ISMRM 24th Annual Meeting & Exhibition • 07-13 May 2016 • Singapore |
|
Weekend Educational Course: Advanced fMRI: Techniques & Applications
Skill Level: Advanced
Organizers: Jay J. Pillai, M.D. & Jonathan R. Polimeni, Ph.D.
Saturday 07 May 2016 |
Overview
This session will cover advanced topics in fMRI acquisition and analysis including data-driven analysis approaches, advanced functional connectivity, and emerging applications of Simultaneous Multi-Slice EPI.
Target Audience
Cognitive neuroscientists, neuroradiologists, clinicians and imaging scientists who currently utilize fMRI and for MR physicists and engineers developing new fMRI methodologies. This course assumes basic knowledge of fMRI and a working knowledge of neuroscience, MR data acquisition, and basic analysis methods.
Educational Objectives
Upon completion of this course, participants should be able to:
- Perform data driven analyses of fMRI data;
- Explain the static and dynamic factors that give rise to observed functional connectivity patterns;
- Employ network analytic approaches to functional connectivity data;
- Recognize artifacts in fMRI time-series data caused by subject motion;
- Evaluate the benefits of calibrated BOLD techniques for measuring brain activity;
and
- Apply rapid acquisition techniques to fMRI studies and appraise the benefits of MultiBand EPI.
|
|
PROGRAM |
| Moderator:
Jay Pillai, Jonathan Polimeni |
13:30
|
Dynamic Functional Connectivity 
Gary H. Glover1
1Stanford University
Dynamic functional connectivity (dFC) uses
region-of-interest or data driven methods to elucidate
temporally-varying changes in resting-state brain
networks. Challenges are the lack of a gold standard for
dFC, the difficulty in discriminating signal from non-neurally
generated BOLD fluctuations, and the tradeoffs between
temporal resolution of the neural dynamics and the
statistical significance of the resulting networks. This
talk will describe the methods and pitfalls to be
avoided in applying these techniques, as well as results
that correlate with independently acquired measures of
behavior and psychometrics.
|
14:05
|
Network Analysis - Permission Withheld
Martijn van den Heuvel
Figure 1. Figure illustrates common graph metrics in
connectomics (described in the text).
|
14:40
|
Clinical Applications of
Functional Connectivity
Steven Stufflebeam
|
15:15
|
Break & Meet the Teachers |
15:50
|
Calibrated BOLD fMRI
Claudine Gauthier1
1Concordia University
Calibrated fMRI techniques are used to extract the
oxidative metabolism component from the BOLD signal
measured in response to a task. Oxidative metabolism is
isolated by first estimating the vascular component of
the BOLD response through a calibration manipulation and
a biophysical model. Various calibration methods have
been proposed using mild hypercapnia, hyperoxia, or a
combination of the two. Extensions of these techniques
now allow measurement of baseline oxidative metabolism.
This course will allow fMRI users to learn about
calibrated fMRI and how it can be used to obtain
quantitative measures of brain activity and resting
metabolism.
|
16:25
|
Multi-Band EPI Applications to fMRI - Permission Withheld
Prantik Kundu1
1Radiology and Psychiatry, Icahn School of
Medicine at Mount Sinai, New York, NY, United States
Multi-band EPI is becoming a standard acquisition scheme
for functional MRI. Here we will evaluate how multi-band
acceleration benefits fMRI. We will address how
accelerating to increase temporal resolution leads to
de-aliasing of nuisance physiological signals and
supports resolving complex BOLD activity. In
accelerating to increase spatial resolution, we will
consider temporal signal-to-noise ratio losses due to
high resolution, and how multi-band compensates through
imaging more volumes. We will assess multi-band
multi-echo fMRI, which incorporates T2* relaxometric
techniques for susceptibility artifact compensation and
thermal noise reduction. Lastly, we will review the
multi-band EPI configuration of the Human Connectome
Project and clinical translatability of its multi-band
approach.
|
17:00
|
Adjournment & Meet the
Teachers |
|
| |
|
|
|
|
| |
The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for physicians. |