Selin Ekici1 and Candace C. Fleischer1
1Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States
1Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States
Utilizing ex
vivo 1H HRMAS NMR and immunoassays to study tumor metabolism and
inflammation in gliomas, IL-8, IL-1B, IL-6, IL-1A, and TNF-α were positively
associated with glutamine, glutathione, and lactate. C-reactive protein was
positively associated with myo-inositol and aspartate.
Figure
1. Schematic
representing the relationship between inflammation and metabolic dysregulation
in the tumor microenvironment.
Figure 2. Significant
associations between tumor metabolite concentrations and the first principal component.
PC-1 contains contributions from IL-1A, IL-1B, IL-6, IL-8, and TNF-α.
