1998

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Single and repeated ketamine treatment induces perfusion changes in sensory and limbic networks in major depressive disorder

Ashish Kaul Sahib¹, Joana Loureiro¹, Megha Vasavada¹, Antoni Kubicki¹, Shantanu H Joshi¹, Kai Wang², Roger P Woods¹, Eliza Congdon¹, Danny J.J. Wang², Michael Boucher¹, Randall Espinoza¹, and Katherine L Narr¹
¹UCLA, Los Angeles, CA, United States, ²University of Southern California, Los Angeles, CA, United States

Initial changes in blood flow are observed in the posterior cingulate and higher order visual areas after subanesthetic ketamine administration. However, repeated exposure to ketamine appears to engage deeper limbic structures and insula.

Effect of ketamine treatment after first infusion (TP2vsTP1). Clusters in red correspond to p<0.01, while clusters in yellow correspond to TFCE correction results (FWE, p<0.05).

CBF change after fourth infusion of ketamine (TP1vsTP3) (p<0.01, uncorrected). The bar plots represent the average CBF in the bilateral hippocampus and right insula across ketamine treatment.