Educational Course
Imaging Perivascular Spaces in the Brain
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Session Topic: CSF flow & Glymphatic Imaging
Session Sub-Topic: Imaging Perivascular Spaces in the Brain
Weekday Course
ORGANIZERS: Nivedita Agarwal, Anja van der Kolk, C. C. Tchoyoson Lim
| Tuesday Parallel 2 Live Q&A | Tuesday, 11 August 2020, 15:15 - 16:00 UTC | Moderators: Lydiane Hirschler |
Skill Level: Basic to Advanced
Session Number: W-06
Overview
In recent years, new evidence has emerged for a role of perivascular spaces in several neurological disorders, including neuroinflammatory and neurodegenerative diseases. The perivascular spaces of patients with these disorders appear enlarged and dilated, which may be a promising biomarker for underlying damage to brain drain mechanisms in these patients. Perivascular spaces contain CSF and are important for the drainage of solutes. This course, part 1 of the "Neurofluids" Educational session, will discuss the anatomy and physiology of perivascular spaces, as well as provide insight into their role in neurological disorders. After a 30-minute break, this session will be followed by a review of emerging methods for imaging the glymphatic system, which is intricately linked to perivascular spaces.
Target Audience
Clinicians and (neuro)scientists interested in the emerging functions of the perivascular spaces and their role in neurological disorders.
Educational Objectives
As a result of attending this course, participants should be able to:
- Explain the anatomy and physiology of perivascular spaces (PVS);
- Assess interactive fluid dynamics within the skull; and
- Articulate the functional significance of dilated PVS (DPVS) in neurological disorders.
| Zooming In on Perivascular Spaces: Brain
Nivedita Agarwal, Roxana Carare
Perivascular spaces are fluid filled spaces around cerebral arterioles in the brain parenchyma. They play an important role in the exchange and drainage of interstitial fluid through mechanisms such as intramural periarterial drainage pathway and the glymphatic system. Such processes may fail and accelerate neurodegeneration in the brain. Neuroimaging methods are still lacking in advancing our knowledge of how exchange and drainage of solutes occurs through these spaces in the brain.
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| Interstitial Fluid Dynamics: A Mathematical Approach
Lynne Bilston
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| Perivascular Spaces & Neurodegeneration
Matt Paradise
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