07:00
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MRI of Brain Demyelination 
Roland G Henry1
1Neurology, University of California, San
Francisco CA, San Francisco, CA, United States
Myelin is essential for normal neuronal function but the
impact of demyelination depends on the other factors
associated with the pathology including impact on
oligodendrocytes, astrocytes, and immune response. The
use of MRI in the study of neurological disorders
includes three major categories: Prognostic value and
patient management, Trial outcome markers to detect
response to treatment, and studies to gain insight into
disease mechanisms. The utility of MRI techniques to
these ends depend on the specificity of the technique
for myelin, the specificity for overall positive
responses, sensitivity to pathological changes and
improvements, and multicenter and clinical feasibility.
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07:25
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MRI of Spinal Cord Demyelination
Daniel S. Reich1
1National Institute of Neurological Disorders
and Stroke, National Institutes of Health, Bethesda, MD,
United States
The spinal cord is heavily affected in multiple
sclerosis and several other demyelinating conditions.
This talk will describe MRI findings in spinal cord
demyelinating diseases; challenges in successfully
imaging the spinal cord, as well as ways of overcoming
those challenges; and recent improvements in spinal cord
structural MRI as applied to multiple sclerosis.
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