Joint Annual Meeting ISMRM-ESMRMB • 16-21 June 2018 • Paris, France

Educational Course
What You Need to Know about Neuroinflammation & the Glymphatic System
What You Need to Know About Neuroinflammation & the Glymphatic System
Weekday Course

ORGANIZERS: Pia Maly Sundgren, Kei Yamada

 
Thursday, 21 June 2018
N01  08:00 - 10:00 Moderators:  Pek-Lan Khong, Danielle van Westen

Skill Level: Intermediate
Session Number: Th-02

Overview
Neuroinflammation and glymphatic system are one of the emerging topics in the field of neuroradiology. Neuroinflammation can be caused by various conditions, including HIV infection and vascular diseases. The glymphatic system is known as a functional waste clearance pathway for the vertebrate CNS, and impairment of this system has correlations with diseases such as Alzheimer's disease.

Target Audience
Clinicians and physicists who are not familiar with these new concepts in the field of neuropathology.

Educational Objectives
As a result of attending this course, participants should be able to:
-Describe the pathophysiology behind neuroinflammation;
-Discuss the mechanism of the glymphatic system; and
-Describe the pathology induced by an impaired glymphatic system.

 

 
08:00
 		   The Glymphatic & Cerebral Small Vessel Disease
Mark van Buchem
08:30
 		   Vasculitis & Neuroinflammation in HIV
Hans Rolf Jäger
09:00
 		   Human Glymphatics Assessed with Intrathecal Gd
Geir Andre Ringstad
Glymphatic MRI (gMRI), utilizing intrathecal Gd as CSF tracer, may demonstrate the capacity for brain clearance of toxic interstitial waste products, such as amyloid-β and tau, which are aggregated in Alzheimer`s disease. There seem to exist important differences between human subjects and previous observations in animal studies. Both glymphatic and brain lymphatic clearance is much slower in man. In iNPH dementia, glymphatic clearance was demonstrated to be reduced.

 
09:30
 		 Diffusion Images for Assessing Glymphatic System
Toshiaki Taoka
Recently introduced “glymphatic system” is a coined word that combines “gl” for glia and “lymphatic” system. In this hypothesis, the perivascular space functions as a conduit for flowing cerebrospinal fluid into brain parenchyma. Activity of the glymphatic system may be evaluated with diffusion images. Lower diffusivity along the perivascular space seems to reflect impairment of the glymphatic system. Diffusion method may be feasible for evaluating the activity of the glymphatic system.

 
10:00
 		   Adjournment & Meet the Teachers
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