy, and heart failure. In
the current study we sought to functionally
characterize the dicer deficient adult
murine heart.
|
15:30 |
3356. |
Relative Area
Change (RAC) Better Reflects Right Ventricular
Ejection Fraction (RVEF) than Longitudinal or
Transverse Functional Measurements in Pulmonary
Hypertension Patients
Andrew James Swift1,2, Smitha
Rajaram1, David Capener1,
Judith Hurdman3, Robin Condliffe3,
Charlie Elliot3, David G Kiely3,
and Jim M Wild1
1Academic Unit of Radiology,
Sheffield, South Yorkshire, United Kingdom, 2NIHR
Cardiovascular Biomedical Research Unit,
Sheffield, United Kingdom, 3Pulmonary
Vascular Disease Unit, Royal Hallamshire
Hospital, Sheffield, United Kingdom
This study in patients with pulmonary
hypertension (PH) assesses the relation of
RAC, transverse and longitudinal RV
measurements with RVEF as calculated from
multislice cine MRI. RVEF is better
reflected by RAC than longitudinal wall
motion or transverse wall motion in patients
with PH. We postulate this is because RAC
assesses RV function in both the transverse
and longitudinal directions. Transverse RV
function showed a similar correlation to
longitudinal function for predicting RVEF in
our mixed cohort of PH patients
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Tuesday May 10th
|
13:30 - 15:30 |
Computer 36 |
13:30 |
3357. |
Evaluation of
cardiac function using noninvasive
phase-contrast MRI, cine MRI and invasive
pressure-volume techniques on pigs at rest and
under pharmacologic stress test ![](play.gif)
Hung-Yu Lin1,2, Darren Freed3,
Trevor Lee3, Rakesh Arora3,
Ayyaz Ali4, Waiel Almoustadi3,
Bo Xiang1, Fei Wang1,
Scott B King1, Boguslaw Tomanek1,
and Ganghong Tian1
1Institute for Biodiagnostics,
National Research Council Canada, Winnipeg,
Manitoba, Cambodia, 2Radiology,
University of Manitoba, Winnipeg, Manitoba,
Canada, 3Cardiac
Sciences Program, St. Boniface Hospital,
Winnipeg, Manitoba, Canada, 4Cardiothoracic
Surgery, Papworth Hospital, Cambridge,
United Kingdom
This study is to validate noninvasive
cardiac output measurement techniques of
phase-contrast MRI and cine MRI using an
invasive pressure-volume loops analysis on a
swine model at rest and under pharmacologic
stress conditions.
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14:00 |
3358. |
Dynamic PVA
Gel Phantom for Material Property Assessment
Using SPAMM-PAV ![](play.gif)
Ziheng Zhang1, Peter B. Brown1,
Donald P. Dione2, Albert J.
Sinusas2, and Smita Sampath1
1Department of Diagnositc
Radiology, Yale University, School of
Medicine, New Haven, CT, United States, 2Section
of Cardiovascular Medicine, Yale University,
School of Medicine, New Haven, CT, United
States
Our goal is to evaluate the future
application of the SPAMM-PAV (Spatial
Modulation of Magnetization with Polarity
Alternated Velocity encoding) technique for
regional quantification of myocardial
material properties through a series of
dynamic phantom experiments. We examine the
sensitivity to detect edge responses in
strain due to sharp changes in material
properties, and the sensitivity to detect
changes in Young’s modulus of elasticity
(Ecc) in gel phantoms with varying
stiffness. Results demonstrate 1) using a
MICSR reconstruction, we are able to achieve
desired strain response, and 2) using
SPAMM-PAV combined with a thick-shell
constitutive model, we can reliably detect
differences in Ecc.
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14:30 |
3359. |
Comparison of
Regional Myocardial Function in the Human and
the Mouse ![](play.gif)
Christakis Constantinides1,
Daniel Rueckert2, and Dimitrios
Perperidis1
1Mechanical and Manufacturing
Engineering, University of Cyprus, Nicosia,
Cyprus, 2Imperial
College London, London, United Kingdom
This work quantifies and compares regional
and global cardiac performance in humans and
mice. Such effort attempts to provide
evidence to validate the hypothesis of
functional scaling from mouse to human. Its
potential clinical significance is in mouse
phenotyping for determining myocardial
dysfunction, in correlation with perfusion
and metabolism.
|
15:00 |
3360. |
Characterization of iron load in rat myocardium
at 7T by R2 map ![](play.gif)
Gyula Kotek1, Matteo Milanesi2,
Gavin Houston3, Piotr Wielopolski1,
Gabriella N. Doeswijk1, Gabriel
P. Krestin1, and Monique Bernsen1
1Radiology, Erasmus MC,
Rotterdam, Netherlands, 2Agilent
Technologies UK Ltd, Netherlands, 3General
Electric Healthcare, Netherlands
R2 and R2* mapping techniques have been used
to index iron overload either from
endogenous sources (e.g. myocardial infarct)
or to track exogenously injected cells
labeled with paramagnetic iron oxide [ref].
The advantages of high field imaging, namely
improved SNR and sensitivity to iron load,
are offset by the considerable challenges of
rodent cardiac imaging at 7T such as
increased macroscopic field inhomogeneities
and short R-R intervals (~180ms). In this
work we assess the robustness of R2
measurement in healthy & infarcted
myocardium, as well as in the presence of
SPIO labeled cells.
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Wednesday May 11th
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13:30 - 15:30 |
Computer 36 |
13:30 |
3361. |
Assessment of
the Right Ventricular Function in Patients with
Chronic Obstructive Pulmonary Disease Using MRI ![](play.gif)
Yan Gao1, Xianging Du2,
Wen Qin2, and Kuncheng Li2
1Department of Radiology, Xuanwu
Hospital of Capital Medical University,
Beijing, Beijing, China, People's Republic
of, 2Department
of Radiology, Xuanwu Hospital of Capital
Medical University, Beijing, China, People's
Republic of
We studied right ventricular function in 46
patients with mild to severe chronic
obstructive pulmonary disease (COPD)
determined by the pulmonary function test
(PFT) using MRI. Our study population
consisted of 30 control subjects. The RVEF
was significantly lower in severe COPD group
than in other groups (p < 0.01). The
correlation was excellent between the MRI
results and forced expiratory volume in 1
sec (r = 0.859 for RVEF, r= -0.839 for RV
MM) in COPD patients. The RVEF and RV MM
measured by MRI correlate well with the
severity of disease as determined by PFT in
COPD patients.
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14:00 |
3362. |
Optimization
of Whole-Heart Cine MRI with a 128 Channel
Receive Coil ![](play.gif)
Himanshu Bhat1, Philipp Hoecht1,
Sven Zuehlsdorff2, Azma Mareyam3,
Boris Keil3, Andreas Potthast4,
Melanie Schmitt4, Lawrence L Wald3,
Michael Hamm1, and David E
Sosnovik3
1Siemens Medical Solutions USA
Inc., Charlestown, MA, United States, 2Siemens
Medical Solutions USA Inc., Chicago, IL,
United States, 3Martinos
Center for Biomedical Imaging, Massachusetts
General Hospital, Boston, MA, United States, 4Siemens
Healthcare, Erlangen, Germany
We have previously reported the development
of a prototype 128 channel receive coil and
MR system for cardiac MR at 3T. Here we
describe further optimization of the system
and its supported sequences, in particular
balanced SSFP. We demonstrate the
feasibility of high quality 2D multi-slice
whole-heart cine imaging with acceleration
factors of upto 6 in a single breath-hold
using the 128 channel receive coil.
|
14:30 |
3363. |
Manual right
ventricle segmentation on short-axis SSFP views:
quantification of the regional inter-observer
variability. ![](play.gif)
Laurent BONNEMAINS1,2, Damien
MANDRY2,3, Pierre-Yves MARIE3,4,
and Pierre-André VUISSOZ2,5
1Cardiologie Infantile, CHU
Nancy, NANCY, France, 2IADI,
Nancy University, NANCY, France, 3Médecine
Nucléaire, CHU Nancy, NANCY, France, 4CIC801,
INSERM, NANCY, France, 5U947,
INSERM, NANCY, France
Short-axis cine-MRI sequences have become
the gold standard for Right Ventricle (RV)
function assessment. This process requires a
manual segmentation of RV endocardium with
known low reproducibility. In a mixed sample
of 90 normal, dilated or hypertrophic RV, we
analysed the regional variations of manual
segmentation between two experienced
observers with different metrics and found
that the infundibular and tricuspid regions
were each responsible for an average of 35
to 40% of the variability in volumes
assessment. The variation in the choice of
end-diastolic and end-systolic phases was
frequent but caused non-significant
volumetric variations.
|
15:00 |
3364. |
Left
Ventricular Volumes, Mass and Function
normalized to the body surface area, age and
gender from CMR in a large cohort of
well-treated Thalassemia Major patients without
myocardial iron overload. ![](play.gif)
Antonella Meloni1, Maria Chiara
Dell'Amico1, Brunella Favilli1,
Giovanni Donato Aquaro1,
Pierluigi Festa1, Elisabetta
Chiodi2, Stefania Renne3,
Gennaro Restaino4, Vincenzo
Positano1, Maria Concetta Galati5,
Massimo Lombardi1, and Alessia
Pepe1
1Fondazione G.Monasterio
CNR-Regione Toscana and Institute of
Clinical Physiology, Pisa, Italy, 2Arcispedale
“S. Anna”, Ferrara, Italy, 3P.O.
