Sunrise Session
Modelling ASL Perfusion Signals
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Session Topic: Educational Q&A: fMRI/Diffusion/Perfusion Sunrise
Session Sub-Topic: Modelling ASL Perfusion Signals
Sunrise Session
ORGANIZERS: Benedikt Poser, Susan Francis, Richard Buxton, Xin Yu
| Tuesday Parallel 1 Live Q&A | Tuesday, 11 August 2020, 13:45 - 14:30 UTC | Moderators: Susan Francis |
Skill Level: Basic to Intermediate
Session Number: S-Tu-04
Overview
This entry-level Sunrise course is part of the four-day series on signal modelling, spanning from fMRI to perfusion micro-structure and diffusion micro-structure modelling. The focus of this session is on the modelling of arterial spin labeling (ASL) data. The aim is to provide curious researchers who want to get started with ASL perfusion MRI signal modelling with a concise but comprehensive overview on the topic, including actual step-by-step live demonstrations. As such, the first speaker of the session will introduce the topic, covering the basics of blood flow measurements, the different ASL strategies for labeling the intravascular signal, the confounding effects of transit time and how they can be minimized and/or modeled, and describe the common models use to explain the ASL signal. The second speaker will give live demonstrations that illustrates these models and walk the audience through the steps of common ASL modelling scenarios.
Target Audience
Any researchers who want to get started with ASL signal modelling.
Educational Objectives
As a result of attending this course, participants should be able to:
- Describe the basic principles and assumptions underlying common tracer-kinetic analysis models for ASL perfusion measurement;
- Describe how ASL principles can be used to measure physiological parameters beyond CBF;
- Explain the scope and limitations of these models; and
- Demonstrate simple modelling tasks themselves.
| Kinetic Modelling of ASL
Patricia Figueiredo, Michael Chappell Video Permission Withheld
This session aims to provide a concise but comprehensive overview of models of arterial spin labelling (ASL) perfusion signals. The basic principles of ASL perfusion imaging based on tracer kinetics will be presented, and common ASL modelling scenarios will be described focusing on perfusion quantification as well as on the exploration of other available haemodynamic information. The session will be organized in three parts, each consisting of a description of the theory underpinning a specific modelling approach, followed by a step-by-step hands-on demonstration of its practical application on real datasets using a freely available tool.
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| Hands-On Perfusion Modelling
Michael Chappell, Patricia Figueiredo Video Permission Withheld
This session aims to provide a concise but comprehensive overview of models of arterial spin labelling (ASL) perfusion signals. The basic principles of ASL perfusion imaging based on tracer kinetics will be presented, and common ASL modelling scenarios will be described focusing on perfusion quantification as well as on the exploration of other available haemodynamic information. The session will be organized in three parts, each consisting of a description of the theory underpinning a specific modelling approach, followed by a step-by-step hands-on demonstration of its practical application on real datasets using a freely available tool.
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