Hui Huang1, Jia Wang1, Miao Zhang2, Wei Liu3, Lihong Tang1, Yibo Zhao4,5, Rong Guo4,5, Yudu Li4,5, Zhi-Pei Liang4,5, Yao Li1, Biao Li2, and Jie Luo1
1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 3Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 4Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Urbana, IL, United States, 5Beckman Institute for Advanced Sciences and Technology, University of Illinois at Urbana Champaign, Urbana, IL, United States
1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 3Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 4Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Urbana, IL, United States, 5Beckman Institute for Advanced Sciences and Technology, University of Illinois at Urbana Champaign, Urbana, IL, United States
We
demonstrated the feasibility and potential of simultaneous PET and 3D high-resolution
MRSI in epilepsy patients.
Our experimental results showed tissue FDG
hypometabolism and decreased NAA in SEEG
diagnosed epileptogenic zone and propagation zone.
Figure 3. Statistical comparison（Mann-Whitney U tests) of gray matter volume change, NAA/Cr, NAA/(Cho+Cr)
and SUVR in the regions that contains EZ/PZ/NIZ. * P < 0.05, ** P <
0.01, *** P < 0.001.
Figure 2. SEEG recordings from patient #4 with TLE arising from left hippocampus.
(A) Examples of ictal discharges around the time of seizure onset; (B) Location
of the SEEG electrodes shown on the 3D brain image.