“Giovanni Paolo II”, Lamezia Terme, Italy, 4Università
Cattolica del Sacro Cuore, Campobasso,
Italy, 5A.O.
"Pugliese-Ciaccio", Catanzaro, Italy
Cardiovascular Magnetic Resonance allows an
accurate and reproducible quantification of
left ventricular (LV) parameters. In
Thalassemia major (TM) patients different
“normal” LV values have been reported. In
this study, the ranges for normal LV
volumes, mass and ejection fraction
normalized to the influence of body surface
area (BSA), age and sex were established
using the data of a large cohort of
well-treated TM patients without myocardial
iron overload.
|
Thursday May 12th
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13:30 - 15:30 |
Computer 36 |
13:30 |
3365. |
Surgical
ventricular restoration fails to improve
regional left ventricular shape in terms of
curvedness ![](play.gif)
Liang Zhong1, Yi Su2,
Srikanth Sola3, Jose L Navia3,
Terrance Chua1, Ghassan Kassab4,
and Ru San Tan1
1National Heart Centre,
Singapore, Singapore, 2Institute
of High Performance Computing, A*STAR,
Singapore, 3Cleveland
Clinic, USA, 4Indiana
University-Purdue University, Indiananpolis,
USA
Adverse left ventricular (LV) remodeling
begins with infarct expansion
post-myocardial infarction (MI) and is
followed by progressive cardiac fibrosis and
impaired contractility of the remaining
cardiomyocytes. Surgical ventricular
restoration (SVR) has been used to treat
ventricular aneurysms and that results in
good patient’s outcomes. However, recent
STICH trial reported that adding SVR to
coronary bypass CABG was not associated with
a greater improvement in reduced
intermediate mortality. It is believed that
LV dilation and distortion occurs post-SVR
operation, which may contribute to worsening
heart failure. This study was hence to
examine the regional LV shape pre- and post
SVR.
|
14:00 |
3366. |
Magnetic
Resonance Analysis of Right Ventricular
Volumetric Function for the Noninvasive
Diagnosis of Pulmonary Hypertension ![](play.gif)
Amir H Davarpanah1, Parmede Vakil1,
Octavia Biris1, Sanjiv Shah2,
Timothy Carroll1, and James Carr1
1Cardiovascular Imaging,
Northwestern University, Chicago, IL, United
States, 2Cardiology,
Northwestern University, Chicago, IL
RV volumetric parameters of decompensation
are useful for differentiating patients with
PH and can be used to noninvasively detect
pulmonary hypertension
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14:30 |
3367. |
A preliminary
assessment of diastolic dysfunction with normal
ejection fraction with cine MRI of the
atrioventricular junction motion ![](play.gif)
Sohae Chung1, Elodie Breton1,
and Leon Axel1
1Radiology Department, NYU
Langone Medical Center, New York, NY, United
States
While systolic cardiac function is commonly
assessed with the simple global measure of
ejection fraction, many patients with
clinical symptoms of heart failure have
normal ejection fraction, indicating that
they are primarily suffering from diastolic
dysfunction. In this study, the motion of
the atrioventricular junction was measured
by using the conventional cardiac cine MRI
to assess abnormalities in motion of the LV
during different phases of diastole. We
performed a retrospective study of 11
patients and compared them with two control
groups, 13 healthy young subjects and 5
healthy older subjects.
|
15:00 |
3368. |
Left
Ventricular Strain through Radial Tagging:
Efficiency and Validity ![](play.gif)
Abbas N Moghaddam1,2, Khaled Z.
Abd-Elmoniem3, Golanz Heidari1,
Stefan Ruehm1, and J. Paul Finn1
1David Geffen School of Medicine,
UCLA, Los Angeles, CA, United States, 2Biomedical
Engineering, Polytechnique University,
Tehran, Iran, 3National
Institute of Diabetes and Digestive and
Kidney Diseases, National Institutes of
Health, Bethesda, MD, United States
Assessment of local contractility of the
left ventricle complements global functional
parameters such as cardiac output and
ejection fraction. The local contraction of
the LV is quantifiable by its
circumferential strain. We have shown that
radial tagging facilitates the extraction of
this parameter directly from the k-Space
data if the density of the radial taglines
is sufficiently high . In this study, we
present our initial findings on the
performance of this approach and validity of
the results.
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Electronic
Posters : Cardiovascular Imaging
|
Click on
to view the abstract pdf and click on
to view the video presentation. |
Myocardial Function: Experimental Models & Human Studies II
Monday May 9th
Exhibition Hall |
14:00 - 16:00 |
Computer 37 |
14:00 |
3369. |
Displacement-encoded and
manganese-enhanced cardiac MRI reveal that nNOS, and not
eNOS, plays the dominant role in modulating calcium cycling
in the mammalian heart ![](play.gif)
Moriel Vandsburger1, Brent A French2,
Kramer M Christopher2, Xiaodong Zhong3,
and Frederick H Epstein2
1Biological Regulation, Weizmann Institute of
Science, Rehovot, Israel, 2University
of Virginia, United States, 3Siemens
Medical Solutions, United States
Nitric oxide (NO) is generated by both endothelial
nitric oxide synthase (eNOS) and neuronal nitric oxide
synthase (nNOS) in the heart, however the role of each
in NO signaling is unclear. In this study, we used
manganese-enhanced MRI to probe the role of each NOS in
modulating L-type calcium channel function, and
cine-DENSE MRI to study the role of each NOS in
contractile function. Our results indicate that nNOS,
and not eNOS, dominates modulation of calcium cycling in
vivo.
|
14:30 |
3370. |
Analysis of segmental
myocardial performance in patients after heart
transplantation ![](play.gif)
Daniela Foell1, Tobias Wengenmayer1,
Bernd Andre Jung2, Elfriede Schilli1,
Anna Lena Stroh1, Christoph Bode1,
Jürgen Hennig2, and Michael Markl2
1Cardiology and Angiology, University
Hospital Freiburg, Freiburg, Germany, 2Diagnostic
Radiology, Medical Physics, University Hospital
Freiburg, Germany
Regional left ventricular motion is altered in
transplant rejection. We used MR tissue phase mapping to
analyze segmental three-directional myocardial
velocities in stable patients after heart
transplantation (HTX, n=9) without signs of rejection.
Compared to healthy controls (n=20) reduced segmental
long-axis velocities in systole and diastole and
increased diastolic radial velocities were found. These
altered peak velocities might be an expression of
remodeling and fibrosis in the transplanted heart. The
knowledge of the alterations in regional motion in the
transplanted heart under stable conditions is essential
in order to use myocardial velocities as diagnostic
tools in transplant rejection.
|
15:00 |
3371. |
Comparison of SNR
Efficiencies and Strain for Cine DENSE Images Acquired using
Conventional EPI, Flyback EPI and Spiral k-space
Trajectories ![](play.gif)
Xiaodong Zhong1, Bruce S Spottiswoode2,
Craig H Meyer3,4, and Frederick H Epstein3,4
1MR R&D Collaborations, Siemens Healthcare,
Atlanta, GA, United States, 2MRC/UCT
Medical Imaging Research Unit, University of Cape Town,
Cape Town, Western Cape, South Africa, 3Radiology
Department, University of Virginia, Charlottesville, VA,
United States, 4Biomedical
Engineering Department, University of Virginia,
Charlottesville, VA, United States
Two-dimensional (2D) cine DENSE provides a time series
of pixel-wise displacement and strain measurements for
the myocardium through the cardiac cycle. Previous cine
DENSE studies used fast imaging techniques such as
echo-planar (EPI) and spiral for rapid k-space
data sampling. In this study, cine DENSE sequences were
developed that employed three different k-space
trajectories, namely conventional bottom-up interleaved
EPI, flyback bottom-up interleaved EPI, and interleaved
spiral. SNR efficiency and myocardial strain measured
with these three techniques were compared. The three
techniques produced similar strain results, although the
SNR efficiency of spiral cine DENSE was higher than the
other two.
