Electronic Posters
: Functional MRI
|
Click on
to view the abstract pdf and click on
to view the video presentation. |
MRI Fluctuations: Artifacts & Information
Monday May 9th
Exhibition Hall |
14:00 - 16:00 |
Computer 56 |
14:00 |
3624. |
The effect of
flip angle on BOLD fMRI sensitivity ![](play.gif)
Javier Gonzalez-Castillo1, Vinai
Roopchansingh2, Peter A.
Bandettini1,2, and Jerzy Bodurka3
1Section on Functional Imaging
Methods, National Institute of Mental
Health, Bethesda, MD, United States, 2Functional
MRI Facility, National Institute of Mental
Health, Bethesda, MD, United States, 3Laureate
Institute for Brain Research, Tulsa, OK,
United States
Flip angles near the Ernst angle are
commonly used in fMRI to maximize image SNR.
However, lower angles provide significant
benefits such as better tissue contrast,
less inflow effect, less through-plane
motion artifacts, and reduced levels of
radio-frequency energy deposition. Recent
research has shown that TSNR, a better
predictor of sensitivity than SNR, stays
fairly constant and close to its maximum
value for a wide range of angles when
physiological noise dominates. Here we
explore the hypothesis that low flip angles
have no detrimental effects on our ability
to detect BOLD neuronal activations; and
might be advised for fMRI experiments
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14:30 |
3625. |
Investigating
cardiac pulsatility in the brain using EPI
sequences: from physiological noise to
physiological information ![](play.gif)
Ilia Makedonov1,2, David E Crane1,
and Bradley J MacIntosh1,3
1Heart and Stroke Foundation
Centre for Stroke Recovery, Toronto, ON,
Canada, 2Institute
of Biomaterials and Biomedical Engineering,
University of Toronto, Toronto, ON, Canada, 3Medical
Biophysics, University of Toronto, Canada
Cardiac noise is usually filtered and
otherwise minimized in resting state BOLD
fMRI scans. One theory posits that
mechanical damage due to cardiac pulsatility
is implicated in brain aging and contributes
to the formation of pathological small
vessel disease. The purpose of this abstract
is to characterize cardiac physiological
signal in BOLD fMRI and to compare young and
elderly groups. Our preliminary results
shows that cohort differences exist between
the extent of cardiac pulsatility in gray
matter in the young and elderly.
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15:00 |
3626. |
A random-walk
driven segmentation of resting state fMRI data:
evaluation of visual cortex sub-communities is
enhanced by physiological noise correction ![](play.gif)
Tommaso Gili1, Ibrahim Eid2,
Kevin Murphy1, Ashley Harris1,
Guido Caldarelli3, Bruno
Maraviglia2, and Richard Geoffrey
Wise1
1Cardiff University Brain
Research Imaging Centre (CUBRIC), School of
Psychology, Cardiff University, Cardiff,
Wales, United Kingdom, 2Dipartimento
di Fisica, Università di Roma Sapienza,
Roma, Italy, 3CNR-ISC
Dipartimento di Fisica, Univeristà di Roma
Sapienza, Roma, Italy
Parcellation of the cortex into individual
subunits based on correlations in
resting-state data opens up the possibility
of developing a subunit atlas analogous to
the Brodmann areas but based on cortical
function rather than cytoarchitecture. Graph
theory is a common methodology for studying
complex networks. Graph-based clustering
approaches have also been applied to the
analysis of brain networks using
resting-state fMRI. Here we used a
random-walk-based algorithm to parcellate
visual cortex in healthy subjects in a
resting-state condition. Moreover we
demonstrate the need for physiological noise
removal to obtain consistent results across
subjects from this functional segmentation
method.
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15:30 |
3627. |
Relationship
between spontaneous fluctuations in end-tidal
PCO2 and apparent resting state functional
connectivity ![](play.gif)
Cécile Madjar1, Claudine Joëlle
Gauthier1,2, Rasmus M Birn3,
and Rick D Hoge1,2
1CRIUGM/UNF, Montréal, Québec,
Canada, 2Physiology/Biomedical
Engineering, University of Montréal,
Montréal, Québec, Canada, 3University
of Wisconsin, Madison, WI, United States
With the ever-increasing number of studies
investigating the default-mode network
(DMN), there has been a growing interest in
trying to take into account the confounding
effects from physiological noise, such as
respiration, while performing connectivity
analysis of fMRI. Variations in respiration
cause fluctuations in end-tidal CO2 (ETCO2)
which have been shown to exert a significant
effect on BOLD fMRI signal. Here we present
data comparing resting-state correlations in
the DMN, as well as task-related
activations, between two conditions: 1)
while tightly controlling for ETCO2
concentrations, and 2) while ETCO2 values
were allowed to vary spontaneously.
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Tuesday May 10th
|
13:30 - 15:30 |
Computer 56 |
13:30 |
3628. |
A simple
method to reduce signal fluctuations in fMRI
caused by the interaction between motion and
coil sensitivities ![](play.gif)
Axel Hartwig1, Mathias Engström1,
Olof Flodmark1, Martin Ingvar1,
and Stefan Skare1
1Clinical Neuroscience,
Karolinska Institute, Stockholm, Sweden
In this study, we show the level of
interaction between head motion and coil
sensitivities for 32-channel fMRI data, in
the absence of fMRI stimulus. The magnitude
of the coil sensitivity induced signal
fluctuations, introduced after image
realignment, are similar to common
BOLD-response levels, why this can affect
the fMRI analysis when motion and the BOLD
response are partially correlated. Our
method involves a measurement of the coil
sensitivity field. By simply normalizing the
fMRI data - prior to realignment - with this
field, the signal fluctuations -
post-realignment - can be largely reduced.
|
14:00 |
3629. |
Identifying
and separating the RF fluctuations from the
measurement noise ![](play.gif)
Costin Tanase1, Jeffrey O'Hara2,
Denise Davis3, Fernando Boada3,
Michael H Buonocore4, and Cameron
S Carter1
1Psychiatry and Behavioral
Sciences, University of California at Davis,
Sacramento, CA, United States, 2Siemens
Medical Solutions, 3University
of Pittsburgh, United States,4Radiology,
University of California Davis, United
States
It is well accepted that the statistical
assessment of fMRI data can be improved by
estimating the measurement noise as well as
the fMRI series fluctuations due to slow
physiological processes. While recent fMRI
literature has characterized a larger array
of increasingly subtler physiological
fluctuations, there is still an overriding
assumption that the “leftover†variance
in the data can be described by
“stationary Gaussian noiseâ€. By
analyzing the QA data, the extracted
temporal series demonstrate the presence of
signal fluctuations that are non-random and
consistent across multiple runs.
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14:30 |
3630. |
Modelling
temporal stability of EPI time series acquired
with multi-channel receiver coils: treatment of
noise correlation ![](play.gif)
Chloe Hutton1, Antoine Lutti1,
and Nikolaus Weiskopf1
1Wellcome Trust Centre for
Neuroimaging, UCL Institute of Neurology,
University College London, London, United
Kingdom
Temporal signal-to-noise ratio (SNR) has
been characterized as a function of image
SNR for fMRI time series allowing
physiological noise to be separated from
thermal noise. This model is only valid for
data acquired with a single-channel receiver
coil. Here we propose an extension of this
model to allow for state-of-the-art
multi-channel acquisition mode, commonly
used for fMRI studies. Using Monte Carlo
simulations and 7T task-free fMRI, we show
improved fit of the extended model for data
where noise correlations are present. This
extended model allows for characterization
of temporal SNR and physiological noise
using data acquired with multi-channel
receiver coils.
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15:00 |
3631. |
Reducing a
Localized Signal Fluctuation Artifact in fMRI
using Spectral-Spatial Fat Saturation ![](play.gif)
Dan Xu1, Jian Zhang2,
Richard Scott Hinks1, and Kevin
F. King1
1Applied Science Laboratory, GE
Healthcare, Waukesha, WI, United States, 2Applied
Science Laboratory, GE Healthcare, Bethesda,
MD, United States
Conventional 1D, spatially non-selective fat
saturation can generate uncrushed fat
signals in areas where crusher is weak
because of reduced gradient linearity. These
fat signals can corrupt in-plane water
signal, and in fMRI, they manifest
themselves as artifacts such as clouds in
image background or localized signal
fluctuation over time. We propose a
spectral-spatial fat saturation method to
remove these artifacts while preserving thin
slice capability, pulse duration, and fat
suppression performance.
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Wednesday May 11th
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13:30 - 15:30 |
Computer 56 |
13:30 |
3632. |
Utility of
T2-Weighted Anatomical Images for fMRI
Physiological Noise Visualization ![](play.gif)
Raquel Phillips1, Vadim Zotev1,
Jonathan Savitz1, Ruben Alvarez1,
W Kyle Simmons1, Patrick
Bellgowan1, Wayne Drevets1,
and Jerzy Bodurka1
1Laureate Institute for Brain
Research, Tulsa, OK, United States
Physiological noise is a major confounding
factor in BOLD fMRI. We will show the
utility of T2-weighted anatomical
fast-spin-echo images for fMRI physiological
noise visualization. We propose a method for
processing T1- and T2-weighted anatomical
high-resolution images that highlights brain
compartmentalization at lower fMRI
resolution. Such images are formed by
computing spatial standard deviation (SDs)
from neighboring voxel intensities within
the anatomical volume. Because of the large
signal difference with fast-spin-echo
between cerebrospinal fluid, grey matter,
and/or vasculature, the T2-based SDs image
predicts well the brain areas where the fMRI
signal temporal variation will be present.
