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ISMRM 21st
Annual Meeting & Exhibition
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20-26 April 2013
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Salt Lake City, Utah, USA |
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WEEKDAY
EDUCATIONAL COURSE |
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Imaging Muscle Structure &
Function |
| SKILL LEVEL:
Intermediate to Advanced |
| ORGANIZERS: Richard
Kijowski, M.D. & William B. Morrison, M.D. |
| Tuesday, 23 April 2013 |
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| OVERVIEW |
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Various aspects of imaging
muscle, including oxygenation and perfusion, fiber microstructure
and organization as well as water and fat composition will be
presented by a panel of experts, with lectures ranging from sequence
development to clinical applications. It is intended to “bridge the
gap” between laboratory research and patient care. Following
didactic lectures a “hot topic” representing a relevant abstract
will be presented by the author, with subsequent discussion by the
panel. |
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| TARGET AUDIENCE |
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This course is directed to
clinicians interested in musculoskeletal MRI as well as researchers
seeking to enhance their knowledge of clinical aspects and
applications of muscle structure, physiology and composition. |
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| EDUCATIONAL OBJECTIVES
Upon completion of this course,
participants should be able to: |
- Apply various MRI
techniques to assess muscle structure and function in clinical
practice and research studies;
- Identify advantages and
disadvantages of different MRI methods to assess muscle
oxygenation and perfusion and muscle fiber structure and
orientation; and
- Develop imaging
strategies to evaluate muscle composition using MRI and MR
spectroscopy.
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PROGRAM |
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Moderators:
Robert D. Boutin, M.D. & Michael D. Noseworthy, Ph.D. |
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13:30 |
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Clinical
Aspects of Muscle Physiology & Pathology |
Robert D. Boutin, M.D.
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13:50 |
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Imaging
Muscle Oxygenation & Perfusion |
Michael D. Noseworthy,
Ph.D. |
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14:10 |
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Imaging
Muscle Fiber Structure & Function |
Shantanu Sinha, Ph.D.
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14:30 |
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Imaging
Muscle Composition |
Dimitrios Karampinos, Ph.D.
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14:50 |
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MR
Spectroscopy |
Laura M. Fayad, M.D.
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15:10 |
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Special
Abstract Presentation |
John S. Thornton, Ph.D. |
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0314. |
Candidate Skeletal Muscle
Outcome Measures for Therapy Trials: Dependence of MRI
Measures Upon Age, Gender and Weight
Jasper M. Morrow1,
Christopher D.J. Sinclair1,2, Arne Fischmann3,
Mary M. Reilly1, Michael G. Hanna1,
Tarek A. Yousry1,2, and John S. Thornton1,2
1MRC Centre for Neuromuscular Diseases, UCL
Institute of Neurology, London, England, United Kingdom, 2Academic
Neuroradiological Unit, UCL Institute of Neurology,
London, England, United Kingdom, 3Department
of Radiology, University of Basel, Basel, Switzerland
We performed
quantitative MR at 3T in lower limbs of 47 volunteers to
investigate the relationship between MR parameters and
subject demographics. Transverse maps of fat-fraction
(3-point Dixon), T2 time (dual-echo TSE) and
magnetisation transfer ratio were analysed at calf and
thigh level. Significant positive correlations between
age and muscle fat-fraction/T2 time and negative
correlation between age and muscle MTR were seen. Weight
showed correlation at thigh level only whilst gender
didn’t exert a major influence. The magnitude of
variation was small compared with expected pathological
changes, strengthening the potential utility of MR
parameters as outcome measures in neuromuscular
diseases.
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15:22 |
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Discussion |
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15:30 |
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Adjournment |
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