Maria A. Fernandez-Seara

The objective of this talk is to introduce the methodology of ASL data acquisition and analysis. Upon attendance, the audience should have a basic understanding of the technique and be able to choose the most adequate pulse sequence for a particular clinical application and the most appropriate acquisition parameters.

Sophie Schmid

Shalini Amukotuwa

Amit Mehndiratta

Perfusion imaging using dynamic susceptibility contrast MRI is widely used in management of brain ischemia and stroke. It is based on change in T2* effect arising from local field inhomogeneity as the contrast flow from the tissue capillary network. Quantitative analysis is completely based on the mathematical understanding of the underlying capillary network model, either a simplified model based approach or a complex model free methods have been used in literature. There are pros and cons of each method, this lecture will discuss few of these important methods and there benefits and limitations.

Atle Bjørnerud

Jaeseok Park

This lecture is to provide fundamental principles of dynamics contrast enhanced (DCE) magnetic resonance imaging (MRI) from the perspective of acquisition. We will talk about T1-weighted dynamic data acquisition for DCE MRI, dynamic T1 (t) quantification with correction of B1 field inhomogeneities, and conversion of T1 maps to concentrations. We move on to delineation of contrast dynamics with time and discuss why we need to have high spatial and temporal resolution for accurate quantification of perfusion and microvascular permeability. Then, I will introduce some of the state-of-the-art, high resolution DCE MRI methods.

Ka-Loh Li

This educational lecture discusses efforts in making accurate, high-spatial resolution, whole brain coverage microvascular parametric maps and reducing dosage of gadolinium based contrast agents (GBCA), using a newly developed dual-temporal resolution (DTR) DCE-MRI processing technique.

Roh-Eul Yoo

DSC-PWI is dependent on the susceptibility effect caused by paramagnetic gadolinium on T2*-weighted imaging. Dynamic contrast-enhanced (DCE) MR imaging is based on T1 shortening induced by a gadolinium-based contrast bolus passing through tissue. Various quantitative model-based and semiquantitative model-free pharmacokinetic parameters, that reflect microcirculatory structure and function, can be derived using the technique. This lecture will focus on the clinical applications of the contrast-based perfusion-weighted imaging techniques in neuroimaging (e.g. tumor, stroke, seizure).