Member-Initiated Symposium
New Innovations & Alternatives to Conventional Contrast Agents
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Session Sub-Topic: New Innovations & Alternatives to Conventional Contrast Agents
Member-Initiated Symposium
ORGANIZERS: Nivin Nyström, Or Perlman, Paula Ramos Delgado
| Friday, 14 August 2020, 12:00 - 12:30 UTC | Moderators: Nivin Nyström & Or Perlman |
Watch the Session RecordingSession Number: MIS-16
Overview
This Symposium was proposed by the Molecular & Cellular Imaging study group. This symposium is organized by trainee members of the Molecular and Cellular Imaging SG of the ISMRM. Gadolinium-based contrast agents (GBCA) are crucial for diagnosing and monitoring neurological, cardiac, and other diseases. They shorten tissue T1 relaxation times in vivo, producing enhancements that yield valuable information, and can reveal the presence of otherwise undetectable lesions. However, many aspects of pathology cannot be detected using GBCA, and there is a pressing need for new technical developments and novel contrast agents to gain a more comprehensive view of disease processes. Furthermore, emerging evidence of gadolinium deposition has led to increased safety concerns about its use, making the need for alternative contrast agents a hot topic. This symposium will highlight state-of-the-art research on alternatives to GBCA, including iron- and manganese-based contrast agents, fluorine-19 and CEST. The session will closely align with the educational sessions on “Non-Gadolinium-Based Exogenous Contrast Agents” and “Cutting-Edge Primers on Preclinical Imaging.” It will feature eight talks from a diverse group of senior scientists and trainees describing basic principles, challenges, and opportunities of each approach in the context of their own cutting-edge primary research. This dynamic symposium will appeal to clinicians, basic scientists, and all researchers interested in pushing beyond conventional approaches into new directions of MR science, biology and medicine.
Target Audience
Clinicians, basic scientists, engineers, and translational researchers involved in molecular and/or cellular imaging methods.
Educational Objectives
As a result of attending this course, participants should be able to:
Upon completion of this course, participants should be able to: - Explain the fundamental concepts underlying iron- and manganese-based contrast agents, fluorine-19 and CEST; - Discuss how pre-clinical studies employing these alternative agents clarify the links between MRI biomarkers, physiology, and pathology (e.g. inflammation, oxidative stress, changes in brain function, tissue pH and Ca2+); - Recognize the translational potential of these alternative agents to add value for novel clinical applications, by moving beyond the limits of conventional contrast agents; and - Recognize the advantages and limitations of these contrast agents compared to conventional agents, as well as the opportunities and future directions for clinical applications.
| Expert talk: Inorganic Nanofluorides as Tunable Small-Sized Nanotracers for 19F-MRI
Amnon Bar-Shir
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| Trainee talk: 19F-MR Imaging of Inflammation in the Heart After Myocardial Infarction
Mariah R.R. Daal
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| Expert talk: Fluorine MRI: En Route to Clinical Imaging
Ruud van Heeswijk
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| Trainee talk: Iopamidol CEST pH Imaging for Noninvasive Monitoring of Kidney Disease & Injury
KowsalyaDevi Pavuluri
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| Expert talk: Iron-Based MRI Contrast Agents: From Nanoparticles to Small Responsive Iron Complexes
Veronica Clavijo Jordan
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| Trainee talk: Manganese-Enhanced MRI: An Early Imaging Biomarker of Cell Viability & Its Application in Acute Myocardial Infarction
Nur Hayati Jasmin
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| Expert talk: Overview for Manganese-Enhanced MRI & Its Nanoparticle Applications
Ichio Aoki
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| Trainee talk: Radiolabeled Iron Oxide/Aluminum Hydroxide Nanoparticles as PET/MRI Contrast Agents for Stem Cell Tracking
Sarah Belderbos
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