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14:00 |
3633. |
Prediction and
correction of physiological noise in fMRI using
machine learning ![](play.gif)
Tom Ash1, John Suckling2,
Martin Walter3, Cinly Ooi2,
Claus Tempelmann4, Adrian
Carpenter1, and Guy Williams1
1Wolfson Brain Imaging Centre,
University of Cambridge, Cambridge, United
Kingdom, 2Brain
Mapping Unit, University of Cambridge,
Cambridge, United Kingdom,3Department
of Psychiatry, University of Magdeburg,
Magdeburg, Germany, 4Department
of Neurology, Otto v. Guericke University,
Magdeburg, Germany
We present a support vector machine based
technique for recreation of partially or
fully absent physiological recording data,
to allow detrending of physiological noise
to occur even in the absence of complete
recordings of the physiological cycles. The
technique uses a multi-class SVM to predict
phase of each physiological cycle from fMRI
image data, after training on prior data.
Using these predicted phase values as inputs
to physiological detrending tool RETROICOR
show similar impact on Fourier transforms of
the data as using recorded values, showing
that they are accurate enough for use as
inputs to detrending tools.
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14:30 |
3634. |
Increased SNR
and activation in Hadamard-encoded fMRI through
physiological noise removal and phase correction ![](play.gif)
Alan Chu1,2, Jon-Fredrik Nielsen1,
Scott J. Peltier1, and Douglas C.
Noll1
1Biomedical Engineering,
University of Michigan, Ann Arbor, MI,
United States, 2University
of Michigan Medical School, Ann Arbor, MI,
United States
Hadamard-encoded fMRI is a multislice
acquisition method that increases SNR.
Because the method uses temporal filtering
on complex data for subslice extraction, the
method is more susceptible to physiological
noise and phase fluctuations when compared
with conventional fMRI, where only the
magnitude is typically used for
determination of voxel activation. In this
work, we introduce both physiological noise
removal and phase correction for
Hadamard-encoded fMRI, and compare the
resulting functional activation with that of
a conventional fMRI scan.
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15:00 |
3635. |
Optimized
physiological noise correction for 3D EPI time
series ![](play.gif)
Antoine Lutti1, Oliver Josephs1,
Dave Thomas2, Rebecca Lawson3,
Jonathan P Roiser3, Chloe Hutton1,
and Nikolaus Weiskopf1
1Wellcome Trust Centre for
Neuroimaging, Institute of Neurology,
University College London, London, United
Kingdom, 2Institute
of Neurology, Department of Brain Repair and
Rehabilitation, University College London,
London, United Kingdom, 3Institute
of Cognitive Neuroscience, University
College London, London, United Kingdom
The use of 3D EPI for the study of brain
activity has been limited due to its high
sensitivity to physiological noise which
counteracts its higher image SNR compared to
2D EPI. In this work, we present an
optimized method for physiological noise
correction of 3D EPI. The impact of the
correction is stronger than for 2D EPI,
showing that the higher susceptibility of 3D
EPI to physiological noise can be overcome,
leading to significantly higher tSNR values.
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Thursday May 12th
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13:30 - 15:30 |
Computer 56 |
13:30 |
3636. |
Physiological
origin of systemic artifacts in functional near
infrared spectroscopy as revealed by fMRI ![](play.gif)
Evgeniya Kirilina1, Alexnader
Jelzow2, Ruediger Bruehl2,
Angela Heine1, Michael Niessing1,
Arthur M. Jacobs1, Bernd
Ittermann2, Heidrun Wabnitz2,
Rainer Macdonald2, and Ilias
Tachtsidis3
1Free University of Berlin,
Berlin, Germany, 2Physikalisch-Technische
Bundesanstalt, Berlin, Germany, 3Department
Medical Physics and Bioengineering,
University College London, London, United
Kingdom
Functional near-infrared spectroscopy (fNIRS)
is a non-invasive technique for studying the
functional organization of the human brain
by measuring haemodynamic responses to
stimuli in the cerebral cortex. A major
challenge of fNIRS is its high sensitivity
to haemodynamic fluctuations in the scalp.
Here, we combined fNIRS, fMRI and peripheral
physiological measurements in order to
explore the physiological origin of
superficial signals in fNIRS and develop a
method to separate them from cortical
signals. Using high resolution fMRI data, we
show that the main origin of artifacts in
fNIRS is task-evoked venous vasoconstriction
in the scalp.
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14:00 |
3637. |
Small-scale
Phase and Magnitude fluctuations in fMRI time
series ![](play.gif)
Gisela E Hagberg1,2, David Balla3,
Hannes M Wiesner4, and Nikos K
Logothetis5
1Physiology of Cognitive
Processes, Max Planck Institute for
Biological Cybernetics, Tübingen, Germany,
Germany, 2Fondazione
Santa Lucia, Rome, Italy, 3High-Field
Magnetic Resonance Center, Max Planck
Institute for Biological Cybernetics,
Tubingen, Germany, 4High-Field
Magnetic Resonance Center, Max Planck
Institute for Biological Cybernetics,
Germany, 5Physiology
of Cognitive Processes, Max Planck Institute
for Biological Cybernetics
We investigated localized fluctuations
during resting state dynamics of 7T phase
and magnitude fMRI signals (voxels of 98 and
64nl) at two echo times (13 and 36ms) in
rats. We could confirm the presence of
TE-dependent signal fluctuations mediated by
BOLD susceptibility that was greatest in
voxels with strong vascular components and
decreased with the distance from such areas.
Interestingly, both high phase and magnitude
instabilities were observed in the callosal
fibers, containing oriented white matter
structures. In view of differences in
susceptibility between these structures and
the surrounding grey matter these
fluctuations may result from minute
displacements caused for instance by heart
pulsations.
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14:30 |
3638. |
Fully
Automated fMRI Denoising Using Multi-Echo fMRI
and TE-Dependent Properties ![](play.gif)
Prantik Kundu1, Souheil J Inati1,
Jennifer W Evans1, Ziad S Saad2,
and Peter A. Bandettini1
1Section on Functional Imaging
Methods, National Institute of Mental
Health, Bethesda, MD, United States, 2Scientific
and Statistical Computing Core, National
Institute of Mental Health, Bethesda, MD,
United States
A novel configuration of spatial ICA was
applied to multi-echo fMRI data. The
combination allowed robust, prior-free, and
fully automated differentiation of
physiological artifact components from BOLD
components using an amplitude model for
TE-dependence. No anatomical templates,
bandpass filtering, physiology regressors,
or motion parameters were required. The
technique was applied to both task and rest
data. Demonstrated is the improvement of
including artifact component timecourses as
baseline regressors in both activation
mapping and seed-voxel functional
connectivity.
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15:00 |
3639. |
Effect of
physiological noise on densely sampled
multi-echo fMRI data ![](play.gif)
Mark Chiew1,2, and Simon James
Graham1,3
1Medical Biophysics, University
of Toronto, Toronto, Ontario, Canada, 2Rotman
Research Institute, Toronto, Ontario,
Canada, 3Imaging
Research, Sunnybrook Health Sciences Centre,
Toronto, Ontario, Canada
Multi-echo functional magnetic resonance
imaging (fMRI) is a technique capable of
providing enhanced contrast-to-noise ratio (CNR)
data in blood oxygenation level dependent
(BOLD) imaging experiments. Here, data is
presented on the relationship between
physiological noise correlations and the CNR
benefits of densely sampled multi-echo fMRI
over traditional fMRI acquisitions, such as
echo-planar imaging. Data from Monte Carlo
simulations and experiment are presented,
and illustrate a decreasing power law
dependence of CNR benefit vs. degree of
noise correlation measured across echoes.
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Electronic
Posters : Functional MRI
|
Click on
to view the abstract pdf and click on
to view the video presentation. |
fMRI Neuroscience Methods & Applications I
Monday May 9th
Exhibition Hall |
14:00 - 16:00 |
Computer 57 |
14:00 |
3640. |
Tumor Induced Alterations
in Hemodynamic Responses in BOLD fMRI: Implications in
Presurgical Functional Brain Mapping ![](play.gif)
Liya Wang1,2, Dandan Chen3,
Jeffery Olson4, Shazia Ali1,
Tianning Fan2, and Hui Mao1,2
1Radiology, Emory University School of
Medicine, Atlanta, GA, United States, 2Center
for Systems Imaging, Emory University, Atlanta, GA,
United States, 3Physics,
Emory University School of Medicine, Atlanta, GA, United
States, 4Neurosurgery,
Emory University School of Medicine, Atlanta, GA, United
States
The blood oxygenation level dependent (BOLD) fMRI has
been widely applied in presurgical planning for brain
tumor resection. Growth of brain tumor is commonly
accompanied by the abnormal blood perfusion, therefore,
may lead to an altered BOLD effect and inaccurate
measurement of functional maps. This study investigated
the effect of the brain tumor to the HDR and BOLD signal
time courses in brain tumor patients and its potential
impact to the presurgical brain mapping.
