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Implementation and optimization of steady state free precession MRI for mapping BBB leakage in mouse brain at 9.4T
Frederick C. Damen1, Steve Zaldua2, Jin Gao3, Weiguo Li3, Leon Tai2, and Kejia Cai1
1Radiology, University of Illinois at Chicago, CHICAGO, IL, United States, 2Anatomy and Cell Biology, University of Illinois at Chicago, CHICAGO, IL, United States, 3Research Resources Center, University of Illinois at Chicago, CHICAGO, IL, United States
In this study we successfully implemented steady state free precession fast imaging for the measurement of the BBB leakage in mouse brain at 9.4T.
Figure 3 Representative ΔM maps (a.u.) at 400ms with b‑values of a) 0 and b) 50 μm2/ms, and c) corresponding relative permeability map, d) Slice selected IR SSFP.
Figure 2 Representative rCBF maps. a) sample inversion time vs signal (bipolar corrected), b) rCBF at maximal contrast (x in graph a), c) time at maximal contrast (x in graph a), d) rCBF at 400ms (+ in graph a).