|
15:30 |
3372. |
Fiber Tracking of the
Human Heart In Vivo ![](play.gif)
Sonia Nielles-Vallespin1, Choukri Mekkaoui2,
Timothy G Reese2, Peter Gatehouse1,
Thorsten Feiweier3, Peter Speier3,
David E Sosnovik2, and David Firmin1
1Cardiovascular MR Unit, Royal Brompton And
Harefield NHS Foundation Trust, London, United Kingdom, 2Martinos
Center for Biomedical Imaging, Massachussetts General
Hospital, Charlestown, MA, United States, 3Siemens
AG Healthcare Sector, Erlangen, Germany
A stack of five 2D slices of the heart was acquired in a
healthy volunteer using a diffusion weighted stimulated
echo (STEAM) single shot EPI sequence, with a total
acquisition time of 40 min. Images were post-processed
to create whole heart helix angle fibre tractography
maps and fractional anisotropy (FA) maps.
|
Tuesday May 10th
|
13:30 - 15:30 |
Computer 37 |
13:30 |
3373. |
Quantification of Left
Ventricular Torsion by Off-Resonance Insensitive CSPAMM
(ORI-CSPAMM) ![](play.gif)
Meral Reyhan1,2, and Daniel B Ennis1,2
1Department of Radiological Sciences,
Diagnostic Cardiovascular Imaging Section, University of
California, Los Angeles, CA, United States, 2Biomedical
Physics Interdepartmental Program, University of
California, Los Angeles, CA, United States
The objective of this study was to evaluate the FAST
(Fourier Analysis of STimulated echoes) method for
quantifying left ventricular (LV) torsion in five
healthy volunteers using Off-Resonance Insensitive
CSPAMM (ORI-CSPAMM), which adds a 180° RF refocusing
pulse in the middle of the motion encoding gradient.
There was excellent agreement between SPAMM and
ORI-CSPAMM torsion estimates with a bias of -1.5° and
95% CIs(-4.0°, 0.9°). The mean peak systolic torsion was
8.9°±2.1° for ORI-CSPAMM and 7.4°±2.2° for SPAMM.
ORI-CSPAMM permits the FAST analysis of LV torsion
during systole and diastole and may report more accurate
values due to the refocusing.
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14:00 |
3374. |
Multichannel RF
Transmission Improves Cardiac Cine bSSFP MRI at 3.0T ![](play.gif)
Oliver M Weber1, and Javier Sanchez Gonzalez1
1Philips Healthcare, Madrid, Spain
Current cardiac MRI at 3.0 T is hampered by inferior
quality of bSSFP cine images. RF transmission with
multiple channels (MTx) increases B1 homogeneity and
allows for shortening of TR. In six volunteers, cardiac
cine bSSFP MRI was performed with and without the use of
MTx. With MTx, TRs were reduced by 0.3-0.4 ms, and
resulting images provided better signal homogeneity and
higher CNR and suffered from fewer artifacts. Usage of
MTx thus greatly enhanced image quality and reliability.
|
14:30 |
3375. |
Time-Evolution of Edema in
Reperfused Acute Myocardial Infarction: Implications for
Assesment of Area-At-Risk ![](play.gif)
Veronica L M Rundell1, Avinash Kali1,
Xiangzhi Zhou1, Ying Liu1, Richard
L Q Tang1, Andreas Kumar2, and
Rohan Dharmakumar1
1Radiology, Northwestern University, Chicago,
IL, United States, 2Laval
University
T2-weighted MRI of acute myocardial infarction (AMI) has
been used to determine Area-At-Risk. To investigate the
resolution time of edema following ischemia-reperfusion
injury, a canine model of reperfused AMI was
investigated using both T2 mapping
and T2 STIR
protocols before and during infarction and again on days
2, 5, 7 and 56 following reperfusion. The percent volume
of hyperintense myocardial regions (edema) peaked on day
2 and 5, respectively on T2-STIR images and T2 maps.
Hyperintensity resolved to pre-infarct levels by week 8.
Imaging approach and time to imaging may be key factors
in determining Area-at-Risk and salvagable myocardium.
|
15:00 |
3376. |
Age-Related Differences of
3D Blood Flow in the Left Heart ![](play.gif)
Daniela Foell1, Steffen Taeger1,
Bernd Andre Jung2, and Michael Markl2
1Cardiology and Angiology, University
Hospital Freiburg, Freiburg, Germany, 2Diagnostic
Radiology, Medical Physics, University Hospital
Freiburg, Germany
Whole heart flow-sensitive 4D MRI was performed to
analyze the complex blood flow in the left atrium and
ventricle in healthy volunteers. The study included
healthy subjects (n=22) equally divided in two
age-groups to investigate the influence on age of atrial
and ventricular flow patterns (existence, extent, and
duration of vortex flow). Older individuals demonstrated
a tendency towards a lower number, degree, duration,
extent and velocity of vortices in the LA. Furthermore
they had significantly less pronounced vortices in the
base of the LV with lower velocities and a reduced
number of vortices in the midventricular parts of the
LV.
|
Wednesday May 11th
|
13:30 - 15:30 |
Computer 37 |
13:30 |
3377. |
Effects of Autologous Bone
Marrow Mononuclear Cells Transplantation through Coronary
Artery Bypass Grafting in Patients with Chronic Myocardial
Infarction Assessed by Magnetic Resonance Imaging: A
Randomized, Double Blind, Placebo-controlled Pilot Trial ![](play.gif)
Minjie Lu1, Shihua Zhao1, Shiliang
Jiang1, Sheng Liu2, Yan Zhang1,
and Zuoxiang He3
1Radiology, Fuwai Hospital, Beijing, Beijing,
China, People's Republic of, 2Cardiac
Surgery, Fuwai Hospital, Beijing, Beijing, China,
People's Republic of, 3Nuclear
Medicne, Fuwai Hospital, Beijing, Beijing, China,
People's Republic of
Recent studies have shown that autologous bone marrow
mononuclear cell (aBM-MNC) transplantation can be
effectively performed in human beings either by the
coronary route or by endoventricular injections.
However, scanty data are available for patients
undergoing coronary artery bypass grafting
(CABG).Accordingly, the aim of this study was to use an
¡°one-stop¡± non-invasive imaging examination-MRI to
evaluate the feasibility and safety of aBM-MNC
transplantation in patients with chronic myocardial
infarction(MI) undergoing CABG.
|
14:00 |
3378. |
Single-Breathhold
Three-Dimensional Cardiac Cine MRI with Retrospective
Cardiac Gating using High Acceleration kat ARC (k- &
adaptive t- Autocalibrating Reconstruction for Cartesian
Sampling) ![](play.gif)
Peng Lai1, Marcus T Alley2,
Shreyas S Vasanawala2, and Anja C.S Brau1
1Global Applied Science Laboratory, GE
Healthcare, Menlo Park, CA, United States, 2Radiology,
Stanford University, Stanford, CA, United States
Quantitative assessment of cardiac function requires 3D
cardiac cine MRI with retrospective gating. Recently
developed kt methods have shown potential for highly
accelerated cine MRI. However, limited work has been
done to address retrospective gating, especially with 3D
cine imaging. This work develops a kat ARC-based fast
dynamic imaging method for retrospectively-gated 3D cine
MRI. Based on our evaluations on 4 volunteers, the
proposed method can achieve 8x acceleration using
8-channel cardiac coils and provide high-quality motion
depiction of the entire ventricle in a single
breathhold.
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14:30 |
3379. |
The effect of through
plane motion on left ventricular regional rotation: a study
using slice-following harmonic phase (SF-HARP) imaging. ![](play.gif)
David Brotman1, Ziheng Zhang2, and
Smita Sampath2
1Fairfield University, Fairfield, CT, United
States, 2Yale
University
Recent studies reveal that regional rotation may be
primarily responsible for the creation of suction
enabling normal diastolic filling, and may serve as an
early diagnostic indicator of diastolic dysfunction.
Here, we highlight the importance of taking into account
through-plane motion when calculating regional rotation.
We employ a combination of slice-following tagged MRI
and harmonic phase tracking (SF-HARP) to compute true
two dimensional trajectories of myocardial material
points, from which rotation is computed. Our results
(rotation curves, and rotation-circumferential
shortening loops) show differences in the computed
rotation values in comparison to conventional tagging.
