Daniel Güllmar1, Renat Sibgatulin1, Stefan Ropele2, and Jürgen R Reichenbach1,3
1Medical Physics Group / IDIR, Jena University Hospital, Jena, Germany, 2Department of Neurology, Medical University of Graz, Graz, Austria, 3Michael-Stifel-Center for Data driven sciences, Friedrich-Schiller-University Jena, Jena, Germany
1Medical Physics Group / IDIR, Jena University Hospital, Jena, Germany, 2Department of Neurology, Medical University of Graz, Graz, Austria, 3Michael-Stifel-Center for Data driven sciences, Friedrich-Schiller-University Jena, Jena, Germany
Diffusion
metrics of the NAWM showed consistent differences between MS patients and healthy
controls. The effect sizes ranged from 0.8 to 1.6. Subdividing the NAWM showed
only an increased effect size for ROIs including the pre-central gyrus.
Fig. 1 Axial, sagittal, coronal and
3D isosurfaces visualization of individual white matter sub-parcellation
generated by an automated white matter tract segmentation (TractSeg) based on
the diffusion data. The color-coded white matter partitions are mapped onto the
FA maps of the corresponding subject. The white outline indicates the full normal-appearing white matter ROI without lesion areas.
Fig. 4 The box plots allow the visual comparison of NAWM
ROI data for the 9 different diffusion metrics used in the analysis. In order
to compare NAWM values to typical lesion values, each subfigure contains also
the box plot for the lesion area. The small diffusion maps in the upper right
corner represent the corresponding diffusion metric maps of an example MS subject.