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Characterization of Brain Tumors using Amide Proton and Nuclear Overhauser Effect at 3 Tesla MR Scanner.
Yuki Kanazawa1, Masafumi Harada1, Mitsuharu Miyoshi2, Takashi Abe1, Yuki Matsumoto1, and Yasushi Takagi3
1Tokushima University, Tokushima, Japan, 2Global MR Applications and Workflow, GE Healthcare Japan, Hino, Japan, 3Department of Neurosurgery, Tokushima University, Tokushima, Japan
CEST imaging with multi-pool Bloch equation model was demonstrated for brain tumors. Distinguishing APT to NOE signal may lead to more detailed characteristics of metabolism in brain tumors than that of MTRasym analysis.
Fig. 4 A 70-year-old male with glioblastoma WHO grade IV (patient No. 4). T2w imege, MTRasym at 3-4 ppm, estimated CEST parameters map, and Z-spectrum were shown. Z-spectrum shows at upper-raw of left side. Yellow allows indicate lesion of tumor and a yellow ellipse ROI.
Fig. 2 Scatter plots of mean MTRasym at 3-4 ppm and each estimated parameter of CEST for each brain tumor.