In conclusion, SF-HARP provides reliable and accurate
quantification of regional rotation in the left
ventricle.
|
15:00 |
3380. |
Pancreatic Exocrine
Function and Cardiac Iron in Patients with Iron Overload and
with Thalassemia ![](play.gif)
Jin Yamamura1, Regine Grosse2,
Andrea Jarisch3, Gritta E. Janka4,
Peter Nielsen5, Gerhard Adam1, and
Roland Fischer5,6
1Diagnostic and Interventional Radiology,
University Medical Center Hamburg-Eppendorf, Hamburg,
Hamburg, Germany, 2Pediatric
Hematology and Oncology, University Medical Center
Hamburg-Eppendorf, 3Stem
Cell Transplant Center, Johann Wolfgang
Goethe-University of Frankfurt, Frankfurt, Germany, 4Pediatric
Hematology and Oncology, University Medical Center
Hamburg-Eppendorf, Hamburg, Germany, 5Department
of Biochemistry and Molecular Biology II: Molecular Cell
Biology, University Medical Center Hamburg-Eppendorf,
Hamburg, Germany, 6Children’s
Hospital & Research Center Oakland, Oakland, California,
United States
In patients with iron overload, assessment of cardiac
iron by fast MRI-R2/R2* methods has become a standard of
care. We measured R2* relaxation rates in the myocardium
by MRI in comparison with the exocrine pancreatic
function by means of serum pancreatic enzyme
determination in patients with ß-thalassemia.Patients at
risk of elevated cardiac iron levels could be identified
by the exocrine pancreatic lipase and amylase function
parameters.
|
Thursday May 12th
|
13:30 - 15:30 |
Computer 37 |
13:30 |
3381. |
Optimal tag distance for
myocardial MR motion analysis of healthy and diseased mice ![](play.gif)
Bastiaan J van Nierop1, Tom J & L Schreurs1,2,
Hans C van Assen2, Gustav J Strijkers1,
and Klaas Nicolay1
1Biomedical NMR, department of Biomedical
Engineering, Eindhoven University of Technology,
Eindhoven, Netherlands, 2Biomedical
Image Analysis, department of Biomedical Engineering,
Eindhoven University of Technology, Eindhoven,
Netherlands
Tagged cinematographic MRI using SPAtial Modulation of
Magnetization (SPAMM) enables assessment of myocardial
tissue displacement in vivo. However, a poorly chosen
tag distance may result in inaccurate estimations of
displacement. Only a few studies address the question,
which tag distance results in the most accurate
estimation of displacement. Therefore, this study aimed
to determine the optimal SPAMM tag distance to
accurately calculate tissue displacement in the mouse
left ventricle, using optical flow analysis. It was
concluded that the most accurate estimations for in vivo
murine myocardial displacements are obtained with tag
distances between 1.0 and 1.5 mm, both in healthy and
hypertrophied hearts.
|
14:00 |
3382. |
Diagnostic Capability and
Reproducibility of Myocardial Strain Measured by DENSE MRI
in Patients with Acute Myocardial Infarction
Kakuya Kitagawa1, Hideki Miyagi1,
Shingo Kato1, Yeonyee Elizabeth Yoon1,
Motonori Nagata1, Shinichi Takase1,
Andreas Sigfridsson2, and Hajime Sakuma1
1Radiology, Mie University Hospital, Tsu,
Mie, Japan, 2Center
for Medical Image Science and Visualization, Linköping
University, Linköping, Sweden
We assessed the hypothesis that myocardial strain
measured by DENSE MRI can accurately diagnose the extent
of LV myocardial injury in patients with AMI. Myocardial
strains were quantified by DENSE MRI and custom made
software in 20 patients with AMI treated with primary
PCI, and were compared with LGE-MRI. Myocardial strains
were significantly reduced in segments with transmural
infarction compared with those without. The LV global
strain showed a good correlation with LV infarct size.
Myocardial strains by DENSE MRI showed high intra- and
inter-observer reproduciblity. DENSE MRI may be highly
useful for monitoring functional recovery of LV
myocardium.
|
14:30 |
3383. |
Free Breathing 3D Imaging
of Right Ventricular Structure and Function using
Respiratory and Cardiac Self-Gated Cine MRI ![](play.gif)
Yanchun Zhu1,2, Jing Liu2, Pascal
Spincemaille2, Thanh D. Nguyen2,
Minisha Kochar3, Debbie W Chen3,
Jonathan Lessick3, Shanglian Bao1,
Liuquan Cheng4, Martin R Prince2,
Yi Wang2, and Jonathan W Weinsaft3
1Beijing Key Lab of Medical Physics and
Engineering, Peking University, Beijing, Beijing, China,
People's Republic of, 2Cornell
Cardiovascular Magnetic Resonance Imaging Laboratory,
Radiology Department,Weill Cornell Medical College, New
York, NY, United States, 3Department
of Medicine, Weill Cornell Medical College, New York,
NY, United States, 4Department
of Radiology, Chinese PLA General Hospital, Beijing,
China, People's Republic of
Free breathing 3D imaging of right ventricular structure
and function using respiratory and cardiac self-gated
cine MRI compare with traditional 2D SSFP cine MRI. The
purpose of this study is to test the utility of 3D SSFP
for RV quantification. 2D and 3D cine MRI were performed
in random order on seven normal volunteers. RV chamber
volumes were measured by manual planimetry at
end-diastole and end systole and used for calculation of
RV ejection fraction. These data demonstrate that free
breathing 3D cine MRI can comprehensively assess RV
structure and function. Future study is necessary to
augment temporal resolution of 3D cine MRI and test
performance for RV assessment in routine clinical
practice.
|
15:00 |
3384. |
Use of oxygen challenge to
assess myocardial oxygenation: A potential tool to image
oxygen metabolism. ![](play.gif)
Marzena M Wylezinska1, Jordi L Tremoleda1,
Joseph Habib2, Daniel Stuckey2,
and Willy Gsell1
1Biological Imaging Centre, Imaging Sciences
Department, MRC Clinical Sciences Centre, Imperial
College London, London, United Kingdom, 2National
Heart and Lung Institute, Imperial College London,
London, United Kingdom
Aerobic metabolism is a vital and fundamental mechanism
of attaining energy in mammals. Due to the diversity of
organic substrates involved, the rate of aerobic
metabolism can only be directly measured through the
oxygen consumption. However, current non-invasive
quantitative techniques (15O-PET, 17O-MRI) have been
limited by both their expense and complexity. We propose
a novel technique in which BOLD-dependent changes in T2*
were measured in conjunction with saturating arterial
blood with oxygen to extract the effects of the
reduction of oxy-haemoglobin. Myocardial T2* was
observed to increase by 15% thus offering a robust
quantitative index of aerobic metabolism.
|
|
|
Electronic
Posters
: Cardiovascular Imaging
|
Click on
to view the abstract pdf and click on
to view the video presentation. |
Myocardial Tissue Characterization: Human Studies
Monday May 9th
Exhibition Hall |
14:00 - 16:00 |
Computer 38 |
14:00 |
3385. |
Assessment of the gray
zone: a comparison of two quantitative methods in heart
failure patients
Tobias Voigt1, Peter Koken1,
Simon G. Duckett2, Anoop K. Shetty2,
Christian Stehning1, Aldo Rinaldi2,
Reza Razavi2, Tobias Schaeffter2,
and Andrea J. Wiethoff3
1Philips Research Laboratories, Hamburg,
Germany, 2Kings
College London, London, United Kingdom, 3Philips
Healthcare, Best, Netherlands
In this study gray zone imaging using quantitative
T1 mapping sequences was investigated. Two different
sequences were compared with respect to gray zone
characterization using spin density and T1 values. A
standard Look Locker T1 mapping sequence was
compared with a modified Look Locker (MOLLI)
sequence including cardiac motion correction. Motion
corrected MOLLI results showed improved delineation
of the myocardial border and a better basis for the
determination of the gray zone extent based on a
clustering of spin density and T1.
|
14:30 |
3386. |
Improved detection of
papillary muscle infarction by high-resolution 3D free
breathing delayed enhancement CMR ![](play.gif)
Thanh D Nguyen1, Jason Chinitz2,
Minisha Kochar2, Debbie Chen3,
Parag Goyal2, Helina Kassahun2,
Martin R Prince1, Yi Wang1,
and Jonathan W Weinsaft2
1Radiology, Weill Cornell Medical
College, New York, NY, United States, 2Medicine/Cardiology,
Weill Cornell Medical College, New York, NY, United
States, 3Cornell
University, Ithaca, NY, United States
Papillary muscle infarction (PMI) is a serious
consequence of acute myocardial infarction (AMI).
