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In Vivo Effect of Gadolinium-Based Contrast Agent on PET Quantification for Breast Imaging
Timothy J Allen1, Leah C Henze Bancroft2, Manoj Kumar2, Tyler Bradshaw2, Roberta M Strigel1,2,3, Alan McMillan1,2, and Amy M Fowler1,2,3
1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, United States
SUVmean and SUVmax values in breast cancers, benign fibroglandular tissue, descending aorta, and liver did not change following injection of a gadolinium-based contrast agent. These results suggest that GBCAs are unlikely to affect PET quantitation in simultaneous PET/MR breast imaging.
Figure 2: SUVmean and SUVmax in known breast cancers does not significantly change following administration of a gadolinium based contrast agent.
Figure 1: PET images pre- and post-injection of a gadolinium based contrast agent demonstrating FDG uptake in a biopsy-proven breast cancer in the posterior left breast. No visual change can be perceived between pre-contrast images and post-contrast images. 30 second dynamic reconstructions of PET data are shown for a pre-contrast frame and 2 post-contrast frames.