1997

Ketamine modulation of Cerebro-Cerebellar Circuitry During Response Inhibition in Major Depression

Joana R. A. Loureiro¹, Ashish K. Sahib¹, Megha Vasavada¹, Antoni Kubicki¹, Shantanu Joshi¹, Benjamin Wade¹, Amber Leaver², Roger Woods¹, Randall Espinoza³, and Katherine Narr¹
¹Neurology, Ahamason-Lovelace Brain Mapping Center, UCLA, Los Angeles, CA, United States, ²Radiology, Center for Translational Imaging, Northwestern University, Chicago, IL, United States, ³Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, United States

Serial-ketamine reduces functional connectivity between the cerebellum and the default and somatomotor networks during response inhibition, highlighting the role of this circuitry in MDD and its treatment.

PPI analysis using DAN-seed1. A) DAN-seed1 mapped into cerebellum surface; B) Radar-plot representing the mean PPI betas obtained between the DAN-seed1 and the 5 selected networks for MDD patients (at T1,T2,T3) and for HC. C) Mean PPI betas for DAN-seed1 to DMN for HC and MDD; D,E) Mean PPI betas for DAN-seed1 to DMN-nodes: posterior cingulate(D), Inferior parietal(E), for HC and MDD patients; F) Mean PPI betas for DAN-seed1 to SOM, for HC and for responders and non-responders; G) Mean PPI betas for DAN-seed1 to motor cortex (SOM-node), for HC and for responders and non-responders.

PPI seeds and target ROIs. A, B) Average zstat maps obtained for HC and MDD at T1 for the response-inhibition task fMRI NoGo-Go contrast mapped on the cerebellum surface (A) and in cortical and subcortical regions (B); C,D) Cole-Anticevic network Atlas adapted from [11] mapped on the cerebellar surface (C) and for cortical and subcortical regions (D); E,F) Final ROIs obtained from the overlap between the map in A,B and selected networks in C,D. Resulting ROIs located in the cerebellum were used as seeds (E) and the ROIs obtained in the cerebrum were used as targets (F) for the PPI analysis.