The objective of this study was to prospectively
compare free-breathing navigator 3D with breath-held
2D delayed enhancement cardiac MR for PMI detection
in a cohort of patients presenting with AMI. 25%
(n=27) had PMI as determined by either 2D or 3D
imaging. Navigator 3D imaging was found to provide
improved detection of PMI compared to breath-held 2D
imaging.
|
15:00 |
3387. |
Non-selective double
inversion recovery pre-pulse for flow-independent black
blood myocardial scar imaging: optimization of the T1
suppression range ![](play.gif)
Sarah Anne Peel1, Geraint Morton1,
Eike Nagel1, and René M Botnar1
1Division of Imaging Sciences and
Biomedical Engineering, King's College London,
London, London, United Kingdom
MRI late gadolinium enhancement using the inversion
recovery sequence is the current gold standard for
the assessment of myocardial viability. Although it
achieves high contrast between infarct and normal
myocardium, there is often poor infarct-to-blood
contrast. In this work we show that the
non-selective double inversion recovery pre-pulse
can be used to suppress blood signal and improve
depiction of sub-endocardial infarcts. Adjustment of
the T1 suppression range allows the user to control
the level of blood suppression. In patient studies,
the time post contrast administration appears to
have a smaller effect on signal characteristics than
the T1 suppression range.
|
15:30 |
3388. |
Three-segment Center
Point Trajectory Model for Segmental Motion Tracking of
Myocardial Infarction ![](play.gif)
Ting Song1,2, Jeffrey A Stainsby3,
Maureen N Hood2,4, and Vincent B Ho2,4
1Global Applied Science Laboratory, GE
Healthcare, Bethesda, MD, United States, 2Radiology,
Uniformed Services University of the Health
Sciences, Bethesda, MD, United States, 3Global
Applied Science Laboratory, GE Healthcare, Toronto,
ON, Canada, 4Radiology,
National Naval Medical Center, Bethesda, MD, United
States
The vascular territory commonly characterizes
clinically ischemic heart disease. We describe an
automated and quantitative approach for the
evaluation of discrete myocardial wall motion in
terms of vascular territory (i.e. LAD, RCA, and
LCX), using a novel wall motion characterization
method called regional center point trajectory
algorithm. The three-segment center point model
enables separate analysis and quantification of
coronary artery disease by their respective vascular
territories, thereby allowing segmental tracking and
quantification of wall motion.
|
Tuesday May 10th
|
13:30 - 15:30 |
Computer 38 |
13:30 |
3389. |
Scar-coronary cardiac
MR imaging acquired by navigator-gated 3D fat-suppressed
delayed-enhancement imaging technique ![](play.gif)
Yasuo Amano1, Tomonari Kiriyama1,
Yoshio Matsumura1, Masaki Tachi1,
Tetsuro Sekine1, and Shinichiro Kumita1
1Nippon Medical School, Tokyo, Japan
Scar-coronary imaging was obtained using a single
navigator-gated 3D fat-suppressed
delayed-enhancement MR imaging sequence. Compared to
the standard 2D delayed-enhancement imaging, the
scar-coronary imaging depicted the myocardial scar
sufficiently with good CNR. The patent proximal
coronary arteries were visualized well by this
imaging. Scar-coronary cardiac MR imaging using a
single navigator-gated 3D fat-suppressed
delayed-enhancement MR imaging study was feasible
for visualization of the myocardial scar and patent
proximal coronary arteries.
|
14:00 |
3390. |
Variations in
Myocardial T1 with Cardiac Cycle at 1.5T ![](play.gif)
Xiaopeng Zhou1,2, Melanie S Kotys3,
Christian Stehning4, Stefan E Fischer3,
Scott D Flamm1, and Randolph M Setser1
1Imaging Institute, Cleveland Clinic,
Cleveland, OH, United States, 2Cleveland
State University, Cleveland, OH, United States, 3Philips
Healthcare, OH, United States,4Philips
Research, Hamburg, Germany
Healthy volunteers (n=5) were imaged at 1.5T to
determine whether myocardial T1 varies throughout
the cardiac cycle. T1 mapping was performed using
MOLLI at 2 left ventricular short axis levels at
end-systole, mid-diastole and end-diastole. T1
variation between time points was smaller than 8%,
which demonstrates that cyclic variation of T1 is
negligible at 1.5T. In addition, no regional
variation in T1 was seen. The myocardial T1 values
are of particular importance for the diagnosis of
myocardial diseases, which warrants further study of
cyclic myocardial T1 changes at higher magnetic
field strengths.
|
14:30 |
3391. |
Myocardial T1
measurement: comparison of modified Look-Locker
inversion recovery (MOLLI) and TI scout ![](play.gif)
Yuan Chang Liu1, Chia-Ying Liu1,
Rob J van der Geest2, Joao Lima3,
David Bluemke4, and Collen Hadigan5
1Department of Radiology, Johns Hopkins
Hospital, Baltimore, MD, United States, 2Department
of Radiology, Leiden University Medical Center,
Netherlands, 3Johns
Hopkins Hospital, 4Radiology
and Imaging Sciences, National Institutes of Health
(NIH), 5National
Institute of Allergy and Infectious Diseases
(NIAID), NIH
Different cardiac MR acquisition sequences have been
used to obtain myocardial T1 values. Among which
available techniques, MOdified Look-Locker
Inversion-recovery (MOLLI) and inversion-recovery
TrueFisp (TI scout) sequences are widely used in
research and clinical settings. We compared
myocardial T1 values derived from both MOLLI and TI
scout techniques in the post gadolinium delayed
enhancement experiments.
|
15:00 |
3392. |
Imaging of the Right
Ventricular Wall at 3T in suspected ARVD: Black-blood
Proton density and T1-w imaging both with and without
fat-saturation compared with multi-echo Dixon technique ![](play.gif)
Caroline Daly1, Tosin Osuntokun1,
Mark Knox1, Deirdre Ward1,
Ross Murphy1, Ruth Dunne1,
Peter Beddy1, James F Meaney1,
Gerard Boyle1,2, Matthew Clemence3,
and Andrew J Fagan1,2
1Centre for Advanced Medical Imaging, St.
James's Hospital / Trinity College, Dublin, Ireland, 2School
of Medicine, Trinity College University of Dublin,
Ireland, 3Philips
Healthcare, Reigate, United Kingdom
Diagnosis of fibrofatty infiltration of the
myocardium, a cardinal feature of Arrhythmogenic
Right Ventricular Dysplasia (ARVD) until the advent
of cardiac MR could only be diagnosed by myocardial
biopsy or at autopsy. Cardiac Magnetic Resonance
offers comprehensive depiction of the anatomy and
function of the right ventricle, and because of he
characteristic appearance of fat on MR images allows
depiction of fat within the wall. Our aim was to
investigate the feasibility of multi-echo Dixon
technique for water fat separation during cardiac
imaging at 3T compared to the standard approach of
black-blood spin-echo imaging with and without fat
suppression.
|
Wednesday May 11th
|
13:30 - 15:30 |
Computer 38 |
13:30 |
3393. |
Myocardial T1 and T2
measurement in patients with cardiac amyloid and
comparison with normal controls ![](play.gif)
James Glockner1
1Radiology, Mayo Clinic, Rochester, MN,
United States
Myocardial tissue relaxation measurements have been
suggested as a potential alternative technique to
post-contrast late gadolinium enhancement imaging
for identification of patients with cardiac amyloid.
This has the advantage of avoiding gadolinium
administration in patients who may have reduced
renal function. Septal myocardial T1 and T2
measurements were performed in 14 patients with
cardiac amyloid diagnosed by positive
echocardiography and contrast-enhanced MRI and
compared with values measured in a group of normal
controls. No significant difference in myocardial
relaxation times was identified, suggesting that
tissue relaxation measurements alone are unlikely to
confidently diagnose cardiac involvement in pateints
with systemic amyloidosis.
|
14:00 |
3394. |
MultiContrast Delayed
Enhancement (MCODE) Improves Interpretation of Cardiac
MRI Delayed Enhancement: A Clinical Validation Study ![](play.gif)
W Patricia Bandettini1, Peter Kellman1,
Christine Mancini1, Oscar Julian Booker1,
Sujethra Vasu1, Steve W Leung1,
Joel R Wilson1, Pamela Vincent1,
Sujata M Shanbhag1, Marcus Y Chen1,
and Andrew Ernest Arai1
1National Heart, Lung, and Blood
Institute, National Institutes of Health, Bethesda,
MD, United States
Multicontrast delayed enhancement (MCODE) is a
technique that has been useful in discriminating
subendocardial myocardial infarction from blood pool
by simultaneously providing a T2-weighted image in
addition to the standard late gadolinium enhancement
(LGE) T1 image, thus allowing distinction between
true enhanced myocardium and blood pool. Our
clinical validation study demonstrates that in over
one-third of cases of abnormal LGE and cases of
questionable LGE, the T2 data acquired using GRE-MCODE
adds diagnostic value to the final interpretation
above that obtained in a LGE T1 image alone.
|
14:30 |
3395. |
Myocardial T2 mapping
with respiratory navigator and non-rigid registration:
comparison of motion compensation techniques ![](play.gif)
Shivraman Giri1, Saurabh Shah2,
Hui Xue3, Jens Guehring3, Sven
Zuehlsdorff2, Yiu-Cho Chung2,
Subha V. Raman1, and Orlando P. Simonetti1
1The Ohio State University, Columbus, OH,
United States, 2Siemens
Healthcare, Chicago, IL, United States, 3Siemens
Corporate Research, Princeton, NJ, United States
In this work, we propose a myocardial T2 mapping
sequence with two motion-compensation schemes:
respiratory navigator and non-rigid registration.