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14:30 |
3641. |
Neural Correlates of
archery Motor Imagery
Jae-Jun Lee1, Jeehye Seo1, Hui-jin
Song1, Seong-Uk Jin1, Ji-Young Kim2,
and Yongmin Chang1,3
1medical & Biological Engineering, Kyungpook
national university, Daegu, Korea, Republic of, 2school
of medicine, Kyungpook national university, Daegu,
Korea, Republic of,3Diagnostic Radiology,
Kyungpook National University, Daegu, Korea, Republic of
Motor imagery was defined as the metal rehearsal of
simple or complex motor acts that is not accompanied by
physical movement. Previous studies provide evidence
that motor imagery is associated with dynamic changes
between performance and the mental rehearsal period that
precedes the voluntary movement as an important
difference between highly trained athletes and
beginners. However, motor imagery of archery and rifle
shooting is seldom studied. In the present study, we
compared the neural correlates of elite archers and
non-archers during mental rehearsal of archery using
functional magnetic resonance imaging (fMRI). Our
results show that the neural networks of expert archers
is more focused and efficiently organized than those of
non-archers. The motor programs of experts are more
efficiently organized and thus they require less energy
to execute. These results are consistent with the notion
of relative economy in the cortical processes of expert
athletes such as golfers and marksmen, relative to
controls, during the specific challenge with which they
are highly practiced.
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15:00 |
3642. |
fMRI Assessment of Effects
of Technique on Neurological Impairment in High School
Football Players ![](play.gif)
Thomas M Talavage1,2, Evan L Breedlove2,
Katherine E Morigaki3, Meghan E Robinson2,
Ruwan D Ranaweera1, Eric A Nauman2,4,
and Larry J Leverenz3
1School of Electrical and Computer
Engineering, Purdue University, West Lafayette, IN,
United States, 2Weldon
School of Biomedical Engineering, Purdue University,
West Lafayette, IN, United States, 3Department
of Health and Kinesiology, Purdue University, West
Lafayette, IN, United States, 4School
of Mechanical Engineering, Purdue University, West
Lafayette, IN, United States
Concussion in sport has received much recent attention.
For two years we have studied high school football
players to elucidate consequences of head collisions on
brain health. We have observed a new group of impaired
players who do not present typical clinical signs of
concussion, but can be detected with fMRI. This
impairment is correlated with number of blows to the
head. We present a case study of two players in our
study, whose (non-)alterations in technique appear to
correlate with assessment of brain health, suggesting
that reducing contact to the head can mitigate brain
injury.
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15:30 |
3643. |
Training shapes Cerebellum
and parieto-frontal network in professional badminton
players ![](play.gif)
Senhua Zhu1, Xin Di1, Hua Jin2,
Pin Wang2, Lei Mo2, Ke Zhou3,
Yan Zhuo3, and Hengyi Rao4
1Department of Psychology, Sun Yat-sen
University, Guangzhou, Guangdong, China, People's
Republic of, 2Department
of Psychology, South China Normal University, Guangzhou,
Guangdong, China, People's Republic of, 3State
Key Laboratory of Brain and Cognitive Science, Beijing,
China, People's Republic of, 4Center
for Functional Neuroimaging, University of Pennsylvania,
Philadelphia, PA, United States
This study used both structural and resting functional
MRI and investigated brain differences between 20
professional badminton players and 18 controls with
voxel based morphometry (VBM) as well as resting
functional connectivity analysis. The findings show that
badminton athletes have greater gray matter
concentration (GMC) and larger amplitude of low
frequency fluctuation (ALFF) in the cerebellum than
controls. Athlete group also demonstrated reduced ALFF
in left superior parietal lobule, and altered
parieto-frontal functional connectivity. Such brain
changes may reflect enhanced visuomotor coordination
skills in professional players after longitudinal
badminton training.
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Tuesday May 10th
|
13:30 - 15:30 |
Computer 57 |
13:30 |
3644. |
Deactivation in Tinnitus
patients and Controls during a Tone Discrimination Task
studied with fMRI ![](play.gif)
Arthur Peter Wunderlich1, Carlos
Schönfeldt-Lecuona2, Robert Christian Wolf2,
and Wolfgang Freund1
1Dept. for Diagnostic and Interventional
Radiology, Univ.-Clinic Ulm, Ulm, Germany, 2Psychiatry
Dept., Univ.-Clinic Ulm, Ulm, Germany
Tinnitus patients and healthy controls were studied by
means of a tone discrimination task which consisted of
tones with differing pitches presented above MR acoustic
noise level with a sound-proven MR-compatible headphone.
The main finding was deactivation of several cortical
and subcortical regions during tone discrimination in
healthy controls, while deactivation was not significant
in the patient group. An interaction analysis revealed
that caudate nucleus, posterior cingulate gyrus and
right superior frontal gyrus showed significantly
stronger deactivation during tone presentation in
controls than in patients. These results are discussed
in the light of recently published studies on
task-related deactivation.
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14:00 |
3645. |
Enhanced Synchronization
of Local Hymodynamic Activity in Mesial Temporal Epilepsy
Network ![](play.gif)
Zhiqiang Zhang1, and Guangming Lu1
1Department of Radiology, Jinling hospital,
Nanjing University School of Medicine, Nanjing, Jiangsu,
China, People's Republic of
Regarding the electrophysiological characteristic of
increased local neural synchronization in epilepsy [1],
the current study aims to investigate the alteration of
the local hemodynamic synchronization in mesial temporal
lobe epilepsy (mTLE) using fMRI.
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14:30 |
3646. |
Reorganization of
functional networks after training with motor imagery in
healthy subjects and a single case of lower limb amputation ![](play.gif)
Barbara Spano'1, Mara Cercignani1,
Marco Bozzali1, Cristiano Pecchioli2,
Giacomo Koch2,3, Carlo Caltagirone3,4,
and Barbara Marconi2
1Neuroimaging Laboratory, Santa Lucia
Foundation, IRCCS, Via Ardeatina 306, 00179 Rome, Italy,
Rome, Lazio, Italy, 2Laboratory
of Clinical and Behavioral Neurology, Santa Lucia
Foundation, IRCCS, Via Ardeatina 306, 00179 Rome, Italy,
Rome, Lazio, Italy, 3Department
of Neuroscience, University of Rome ‘Tor Vergata’, Viale
Oxford 81, 00133 Rome, Italy, Italy, 4Department
of Clinical and Behavioural Neurology, Santa Lucia
Foundation, IRCCS, Via Ardeatina 306, 00179 Rome, Italy,
Rome, Lazio, Italy
This paper describes, using fMRI, the effects of a
2-week training with foot motor imagery in driving
cortical reorganization in a group of HS. The results
suggest that mental practice with motor imagery is able
to induce changes in the pattern of fMRI activations
during motor tasks, mainly due to recruitment of
association cortex. The effects of motor imagery
training were also investigated in a single amputee,
showing modifications of the functional activation of
the primary motor cortex.
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15:00 |
3647. |
Imaginary toe-tapping
causes classic motor hand area activation in bilateral upper
limb amputees ![](play.gif)
Feng Zhao1,2, Hong-Jian He3,
Xiao-Jing Yu2, Yi-Xiang Wang1, and
Shi-Zheng Zhang2
1Department of Imaging and Interventional
Radiology, The Chinese University of Hong Kong, Shatin,
N.T., Hong Kong, China, People's Republic of, 2Department
of Radiology, Sir Run Run Shaw Hospital, Hang Zhou, Zhe
Jiang, China, People's Republic of, 3Bio-X
laboratory of Physics Department, Zhejiang University,
Hang Zhou, Zhe Jiang, China, People's Republic of
Shift of cortical representation from neighbouring areas
to the deafferented cortical representation after
amputation has been reported. This study used fMRI to
investigate cortical activation in bilateral upper limb
amputees when they executed real and imagined
toe-tapping. The result revealed the cortical area
representing the missing hand was activated by executed
and imagined toe tapping in amputees, which wasn¡¯t
found in controls. These results suggested that after
amputation the cortical reorganization is not limited to
the adjacent cortex, and the area representing the
missing hand also controls the real foot movement as
well as the imagined foot movement.
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Wednesday May 11th
|
13:30 - 15:30 |
Computer 57 |
13:30 |
3648. |
Self-regulation of
Amygdala Activation with Real-Time fMRI Neurofeedback ![](play.gif)
Vadim Zotev1, Frank Kruger2,
Raquel Phillips1, Ruben Alvarez1,
W Kyle Simmons1, Pat Bellgowan1,
Wayne Drevets1, and Jerzy Bodurka1
1Laureate Institute for Brain Research,
Tulsa, OK, United States, 2Department
of Molecular Neuroscience, George Mason University,
Fairfax, VA, United States
Real-time fMRI neurofeedback allows a person to
self-regulate activation in a specific brain region. We
explore feasibility of amygdala activity self-regulation
in emotional processing. A custom rtfMRI system was used
to measure fMRI activation and provide
region-of-interest neurofeedback as a variable-height
bar. Twenty-one healthy male subjects were asked to feel
happy so as to raise the bar. Eleven subjects
experienced left amygdala neurofeedback. Ten received
"sham" neurofeedback from the horizontal segment of
intraparietal sulcus. Increased left amygdala activation
was observed across training runs only with real
neurofeedback. Our results demonstrate that healthy
subjects can self-regulate amygdala function.
