Caroline Köhler1, Hannes Wahl1, Tjalf Ziemssen2, Paul Kuntke1, Jennifer Linn1, and Hagen H. Kitzler1
1Institut und Poliklinik für Diagnostische und Interventionelle Neuroradiologie, University Hospital Carl Gustav Carus, Dresden, Germany, 2Neurology, University Hospital Carl Gustav Carus, Dresden, Germany
1Institut und Poliklinik für Diagnostische und Interventionelle Neuroradiologie, University Hospital Carl Gustav Carus, Dresden, Germany, 2Neurology, University Hospital Carl Gustav Carus, Dresden, Germany
A significant reduction (6%-70%) and
heterogeneity of myelin water fraction in MS lesions was detected within patients and between
patients. Patients
with a higher degree of disability of EDSS ≥ 4 significantly have
lower MWF values than patients with EDSS < 2.5
Fig. 2 Group differences in median MWF in lesions for patients with low (EDSS <
2.5) and moderate disability (EDSS > 4)
Fig.
1 Distribution of MWF of individual lesions for n=112
RRMS patients with varying MWF loss, reflecting different stages of
demyelination