ISMRM20 Educational: Emerging Methods for Imaging the Glymphatic System

Educational Course

Emerging Methods for Imaging the Glymphatic System

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Session Topic: CSF flow & Glymphatic Imaging

Session Sub-Topic: Emerging Methods for Imaging the Glymphatic System

Weekday Course

ORGANIZERS: Thomas Okell, Krishna Nayak

Tuesday Parallel 2 Live Q&A

Tuesday, 11 August 2020, 15:15 - 16:00 UTC

Moderators: Lydiane Hirschler

Skill Level: Intermediate

Session Number: W-04

Overview
The glymphatic system has recently been proposed as a mechanism through which the brain can remove waste products via perivascular channels, and its dysfunction is implicated in a range of conditions, including Alzheimer's disease. In this course, we will explore some exciting new methods for imaging the function of the glymphatic system, from invasive contrast-agent injections through to non-invasive approaches.

Target Audience
Clinicians and scientists interested in the glymphatic system.

Educational Objectives
As a result of attending this course, participants should be able to:
- Outline a set of different approaches for imaging the glymphatic system with MRI;
- Explain what aspect of the glymphatic system each approach is sensitive to; and
- Compare the advantages and disadvantages of different glymphatic imaging techniques.

		Contrast Agent-Based Methods for Visualizing Glymphatic System Toshiaki Taoka Watch the Video The glymphatic system hypothesis is a concept associated with the dynamics of cerebrospinal fluid and interstitial fluid in the central nervous system. Tracer studies are one of the most efficient methods to visualize or evaluate mass transport systems in the living body. Tracer study using gadolinium based contrast agent is a method that provides tomographic images and evaluation of the whole brain which can be also applied to human subjects.
		Non-Invasive Approaches Yolanda Ohene Watch the Video Emerging non-invasive imaging approaches have been developed to investigate aspects of the glymphatic system. Many of these techniques have potential as clinical tools to better understand the human glymphatic system in health and disease. In this lecture, I will review these emerging non-invasive techniques and how they have been applied to probe the glymphatic system.