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14:00 |
3649. |
fMRI of the human amygdala
using ultra-high field MRI. Parcellation of emotional human
non-linguistic sounds ![](play.gif)
Eugenia Solano-Castiella1, Bibek Dhital1,
Domenica Wilfling1, Tom Fritz1,
Erik Türke1, Enrico Reimer1,
Robert Trampel1, and Robert Turner1
1Neurophysics, Max Planck Institute for Human
Cognitive and Brain Sciences, Leipzig, Sachsen, Germany
Localization within the body of the amygdala of
representations of specific emotions has been little
studied. The fMRI spatial resolution commonly available
with 3T is prone to susceptibility artifact, and has
insufficient spatial precision to distinguish different
emotion-related activations. We performed high
resolution fMRI at 7T MRI using a 24-channel RF receive
coil, with a range of auditory nonverbal emotional human
vocalizations. Probabilistic amygdala parcellations,
obtained in-vivo, assisted localization of emotions
within the amygdala. Use of 7T fMRI and such amygdala
maps enables correlation of the functional organization
of emotion representation with its anatomical substrate.
|
14:30 |
3650. |
Spin-Echo BOLD Temporal
Dynamics in the Rat Superior Colliculus and Lateral
Geniculate Nucleus ![](play.gif)
Condon Lau1,2, Jevin W Zhang1,2,
Matthew M Cheung1,2, Iris Y Zhou1,2,
Kevin C Chan1,2, and Ed X Wu1,2
1Laboratory of Biomedical Imaging and Signal
Processing, The University of Hong Kong, Hong Kong, Hong
Kong SAR, China, People's Republic of, 2Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Hong Kong, Hong Kong SAR, China, People's
Republic of
In rats, the superior colliculus (SC) and lateral
geniculate nucleus (LGN) are the main destinations for
retinal ganglion cells and are important subcortical
structures for vision. BOLD fMRI is used to measure the
SC and LGN’s hemodynamic responses, in Sprague-Dawley
rats, following short duration (1s) visual stimulation.
The most significant responses are concentrated in the
contralateral LGN and superficial, medial half of the
SC. The SC’s response reaches 25% of maximum amplitude
0.2±0.2s faster than the LGN. However, the LGN’s
response diminishes more rapidly. These temporal
differences are likely due to vessel dilation rate
heterogeneities.
|
15:00 |
3651. |
Neurophysiological
verification that unilateral tactile stimulation evokes
contralateral cortical but bilateral thalamic activations ![](play.gif)
Basavaraju G Sanganahalli1,2, Peter Herman1,2,
Douglas L Rothman2,3, Hal Blumenfeld2,4,
and Fahmeed Hyder2,3
1Diagnostic Radiology, Yale University, New
Haven, CT, United States, 2Quantitative
Neuroscience with Magnetic Resonance in Medicine (QNMR),
Yale University, New Haven, CT, United States, 3Diagnostic
Radiology and Biomedical Engineering, Yale University,
New Haven, CT, United States, 4Neurology,
Neurosurgery, Neuroscience, Yale University, New Haven,
CT, United States
We used 11.7T fMRI (i.e., BOLD and CBV) and
electrophysiology to study thalamocortical activations
in anesthetized rats. We detected contralateral cortical
but bilateral subcortical activations during forepaw
stimulation with fMRI and these localized activations
were confirmed by independent neural recordings. There
were no significant differences between contralateral
and ipsilateral thalamic responses, but the thalamic
activations were more pronounced in medial and lateral
portions of the laterodorsal thalamic nucleus. These
experiments provide early insights into understudied
interactions between cortical and subcortical areas and
which should provide a mechanistic basis to understand
sensory signal processing in the brain.
|
Thursday May 12th
|
13:30 - 15:30 |
Computer 57 |
13:30 |
3652. |
Functional Magnetic
Resonance Imaging of the Effects of a 60 Hz 3000 μT Magnetic
Field on Resting State Brain Blood Flow
Jodi Miller1,2, Julien Modolo1,2,
Michael Corbacio1,2, Daniel Goulet3,
Jacques Lambrozo4, Michel Plante3,
Martine Souques4, Frank S Prato1,2,
Alex W Thomas1,2, and Alexandre W Legros1,2
1Medical Biophysics, University of Western
Ontario, London, Ontario, Canada, 2Imaging,
Lawson Health Research Institute, London, Ontario,
Canada, 3Hydro-Québec,4Service
des Études Médicales, EDF
This work investigates the effects of a 60 minute, 60
Hz, 3000 ìT magnetic field exposure on resting state
blood flow with ASL. Seven healthy subjects were exposed
to the magnetic field and seven subjects were in the
sham group. SPM8 was used to analyze the data and found
significant regions of activation in both groups within
the resting state network. Subjects were unable to
detect the magnetic field, as determined by a Field
Status Questionnaire. The findings are consistent with
EEG studies of MF exposure. Additional subjects are
required to further explore the results of this pilot
study and to determine the duration of the observed
effects.µ
|
14:00 |
3653. |
BOLD responses according
to stimulation orders and manipulation methods ![](play.gif)
Geon-Ho Jahng1, Seong-In Bae2, and
Sabina Lim2
1Department of Radiology, Kyung Hee
University Hospital-Gangdong, Kyung Hee University,
Seoul, Seoul, Korea, Republic of, 2Department
of Meridian and Acupuncture, Graduate School of Applied
Eastern Medicine, Seoul, Seoul, Korea, Republic of
To investigate the BOLD response depending on three
parameters, stimulation order, manipulation method and
the side (left/right) of acupoint, 14 healthy subjects
were recruited and received acupuncture or placebo
stimulation on left or right acupoint of ST36. To
investigate the effect of the stimulation order,
placebo/acupuncture stimulations were performed at the
right acupoint and then left acupoint. To investigate
the effect of the manipulation method, the needle was
inserted and stimulated during only the activation
period and then the needle was removed during the
baseline scans. BOLD signals were measured at 3T MRI and
investigated using SPM8.
|
14:30 |
3654. |
GABA, glutamate, and
perfusion changes during working memory ![](play.gif)
Lars Michels1, Ernst Martin1,
Peter Klaver2, Richard Edden3,
Daniel Brandeis4, Rafael Lüchinger4,
David Lythgoe5, Fernando Zelaya5,
and Ruth L O'Gorman1
1University Children's Hospital, Zürich,
Switzerland, 2Department
of Psychology, University of Zürich, Zürich,
Switzerland, 3Russell
H Morgan Department of Radiology and Radiological
Sciences, Johns Hopkins University, Baltimore, MD,
United States, 4Department
of Child and Adolescent Psychiatry, University of
Zürich, Zürich, Switzerland,5Centre for
Neuroimaging Sciences, Institute of Psychiatry, London,
United Kingdom
Recent studies have uncovered a link between resting
GABA levels and resting perfusion, BOLD, and changes in
cerebral blood volume during stimulation, but the
relationship between neurotransmitter and haemodynamic
activity during cognition is unknown. This study
investigates whether modulations in GABA and glutamate
can be detected during working memory (WM) and whether
these neurotransmitter changes correlate with perfusion
measures. GABA levels increased significantly during the
first WM task and then decreased across subsequent task
runs. Resting GABA levels correlated inversely to the
change in perfusion during WM, and the change in Glx
during WM correlated inversely with the resting
perfusion.
|
15:00 |
3655. |
Anesthetic Effects of
Propofol on the Brain – Preliminary Results from MRI and MRS
in Normal Human Subjects ![](play.gif)
Maolin Qiu1, Ramachandran Ramani2,
and R Todd Constable1,3
1Diagnostic Radiology, Yale University School
of Medicine, New Haven, CT, United States, 2Anesthesia,
Yale University School of Medicine, New Haven, CT,
United States,3Biomedical Engineering,
Neurosurgery, Yale University School of Medicine, New
Haven, CT, United States
Preclinical studies suggest that propofol potentiates
GABA activity, promotes GABA release, and inhibits
Glutamate release. We employ both MRI and MRS to examine
the anesthetic effects of propofol on regional CBF,
intrinsic connectivity, and concentration or release of
GABA, Glutamate and Glutamine in the normal human brain.
