ISMRM20 Sunrise: Non-Gadolinium-Based Exogenous Contrast Agents

Sunrise Session

Non-Gadolinium-Based Exogenous Contrast Agents

Back to Program-at-a-Glance

Session Topic: Educational Q&A: MRS Sunrise

Session Sub-Topic: Non-Gadolinium-Based Exogenous Contrast Agents

Sunrise Session

ORGANIZERS: Hai-Ling Cheng, Kannie WY Chan

Wednesday Parallel 2 Live Q&A

Wednesday, 12 August 2020, 13:45 - 14:30 UTC

Moderators:

Skill Level: Basic to Intermediate

Session Number: S-M-05

Overview
Contrast-enhanced MR imaging can be performed using materials both metallic (e.g. manganese, iron) and non-metallic (e.g. glucose) that are alternatives to gadolinium, the current workhorse approved for clinical examinations. This sunrise course provides an overview of the research progress made to date on non-gadolinium-based agents and their future potential in the clinic as complements for contrast-enhanced MR imaging.

Target Audience
This sunrise course is geared towards the physicist, chemist, or physician who needs to explore and advance non-gadolinium-based contrast-enhanced MRI in specific applications and patient populations.

Educational Objectives
As a result of attending this course, participants should be able to:
- Describe alternatives to gadolinium for contrast-enhanced MR examinations;
- Describe the mechanisms of contrast enhancement for different agents;
- Evaluate the advantages and limitations of these non-gadolinium sources of contrast; and
- Identify applications where non-gadolinium based MR imaging is desirable or required.

		MRI With Non-Gadolinium Metals Ali Barandov Watch the Video A new class of non-gadolinium cell-permeable MRI contrast agents have been developed for monitoring intracellular analytes and processes at the molecular level. In this talk, we discuss the design, synthesis and applications of such probes for acquiring spatially resolved functional images of fluctuations in concentrations of specific analytes in the brains of living subjects. By improving the technology with more sensitive contrast agents and better brain delivery strategies, it will be possible to measure and map an expanding array of neurophysiological processes in animals and ultimately in humans.
		Dynamic Glucose-Enhanced MRI Xiang Xu Watch the Video