Their combined application provides complementary
motion-compensation, with navigator providing
reproducible positioning of the heart in all
directions, and registration correcting for any
residual in-plane motion. Results show a significant
reduction in motion-induced T2 variability in
myocardial T2 maps. The proposed sequence permits
reliable T2 mapping without subject breath-hold and
may enable 3D T2 maps of the myocardium in future.
|
15:00 |
3396. |
Preliminary
Investigation of the use of Multi-transmit for
Myocardial T2 and T2* Quantification in Normal
Volunteers at 3T ![](play.gif)
Hua Guo1,2, Ed X. Wu3,4,
Wenchuan Wu1,2, Xiangyang Ma5,
Guangzhi Wang1,2, and Chun Yuan2,6
1Biomedical Engineering Department,
Tsinghua University, Beijing, Beijing, China,
People's Republic of, 2Center
for Biomedical Imaging Research, Tsinghua
University, Beijing, Beijing, China, People's
Republic of, 3Laboratory
of Biomedical Imaging and Signal Processing, The
University of Hong Kong, Hong Kong, Hong Kong, 44Department
of Electrical and Electronic Engineering, The
University of Hong Kong, Hong Kong, Hong Kong, 5Philips
Research Asia, Shanghai, China, People's Republic
of, 6Department
of Radiology, University of Washington, Seattle, WA,
United States
Increased B0 and B1 inhomogeneity, together with
increased motion artifacts, present challenges for
cardiac imaging and quantification at 3T. Although
breathhold acquisition method can improve the
reproducibility of T2* and T2 measurement, the B1
nonuniformity may deteriorate their accuracy and
confound the final diagnosis for monitor iron
overload in patients with thalassaemia major. This
study measured myocardial T2* and T2 in normal
subjects at 3T with multi-transmit technology using
single-breathhold acquisitions. The preliminary
results demonstrated the effectiveness of the
multi-transmit technique for myocardial T2* and T2
quantification improvement at 3T.
|
Thursday May 12th
|
13:30 - 16:00 |
Computer 38 |
13:30 |
3397. |
Distribution of
Cardiac Iron measured by MRI-R2* ![](play.gif)
Jin Yamamura1, Regine Grosse2,
Joachim Graessner3, Gritta Janka2,
Gerhard Adam1, and Roland Fischer4,5
1Diagnostic and Interventional Radiology,
University Medical Center Hamburg-Eppendorf,
Hamburg, Hamburg, Germany, 2Pediatric
Hematology and Oncology, University Medical Center
Hamburg-Eppendorf, Hamburg, Germany, 3Siemens
AG, Hamburg, Germany, 4Department
of Biochemistry and Molecular Biology II: Molecular
Cell Biology, University Medical Center Hamburg-Eppendorf,
Hamburg, Hamburg, Germany, 5Children’s
Hospital & Research Center Oakland, Oakland,
California, United States
Iron overload in the heart is the leading cause of
death for thalassemia patients receiving chronic
blood transfusions. The measurement of the septal
R2* (= 1/T2*) in a mid-papillary short axis slice
can be used for artifact-free cardiac iron
measurements. The purpose of this study was to
identify the variation of the transverse relaxation
rate R2* in a left ventricular mid-papillary cardiac
slice and to find out the most appropriate site to
measure the cardiac iron with the least artifacts
and boundary effects. The measurement of MRI-R2* in
the interventricular septum is the least affected
method by boundary effects to detect patients with
iron overload at risk of developing heart failure.
|
14:00 |
3398. |
Characterization of
the Failing Human Heart via Diffusion Tensor Imaging: an
Ex-Vivo Study ![](play.gif)
Osama M Abdullah1,2, Stavros G. Drakos3,
Divya Ratan Verma3, Josef Stehlik3,
Abdallah G Kfoury3, Craig H Selzman3,
Craig Myrick4, Greg Russel4,
Dean Y. Li3, and Edward W Hsu1
1Bioengineering, University of Utah, Salt
Lake City, UT, United States, 2Small
Animal Core Research, University of Utah, Salt Lake
City, UT, United States, 3UTAH
Cardiac Transplant Program, University of Utah &
Intermountain Medical Center, Salt Lake City, UT,
United States, 4Intermountain
Donor Services, Salt Lake City, UT, United States
Diffusion tensor imaging was used to characterize
heart specimens from normal donors and chronic heart
failure, which via histology is known to include
increased interstitial fibrosis, cardiomyocyte
hypertrophy, and reduced microvascular density.
Results show that failing hearts have decreased
fractional anisotropy, but increased mean,
longitudinal, and axial diffusivities. These
findings are consistent with the histopathology and
demonstrate a potential role for DTI in
characterizing the failing human heart.
|
14:30 |
3399. |
Myocardial Fat
Deposition In Dilated Cardiomyopathy_Assessment by Using
MR Water-Fat Separation Imaging ![](play.gif)
Minjie Lu1, Shihua Zhao1,
Shiliang Jiang1, Yang Zhang1,
Jing An2, Jerecic Renate3, and
Saurabh Shah4
1Radiology, Fuwai Hospital, Beijing,
Beijing, China, People's Republic of, 2Siemens
Mindit Magnetic Resonance, Siemens Healthcare, MR
Collaboration NE Asia., Beijing, China, People's
Republic of, 3Siemens
Limited China, Siemens Healthcare, MR Collaboration
NE Asia, Beijing, Germany, 4Siemens
Healthcare, Chicago, IL, United States
Fat deposition has a high prevalence in
arrhythmogenic right ventricular cardiomyopathy(ARVC).
The incidence was reported approximately 68% in ARVC.
While it is unclear in dilated cardiomyopathy. In
this study, we use the latest water fat separation
sequence to evaluate fat deposition in dilated
cardiomyopathy(DCM) and found that fat deposition is
quite common in DCM and it is associated with DCM
characteristics including fibrosis volume and left
ventricular function.
|
|
|
Electronic
Posters
: Cardiovascular Imaging
|
Click on
to view the abstract pdf and click on
to view the video presentation. |
Experimental Myocardial Imaging & Flow Imaging
Monday May 9th
Exhibition Hall |
14:00 - 16:00 |
Computer 39 |
14:00 |
3400. |
MR diffusion tensor
investigation of transmural heterogeneity of myocardium
structural remodeling in postinfarct porcine model ![](play.gif)
Yin Wu1,2, and Ed X. Wu2,3
1Paul C. Lauterbur Research Centre for
Biomedical Imaging, Shenzhen Institutes of Advanced
Technology, Shenzhen, Guangdong, China, People's
Republic of, 2Laboratory
of Biomedical Imaging and Signal Processing, The
University of Hong Kong, Pokfulam, Hong Kong, 3Department
of Electrical and Electronic Engineering, The
University of Hong Kong, Pokfulam, Hong Kong
Previous DTI studies of infarcted heart
predominantly focused on the overall myocardial
diffusion changes within a certain region. In this
study, transmural heterogeneity of myocardium
structural remodeling was examined in postinfarct
porcine model. Significant reduction of mean
apparent diffusion coefficient, axial and radial
diffusivities was found to occur earlier around
endocardium, indicating that myocardium structural
remodeling is transmurally heterogeneous and the
endocardium is more vulnerable to infarct injury.