Our preliminary data suggest the GABA receptor may be
the most sensitive of all neurocepors and play an
important role in propofol anesthesia. Propofol affects
regional CBF in a drug-specific manner. Although CBF and
ICC show similar spatial patterns, CBF is more
responsive to changes in brain’s activity than ICC. The
robustness of the ICC measure to external anesthetic
state suggests that ICC reflect a fundamental and
intrinsic property of functional brain organization.
|
|
|
Electronic
Posters
: Functional MRI
|
Click on
to view the abstract pdf and click on
to view the video presentation. |
fMRI Neuroscience Methods & Applications II
Monday May 9th
Exhibition Hall |
14:00 - 16:00 |
Computer 58 |
14:00 |
3656. |
Event-related
Olfactory fMRI ![](play.gif)
Xiaoyu Sun1, Christopher W Weitekamp1,
Jianli Wang1, Jeffrey Vesek1,
and Qing X Yang1,2
1Radiology, Penn State College of
Medicine, Hershey, PA, United States, 2Neurosurgery,
Penn State College of Medicine, Hershey, PA, United
States
In recent olfactory fMRI studies, the subjects were
trained to follow instructions for respiration or
sniffing to synchronize the odor stimulation. Such
methods will fail in studying patients that are not
able to follow the instructions. Here we present an
event-related paradigm design and post-processing
tools for olfactory fMRI without requirement to
control the subject’s respiration or sniffing. Our
data showed that the subject’s respiratory
modulation of the olfactory stimulation paradigm
significantly confounded the BOLD signal. The
presented event-related design and corresponding
data processing method are simple and effective for
generating olfactory fMRI results with minimal
confounding variability.
|
14:30 |
3657. |
Dynamic Behavior of
BOLD Signal in Olfactory Neural Networks ![](play.gif)
Prasanna Karunanayaka1, Christopher W
Weitekamp1, Jianli Wang1,
Megha M Patel1, Jeffrey Vesek1,
Xiaoyu Sun1, Paul J Eslinger2,3,
James R Connor4, and Qing X Yang1,4
1Radiology, Center for NMR Research, Penn
State University College of Medicine, Hershey, PA,
United States, 2Neurology,
Penn State University College of Medicine, Hershey,
PA, United States, 3Neural
& Behavioral Sciences, Penn State University College
of Medicine, Hershey, PA, United States, 4Neurosurgery,
Penn State University College of Medicine, Hershey,
PA, United States
The pattern of BOLD response during the time course
of a standardized olfactory stimulation paradigm was
investigated and characterized using group
independent component analysis (ICA). Group ICA is
quickly becoming a preferred functional MRI data
analysis technique due to its ability to reveal the
underlying networks of the human brain subserving
cognitive functions. Group ICA does not require a
priori knowledge of the hemodynamic response
function (HRF), which may vary across subjects and
paradigm conditions.
|
15:00 |
3658. |
Optimized fMRI imaging
protocol and hardware for studying the orbitofrontal
cortex in the presence of olfactory stimulation ![](play.gif)
Johnny Ng1,2, Heather Berlin3,
Wayne Goodman3, Emily Eaves1,
David Carpenter1, and Cheuk Tang1,3
1Radiology, Mount Sinai School of
Medicine, New York, NY, United States, 2Biomedical
Engineering Dept., City College of New York, New
York, NY, United States,3Psychiatry,
Mount Sinai School of Medicine, New York, NY, United
States
Orbitofrontal cortex (OFC) is the key structure
affected in obsessive-compulsive disorder (OCD).
There is a well-established relationship between
olfactory identification and the OFC. There are
limited studies in this area with functional
magnetic resonance imaging (fMRI), which showed
activations in the OFC during olfactory stimulation
with pleasant and unpleasant odorant stimuli. There
are two main issues which limiting studies in this
area: the non-availability of olfactometers and it
is problematic imaging OFC due to susceptibility
artifacts. The aim of this study is to optimized
fMRI imaging protocol for the OFC in OCD patients
with the in-house built olfactometer.
|
15:30 |
3659. |
An MR Compatible
Olfactometer for Clinical Research Use ![](play.gif)
Johnny Ng1,2, Emily Evaes1,
David Carpenter1, and Cheuk Ying Tang1,3
1Dept. Radiology, Mount Sinai School of
Medicine, New York, New York, United States, 2Biomedical
Engineering Dept., City College of New York, New
York, New York, United States, 3Dept.
Psychiatry, Mt. Sinai School of Medicine, New York,
New York, United States
Interest in the fMRI of the human olfactory system
has increased in recent years. The aim of this study
is to build a cost effective MR olfactometer
suitable for clinical and laboratory environments.
An apparatus was built to determine the temporal
resolution and the delay time of the custom-built
olfactometer. Six healthy subjects participated in
testing the olfactometer with six odorant stimuli.
The olfactometer has a very short delay time, less
than 1 second. Activations were found in the
piriform cortex, insular cortex and DLPFC.
|
Tuesday May 10th
|
13:30 - 15:30 |
Computer 58 |
13:30 |
3660. |
One Night Total Sleep
Deprivation Alters Neural Correlates of Risk-Taking ![](play.gif)
Hengyi Rao1,2, Dan Luftig2,
Julian Lim2, John A. Detre1,
and Daivid F Dinges2
1Center for Functional Neuroimaging,
University of Pennsylvania, Philadelphia, PA, United
States, 2Unit
for Experimental Psychiatry, University of
Pennsylvania, Philadelphia, PA, United States
Little is known about the effects of sleep
deprivation on neural correlates of risk-taking. The
present study used functional MRI and examined the
effects of 24hr of total sleep deprivation (TSD) on
risk-taking during a modified balloon analog risk
task (BART) in 27 normal subjects. One night TSD did
not alter the BART risk-taking behavior, nor the
risk-induced brain activation patterns. However, TSD
decreased insula activation during the loss events
and impaired the negative correlation between
risk-taking behavior and neural activation in insula
and striatum, suggesting that sleep deprivation may
alter neural responses during risk-taking before
actual behavioral changes.
|
14:00 |
3661. |
Discriminant analysis
and prediction of aMCI subjects and normal controls
using encoding and recognition fMRI tasks ![](play.gif)
Dietmar Cordes1, Mingwu Jin1,
Tim Curran2, Victoria Pelak3,
and Rajesh Nandy4
1C-TRIC and Dept. of Radiology,
University of Colorado-Denver, Aurora, CO, United
States, 2Dept.
of Psychology and Neuroscience, University of
Colorado-Boulder, Boulder, CO, United States, 3Dept.
of Neurology, University of Colorado-Denver, Aurora,
CO, United States, 4Depts.
of Biostatistic and Psychology, University of
California-Los Angeles, Los Angeles, CA, United
States
Focusing on activation in subregions of the medial
temporal lobe (CA1, CA23DG, SUB, ERC, PRC, FUS, PHC)
we used discriminant analysis applied to data from
three different memory paradigms to investigate the
degree of separation of the aMCI group from the
normal control group as a function of the type of
paradigm (outdoor pictures, faces-and-occupations,
unrelated word pairs) and type of contrast
(encoding-control, recognition-control,
encoding-recognition, old-control, new-control,
old-new). Results indicate optimum separation of
groups for the face-and-occupation paradigm for
contrast recognition-control. Prediction accuracy
using the leave-one-out method is 75% using
activations in left CA1, left SUB and left PHC.
|
14:30 |
3662. |
fMRI of Working Memory
in Military Traumatic Brain Injury ![](play.gif)
John Graner1, Hai Pan1,
Ping-Hong Yeh1, Binquan Wang1,
Terrence R Oakes1,2, Wei Liu1,2,
Louis M French3, Fletcher Munter2,
and Gerard Riedy2,4
1TBI Image Analysis Lab, Uniformed
Services University of the Health Sciences / HJF,
Bethesda, MD, United States, 2National
Capital Neuroimaging Consortium, Walter Reed Army
Medical Center, Washington, DC, United States, 3Defense
and Veterans Brain Injury Center, Walter Reed Army
Medical Center, Washington, DC, United States,4National
Intrepid Center of Excellence, Bethesda, MD, United
States
Fourteen (14) USA military TBI victims and 11
control subjects underwent fMRI while performing an
N-back working memory task. Significant group
differences were seen in the cerebellum in the
3-back vs. 1-back contrast. A preliminary
investigation of heterogeneity within the group
analysis results also suggests greater activation
variability in the TBI population that may need to
be accounted for when attempting traditional
voxel-based group analysis.
|
15:00 |
3663. |
Working memory
impairment in Fibromyalgia patients : fMRI study
Jeehye Seo1, Jae-jun Lee1,
Hui-jin Song1, Seong-Uk Jin1,
Ji-Young Kim2, and Yongmin Chang1,3
1Medical & Biological Engineering,
Kyungpook National University, Daegu, Korea,
Republic of, 2school
of medicine, Kyungpook National University, Daegu,
Korea, Republic of,3Diagnostic Radiology,
Kyungpook National University, Daegu, Korea,
Republic of
Fibromyalgia (FM) is a disorder of uncertain
etiology characterized by widespread chronic pain,
stiffness, and depression. Patients with FM commonly
report cognitive complaints, including memory and
attention problems. The aim of this study is to
elucidate the differences in neural activation
related to working memory between FM patients and
healthy subjects. We also investigated differences
in deactivation of the default network during
performance of working memory between two groups.
