Tingting Zhang¹ and Dengbin Wang^1
1Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong Medical University, Shanghai, China, Shanghai, China, People's Republic of

This study is to access the differential value in Pancreatic Carcinoma (PC) and Mass-Forming focal Pancreatitis (FP) with qualitative and quantitative analysis of DCE-MRI and DWI. Pancreatic TIC types and sub-types from DCE-MRI and ADC value and tumor-to-pancreas contrast ratio of ADC value from DWI were compared between PC and FP. We found significant differences in TIC and ADC value and ADC tumor-to-pancreas contrast ratio between PC and FP. DCE-MRI and DWI were discovered to provide reliable information for differentiating PC from FP, while the combination of them can achieve a higher sensitivity and specificity.

Khushbu Agarwal¹, Rani Gupta Sah¹, Uma Sharma¹, Smriti Hari², Sandeep Mathur³, Vurthaluru Seenu⁴, Rajinder Parshad⁴, and Naranamangalam R Jagannathan^1
1Department of NMR and MRI Facility, All India Institute of Medical Sciences, Delhi, India, ²Department of Radio-diagnosis, All India Institute of Medical Sciences, Delhi, India, ³Department of Pathology, All India Institute of Medical Sciences, Delhi, India, ⁴Department of Surgical Disciplines, All India Institute of Medical Sciences, Delhi, India

Potential of apparent diffusion coefficient (ADC) in differentiating various sub-types of malignant and benign breast tumors using diffusion weighted MRI and its association with different hormonal status in breast cancer patients was studied. A significantly lower ADC of malignant compared to benign and healthy breast tissues was observed. The ADC of fibroadenomas was lower compared to fibrocystic with fibroadenoma and cystic lesions and higher in cystic and fibrocystic lesions than benign ductal epithelial cells. No association of ADC with molecular biomarkers ER, PR and Her2neu was seen. Results showed the utility of ADC in differentiating various types of breast tissues.

Yanjun Li¹, Shumin Tao¹, Dandan Zheng², Yong Zhang², and Guangming Lu^1
1Medical Imaging, Jingling Hospital, School of Medicine, Nanjing University, Nanjing, China, People's Republic of, ²GE Healthcare, MR Research China, Beijing, China, People's Republic of

Diffusion-weighted imaging (DWI) in human transplantation was regarded as a promising indicator for dectecting graft dysfunction.According to the IVIM theory, ADC integrates the effects of both diffusion of water molecules and microcirculation of blood in capillaries. By separating diffusion and perfusion, we could observe each component’s contribution to the changes of ADC values. Furthermore, the exchanges of intracellular water molecules with extracellular’s may have impact on ADC. Thus, AQP ADC might reflect quantitative water channel expression.

TANG Min¹, Xiaoqin LIU¹, Xiaoling ZHANG¹, Kaining Shi², and Kaining Shi^2
1Shaanxi Provincial People`s Hospital, Xi’an, China, People's Republic of, ²Clinical science, Philips Healthcare China, Xi’an, China, People's Republic of

The purpose of this study is to explore the feasibility of assessing perfusion and diffusion information of placenta with different FGR types using Intravoxel Incoherent Motion MR Imaging .we find that there are different diffusion and perfusion characteristic in different in placenta of FGR hypotype.  

Yihao Guo¹, Zhentai Lu¹, Yingjie Mei², Jing Zhang³, Yikai Xu³, Feng Huang⁴, Ed. X. Wu^5,6, and Yanqiu Feng^1,5,6
1School of Biomedical Engineering and Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, GuangZhou, China, People's Republic of, ²Philips Healthcare, GuangZhou, China, People's Republic of, ³Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, GuangZhou, China, People's Republic of, ⁴Philips Healthcare(Suzhou), Suzhou, China, People's Republic of, ⁵Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, People's Republic of, ⁶Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China, People's Republic of

Respiration-induced misalignment between multiple b-value liver DW image scan severely reduce the accuracy and stability of IVIM parameter quantification, especially in the presence of small focal lesions. These small lesions usually exhibit significantly differentintensity in different b-value images, but have similar structural information.  This work introduces modality independent neighborhood descriptor to extract the structural information of small lesions for improved realignment between multiple b-value images.  Preliminary results show that this structure-based registration method can well correct respiration-induced misalignment between multiple b-value images with small lesions, improve the IVIM model fitting quality, and reduce variance in quantified parameters. 

