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Yield of peri-ictal arterial spin-labelling MRI perfusion in refractory epilepsy
Jitender Saini1, Sarbesh Tiwari2, Sanjib Sinha3, Ravindranadh Chowdary M3, and Raghavendra K3
1Nueroimaging and Interventional Radiology, National Institute of Mental Health and, Bangalore, India, 2Diagnostic and Interventional Radiology, All India Institute of Medical Sciences,, Jodhpur, India, 3Neurology, National Institute of Mental Health and, Bangalore, India
In this study, we have reported that ASL perfusion could be incorporated into the presurgical evaluation of all patients with localisation related epilepsy as it may reveal seizure induced alteration in brain perfusion and may help identifying the location and extent of the epileptogenic zone.   
Figure 1: The first row demonstrate the video-EEG (Image a.) showed ictal onset from the left frontocentral region. Second row- The sMRI images [(b, c)- axial & (d)- coronal] was interpreted as normal on consensus. ASL-T1MPRAGE coregistered images [(e, f) axial and (g) coronal] revealed hyperperfusion along left cerebral hemisphere with increased perfusion predominantly at left frontal and temporal lobes. Thus, though structural MRI was normal, the seizure could be lateralized both on ASL and video-EEG