Nineteen FM patients and 22 healthy subjects
performed an n-back memory task. We found that
healthy subjects showed better performance in terms
of accuracy and reaction times during the task. In
between-group analyses, FM patients showed reduced
activation in the dorsolateral and ventrolateral
prefrontal cortex, dorsal cingulate cortex, and
inferior parietal cortex. There were no differences
in neural deactivation between FM patients and
healthy subjects during performance of the n-back
test. These results suggest that working memory
impairment in FM patients may be attributable to
differences in neural activation of the
frontoparietal network rather than deactivation of
the default network.
|
Wednesday May 11th
|
13:30 - 15:30 |
Computer 58 |
13:30 |
3664. |
Investigating the
neural base of hearing one's own name by fMRI ![](play.gif)
Toshiki Nakane1,2, Miyakoshi Makoto2,
Toshi Nakai2, and Shinji Naganawa1
1Nagoya University Graduate School of
Medicine, Nagoya, Aichi, Japan, 2NCGG,
Ohbu, Aichi, Japan
We performed an fMRI study to separate the effect of
attention from self-referential processes. For this
purpose, three categories of names, namely one's
own, repeated, and unfamiliar, were presented as
stimuli, followed by high or low beep sounds.
Participant's task was to judge one's own/repeated
or unfamiliar (attended task), and to judge beep
high or low (unattended task). Results showed fCMS
involvement when both self-relevance AND attention
were needed. We concluded that fCMS is not always
sensitive to self-relevance, but only when
self-relevance is task-relevant.
|
14:00 |
3665. |
Empathic brain
responses to other's pain was modulated by simple group
categorization: An fMRI study ![](play.gif)
Yang Hu1,2, Mingxia Fan3,
Wenjing Li2, Peijia Huang2,
and Zhaoxin Wang1,3
1Institute of Cognitive Neuroscience,
Shanghai Key Laboratory of Brain Functional
Genomics, East China Normal University, Shanghai,
China, People's Republic of,2Department
of Psychology, School of Psychology and Cognitive
Science, East China Normal University, Shanghai,
China, People's Republic of, 3Shanghai
Key Laboratory of MRI, East China Normal University,
Shanghai, China, People's Republic of
The current study aimed to investigate whether
simple group categorization can modulate the neural
correlates of empathy for other¡¯s pain using a
modified minimal paradigm. Participants were
randomly assigned to two groups and were instructed
to memorize novel faces of in-/out-group members.
They were then sent to the MRI scanner to rate the
pain intensity felt by their in-/out-group members.
We found that increased activation in right anterior
insula was detected while participants see their
in-group members receiving painful stimulation in
relevant to out-group members, indicating that
empathic concern for other¡¯s pain could be
modulated by simple group categorization.
|
14:30 |
3666. |
Disrupted Sensory
Projection and Preserved Integrative Network in
Propofol-Induced Anesthesia ![](play.gif)
Xiaolin Liu1, Kathryn K. Lauer2,
Stephen M. Rao3, Shijiang Li1,
and Anthony G. Hudetz2
1Biophysics, Medical College of
Wisconsin, Milwaukee, WI, United States, 2Anesthesiology,
Medical College of Wisconsin, Milwaukee, WI, United
States, 3Schey
Center for Cognitive Neuroimaging, Cleveland Clinic,
Cleveland, Ohio, United States
In this study, we described our investigation into
the integrative mechanisms of general anesthesia
using a compelling verbal memory experimental
paradigm that allows neuroimaging characterization
of consciousness in waking, anesthesia, and
emergence. Our neuroimaging methodology was
specifically designed to understand the
anesthetic-induced changes of temporal coherence in
the brain at different hierarchical levels of the
cognitive processing, providing a consistent
interpretation with the conception of the anesthetic
mechanisms as the information disintegration or the
cognitive unbinding. The findings reveal a
differential effect of propofol anesthesia on
sensory and cognitive systems and provide direct
imaging evidence for information disintegration as a
mechanism of anesthetic-induced unconsciousness.
|
15:00 |
3667. |
The Neural Basis of
Auditory Processing Disorder ![](play.gif)
Vincent Jerome Schmithorst1, Scott Kerry
Holland1, and Elena Plante2
1Radiology, Children's Hospital Medical
Center, Cincinnati, OH, United States, 2Speech,
Language, and Hearing Sciences, University of
Arizona, Tucson, AZ, United States
Auditory Processing Disorder (APD) in children is
diagnosed on the basis of behavioral tests which can
be confounded by attentional or language deficits.
We investigate the hypothesis that APD, as currently
diagnosed by clinicians, stems from a deficit in
cross-modal inhibition (the inhibition of neural
processing of other sensory inputs). Performance of
behavioral audiology measures was correlated with
brain activation during a basic auditory stimulation
task using fMRI. Results suggest that performance on
tests of auditory processing used to diagnose APD is
predicted by cross-modal inhibition of secondary
visual areas and the parahippocampal gyrus,
associated with repression of irrelevant
information.
|
Thursday May 12th
|
13:30 - 15:30 |
Computer 58 |
13:30 |
3668. |
Classical music
enhances the local functional connectivity density in
the brain ![](play.gif)
Ruiliang Wang1, Gene-Jack Wang2,
Frank Telang3, Rita Z Goldstein4,
Nora D Volkow5, and Dardo Tomasi5
1Medical, Brookhaven National Laboratory,
Upton, NY, United States, 2Brookhaven
Nationa Laboratory, 3medical,
Brookhaven National Laboratory, 4Brookhaven
National Laboratory, 5National
Institute on Drug Abuse, National Institute on
Health
We used magnetic resonance imaging and functional
connectivity density mapping (FCDM) to map hubs with
high local functional connectivity density (lFCD)in
70 healthy men (age: 18-55). Two resting conditions
were tested: 1) when the subjects rested with their
eyes open (baseline condition), and 2) while they
were listening to classical music (music condition).
Our findings suggest that in resting conditions,
music can increase the local functional connectivity
of the brain. These findings are consistent with the
involvement of brain regions in processing rhythm
(dorsolateral prefrontal and parietal cortices and
cerebellum), tonality (temporal and medial
prefrontal cortices) and emotions (limbic cortex).
|
14:00 |
3669. |
Middle Frontal Gyrus
as a Potential Neural Indicator for Musical Imagery ![](play.gif)
Kirsteen Davidson-Kelly1, Sujin Hong1,
Janani Dhinakaran2, Joseph Sanders3,
Calum Gray4, Edwin J.R. van Beek4,
Neil Roberts4, and Katie Overy1
1Music, University of Edinburgh,
Edinburgh, United Kingdom, 2Carl
von Ossietzky University of Oldenburgh, Germany, 3Guildhall
School of Music & Drama, London, United Kingdom, 4Clinical
Research Imaging Centre (CRIC), Queen’s Medical
Research Institute (QMRI), University of Edinburgh,
Edinburgh, United Kingdom
Musical imagery is an expert learning strategy with
potential to enhance performance, reduce physical
overuse and decrease anxiety. In this fMRI study we
scanned a professional pianist with vivid imagery
skills during imagined and simulated motor
performance of memorised music. The motor system
(SMA, pre-motor cortex, cerebellum) was activated
during both tasks, while M1 was activated during
performance only. Interestingly, the MFG showed
differential activation for imagery (bilateral) and
performance (left-sided only), possibly indicating a
shift/increase in attention. We conclude that the
MFG could provide an index of the effectiveness of
musical imagery as a learning strategy.
|
14:30 |
3670. |
"Dual-Use" fMRI in
children: assessing language and visuospatial functions
with one task ![](play.gif)
Marko Wilke1, Kathina Ebner2,
Till-Karsten Hauser3, and Karen Lidzba2
1Pediatric Neurology & Developmental
Medicine, University Children's Hospital Tübingen,
Tübingen, BW, Germany, 2Pediatric
Neurology & Developmental Medicine, University
Children's Hospital Tübingen, Tübingen, Germany, 3Diagnostic
and Interventional Neuroradiology, Radiological
Clinic, Tübingen, Germany
Functional MRI in children is still challenging. We
here suggest that appropriately-designed fMRI tasks
may be analyzed in the active>control as well as the
control>active condition, allowing to assess two
cognitive domains in one task. Results from a
"dual-use" task assessing language and visuospatial
functions are compared with a dedicated task
designed to assess visuospatial functions. The
implications of such an approach are discussed.
|
15:00 |
3671. |
Song and Speech –
Perception and Covert Production: New Findings using
Multi-Voxel Pattern Analysis ![](play.gif)
Dirk Goldhahn1, Daniel E Callan2,
Gabriele Lohmann1, and Robert Turner1
1Department of Neurophysics, Max Planck
Institute for Human Cognitive and Brain Sciences,
Leipzig, Germany, 2ATR
Computational Neuroscience Laboratories, Kyoto,
Japan
Multi-Voxel Pattern Analysis (MVPA) is a powerful
technique for the analysis of fMRI data. It uses the
information present in multiple voxels to
distinguish between experimental conditions. In this
abstract we apply MVPA to examine brain regions
differentially involved with listening to and covert
production of song relative to speech. We present
new findings that univariate analysis failed to
discover, and investigate what underlies this
discrepancy. As a particular example the superior
temporal gyri are discussed, which show highly
differential activity for the contrast of covert
production of song versus covert production of
speech only when using MVPA.
