Bretta Russell-Schulz1, Irene M Vavasour1,2,3, Hanwen Liu2,4, Cornelia Laule2,3,4,5, Erin L MacMillan1,6,7, Alex L MacKay1,3,4, Carolyn Sparrey2,8, and Bonita Sawatzky2,9
1UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, 2International Collaboration on Repair and Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada, 3Radiology, University of British Columbia, Vancouver, BC, Canada, 4Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 5Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, 6SFU ImageTech Lab, Simon Fraser University, Surrey, BC, Canada, 7Philips Canada, Marham, ON, Canada, 8School of Mechatronic Systems Engineering, Simon Fraser University, Surrey, BC, Canada, 9Orthopaedics, University of British Columbia, Vancouver, BC, Canada
1UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, 2International Collaboration on Repair and Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada, 3Radiology, University of British Columbia, Vancouver, BC, Canada, 4Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 5Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, 6SFU ImageTech Lab, Simon Fraser University, Surrey, BC, Canada, 7Philips Canada, Marham, ON, Canada, 8School of Mechatronic Systems Engineering, Simon Fraser University, Surrey, BC, Canada, 9Orthopaedics, University of British Columbia, Vancouver, BC, Canada
We successfully used a normative myelin water atlas to investigate
possible subject-level myelin water differences in Amyoplasia brain. Small reductions
in corticospinal tract myelin were observed, while the remainder of the brain
examined was similar to the control atlas.
Figure 1: Mid-slice axial Myelin Water Fraction maps for each Amyoplasia
participant using a
32-echo T2 GRASE (240x240, reconstructed image dataset was 40 slices,
slice thickness=2.5mm, TR=1056ms, echo spacing of 10ms, acquisition
time ~7.5min).
Figure 2: Thresholded z-score maps overlaid on 3DT1-weighted scans for each Amyoplasia participant compared to open-source 3T 32-echo GRASE MWF
atlas. Maps were thresholded at 2 standard deviations above (in red) or below (in blue).
