ISMRM21 - Macromolecular Proton Fraction (MPF): An Emerging Quantitative Myelin Biomarker for Preclinical & Clinical Studies

Macromolecular Proton Fraction (MPF): An Emerging Quantitative Myelin Biomarker for Preclinical & Clinical Studies

Member-Initiated Symposium

Tuesday, 18 May 2021

Concurrent 8

16:00 - 18:00

Moderators: Anna Naumova & Vasily Yarnykh

Session Number: MIS-10

Parent Session: Macromolecular Proton Fraction (MPF): An Emerging Quantitative Myelin Biomarker for Preclinical & Clinical Studies

Session Number:MIS-10

Organizers
Anna Naumova, Vasily Yarnykh

Overview
The development of imaging methods for quantitative assessment of myelin has been an area of active research for more than decade. Macromolecular proton fraction (MPF), a parameter derived from magnetization transfer (MT) imaging has received particular attention as a myelin biomarker validated by a number of histological studies in animal models. A recently developed fast MPF mapping methodology revealed the opportunity of clinical translation of MPF measurements providing a simple and robust tool for myelin imaging. Fast MPF mapping offers several practical advantages including high-resolution neuroanatomical applications, independence of magnetic field strength, high reproducibility, insensitivity to confounders associated with tissue relaxation and microstructure, and easy protocol harmonization across MRI equipment of different manufacturers. The proposed symposium is focused on the application of MPF as a myelin biomarker for a broad range of pre-clinical and clinical applications. The symposium properly fits to the ISMRM Annual Meeting content, since the dissemination of novel quantitative MRI methods is of paramount importance for the MRI community. The symposium will contain four lectures followed by open discussion. The lectures will describe the principles of quantitative MT imaging and the technical background of fast MPF mapping, summarize the histological evidence supporting the utility of MPF as a myelin biomarker, and review recent neuroscience applications.

Target Audience
Researchers and clinicians interested in quantitative MRI techniques for neuroscience.

Educational Objectives
As a result of attending this course, participants should be able to:
Upon completion of this course, participants should be able to: - Describe the physical principles of quantitative magnetization transfer MRI; - Identify experimental methodology and reconstruction algorithms for fast clinically targeted mapping of the macromolecular proton fraction (MPF) with the use of commonly available human and animal MRI equipment; - Name the advantages and challenges in the application of MPF as a myelin biomarker in clinical and preclinical studies; and - Recognize state-of-the-art applications of MPF mapping in human brain diseases, animal models, and brain development studies.

			Magnetization Transfer Contrast: Historical Perspective Greg Stanisz Sunnybrook Research Institute
			Fast Macromolecular Proton Fraction Mapping: Physical Principles & Clinical Applications Alexey Samsonov University of Wisconsin – Madison
			Histological Validation & Preclinical Applications of MPF as Myelin Biomarker Marina Khodanovich Tomsk State University
			High-Resolution 3D Macromolecular Proton Fraction Mapping of the Human Brain: A New Tool for Quantitative Neuroscience Neva Corrigan University of Washington