|
|
|
Electronic
Posters
: Functional MRI
|
Click on
to view the abstract pdf and click on
to view the video presentation. |
Animal fMRI
Monday May 9th
Exhibition Hall |
14:00 - 16:00 |
Computer 59 |
14:00 |
3672. |
BOLD fMRI of the
Visual System in Awake and Anesthetized Rats ![](play.gif)
Der-Yow Chen1, Stephen Dodd1,
Afonso Silva1, and Alan Koretsky1
1LFMI, NINDS, NIH, Bethesda, MD, United
States
In the present study, we compare the BOLD fMRI of
the visual system in awake and alpha-chloralose
anesthetized rats. A head post was implanted to
minimize the head motion and rats were trained to
accustom to a restrainer. Brain activity in response
to various frequencies of flashing light was
explored. Awake rats showed significant fMRI
activation in the lateral geniculate nucleus,
superior colliculus, and the visual cortex,
especially in response to high frequencies. On the
contrary, less activation were found in these
regions of anesthetized rats. These findings
indicate that fMRI experiments in awake rats may be
more appropriate to study the function of visual
system.
|
14:30 |
3673. |
Neurophysiological
underpinnings of ketamine-induced negative BOLD response
and interactions with anaesthesia ![](play.gif)
Naranjargal Dashdorj1, Mirjam I Schubert1,
Malcolm Prior2, Rob Mason3,
and Dorothee P Auer1
1Academic Radiology, University of
Nottingham, Nottingham, Nottinghamshire, United
Kingdom, 2Brain
and Body Centre, University of Nottingham,
Nottingham, United Kingdom, 3School
of Biomedical Sciences, University of Nottingham,
Nottingham, United Kingdom
Pharmacological magnetic resonance imaging (phMRI)
is an increasingly popular tool to study drug
effects on brain function using the blood oxygen
level dependent (BOLD) signal. However, the nature
of the drug induced BOLD signal change is still not
well understood; in particular its relationship with
the underlying neural activity. Additionally, the
majority of animal phMRI studies require
anaesthesia, which may interact with the
investigated drug. The neurophysiological
underpinnings of BOLD signal changes were directly
studied in few hallmark studies. It remains however
unclear whether a similar relation between LFP and
BOLD signal change exist for pharmacological fMRI
under different anaesthetic protocol. In this study
we compared ketamine-induced BOLD changes with
electrophysiological recordings in rodent brain
under two different anaesthetic protocols.
|
15:00 |
3674. |
Ketamine-evoked
Functional Connectivity Changes in Isoflurane
Anaesthetised Rats ![](play.gif)
Naranjargal Dashdorj1, Mirjam I Schubert1,
Rob Mason2, and Dorothee P Auer1
1Academic Radiology, University of
Nottingham, Nottingham, Nottinghamshire, United
Kingdom, 2School
of Biomedical Sciences, University of Nottingham,
Nottingham, United Kingdom
In recent years synchronised low-frequency
spontaneous fluctuations detected by fMRI BOLD
signal has been widely applied to study functional
connectivity networks in human subjects. Although,
the nature of functional connectivity detected by
spontaneous BOLD fMRI and its underlying neural
correlates have not been well understood yet. Animal
studies provide wider possibility of invasive and
non-invasive methods. Hence, the applications of
BOLD fMRI functional connectivity in animal studies
are expected to facilitate in-depth understanding of
low-frequency BOLD fluctuations. In particular,
using psychoactive compound to study changes in
functional connectivity would allow us to study
changes in a given animal on same background neural
activity. This study examined the spatiotemporal
dynamics under isoflurane anaesthesia.
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15:30 |
3675. |
Alternating Phase
Coherence of Spontaneous Hemodynamic Oscillation is
Sensitive to Anesthesia Levels ![](play.gif)
Xiao Liu1, Xiao-Hong Zhu1, Yi
Zhang1, and Wei Chen1
1CMRR, Radiology, University of
Minnesota, Minneapolis, MN, United States
In this study, we observed strong ~0.1 Hz
hemodynamic (CBF and BOLD) oscillations in cats
anesthetized with alpha-chloralose. The
inter-hemispheric (i.e., left versus right V1, and
left versus right LGN) phase coherence of
hemodynamic oscillations is alternating between
positive and negative values over time. Moreover,
the relative proportions of positive and negative
correlations changes with anesthesia level with more
negative correlations under the deeper anesthesia.
The results may suggest that the increased
anesthesia level can impair the brain’s capability
of synchronizing activity across different regions
and result in less phase coherence even at the early
thalamic brain regions.
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Tuesday May 10th
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13:30 - 15:30 |
Computer 59 |
13:30 |
3676. |
BOLD fMRI
investigation of rat auditory system ![](play.gif)
Matthew Man Hin Cheung1,2, Iris Y Zhou1,2,
Kevin C. Chan1,2, Frank Y Lee1,2,
Leon C. Ho1,2, Condon Lau1,2,
and Ed X. Wu1,2
1Laboratory of Biomedical Imaging and
Signal Processing, The University of Hong Kong,
Pokfulam, Hong Kong SAR, China, People's Republic
of, 2Department
of Electrical and Electronic Engineering, The
University of Hong Kong, Pokfulam, Hong Kong SAR,
China, People's Republic of
In this study, auditory system was investigated in
rodents by BOLD fMRI at 7T. Auditory pathway and
various components were revealed by BOLD responses
in agreement with the known auditory neuroanatomy by
other methods. Tonotopic mapping in inferior
colliculus was also demonstrated for the first time
by fMRI. Such non-invasive study of functional
hemodynamic responses in auditory system will
provide a valuable tool in hearing research of
normal and diseased models. This was by far the
first BOLD fMRI study of rodent auditory system.
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14:00 |
3677. |
BOLD Response
Dependence on the Stimulation Light Intensity in the Rat
Superior Colliculus ![](play.gif)
Jevin W Zhang1,2, Condon Lau1,2,
Matthew M Cheung1,2, Kyle Xing1,2,
Iris Y Zhou1,2, Kevin C Chan1,2,
and Ed X Wu1,2
1Laboratory of Biomedical Imaging and
Signal Processing, The University of Hong Kong, Hong
Kong, Hong Kong SAR, China, People's Republic of, 2Department
of Electrical and Electronic Engineering, The
University of Hong Kong, Hong Kong, Hong Kong SAR,
China, People's Republic of
In rats, the superior colliculus (SC) is the main
destination for retinal ganglion cells and is an
important subcortical structure for vision. Its
light intensity dependence has not been extensively
studied with functional imaging. BOLD fMRI is used
to measure the SC’s hemodynamic response, in
Sprague-Dawley rats, to visual stimulation at five
intensity levels (4.2x10-3 to
0.74W/m2). Significant responses are
observed at all intensity levels. Less of the SC
responds to 4.2x10-3W/m2 stimulation
than to higher intensity stimuli (p<0.05). The
response amplitude during 4.2x10-3W/m2 stimulation
is also significantly lower than during 7.6x10-2 and
0.23W/m2 stimulation
(p<0.05).
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14:30 |
3678. |
BOLD fMRI Study of the
Rat Superior Colliculus Responding to a Moving Visual
Stimulus ![](play.gif)
Condon Lau1,2, Jevin W Zhang1,2,
Matthew M Cheung1,2, Kyle Xing1,2,
Iris Y Zhou1,2, Kevin C Chan1,2,
and Ed X Wu1,2
1Laboratory of Biomedical Imaging and
Signal Processing, The University of Hong Kong, Hong
Kong, Hong Kong SAR, China, People's Republic of, 2Department
of Electrical and Electronic Engineering, The
University of Hong Kong, Hong Kong, Hong Kong SAR,
China, People's Republic of
In rats, the superior colliculus (SC) is the main
destination for retinal ganglion cells and is an
important subcortical structure for vision. Many of
its neurons are highly sensitive to moving objects.
BOLD fMRI is used to measure the SC’s hemodynamic
response, in Sprague-Dawley rats, to a visual
stimulus moving at five speeds between 7 and 164°/s.
Significant responses are observed at all speeds
tested. The maximum response amplitude occurred at
41 and 82°/s and the minimum at 164°/s. The number
of responsive voxels was lowest at 164°/s. These
findings appear to be in agreement with electrical
recording studies.
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15:00 |
3679. |
BOLD signal
differences in the somatosensory and visual pathways ![](play.gif)
Daniil Aksenov1,2, Limin Li1,2,
Michael Miller1,2, and Alice Wyrwicz1,2
1NorthShore University Health System,
Evanston, IL, United States, 2Pritzker
School of Medicine, University of Chicago, Chicago,
IL, United States
In order to examine the local differences in BOLD
signal, fMRI data were obtained from awake rabbits
using either whisker or visual stimulation, and the
BOLD responses in cortical and subcortical
structures of the pathways were compared within and
between each sensory system. Early results reveal
striking differences in the shape of BOLD time
courses in terms of adaptation (i.e., decrease to a
plateau following an initial peak) between in the
visual and whisker pathways. These results suggest
that visual cerebral cortical versus subcortical and
whisker cortical regions are characterized by
different hemodynamic properties.
