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Multinuclear Imaging & Spectroscopy: Methods & Applications
Weekday Course
ORGANIZERS: Wolfgang Bogner, Gregory Metzger
Wednesday, 20 June 2018
| S03 |
08:15 - 10:15 |
Moderators: Wolfgang Bogner, Greg Metzger |
Skill Level: Intermediate
Session Number: W-04
Overview
This session will first provide a general overview of multinuclear imaging and spectroscopy, including both hardware and field strength dependencies. In-depth discussion will follow with a focus on multinuclear imaging and spectroscopy with a focus on acquisition methods, reconstruction considerations, and the types of physiological processes these unique techniques can assess.
Target Audience
This course is geared towards the technical or clinical researcher with an interest in exploring the methods and potential of non-proton imaging.
Educational Objectives
As a result of attending this course, participants should be able to:
-Describe the system requirements, field strength dependencies, and general technical challenges of X-nuclei MRI/MRS;
-Explain the added value of X-nuclei MRI/MRS; and
-Give examples of which research fields benefit from advanced X-nuclei MRI/MRS.
08:15
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 Basic Principles for Imaging Non-Proton Nuclei
Guillaume Madelin
Non-proton MRI (X-nuclei MRI) can provide new information on living tissues that is not available with proton (1H) MRI. Certain X-nuclei such as sodium (23Na), phosphorus (31P), oxygen (17O), potassium (39K), Chlorine (35Cl), and others, play an important role in the body metabolism (such as ion homeostasis, propagation of action potential, energy metabolism) and can also be detected with magnetic resonance imaging.
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08:40
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Sodium (23Na) & Imaging Membrane Potential
Armin Michael Nagel
Ions such as sodium (Na+), chlorine (Cl-) and potassium (K+) play an important role in many cellular physiological processes. In healthy tissue, the extracellular concentration of Na+ is approximately ten-fold higher than the intracellular concentration. A breakdown of this concentration gradient or an increase of the intracellular Na+ content can be used as an early marker in many disease processes. In this presentation, the focus will be on musculoskeletal and brain-related applications of Na+ MRI. In addition, the required hardware, as well as image acquisition and post-processing techniques that are suitable for Na+, K+, and Cl- MRI will be discussed.
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09:05
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Multinuclear Spectroscopy & Imaging of 31P & 13C
Chris Boesch
Early in history of MR, the enormous added value of multinuclear MRI/MRS has been recognized; however, the technical challenges (low sensitivity, difficult volume selection, need for extra hardware, no generally available internal concentration standards, etc.) limited the applications considerably. In particular 13C and 31P can serve as reporters in many metabolic pathways and increased membrane turnover in tumor biology. Ultrahigh field strengths and hyperpolarized 13C substances overcome now many of the obstacles and foster new applications. The lecture shall emphasize the added value, summarize the methodological limitations, and list some representative applications of 13C- and 31P-MRI/MRS.
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09:30
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Exploring Metabolism with 17O
Xiao-Hong Zhu
In recent years, with technology advancement and increasing availability of the high/ultrahigh field MR scanners, in vivo 17O MR spectroscopy & imaging has emerged as a valuable tool for noninvasively exploring metabolism in living organ or tissue because of the greatly improved 17O MR sensitivity at higher field. Quantifying regional cerebral metabolic rate of oxygen (CMRO2) and its changes in animal or human brains may be the most important use of 17O MR. In this talk, I will present an overview of the 17O MRS/MRI technique, including the key aspects of the methodology and examples of potential applications.
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09:55
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Panel Discussion |
10:20
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Adjournment & Meet the Teachers |
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