Osama M Abdullah¹, MarJanna Dahl², Gavin Yeip¹, Julia Cortino¹, Arnold David Gomez³, Thomas Seidel¹, Frank Sachse¹, Kurt Albertine², and Edward W Hsu^1
1Bioengineering, University of Utah, Salt Lake ity, UT, United States, ²Pediatric Neonatology, University of Utah, Salt Lake ity, UT, United States, ³Electrical and Computer Engineering, Johns Hopkins, Baltimore, MD, United States

Diffusion tensor imaging (DTI) has emerged as the method of choice for noninvasive quantifications of myocardial microstructure. However, the origins and behaviors of DTI measurements as functions of myocardial remodeling during development remain poorly understood. In this work, conventional and bi-compartmental DTI and histological correlation were performed on an animal model of myocardial development to investigate the effects of tissue remodeling. Results indicate that tissue remodeling during development manifests in progressively increased DTI transverse diffusivities, decreased fractional anisotropy, and unchanged fiber orientation. The findings show that DTI can be used to noninvasively characterize microstructural remodeling of the myocardium during development.

Zhuo Shi¹, Xinming Zhao¹, Ouyang Han¹, and Lizhi Xie^2
1Department Of Imaging Diagnosis,Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing China, Beijing, China, People's Republic of, ²GE Healthcare, MR Research China, Beijing, Beijing, China, People's Republic of

DWI plays an important role in detecting and characterizing liver lesions or tumors. There are three kinds of liver DWI acquisitions are commonly used in hepatic DWI: breath-hold , respiratory-triggered,free-breathing. This work compares the advantages and disadvantages of diagnosing focal liver lesions, to find the best acquisition sequence for different situations.

Edward Sutherland ¹, Luís F Gonçalves^1,2,3, and Yuxiang Zhou^1,3
1William Beaumont Hospital School of Medicine, Oakland University, Rochester, MI, United States, ²Department of Obstetrics and Gynecology, Beaumont Health, Royal Oak, MI, United States, ³Diagnostic Radiology and Molecular Imaging, Beaumont Health, Royal Oak, MI, United States

Magnetic resonance diffusion weighted imaging (DWI) has been widely used to quantitatively measure the random motion of water molecules within a voxel of tissue and represents this information in the form of apparent diffusion coefficient (ADC) maps. As the ADC map has been shown to be influenced by circulatory motion and perfusion at low b-values, we hypothesize that ADC values obtained from the placenta may vary as a function of distance to the umbilical cord insertion. In this retrospective study, 78 healthy placentas were evaluated by MR-DWI. We conclude that ADC values of placental tissues obtained at high b-values do not vary in normal human placentas as a function of distance to umbilical cord insertion.

Sisi Liang¹, Narina Norddin², Eleftheria Panagiotaki ³, Andre Bongers⁴, Peng Shi¹, Laurence Gluch⁵, and Roger Bourne^2
1College of Engineering and Science, Victoria University, Melbourne, Australia, ²Discipline of Medical Radiation Sciences, Faculty of Health Sciences, University of Sydney, Sydney, Australia, ³Center for Medical Image Computing, University College London, London, United Kingdom, ⁴Biological Resource Imaging Laboratory, University of New South Wales, Sydney, Australia, ⁵The Strathfield Breast Centre, Strathfield, Australia

DWI signal attenuation measured in biological tissue is widely observed to be non-monoexponential. One important diffusion characteristic underlying that complex behavior is restriction and hindrance to water diffusion.  This study compared multi-component restricted and unrestricted models of diffusion in the glandular part of breast tissue. The results show that multi-component restricted and anisotropic models explain the data best. This finding is consistent with the presence of distinct diffusion microenvironments in breast tissue. Development of clinical DWI methods that incorporate these features may improve breast cancer assessment.

Can Cui¹, Yujiao Zhao¹, Yu Zhang ², and Wen Shen^3
1Radiology, Tianjin First Center Clinical College, Tianjin Medical University, Tianjin, China, People's Republic of, ²Philips Healthcare, Beijing, China, People's Republic of, ³Radiology, Tianjin First Center Hospital, Tianjin, China, People's Republic of

The aim of this study was to investigate the clinical application of DTI fiber tractography on evaluating the levator ani injury after first vaginal delivery. Thirty-five primiparous women with 6 weeks after vaginal delivery and twenty-five age-matched nulliparous women volunteers as control group were included. The primiparas women were divided into 2 subgroups by the existence of pelvic organ prolapse. DTI with fiber tractography provided satisfactory 3D representation of pubovisceralis while the study of iliococcygeus was more difficult. No significant differences of FA and ADC values were found among primiparous normal group, primiparous POP group and control group for pubovisceralis.