The experimental findings suggest the necessity of
examining transmural variation of myocardium
structural remodeling, and demonstrate DTI is a
sensitive tool to reveal the subtle change of tissue
structure at cellular level.
|
14:30 |
3401. |
Impact of b-value on
DTI indices of left ventricular porcine myocardium: a
preliminary study ![](play.gif)
Yin Wu1,2, Chao Zou1,2, Lijuan
Zhang1,2, Wei Liu1,2, Rui-Bin
Dai1,2, Na Zhang1,2, and Xin
Liu1,2
1Paul C. Lauterbur Research Centre for
Biomedical Imaging, Shenzhen Institutes of Advanced
Technology, Shenzhen, Guangdong, China, People's
Republic of, 2Key
Laboratory of Biomedical Informatics and Health
Engineering, Chinese Academy of Sciences, Shenzhen,
Guangdong, China, People's Republic of
Conventional DTI assumes a free Gaussian process of
water diffusion, which may not apply in tissues with
complex structures. In this study, effect of
b-values on myocardium DTI indices (FA, mean
diffusivity, axial and radial diffusivities) was
assessed and two fitting models for DWI data were
evaluated on LV myocardium. DTI indices
substantially decreased with increasing b values.
Stat model demonstrated a better fitting for the DWI
signals than Monoexp model. This study confirmed the
conspicuous influence of b-value on DTI indices
quantification, and demonstrated the necessity of
optimizing b-value and DWI fitting model for better
characterizing the myocardium microstructure.
|
15:00 |
3402. |
The Tractographic
Propagation Angle: A Novel Tool to Detect Infarction and
Characterize Myocardial Microstructure ![](play.gif)
Choukri Mekkaoui1, Shuning Huang1,
Guangping Dai1, Timothy G Reese1,
Udo Hoffmann2, Marcel P Jackowski3,
and David Sosnovik4
1Radiology, Harvard Medical School,
Massachusetts General Hospital, Martinos Center For
Biomedical Imaging, Charlestown, MA, United States, 2Radiology,
Massachusetts General Hospital, Harvard Medical
School, United States, 3Computer
Science, University of São Paulo, Institute of
Mathematics and Statistics, São Paulo, Brazil,4Cardiology,
Harvard Medical School, Massachusetts General
Hospital, Martinos Center For Biomedical Imaging,
Charlestown, MA, United States
The normal angle between adjacent eigenvectors along
myofiber tracts remains unknown. We term this angle
the tractographic propagation angle (PA).
Consequently, the correct upper limit or threshold
angle to use in tractographic reconstructions of the
myocardium remains unknown. Here we characterize the
propagation angle (PA) in
vivoin normal and ex
vivo in
infarcted hearts. We show that PA is homogenous and
low (2-4 degrees) in normal myocardium. In infarcted
myocardium, PA rises dramatically and has the
potential to facilitate the robust detection of
myocardial infarcts.
|
15:30 |
3403. |
A Comparison of
Delayed Contrast Enhanced and T1rho MRI for Assessment
of LV Remodeling ![](play.gif)
Gerald Zsido1, Walter RT Witschey2,
Kevin Koomalsingh1, Joseph H Gorman1,
Robin Hinmon1, James J Pilla1,
Ravinder Reddy3, Maxim Zaitsev2,
and Robert Gorman1
1Cardiothoracic Surgery, University of
Pennsylvania, Philadelphia, PA, United States, 2Medical
Physics, University Medical Center Freiburg,
Freiburg i. Breisgau, Baden Württemburg, Germany, 3Radiology,
University of Pennsylvania, Philadelphia, PA, United
States
Cardiac output progressively deteriorates following
myocardial infarction on account of left ventricular
myocardial infarction. Recently, a method for spin
locked MRI was shown to overcome low frequency
mechanisms of nuclear relaxation, enhancing
relaxation and improving contrast compared to
conventional T2-weighted imaging of MI. In this
study, T1 MRI
was performed in a swine model of MI to measure mean
relaxation times in the myocardium, borderzone,
several animals and compared to delayed contrast
enhanced (DCE) MRI in a septum based model of MI,.
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Tuesday May 10th
|
13:30 - 15:30 |
Computer 39 |
13:30 |
3404. |
Rapid relative
pressure map computation from velocity-encoded
phase-contrast measurements ![](play.gif)
Gerard R. Crelier1,2, David Brunner2,
Sebastian Kozerke2, and Peter Boesiger2
1GyroTools LLC, Winterthur, Switzerland, 2Institute
for Biomedical Engineering, University and ETH
Zurich, Zurich, Switzerland
Intravascular relative pressure maps can be
calculated from velocity vector fields as obtained
with velocity-encoded phase-contrast MR imaging. An
efficient iterative solver for the pressure Poisson
equation in arbitrary shaped computational domains
is presented.
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14:00 |
3405. |
Quantification of
Vessel-Encoded Arterial Spin Labeling Dynamic
Angiography with Auto-Calibration ![](play.gif)
Thomas William Okell1, Michael Andrew
Chappell1,2, Ursula G Schulz3,
and Peter Jezzard1
1FMRIB Centre, Department of Clinical
Neurosciences, University of Oxford, Oxford,
Oxfordshire, United Kingdom, 2Institute
of Biomedical Engineering, University of Oxford,
Oxford, Oxfordshire, United Kingdom, 3Stroke
Prevention Research Unit, Department of Clinical
Neurosciences, University of Oxford, Oxford,
Oxfordshire, United Kingdom
A theoretical framework for the quantification of
vessel-encoded arterial spin labeling dynamic
angiography is presented and illustrated by
application in a healthy volunteer and patient with
vertebral stenosis. The calibration factor that
relates the measured signal to blood volume can be
robustly determined using the same data, avoiding
the need for separate calibration scans. The derived
volume flow rates are consistent with those in the
literature and capable of clearly showing the level
of collateral flow in patient studies.
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14:30 |
3406. |
Off-pump Left
Ventricular Apical to Descending Aortic Conduits in
Adults with Aortic Stenosis: Postoperative Cardiodynamic
Evaluation with Cardiac MRI ![](play.gif)
Stephanie Clement-Guinaudeau1, Adrian Lam2,
Stuart N Hurst1, Robert L Eisner1,
Muralidhar Padala1, Vinod H Thourani1,
and John N Oshinski1,2
1Emory University, Atlanta, GA, United
States, 2Georgia
Institute of Technology, Atlanta, GA, United States
Off-pump apico-aortic conduit (ACC) is an
alternative to aortic valve replacement in patients
with calcified aortic root. In 10 patients with ACC,
hemodynamic data was collected using phase contrast
magnetic resonance (PCMR) imaging. Conduit flow was
68,7+/-13,6% of total cardiac output and flow
through the native aortic valve was 31,3+/13,6% of
cardiac output. In the descending aorta there was
15,8+/-9,9% of cardiac output that flowed in a
reverse upward direction from the conduit and
51,4+/-12,2% of cardiac output was directed caudally
below the conduit. ACC surgery results in a change
in hemodynamics that can be well studied using PCMR.
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15:00 |
3407. |
Assessment of
Myocardial Twist motion by Velocity Encoded MRI in LA -
Orientation ![](play.gif)
Anja Lutz1, Axel Bornstedt1,
Patrick Etyngier2, Robert Manzke3,
Wolfgang Rottbauer1, G Ulrich Nienhaus4,
and Volker Rasche1
1University Hospital of Ulm, Ulm, BW,
Germany, 2Medisys
Research Lab, Philips Healthcare, Sureness, France, 3Philips
Research NA, Briarcliff Manor, United States,4Karlsruhe
Institute of Technology, Karlsruhe, Germany
The rotational motion of the heart is an important
parameter for the assessment of cardiac function in
patients with cardiac diseases. The aim of this
study was to investigate the feasibility of velocity
encoded MRI to retrieve the twisting motion of the
heart from 6 slices acquired in long axes geometry
with equidistant radial spacing. Therefore, a black
blood prepared, respiratory navigated, segmented and
velocity encoded cardiac triggered gradient echo
sequence was used. Maximal myocardial twisting was
observed in the lateral wall after approx. 36% of
the RR cycle.
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Wednesday May 11th
|
13:30 - 15:30 |
Computer 39 |
13:30 |
3408. |
Serial assessment of
hyperintense post-infarct myocardial edema in mice by
T2-weighted MRI ![](play.gif)
Ronald J Beyers1, R. Scott Smith1,
Yaqin Xu1, Brent A French1,
and Frederick H Epstein1
1University of Virginia, Charlottesville,
VA, United States
Following myocardial infarction (MI), a need exists
to differentiate the acute MI from surrounding
salvaged area (SA) that together defines the area at
risk (AAR). T2w cardiac MRI (T2w CMR) quantifies
edema that delineates the AAR, while late
gadolinium-enhanced (LGE) CMR quantifies the MI.
Past T2w CMR studies have focused on larger mammals,
but not mice. Using mice is now common in
cardiovascular studies, including the MI model.