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Wednesday May 11th
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13:30 - 15:30 |
Computer 59 |
13:30 |
3680. |
Anatomical, BOLD,
Blood Flow MRI of Non-Human Primate (Baboon) Retina ![](play.gif)
Yi Zhang1,2, Hsiao-Ying Wey1,2,
Oscar San Emeterio Nateras2, Qi Peng1,2,
and Timothy Q. Duong1,2
1Research Imaging Institute, University
of Texas Health Science Center at San Antonio, San
Antonio, TX, United States, 2Radiology,
University of Texas Health Science Center at San
Antonio, San Antonio, TX, United States
In rodent models, layer-specific resolution of
anatomical, blood flow and functional MRI has been
reported. As a first step toward translation, we
investigated the feasibility of multimodal retinal
MRI on anesthetized large non-human primate (baboon)
using a standard clinical 3-Tesla scanner. Baboon
was chosen because it has large eyes and better
recapitulates human retinal diseases. Anesthesia and
paralysis were used to exclude movement artifacts,
such that we could focus on evaluating hardware
feasibility and pulse sequence parameters for
high-resolution multimodal MRI of the retina on a
clinical scanner. These findings offer encouraging
data to explore human applications.
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14:00 |
3681. |
BOLD-fMRI study of
Effect of Dark-rearing on Postnatal Visual Development ![](play.gif)
Joe Shi Cheng1,2, Kevin C. Chan1,2,
Iris Y Zhou1,2, Matthew M Cheung1,2,
Condon Lau1,2, and Ed X Wu1,2
1Laboratory of Biomedical Imaging and
Signal Processing, The University of Hong Kong, Hong
Kong SAR, China, People's Republic of, 2Department
of Electrial and Electronic Engineering, The
University of Hong Kong, Hong Kong SAR, China,
People's Republic of
Environmental inputs play a significant role in
visual system development. However, current studies
on the effects of visual input deprivation
(dark-rearing) mainly use histological,
electrophysiological, and optical imaging
techniques. The result of this study demonstrated
for the first time an in vivo approach for
simultaneously assessing the functional
developmental changes in rat cortical and
subcortical visual system, and found that the visual
cortex’s BOLD response is reduced by dark-rearing
(p<0.05) while that of the subcortical visual nuclei
(superior colliculus and lateral geniculate nucleus
) are less affected.
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14:30 |
3682. |
Optogenetically
induced BOLD of excitatory neurons in the mouse
hippocampus at 9.4T: identification of a hippocampal
network ![](play.gif)
Wolfgang Weber-Fahr1, Alexander Sartorius2,
Natlia Gass1, Zhijun Li3, and
Wolfgang Kelsch2,3
1Neuroimaging, Central Institute of
Mental Health, Mannheim, Germany, 2Psychiatry,
Central Institute of Mental Health, Mannheim,
Germany, 3Clinical
Neurobiology, Ruprecht-Karls-Universität,
Heidelberg, Germany
It was shown recently in rats that BOLD activation
in a particular region can be caused by optogenetic
stimulation. In this study we were interested in the
hippocampal network in mice and induced expression
of channelrhodopsin-2 in Ca2+/calmodulin-dependent
protein kinase II-expressing neurons by viral
injection. Laser stimulation was periodically
applied through an optical fiber in the left
hippocampus with a block design while fMRI data was
aquired. We found activation in a large area of the
targeted hippocampus. Interestingly, we also we
found a corresponding significant activation in
areas outside the stimulated region in the primary
somatosensory and motor cortices.
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15:00 |
3683. |
Study of Brain
Activation in Small Animals using PET/MR Imaging ![](play.gif)
Hans F Wehrl1, Florian C Maier1,
Petros Martirosian2, Gerald Reischl3,
Fritz Schick2, and Bernd J Pichler1
1Laboratory for Preclinical Imaging and
Imaging Technology of the Werner Siemens-Foundation,
University of Tuebingen, Tuebingen, Germany, 2Section
on Experimental Radiology, University of Tuebingen,
Tuebingen, Germany, 3Radiopharmacy
and PET-Center, University of Tuebingen, Tuebingen,
Germany
Brain activation was studied by small animal [15O]H2O
PET and BOLD fMRI measurements. Qualitatively PET
and MR activation information correlates, however
discrepancies are observed concerning the
statistical significance, spatial extend as well as
spatial location of the activation centers, which
arise from methodological as well as physiological
differences between the observed PET and MR signal.
These studies open the scene for further research of
brain metabolism using PET/MR imaging techniques,
combining the sensitivity of PET with the the
functional imaging capabilities of MR.
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Thursday May 12th
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13:30 - 15:30 |
Computer 59 |
13:30 |
3684. |
Rat Brain Possesses a
Default Mode Network ![](play.gif)
Hanbing Lu1, Qihong Zou1,
William Rea1, Elliot A Stein1,
and Yihong Yang1
1National Institute on Drug Abuse, NIH,
Baltimore, MD, United States
We have identified coherent, spontaneous activity
within a specific brain network in rats that mirrors
the default mode network (DMN) previously reported
in human and non-human primates, suggesting that
operations performed by the DMN may be a fundamental
physiological process in the mammalian brain. Our
data raise interesting questions about the functions
of DMN across species, and open novel opportunity to
investigate the physiological basis of DMN using
rodent model.
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14:00 |
3685. |
resting state networks
in (transgenic) mice: differential effects of genetic
background, sensory stimulation, and pharmacological
intervention ![](play.gif)
Silke Kreitz1, Cornelia Heindl-Erdmann1,
Roland Axmann2, Jochen Zwerina2,
Josef Penninger3, Georg Schett2,
Kay Brune1, and Andreas Hess1
1Institute for Pharmacology and
Toxicology, FAU Erlangen-Nuremberg, Erlangen,
Germany, 2Internal
Medicine 3, Rheumatology and Immunology, FAU
Erlangen-Nuremberg, Erlangen, Germany, 3Institute
of Molecular Biology, Austrian Academy of Sciences,
Vienna, Austria
Resting state analysis of brain activity in
(transgenic) mice was performed before and after
peripheral heat stimulation. “Painless” mice (DREAM
-/-), having permanent analgesia due to modification
of the dynorphin pain pathway, showed no change in
their resting state network connectivity after the
painful stimulation compared to wild-type mice.
Pharmacological compensation of their genetic
modification, reestablished plastic effects of the
painful stimulation on the resting state network.
These results demonstrate the usefulness of non
invasive fMRI in transgenic mice and molecular
defined pharmacological intervention to further
investigation of functional connectivity in pain
research.
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14:30 |
3686. |
Resting-state
Functional Connectivity Alterations after Corpus
Callosotomy in Rats ![](play.gif)
Iris Yuwen Zhou1,2, Y X Liang3,
Kevin C. Chan1,2, Matthew M. Cheung1,2,
Condon Lau1,2, K F So3, and Ed
X Wu1,2
1Laboratory of Biomedical and Signal
Processing, The University of Hong Kong, Hong Kong
SAR, China, People's Republic of, 2Department
of Electrical and Electronic Engineering, The
University of Hong Kong, Hong Kong SAR, China,
People's Republic of, 3Department
of Anatomy, The University of Hong Kong
Resting-state fcMRI has been increasingly used in
the diagnosis of a variety of brain diseases.
However, the underlying mechanism of the spontaneous
fluctuations in fcMRI signals remains largely
unexplored. In this study, we employed a
well-controlled animal model of corpus callosotomy
to evaluate the role of corpus callosum (CC) in the
interhemispheric functional connectivity. It was
found that a strikingly loss of interhemispheric
correlation after the complete transection of CC
while the intrahemispheric connections was preserved
and seemed to be expanded. The results of this study
provide direct evidence of the role of CC in
spontaneous neural activity.
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15:00 |
3687. |
Restoration of
Interhemispheric Resting-State Connectivity in S1FL
Following Median Nerve Injury and Surgical Repair ![](play.gif)
Christopher Paul Pawela1,2, Bharat B
Biswal3, Rupeng Li2, Anthony G
Hudetz4, and James S Hyde2
1Department of Plastic Surgery, Medical
College of Wisconsin, Milwaukee, WI, United States, 2Department
of Biophysics, Medical College of Wisconsin,
Milwaukee, WI, United States, 3Department
of Radiology, University of Medicine and Dentistry
of New Jersey, Newark, NJ, United States, 4Department
of Anesthesiology, Medical College of Wisconsin,
Milwaukee, WI, United States
Resting-State Functional Connectivity MRI (fcMRI) is
finding application in studying a variety of brain
disorders. The underlying physiological basis of the
BOLD resting-state fluctuations is still unknown. In
this study, manipulation of the peripheral nervous
system is performed to modify signal input into the
thalamocortical system and disrupt interhemispheric
correlation of the sensorimotor system. This study
demonstrates the bilateral nature of resting-state
correlation and may provide insight into the
phenomenon.
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