PET-MRI: Devices, Radiotracers & Applications - ISMRM 24th Annual Meeting & Exhibition

ISMRM 24th Annual Meeting & Exhibition • 07-13 May 2016 • Singapore

Weekend Educational Course: PET-MRI: Devices, Radiotracers & Applications

Skill Level: Intermediate

Organizers: Andrei H. Iagaru, M.D., Ryan Niederkohr, M.D., N. Jon Shah, Ph.D. & Greg Zaharchuk, M.D., Ph.D.

Saturday 07 May 2016

Overview
This course will cover the topic of PET/MRI, ranging from technical development to clinical applications. Technical development will include understanding basic MR approaches to attenuation correct and motion correction. A session will discuss radiotracers from chemistry to new agents to regulatory issues confronting the new investigator. Finally, we will provide a broad overview of clinical and research applications within the body and in the brain.

Target Audience
MRI scientists and clinicians interested in combined PET-MRI. Nuclear Medicine physicians and researchers interested in learning more about combined PET-MRI.

Educational Objectives
Upon completion of this course, participants should be able to:

To learn basics of PET/MRI scanner design and attenuation correction algorithms;
To understand how radiotracers are made and novel organ- and function-specific probes; and

To develop time-efficient PET/MRI workflow for various clinical applications.

PROGRAM

Moderators: N.Jon Shah, Greg Zaharchuk

Physics & Technology Issues in PET/MRI

07:30		PET/MRI Scanner Overview Jae Sung Lee¹ ¹Department of Nuclear Medicine, Seoul National University, Seoul, Korea, Republic of
08:00		Attenuation & Motion Correction Strategies for PET Using PET/MRI Youngho Seo¹ ¹Department of Radiology and Biomedical Imaging, University of California, San Francisco Attenuation correction (AC) for PET reconstruction using PET/MRI is not trivial. MRI-based segmentation, atlas registration, and time-of-flight derived attenuation coefficients are most commonly applied and studied approaches for AC. Motion management of PET reconstruction, aided by the temporal resolution of MR-based signal, is promising, but still requires extensive investigation and robust method development.
08:30		Time-of-Flight: Do We Need It in PET/MRI? Christoph Lerche¹ ¹Institute for Neuroscience and Medicine, Forschungszentrum Jülich GmbH, Jülich, Germany The aim of this presentation is to introduce the participant into Time-of-Flight (ToF) Positron Emission Tomography. General concepts of ToF-PET, fundamental limits and most important characteristics of the key components scintillator and photo detector will be discussed. The correlation between timing resolution and image SNR, which is the main benefit of the timing measurement, will be introduced by means of examples from real patient examinations and simulations. Special emphasis will be put on completely new imaging application enabled by ToF-PET and on the potential of ToF-PET for simultaneous MR/PET imaging.
09:00		Future Directions in PET/MRI - Permission Withheld Craig Levin¹ ¹Radiology, Stanford University, Stanford, CA, United States
09:30		Break & Meet the Teachers

PET Radiopharmacy

10:00		PET Radiopharmacy 101 Frederick T. Chin¹ ¹Stanford University
10:30		Radiation Safety & Procedures - Permission Withheld S. Somanesan¹ ¹Singapore General Hospital Knowing how to protect oneself from radiation is an important aspect in the healthcare imaging workplace. Besides self-protection, knowledge about radiation can also aid healthcare professionals safeguard the health of their patients from excessive radiation. This talk serves to provide participants a basic understanding of ionizing radiation, X-rays and radiobiology, as well as unravel the mystery of minimizing radiation doses in medical imaging.
11:00		Beyond FDG: New Tracers Dale L Bailey¹ ¹University of Sydney, Sydney, Australia PET/MRI has the potential to offer not just structure/function characterisation, but structure/function/tissue characterisation in a way that conventional CT combined with PET cannot provide. This talk will explore options beyond conventional FDG whole body PET/CT for detailed characterisation of the individual patient and their disease.
11:30		Regulatory Issues for Radiotracers around the World David Dick¹ ¹Radiology, University of Iowa This presentation will highlight the differences between PET radiopharmaceuticals and MRI contrast agents with respect to regulatory approval in order to educate those working with PET/MRI on the regulatory framework under which PET radiopharmaceuticals can be administered.
12:00		Lunch & Meet the Teachers

Clinical Hybrid Imaging Throughout the Body

13:30		Interpreting FDG PET images - a Crash Course Eric M. Rohren¹ ¹Baylor College of Medicine
14:00		Clinical PET/MRI: Workflow Considerations Marius Mayerhoefer¹ and Matthias Eiber² ¹Medical University of Vienna, Vienna, Austria, ²Technical University of Munich, Munich, Germany
14:30		Oncological PET/MRI: Where Will it Replace PET/CT? Thomas Hope¹ ¹University of California, San Francisco
15:00		Cardiac PET/MRI Osman Ratib The development of hybrid PET/MRI imaging devices provides new perspectives in cardiovascular imaging. While these two imaging modalities (PET and MRI) have gained well-established diagnostic value in clinical practice, the ability to acquire both modalities in a single session opens new perspectives in workflow and in assessment and quantitative evaluation of cardiovascular diseases. The development of new PET tracer will certainly add to the value of clinical applications of hybrid PET/MRI in the futur
15:30		Pediatric PET/MRI Jonathan McConathy
16:00		Break & Meet the Teachers

Neuroimaging with PET/MRI

16:30		Role of PET/MRI in Brain Tumors Fernando Emilio Boada¹ ¹Radiology, New York University, New York, NY, United States This presentation discusses the synergies that make MRI/PET a unique hybrid technology that could be used effectively to improve the diagnostic and prognostic information from each of its component modalities.
17:00		Brain Perfusion & Permeability Imaging Tadashi Nariai¹ ¹Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan Educational Lecture to discuss on the clinical usefulness of combined use of PET and physiological imaging with MRI. Focus is set on chronic occlusive cerebrovascular diseases and malignant brain tumor.
17:30		Functional Imaging with PET/MRI Joseph Mandeville Among many potential applications of simultaneous PET and fMRI, this talk focuses on paradigms of function (fMRI) versus occupancy (PET) and combinations that investigate flow-metabolism coupling or oxygen versus glucose utilization. PET/fMRI can help clarifying aspects of receptor-based imaging using either drug or tasks that elevate neurotransmitter levels. The combined information has the potential to form new biomarkers with clinical utility. Metabolic imaging using PET in conjunction with fMRI measurements of CBF and CMRO2 can be done simultaneously within a single imaging session. This talk focuses on PET capabilities and possibilities for combining PET and fMRI information.
18:00		Adjournment & Meet the Teachers

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