Here, we applied T2w CMR in post-MI mice to quantify
the AAR, along with LGE CMR to quantify MI, to track
the AAR, MI, and SA size relationships for 33 days.
|
14:00 |
3409. |
Imaging of
inflammation using VSOP at multiple time points in a
mouse model of myocardial infarction ![](play.gif)
Andrea Protti1, Xuebin Dong1,
Marcelo Andia2, Sanjay Chaubey1,
Bin Yu1, Matthias Taupitz3,
Rene Botnar2, and Ajay M Shah1
1Cardiovascular Division, King’s College
London BHF Centre of Excellence, London, UK, United
Kingdom, 2Division
of Imaging Sciences and Biomedical Engineering,
King’s College London BHF Centre of Excellence,
London, UK, United Kingdom, 3Department
of Radiology, Charite-Universitaetsmedizin, Berlin,
Germany
Myocardial infarction (MI) represents an acute
injury of the myocardium and triggers the
recruitment of monocytes and subsequent accumulation
of macrophages at the site of injury. Despite
intensive research in this field it is still poorly
understood how many and which type of monocytes are
involved in the migration into the infarct zone.
Non-invasive imaging methods is therefore of great
interest for the in-vivo investigation of the
inflammatory response post MI. In this work, we
investigate VSOP for direct imaging of inflammation
in a mouse model of MI. We investigated several time
points after MI and with different injection
protocols.
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14:30 |
3410. |
Dual Manganese- and
Delayed-Enhanced MRI Detects Myocardial Border Zone
Viability in a Murine Myocardial Injury Model ![](play.gif)
Ildiko Toma1, Michael Qian2,
Jaehoon Chung1, Yongquan Gong3,
Rajesh Dash1, Robert C Robbins4,
Philip Harnish5, and Phillip C Yang1
1Medicine/Cardiovascular Medicine,
Stanford University, Stanford, California, United
States, 2University
of California, Berkeley, Berkeley, California,
United States,3Radiology, Stanford
University, Stanford, California, United States, 4Cardiothoracic
Surgery - Adult Cardiac Surgery, Stanford
University, Stanford, California, United States, 5Eagle
Vision Pharmaceutical Corp., United States
Delayed enhancement MRI (DEMRI) identifies
non-viable myocardium, but is non-specific and may
overestimate nonviable territory. Manganese enhanced
MRI (MEMRI) signal identifies manganese in viable
cells. We performed dual-contrast myocardial
assessment, combining DEMRI and MEMRI in a diabetic
murine acute infarct model to characterize border
zone viability in vivo. MEMRI demonstrated smaller
scar volume and percentage compared to DEMRI.
Dual-contrast MEMRI-DEMRI may identify at-risk but
viable myocardial cells within transmural DEMRI
regions.
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15:00 |
3411. |
Implications of 2D
slice profile deformations for rapid myocardial T1/T2
quantification using DESPOT ![](play.gif)
Matthias Alexander Dieringer1,2, Michael
Deimling2,3, Davide Santoro2,
Flavio Carinci2,4, Jeanette Schulz-Menger1,2,
and Thoralf Niendorf1,2
1Experimental and Clinical Research
Center (ECRC), Charité Campus Buch,
Humboldt-University, Berlin, Germany, 2Berlin
Ultrahigh Field Facility, Max-Delbrueck Center for
Molecular Medicine, Berlin, Germany, 3Siemens
Healthcare, Erlangen, Germany, 4Department
of physics, Insubria University, Como, Italy
3D-DESPOT1/2 have been proposed for rapid and
accurate T1 and T2 quantification of the brain. A 2D
cardiac application with short repetition times (TR)
evokes T1 and flip angle dependent saturation
phenomena that deform the slice profile and hence
bear the potential to render T1/T2 quantification
inaccurate. Although these phenomena are known for
several years its impact on T1 and T2 quantification
using DESPOT has not been examined yet. This study
examines the impact of slice profile deformation on
the signal of 2D FLASH and 2D b-SSFP and
demonstrates its implications for rapid T1 and T2
quantification using DESPOT1/2.
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Thursday May 12th
|
13:30 - 15:30 |
Computer 39 |
13:30 |
3412. |
Normal distribution on
blood flow helicity in the healthy aorta ![](play.gif)
Ramona Lorenz1, Jelena Bock1,
Jan Gerrit Korvink2,3, and Michael Markl1
1Dept. of Radiology, Medical Physics,
University Medical Center Freiburg, Freiburg,
Germany, 2Dept.
of Microsystems Engineering - IMTEK, University of
Freiburg, Freiburg, Germany, 3Freiburg
Institute of Advanced Studies (FRIAS), University
Freiburg, Freiburg, Germany
3D blood flow characteristics in the aorta play an
important part in the health of individuals.
However, in vivo blood flow patterns are complex and
dependent on the individual geometry and shape of
the aorta. This study provides a fully quantitative
analysis and detailed evaluation of the spatial and
temporal distribution of mean and peak mean helicity
for 12 healthy subjects and in up to 24 analysis
planes equally distributed along the aorta. All 12
healthy subjects showed consistent directions of
rotation over the entire aorta with high systolic
clockwise helicity and a good inter-individual
agreement in the aortic arch.
|
14:00 |
3413. |
In-vivo validation of
5-point PC-VIPR for hemodynamic assessment of the
hepatic and splanchnic hemodynamics in swine ![](play.gif)
Alex Frydrychowicz1, Emily Winslow2,
Dan Consigny1, Eric Niespodzany1,
Eric Bultman1, Alejandro Roldán-Alzate1,
Kevin M Johnson3, Oliver Wieben4,
and Scott B Reeder1
1Department of Radiology, University of
Wisconsin - Madison, Madison, WI, United States, 2Department
of Surgery, University of Wisconsin - Madison,
Madison, WI, United States, 3Department
of Medical Physics, University of Wisconsin -
Madison, Madison, WI, United States, 4Departments
of Radiology and Medical Physics, University of
Wisconsin - Madison, Madison, WI, United States
Hepatic and splanchnic blood flow is of particular
interest in liver disease such as cirrhosis and
portal hypertension. However, comprehensive
assessment of flow and morphology is challenging,
especially because of the liver’s dual blood supply
and complex anatomy. 4D MR velocity mapping is a
promising approach to overcome shortcomings of
existing diagnostic approaches. This validation
study compared a novel radially undersampled 5-point
velocity encoding strategy that provides
high-resolution, large volume coverage and increased
velocity sensitivity with the de facto standard of
reference perivascular ultrasound. Excellent
correlation and an acceptable measurement bias was
found for both methods.
|
14:30 |
3414. |
Whole Heart 4D
Hemodynamics in Patients with Transposition of the Great
Arteries after Switch Procedure ![](play.gif)
Julia Geiger1, Raoul Arnold2,
Zoltan Csatari1, Mathias Langer1,
and Michael Markl1
1Radiology and Medical Physics,
University Hospital Freiburg, Freiburg, Germany, 2Pediatric
Cardiology, University Hospital Freiburg, Freiburg,
Germany
The purpose of this study was to employ whole heart
flow-sensitive 4D MRI for the identification and
quantification of altered aortic and pulmonary
hemodynamics in patients with transposition of the
great arteries (d-TGA) after arterial switch
procedure. Compared to healthy volunteers,
significantly increased peak velocities were
observed in the modified pulmonary trunk and
arteries located fully anterior to the aorta. A
correlation between the surgically altered TP
positions with the occurrence of vortex flow
indicates the potential of 4D flow analysis to
evaluate the impact of changes in vascular geometry
on regional hemodynamics.
|
15:00 |
3415. |
Analysis of Complex
Cardiovascular Flow with Three Component Acceleration
Encoded MRI ![](play.gif)
Alex J Barker1, Felix Staehle1,
Jelena Bock1, Bernd A Jung1,
and Michael Markl1
1Medical Physics, Dept. of Radiology,
University Medical Center Freiburg, Freiburg,
Germany
The measurement of local blood acceleration provides
valuable functional information regarding normal and
deranged local flow characteristics (e.g. vortex
formation). Acceleration data may be estimated from
standard velocity encoded images which, however,
suffer from noise amplification when calculating
spatiotemporal velocity derivatives. As a result,
this paper presents the in-vitro and in-vivo
implementation of a gradient-optimized acceleration
encoded PC-MRI sequence developed to shorten TE and
thus the scan duration, especially when performing
4D scans (3D, time-resolved scans). In addition, a
simple contrast mechanism to visualize complex flow
events such as boundary layer separation, turbulent
reattachment, and vortex formation is discussed.
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