Agnès Paasche¹, Jérémie Bettoni¹, Stéphanie Dakpé¹, and Olivier Balédent^1
1CHU AMIENS-PICARDIE, AMIENS, France

2D ungated PC-MRI could be accurate enough to assess cervicofacial vascularization where vessels are often less than 4 mm in diameter but hey are sensitive to the pulsatile flow and their accuracy and precision should be evaluate. We have designed a phantom model to determine the better MRI parameters for pulsatile flow in pipes of one millimeter of diameter. 108 sequences have been tested and 2 were selected as accurate and precise even in case of high pulsatility. The duration of the acquisition was 15 second. 2D ungated sequences should be suitable for daily clinical practice in small vessels evaluation.

Ping Liu¹, Gui-hua Jiang¹, and Jing Zhang^2
1Radiology, Guangdong Second Provincial General Hospital, Guangzhou, China, ²Radiology, The Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China

Dysthyroid optic neuropathy (DON) is the most serious complication of Thyroid-Associated Ophthalmopathy(TAO). Untimely and ineffective treatment of could lead to permanent blindness. Early detection is the principle factor for timely intervention. Diffusion tensor imaging(DTI) is a noninvasive tool to reveal microstructural or non-overt damage and quantify pathological processes of nerve fiber bundle. We applied the multi-parametric of optic nerve to identify the DON from TAO. The result reveals that DTI can be considered a useful and noninvasive tool to differentiate DON from TAO with higher accuracy.

Yu Chen¹, Tong Su¹, Zhuhua Zhang¹, Zhentan Xu¹, Xiaoqi Wang², Huadan Xue¹, and Zhengyu Jin^1
1Peking Union Medical College Hospital, Beijing, China, ²Philips HealthCare, Beijing, China, Beijing, China

This study was to prospectively evaluate APT imaging for the parotid glands and lesions. 32 patients, confirmed cancer in parotid glands, underwent 3D TSE APTw imaging. Scores for integrity and for hyperintensity artifacts of both tumor lesions and normal parotid glands were evaluated. Tumor lesions had better integrity score than normal parotid glands. Scores for hyperintensity artifacts in APTw images showed no significant difference between tumor lesions and normal parotid glands. Most APTw images of parotid glands lesions were scored with good integrity and had acceptable image quality, while challenges still exist in some cases.

Huimin Zhang¹, Qiyong Ai¹, Queenie Chan², Ann D. King¹, and Weitian Chen^1
1Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Philips Healthcare, Hong Kong, Hong Kong

T_1ρ relaxation, known as the spin‐lattice relaxation time in the rotating frame, is sensitive to molecular interactions including dipolar interactions, chemical exchange, and diffusion. T_1ρ is often measured by mono-exponential relaxation models. Bi-exponential T_1ρ relaxation have been previously observed in muscle, cartilage, menisci and brain. We report our observation of bi-exponential T_1ρ relaxation in parotid glands.

Maggie M Fung¹, Amaresha Konar Shridhar², Arnaud Guidon³, Amita Shukla-Dave^2,4, and Vaios Hatzoglou^4
1MR Apps & Workflow, GE Healthcare, New York City, NY, United States, ²Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York City, NY, United States, ³MR Apps & Workflow, GE Healthcare, Boston, MA, United States, ⁴Department of Radiology, Memorial Sloan Kettering Cancer Center, New York City, NY, United States

The purpose of this study is to investigate the distortion correction performance and ADC value consistency of the single shot EPI (SSEPI), multi-shot EPI (MUSE) and reverse polarity gradient (RPG) method in phantom, and head & neck cancer patients. We observed improved distortion correction performance in MUSE, and best distortion correction in MUSE plus RPG method. Improved anatomical details, reduced artifacts and improved perceived clinical utility were also observed in MUSE (with and without RPG) as compare to SSEPI. ADC values remained consistent between these techniques.

Weike Zeng¹, Mengzhu Wang², Yaxuan Pi³, Yi Li³, Xu Yan⁴, Guang Yang⁵, and Jun Shen^6
1Deptpartment of Radiology, SUN YAT-SEN Memorial Hospital, SUN YAT-SEN University, Guangzhou, China, ²MR Scientific Marketing, Siemens Healthcare, Guangzhou, China, ³department of NEUROLOGY, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China, ⁴MR Scientific Marketing, Siemens Healthineers, Shanghai, China, ⁵Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China, ⁶Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

Mean apparent propagator (MAP)-MRI, which builds a powerful analytical framework based on the random motion distribution of real water molecules, can more accurately and comprehensively characterize microstructure features of brain tissues than conventional diffusion imaging. This study investigated the application of MAP-MRI in the early diagnosis of radiation-induced brain injury in patients with nasopharyngeal carcinoma, compared with diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI).

Yao Chia Shih¹, Yeow Hoay Koh², Soo Lee Lim¹, Yen San Kiew¹, Ee Wei Lim², See Mui Ng¹, Leon Qi Rong Ooi², Wen Qi Tan^1,3, Helmut Rumpel¹, Eng King Tan^2,3, and Ling Ling Chan^1,3
1Department of Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore, ²Department of Neurology, National Neuroscience Institute – Outram Campus, Singapore, Singapore, ³Duke-NUS Medical School, Singapore, Singapore

The impact of simultaneous multi-slice imaging (SMS) with short repetition time (TR) accelerated acquisition on diffusion tensor imaging (DTI) combined with readout-segmented echo planar imaging (RESOLVE) on the intra-cranial nerves is unexplored. Compared to non-SMS RESOLVE-DTI, two SMS RESOLVE-DTI protocols showed higher pontine signal-to-noise ratio (SNR). Consistent measures of different DTI metrics of cisternal trigeminal nerves across the three RESOLVE-DTI protocols and significant positive correlations of mean DTI metrics in pairwise comparison across these suggest that SMS RESOLVE-DTI allows fast and reliable evaluation of the microstructural integrity of the cisternal trigeminal nerve, with possible utility in trigeminal neuralgia.

Ramesh Paudyal¹, Jung Hun Oh¹, Vaios Hatzoglou², Andre L. Moreira ³, Ashok shaha⁴, R. Michael Tuttle⁵, and Amita Shukla-Dave^1,2
1Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ²Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ³Pathology, NYU Langone Medical Center, New York, NY, United States, ⁴Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ⁵Medicine, Memorial Sloan Kettering Cancer Center, New, NY, United States

Accurate risk stratification and predicting tumor aggressiveness is critically important for the management of papillary thyroid cancer. The results from the present study predict tumor aggressiveness in papillary thyroid cancer using noninvasive multi-parametric MRI (i.e. non-Gaussian intravoxel incoherent motion (NG-IVIM) diffusion weighted (DW) and dynamic contrast-enhanced (DCE)-MRI). The surrogate biomarkers of tumor vascularity (K^trans) and tumor cellularity (D) were negatively correlated. The kurtosis coefficient (K) reflecting tissue microstructure showed a moderate and significant correlation with the contrast agent leakage space (v_e). DWI and DCE-MRI derived metrics can predict tumor aggressiveness in PTC.